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Protein

27725_FusoPortal_Gene_1366

Length

355 amino acids

Protein family membership

Aminotransferase class IV (IPR001544)
- Branched-chain aminotransferase (IPR033939)
  - Branched-chain amino acid aminotransferase II (IPR005786)

Homologous superfamilies

Homologous superfamily
5 - 350
Aminotransferase-like, PLP-dependent enzymes (IPR036038)

1 50 100 150 200 250 300 355

Domains and repeats

None predicted.

Detailed signature matches

IPR036038

Aminotransferase-like, PLP-dependent enzymes

SSF56752 (D-aminoac...)

5 - 350

SUPERFAMILY
SSF56752 (D-aminoacid aminotransferase-like PLP-dependent enzymes)

IPR001544

Aminotransferase class IV

PF01063 (Aminotran_4)

68 - 309

Pfam
PF01063 (Aminotran_4)

IPR033939

Branched-chain aminotransferase

cd01557 (BCAT_beta_...)

53 - 341

CDD
cd01557 (BCAT_beta_family)

IPR005786

Branched-chain amino acid aminotransferase II

TIGR01123

41 - 353

TIGRFAMs
TIGR01123 (TIGR01123)
PIRSF006468 (BCAT1)

1 - 355

PIRSF
PIRSF006468 (BCAT1)

no IPR

Unintegrated signatures

G3DSA:3.20.10.10

173 - 349

GENE3D
G3DSA:3.20.10.10 (G3DSA:3.20.10.10)
G3DSA:3.30.47...

1 - 172

GENE3D
G3DSA:3.30.470.10 (G3DSA:3.30.470.10)
PTHR11825 (SUBGROUP...)

4 - 351

PANTHER
PTHR11825 (SUBGROUP IIII AMINOTRANSFERASE)
PTHR11825:SF44 (BRA...)

4 - 351

PANTHER
PTHR11825:SF44 (BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE)

Residue annotation

homodimer interfac...

53S

homodimer interface
53S, 54M, 55N, 56P, 57A, 60V, 61L, 62H, 63Y, 64A, 66E, 68F, 99R, 136R, 138F, 144V, 145A, 146V, 150P, 157I, 196G, 201S, 203I, 207E, 221D
CDD
cd01557 (BCAT_beta_family)

54M

homodimer interface
53S, 54M, 55N, 56P, 57A, 60V, 61L, 62H, 63Y, 64A, 66E, 68F, 99R, 136R, 138F, 144V, 145A, 146V, 150P, 157I, 196G, 201S, 203I, 207E, 221D
CDD
cd01557 (BCAT_beta_family)

55N

homodimer interface
53S, 54M, 55N, 56P, 57A, 60V, 61L, 62H, 63Y, 64A, 66E, 68F, 99R, 136R, 138F, 144V, 145A, 146V, 150P, 157I, 196G, 201S, 203I, 207E, 221D
CDD
cd01557 (BCAT_beta_family)

56P

homodimer interface
53S, 54M, 55N, 56P, 57A, 60V, 61L, 62H, 63Y, 64A, 66E, 68F, 99R, 136R, 138F, 144V, 145A, 146V, 150P, 157I, 196G, 201S, 203I, 207E, 221D
CDD
cd01557 (BCAT_beta_family)

57A

homodimer interface
53S, 54M, 55N, 56P, 57A, 60V, 61L, 62H, 63Y, 64A, 66E, 68F, 99R, 136R, 138F, 144V, 145A, 146V, 150P, 157I, 196G, 201S, 203I, 207E, 221D
CDD
cd01557 (BCAT_beta_family)

60V

homodimer interface
53S, 54M, 55N, 56P, 57A, 60V, 61L, 62H, 63Y, 64A, 66E, 68F, 99R, 136R, 138F, 144V, 145A, 146V, 150P, 157I, 196G, 201S, 203I, 207E, 221D
CDD
cd01557 (BCAT_beta_family)

61L

homodimer interface
53S, 54M, 55N, 56P, 57A, 60V, 61L, 62H, 63Y, 64A, 66E, 68F, 99R, 136R, 138F, 144V, 145A, 146V, 150P, 157I, 196G, 201S, 203I, 207E, 221D
CDD
cd01557 (BCAT_beta_family)

62H

homodimer interface
53S, 54M, 55N, 56P, 57A, 60V, 61L, 62H, 63Y, 64A, 66E, 68F, 99R, 136R, 138F, 144V, 145A, 146V, 150P, 157I, 196G, 201S, 203I, 207E, 221D
CDD
cd01557 (BCAT_beta_family)

63Y

homodimer interface
53S, 54M, 55N, 56P, 57A, 60V, 61L, 62H, 63Y, 64A, 66E, 68F, 99R, 136R, 138F, 144V, 145A, 146V, 150P, 157I, 196G, 201S, 203I, 207E, 221D
CDD
cd01557 (BCAT_beta_family)

64A

homodimer interface
53S, 54M, 55N, 56P, 57A, 60V, 61L, 62H, 63Y, 64A, 66E, 68F, 99R, 136R, 138F, 144V, 145A, 146V, 150P, 157I, 196G, 201S, 203I, 207E, 221D
CDD
cd01557 (BCAT_beta_family)

66E

homodimer interface
53S, 54M, 55N, 56P, 57A, 60V, 61L, 62H, 63Y, 64A, 66E, 68F, 99R, 136R, 138F, 144V, 145A, 146V, 150P, 157I, 196G, 201S, 203I, 207E, 221D
CDD
cd01557 (BCAT_beta_family)

68F

homodimer interface
53S, 54M, 55N, 56P, 57A, 60V, 61L, 62H, 63Y, 64A, 66E, 68F, 99R, 136R, 138F, 144V, 145A, 146V, 150P, 157I, 196G, 201S, 203I, 207E, 221D
CDD
cd01557 (BCAT_beta_family)

99R

homodimer interface
53S, 54M, 55N, 56P, 57A, 60V, 61L, 62H, 63Y, 64A, 66E, 68F, 99R, 136R, 138F, 144V, 145A, 146V, 150P, 157I, 196G, 201S, 203I, 207E, 221D
CDD
cd01557 (BCAT_beta_family)

136R

homodimer interface
53S, 54M, 55N, 56P, 57A, 60V, 61L, 62H, 63Y, 64A, 66E, 68F, 99R, 136R, 138F, 144V, 145A, 146V, 150P, 157I, 196G, 201S, 203I, 207E, 221D
CDD
cd01557 (BCAT_beta_family)

138F

homodimer interface
53S, 54M, 55N, 56P, 57A, 60V, 61L, 62H, 63Y, 64A, 66E, 68F, 99R, 136R, 138F, 144V, 145A, 146V, 150P, 157I, 196G, 201S, 203I, 207E, 221D
CDD
cd01557 (BCAT_beta_family)

144V

homodimer interface
53S, 54M, 55N, 56P, 57A, 60V, 61L, 62H, 63Y, 64A, 66E, 68F, 99R, 136R, 138F, 144V, 145A, 146V, 150P, 157I, 196G, 201S, 203I, 207E, 221D
CDD
cd01557 (BCAT_beta_family)

145A

homodimer interface
53S, 54M, 55N, 56P, 57A, 60V, 61L, 62H, 63Y, 64A, 66E, 68F, 99R, 136R, 138F, 144V, 145A, 146V, 150P, 157I, 196G, 201S, 203I, 207E, 221D
CDD
cd01557 (BCAT_beta_family)

146V

homodimer interface
53S, 54M, 55N, 56P, 57A, 60V, 61L, 62H, 63Y, 64A, 66E, 68F, 99R, 136R, 138F, 144V, 145A, 146V, 150P, 157I, 196G, 201S, 203I, 207E, 221D
CDD
cd01557 (BCAT_beta_family)

150P

homodimer interface
53S, 54M, 55N, 56P, 57A, 60V, 61L, 62H, 63Y, 64A, 66E, 68F, 99R, 136R, 138F, 144V, 145A, 146V, 150P, 157I, 196G, 201S, 203I, 207E, 221D
CDD
cd01557 (BCAT_beta_family)

157I

homodimer interface
53S, 54M, 55N, 56P, 57A, 60V, 61L, 62H, 63Y, 64A, 66E, 68F, 99R, 136R, 138F, 144V, 145A, 146V, 150P, 157I, 196G, 201S, 203I, 207E, 221D
CDD
cd01557 (BCAT_beta_family)

196G

homodimer interface
53S, 54M, 55N, 56P, 57A, 60V, 61L, 62H, 63Y, 64A, 66E, 68F, 99R, 136R, 138F, 144V, 145A, 146V, 150P, 157I, 196G, 201S, 203I, 207E, 221D
CDD
cd01557 (BCAT_beta_family)

201S

homodimer interface
53S, 54M, 55N, 56P, 57A, 60V, 61L, 62H, 63Y, 64A, 66E, 68F, 99R, 136R, 138F, 144V, 145A, 146V, 150P, 157I, 196G, 201S, 203I, 207E, 221D
CDD
cd01557 (BCAT_beta_family)

203I

homodimer interface
53S, 54M, 55N, 56P, 57A, 60V, 61L, 62H, 63Y, 64A, 66E, 68F, 99R, 136R, 138F, 144V, 145A, 146V, 150P, 157I, 196G, 201S, 203I, 207E, 221D
CDD
cd01557 (BCAT_beta_family)

207E

homodimer interface
53S, 54M, 55N, 56P, 57A, 60V, 61L, 62H, 63Y, 64A, 66E, 68F, 99R, 136R, 138F, 144V, 145A, 146V, 150P, 157I, 196G, 201S, 203I, 207E, 221D
CDD
cd01557 (BCAT_beta_family)

221D

homodimer interface
53S, 54M, 55N, 56P, 57A, 60V, 61L, 62H, 63Y, 64A, 66E, 68F, 99R, 136R, 138F, 144V, 145A, 146V, 150P, 157I, 196G, 201S, 203I, 207E, 221D
CDD
cd01557 (BCAT_beta_family)
substrate-cofactor...

63Y

substrate-cofactor binding pocket
63Y, 68F, 92R, 148V, 194K, 199Y, 230E, 257V, 258T, 300T
CDD
cd01557 (BCAT_beta_family)

68F

substrate-cofactor binding pocket
63Y, 68F, 92R, 148V, 194K, 199Y, 230E, 257V, 258T, 300T
CDD
cd01557 (BCAT_beta_family)

92R

substrate-cofactor binding pocket
63Y, 68F, 92R, 148V, 194K, 199Y, 230E, 257V, 258T, 300T
CDD
cd01557 (BCAT_beta_family)

148V

substrate-cofactor binding pocket
63Y, 68F, 92R, 148V, 194K, 199Y, 230E, 257V, 258T, 300T
CDD
cd01557 (BCAT_beta_family)

194K

substrate-cofactor binding pocket
63Y, 68F, 92R, 148V, 194K, 199Y, 230E, 257V, 258T, 300T
CDD
cd01557 (BCAT_beta_family)

199Y

substrate-cofactor binding pocket
63Y, 68F, 92R, 148V, 194K, 199Y, 230E, 257V, 258T, 300T
CDD
cd01557 (BCAT_beta_family)

230E

substrate-cofactor binding pocket
63Y, 68F, 92R, 148V, 194K, 199Y, 230E, 257V, 258T, 300T
CDD
cd01557 (BCAT_beta_family)

257V

substrate-cofactor binding pocket
63Y, 68F, 92R, 148V, 194K, 199Y, 230E, 257V, 258T, 300T
CDD
cd01557 (BCAT_beta_family)

258T

substrate-cofactor binding pocket
63Y, 68F, 92R, 148V, 194K, 199Y, 230E, 257V, 258T, 300T
CDD
cd01557 (BCAT_beta_family)

300T

substrate-cofactor binding pocket
63Y, 68F, 92R, 148V, 194K, 199Y, 230E, 257V, 258T, 300T
CDD
cd01557 (BCAT_beta_family)
catalytic residue ...

194K

catalytic residue
194K
CDD
cd01557 (BCAT_beta_family)

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0009081 branched-chain amino acid metabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0004084 branched-chain-amino-acid transaminase activity

Cellular Component