27725_FusoPortal_Gene_1467

Protein

27725_FusoPortal_Gene_1467

Length

387 amino acids

Protein family membership

Cys/Met metabolism, pyridoxal phosphate-dependent enzyme (IPR000277)

Homologous superfamilies

Homologous superfamily
6 - 258
Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (IPR015421)
260 - 387
Pyridoxal phosphate-dependent transferase, subdomain 2 (IPR015422)
Homologous superfamily
29 - 382
Pyridoxal phosphate-dependent transferase (IPR015424)

1 50 100 150 200 250 300 350 387

Domains and repeats

None predicted.

Detailed signature matches

IPR015421

Pyridoxal phosphate-dependent transferase, major region, subdomain 1
1. G3DSA:3.40.64...
  
  6 - 258
  
  GENE3D
  G3DSA:3.40.640.10 (G3DSA:3.40.640.10)
IPR015424

Pyridoxal phosphate-dependent transferase
1. SSF53383 (PLP-depen...)
  
  29 - 382
  
  SUPERFAMILY
  SSF53383 (PLP-dependent transferases)
IPR015422

Pyridoxal phosphate-dependent transferase, subdomain 2
1. G3DSA:3.90.11...
  
  260 - 387
  
  GENE3D
  G3DSA:3.90.1150.10 (G3DSA:3.90.1150.10)
IPR000277

Cys/Met metabolism, pyridoxal phosphate-dependent enzyme
1. cd00614 (CGS_like)
  
  25 - 380
  
  CDD
  cd00614 (CGS_like)
2. PTHR11808 (TRANS-SU...)
  
  6 - 381
  
  PANTHER
  PTHR11808 (TRANS-SULFURATION ENZYME FAMILY MEMBER)
3. PIRSF001434 (CGS)
  
  1 - 383
  
  PIRSF
  PIRSF001434 (CGS)
4. PS00868 (CYS_MET_ME...)
  
  199 - 213
  
  PROSITE patterns
  PS00868 (CYS_MET_METAB_PP)
5. PF01053 (Cys_Met_Me...)
  
  9 - 352
  
  Pfam
  PF01053 (Cys_Met_Meta_PP)

no IPR

Unintegrated signatures

PTHR11808:SF72 (CYS...)

6 - 381

PANTHER
PTHR11808:SF72 (CYSTATHIONINE BETA LYASE)

Residue annotation

homodimer interfac...

32Q

homodimer interface
32Q, 33T, 34A, 35T, 37G, 38A, 55Y, 57R, 83S, 84S, 86M, 87G, 110F, 115L, 118K, 206T, 214D, 216I, 232W, 244A, 246M, 247T, 333N
CDD
cd00614 (CGS_like)

33T

homodimer interface
32Q, 33T, 34A, 35T, 37G, 38A, 55Y, 57R, 83S, 84S, 86M, 87G, 110F, 115L, 118K, 206T, 214D, 216I, 232W, 244A, 246M, 247T, 333N
CDD
cd00614 (CGS_like)

34A

homodimer interface
32Q, 33T, 34A, 35T, 37G, 38A, 55Y, 57R, 83S, 84S, 86M, 87G, 110F, 115L, 118K, 206T, 214D, 216I, 232W, 244A, 246M, 247T, 333N
CDD
cd00614 (CGS_like)

35T

homodimer interface
32Q, 33T, 34A, 35T, 37G, 38A, 55Y, 57R, 83S, 84S, 86M, 87G, 110F, 115L, 118K, 206T, 214D, 216I, 232W, 244A, 246M, 247T, 333N
CDD
cd00614 (CGS_like)

37G

homodimer interface
32Q, 33T, 34A, 35T, 37G, 38A, 55Y, 57R, 83S, 84S, 86M, 87G, 110F, 115L, 118K, 206T, 214D, 216I, 232W, 244A, 246M, 247T, 333N
CDD
cd00614 (CGS_like)

38A

homodimer interface
32Q, 33T, 34A, 35T, 37G, 38A, 55Y, 57R, 83S, 84S, 86M, 87G, 110F, 115L, 118K, 206T, 214D, 216I, 232W, 244A, 246M, 247T, 333N
CDD
cd00614 (CGS_like)

55Y

homodimer interface
32Q, 33T, 34A, 35T, 37G, 38A, 55Y, 57R, 83S, 84S, 86M, 87G, 110F, 115L, 118K, 206T, 214D, 216I, 232W, 244A, 246M, 247T, 333N
CDD
cd00614 (CGS_like)

57R

homodimer interface
32Q, 33T, 34A, 35T, 37G, 38A, 55Y, 57R, 83S, 84S, 86M, 87G, 110F, 115L, 118K, 206T, 214D, 216I, 232W, 244A, 246M, 247T, 333N
CDD
cd00614 (CGS_like)

83S

homodimer interface
32Q, 33T, 34A, 35T, 37G, 38A, 55Y, 57R, 83S, 84S, 86M, 87G, 110F, 115L, 118K, 206T, 214D, 216I, 232W, 244A, 246M, 247T, 333N
CDD
cd00614 (CGS_like)

84S

homodimer interface
32Q, 33T, 34A, 35T, 37G, 38A, 55Y, 57R, 83S, 84S, 86M, 87G, 110F, 115L, 118K, 206T, 214D, 216I, 232W, 244A, 246M, 247T, 333N
CDD
cd00614 (CGS_like)

86M

homodimer interface
32Q, 33T, 34A, 35T, 37G, 38A, 55Y, 57R, 83S, 84S, 86M, 87G, 110F, 115L, 118K, 206T, 214D, 216I, 232W, 244A, 246M, 247T, 333N
CDD
cd00614 (CGS_like)

87G

homodimer interface
32Q, 33T, 34A, 35T, 37G, 38A, 55Y, 57R, 83S, 84S, 86M, 87G, 110F, 115L, 118K, 206T, 214D, 216I, 232W, 244A, 246M, 247T, 333N
CDD
cd00614 (CGS_like)

110F

homodimer interface
32Q, 33T, 34A, 35T, 37G, 38A, 55Y, 57R, 83S, 84S, 86M, 87G, 110F, 115L, 118K, 206T, 214D, 216I, 232W, 244A, 246M, 247T, 333N
CDD
cd00614 (CGS_like)

115L

homodimer interface
32Q, 33T, 34A, 35T, 37G, 38A, 55Y, 57R, 83S, 84S, 86M, 87G, 110F, 115L, 118K, 206T, 214D, 216I, 232W, 244A, 246M, 247T, 333N
CDD
cd00614 (CGS_like)

118K

homodimer interface
32Q, 33T, 34A, 35T, 37G, 38A, 55Y, 57R, 83S, 84S, 86M, 87G, 110F, 115L, 118K, 206T, 214D, 216I, 232W, 244A, 246M, 247T, 333N
CDD
cd00614 (CGS_like)

206T

homodimer interface
32Q, 33T, 34A, 35T, 37G, 38A, 55Y, 57R, 83S, 84S, 86M, 87G, 110F, 115L, 118K, 206T, 214D, 216I, 232W, 244A, 246M, 247T, 333N
CDD
cd00614 (CGS_like)

214D

homodimer interface
32Q, 33T, 34A, 35T, 37G, 38A, 55Y, 57R, 83S, 84S, 86M, 87G, 110F, 115L, 118K, 206T, 214D, 216I, 232W, 244A, 246M, 247T, 333N
CDD
cd00614 (CGS_like)

216I

homodimer interface
32Q, 33T, 34A, 35T, 37G, 38A, 55Y, 57R, 83S, 84S, 86M, 87G, 110F, 115L, 118K, 206T, 214D, 216I, 232W, 244A, 246M, 247T, 333N
CDD
cd00614 (CGS_like)

232W

homodimer interface
32Q, 33T, 34A, 35T, 37G, 38A, 55Y, 57R, 83S, 84S, 86M, 87G, 110F, 115L, 118K, 206T, 214D, 216I, 232W, 244A, 246M, 247T, 333N
CDD
cd00614 (CGS_like)

244A

homodimer interface
32Q, 33T, 34A, 35T, 37G, 38A, 55Y, 57R, 83S, 84S, 86M, 87G, 110F, 115L, 118K, 206T, 214D, 216I, 232W, 244A, 246M, 247T, 333N
CDD
cd00614 (CGS_like)

246M

homodimer interface
32Q, 33T, 34A, 35T, 37G, 38A, 55Y, 57R, 83S, 84S, 86M, 87G, 110F, 115L, 118K, 206T, 214D, 216I, 232W, 244A, 246M, 247T, 333N
CDD
cd00614 (CGS_like)

247T

homodimer interface
32Q, 33T, 34A, 35T, 37G, 38A, 55Y, 57R, 83S, 84S, 86M, 87G, 110F, 115L, 118K, 206T, 214D, 216I, 232W, 244A, 246M, 247T, 333N
CDD
cd00614 (CGS_like)

333N

homodimer interface
32Q, 33T, 34A, 35T, 37G, 38A, 55Y, 57R, 83S, 84S, 86M, 87G, 110F, 115L, 118K, 206T, 214D, 216I, 232W, 244A, 246M, 247T, 333N
CDD
cd00614 (CGS_like)
pyridoxal 5'-phosp...

84S

pyridoxal 5'-phosphate binding site
84S, 85G, 86M, 110F, 182D, 185F, 204S, 206T, 207K
CDD
cd00614 (CGS_like)

85G

pyridoxal 5'-phosphate binding site
84S, 85G, 86M, 110F, 182D, 185F, 204S, 206T, 207K
CDD
cd00614 (CGS_like)

86M

pyridoxal 5'-phosphate binding site
84S, 85G, 86M, 110F, 182D, 185F, 204S, 206T, 207K
CDD
cd00614 (CGS_like)

110F

pyridoxal 5'-phosphate binding site
84S, 85G, 86M, 110F, 182D, 185F, 204S, 206T, 207K
CDD
cd00614 (CGS_like)

182D

pyridoxal 5'-phosphate binding site
84S, 85G, 86M, 110F, 182D, 185F, 204S, 206T, 207K
CDD
cd00614 (CGS_like)

185F

pyridoxal 5'-phosphate binding site
84S, 85G, 86M, 110F, 182D, 185F, 204S, 206T, 207K
CDD
cd00614 (CGS_like)

204S

pyridoxal 5'-phosphate binding site
84S, 85G, 86M, 110F, 182D, 185F, 204S, 206T, 207K
CDD
cd00614 (CGS_like)

206T

pyridoxal 5'-phosphate binding site
84S, 85G, 86M, 110F, 182D, 185F, 204S, 206T, 207K
CDD
cd00614 (CGS_like)

207K

pyridoxal 5'-phosphate binding site
84S, 85G, 86M, 110F, 182D, 185F, 204S, 206T, 207K
CDD
cd00614 (CGS_like)
substrate-cofactor...

84S

substrate-cofactor binding pocket
84S, 85G, 86M, 110F, 153E, 182D, 204S, 206T, 207K, 216I
CDD
cd00614 (CGS_like)

85G

substrate-cofactor binding pocket
84S, 85G, 86M, 110F, 153E, 182D, 204S, 206T, 207K, 216I
CDD
cd00614 (CGS_like)

86M

substrate-cofactor binding pocket
84S, 85G, 86M, 110F, 153E, 182D, 204S, 206T, 207K, 216I
CDD
cd00614 (CGS_like)

110F

substrate-cofactor binding pocket
84S, 85G, 86M, 110F, 153E, 182D, 204S, 206T, 207K, 216I
CDD
cd00614 (CGS_like)

153E

substrate-cofactor binding pocket
84S, 85G, 86M, 110F, 153E, 182D, 204S, 206T, 207K, 216I
CDD
cd00614 (CGS_like)

182D

substrate-cofactor binding pocket
84S, 85G, 86M, 110F, 153E, 182D, 204S, 206T, 207K, 216I
CDD
cd00614 (CGS_like)

204S

substrate-cofactor binding pocket
84S, 85G, 86M, 110F, 153E, 182D, 204S, 206T, 207K, 216I
CDD
cd00614 (CGS_like)

206T

substrate-cofactor binding pocket
84S, 85G, 86M, 110F, 153E, 182D, 204S, 206T, 207K, 216I
CDD
cd00614 (CGS_like)

207K

substrate-cofactor binding pocket
84S, 85G, 86M, 110F, 153E, 182D, 204S, 206T, 207K, 216I
CDD
cd00614 (CGS_like)

216I

substrate-cofactor binding pocket
84S, 85G, 86M, 110F, 153E, 182D, 204S, 206T, 207K, 216I
CDD
cd00614 (CGS_like)
catalytic residue ...

207K

catalytic residue
207K
CDD
cd00614 (CGS_like)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003824 catalytic activity
GO:0030170 pyridoxal phosphate binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

27725_FusoPortal_Gene_1467

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component