27725_FusoPortal_Gene_1536

Protein

27725_FusoPortal_Gene_1536

Length

478 amino acids

Protein family membership

None predicted.

Homologous superfamilies

Homologous superfamily
229 - 310
Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily (IPR036097)
Homologous superfamily
300 - 475
Histidine kinase/HSP90-like ATPase superfamily (IPR036890)

1 50 100 150 200 250 300 350 400 450 478

Domains and repeats

Domain
170 - 222
HAMP domain (IPR003660)
242 - 310
Signal transduction histidine kinase, dimerisation/phosphoacceptor domain (IPR003661)
352 - 457
Histidine kinase/HSP90-like ATPase (IPR003594)
Domain
251 - 461
Histidine kinase domain (IPR005467)

1 50 100 150 200 250 300 350 400 450 478

Detailed signature matches

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily
1. SSF47384 (Homodimer...)
  
  229 - 310
  
  SUPERFAMILY
  SSF47384 (Homodimeric domain of signal transducing histidine kinase)
IPR036890

Histidine kinase/HSP90-like ATPase superfamily
1. G3DSA:3.30.56...
  
  313 - 475
  
  GENE3D
  G3DSA:3.30.565.10 (G3DSA:3.30.565.10)
2. SSF55874 (ATPase do...)
  
  300 - 457
  
  SUPERFAMILY
  SSF55874 (ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase)
IPR003660

HAMP domain
1. PS50885 (HAMP)
  
  170 - 222
  
  PROSITE profiles
  PS50885 (HAMP)
2. cd06225 (HAMP)
  
  172 - 219
  
  CDD
  cd06225 (HAMP)
3. PF00672 (HAMP)
  
  172 - 218
  
  Pfam
  PF00672 (HAMP)
IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain
1. cd00082 (HisKA)
  
  242 - 306
  
  CDD
  cd00082 (HisKA)
2. PF00512 (HisKA)
  
  245 - 310
  
  Pfam
  PF00512 (HisKA)
IPR005467

Histidine kinase domain
1. PS50109 (HIS_KIN)
  
  251 - 461
  
  PROSITE profiles
  PS50109 (HIS_KIN)
IPR003594

Histidine kinase/HSP90-like ATPase
1. PF02518 (HATPase_c)
  
  352 - 457
  
  Pfam
  PF02518 (HATPase_c)
2. cd00075 (HATPase_c)
  
  356 - 457
  
  CDD
  cd00075 (HATPase_c)

no IPR

Unintegrated signatures

Coil

210 - 241

COILS
Coil (Coil)
G3DSA:1.10.28...

250 - 306

GENE3D
G3DSA:1.10.287.130 (G3DSA:1.10.287.130)
G3DSA:3.30.45...

209 - 249

GENE3D
G3DSA:3.30.450.20 (G3DSA:3.30.450.20)
PTHR42878 (FAMILY N...)

2 - 460

PANTHER
PTHR42878 (FAMILY NOT NAMED)
PTHR42878:SF3 (SUBF...)

2 - 460

PANTHER
PTHR42878:SF3 (SUBFAMILY NOT NAMED)
SSF158472 (HAMP dom...)

172 - 221

SUPERFAMILY
SSF158472 (HAMP domain-like)

Residue annotation

dimerization inter...

172M

dimerization interface
172M, 173T, 176I, 177L, 179I, 180K, 183T, 184Q, 186I, 202E, 203I, 205E, 206L, 209A, 210I, 212R, 213M, 216T, 217L
CDD
cd06225 (HAMP)

173T

dimerization interface
172M, 173T, 176I, 177L, 179I, 180K, 183T, 184Q, 186I, 202E, 203I, 205E, 206L, 209A, 210I, 212R, 213M, 216T, 217L
CDD
cd06225 (HAMP)

176I

dimerization interface
172M, 173T, 176I, 177L, 179I, 180K, 183T, 184Q, 186I, 202E, 203I, 205E, 206L, 209A, 210I, 212R, 213M, 216T, 217L
CDD
cd06225 (HAMP)

177L

dimerization interface
172M, 173T, 176I, 177L, 179I, 180K, 183T, 184Q, 186I, 202E, 203I, 205E, 206L, 209A, 210I, 212R, 213M, 216T, 217L
CDD
cd06225 (HAMP)

179I

dimerization interface
172M, 173T, 176I, 177L, 179I, 180K, 183T, 184Q, 186I, 202E, 203I, 205E, 206L, 209A, 210I, 212R, 213M, 216T, 217L
CDD
cd06225 (HAMP)

180K

dimerization interface
172M, 173T, 176I, 177L, 179I, 180K, 183T, 184Q, 186I, 202E, 203I, 205E, 206L, 209A, 210I, 212R, 213M, 216T, 217L
CDD
cd06225 (HAMP)

183T

dimerization interface
172M, 173T, 176I, 177L, 179I, 180K, 183T, 184Q, 186I, 202E, 203I, 205E, 206L, 209A, 210I, 212R, 213M, 216T, 217L
CDD
cd06225 (HAMP)

184Q

dimerization interface
172M, 173T, 176I, 177L, 179I, 180K, 183T, 184Q, 186I, 202E, 203I, 205E, 206L, 209A, 210I, 212R, 213M, 216T, 217L
CDD
cd06225 (HAMP)

186I

dimerization interface
172M, 173T, 176I, 177L, 179I, 180K, 183T, 184Q, 186I, 202E, 203I, 205E, 206L, 209A, 210I, 212R, 213M, 216T, 217L
CDD
cd06225 (HAMP)

202E

dimerization interface
172M, 173T, 176I, 177L, 179I, 180K, 183T, 184Q, 186I, 202E, 203I, 205E, 206L, 209A, 210I, 212R, 213M, 216T, 217L
CDD
cd06225 (HAMP)

203I

dimerization interface
172M, 173T, 176I, 177L, 179I, 180K, 183T, 184Q, 186I, 202E, 203I, 205E, 206L, 209A, 210I, 212R, 213M, 216T, 217L
CDD
cd06225 (HAMP)

205E

dimerization interface
172M, 173T, 176I, 177L, 179I, 180K, 183T, 184Q, 186I, 202E, 203I, 205E, 206L, 209A, 210I, 212R, 213M, 216T, 217L
CDD
cd06225 (HAMP)

206L

dimerization interface
172M, 173T, 176I, 177L, 179I, 180K, 183T, 184Q, 186I, 202E, 203I, 205E, 206L, 209A, 210I, 212R, 213M, 216T, 217L
CDD
cd06225 (HAMP)

209A

dimerization interface
172M, 173T, 176I, 177L, 179I, 180K, 183T, 184Q, 186I, 202E, 203I, 205E, 206L, 209A, 210I, 212R, 213M, 216T, 217L
CDD
cd06225 (HAMP)

210I

dimerization interface
172M, 173T, 176I, 177L, 179I, 180K, 183T, 184Q, 186I, 202E, 203I, 205E, 206L, 209A, 210I, 212R, 213M, 216T, 217L
CDD
cd06225 (HAMP)

212R

dimerization interface
172M, 173T, 176I, 177L, 179I, 180K, 183T, 184Q, 186I, 202E, 203I, 205E, 206L, 209A, 210I, 212R, 213M, 216T, 217L
CDD
cd06225 (HAMP)

213M

dimerization interface
172M, 173T, 176I, 177L, 179I, 180K, 183T, 184Q, 186I, 202E, 203I, 205E, 206L, 209A, 210I, 212R, 213M, 216T, 217L
CDD
cd06225 (HAMP)

216T

dimerization interface
172M, 173T, 176I, 177L, 179I, 180K, 183T, 184Q, 186I, 202E, 203I, 205E, 206L, 209A, 210I, 212R, 213M, 216T, 217L
CDD
cd06225 (HAMP)

217L

dimerization interface
172M, 173T, 176I, 177L, 179I, 180K, 183T, 184Q, 186I, 202E, 203I, 205E, 206L, 209A, 210I, 212R, 213M, 216T, 217L
CDD
cd06225 (HAMP)
dimer interface cd...

248F

dimer interface
248F, 252V, 256L, 259P, 263I, 266Y, 283Y, 287I, 290E, 294M, 297L, 301L
CDD
cd00082 (HisKA)

252V

dimer interface
248F, 252V, 256L, 259P, 263I, 266Y, 283Y, 287I, 290E, 294M, 297L, 301L
CDD
cd00082 (HisKA)

256L

dimer interface
248F, 252V, 256L, 259P, 263I, 266Y, 283Y, 287I, 290E, 294M, 297L, 301L
CDD
cd00082 (HisKA)

259P

dimer interface
248F, 252V, 256L, 259P, 263I, 266Y, 283Y, 287I, 290E, 294M, 297L, 301L
CDD
cd00082 (HisKA)

263I

dimer interface
248F, 252V, 256L, 259P, 263I, 266Y, 283Y, 287I, 290E, 294M, 297L, 301L
CDD
cd00082 (HisKA)

266Y

dimer interface
248F, 252V, 256L, 259P, 263I, 266Y, 283Y, 287I, 290E, 294M, 297L, 301L
CDD
cd00082 (HisKA)

283Y

dimer interface
248F, 252V, 256L, 259P, 263I, 266Y, 283Y, 287I, 290E, 294M, 297L, 301L
CDD
cd00082 (HisKA)

287I

dimer interface
248F, 252V, 256L, 259P, 263I, 266Y, 283Y, 287I, 290E, 294M, 297L, 301L
CDD
cd00082 (HisKA)

290E

dimer interface
248F, 252V, 256L, 259P, 263I, 266Y, 283Y, 287I, 290E, 294M, 297L, 301L
CDD
cd00082 (HisKA)

294M

dimer interface
248F, 252V, 256L, 259P, 263I, 266Y, 283Y, 287I, 290E, 294M, 297L, 301L
CDD
cd00082 (HisKA)

297L

dimer interface
248F, 252V, 256L, 259P, 263I, 266Y, 283Y, 287I, 290E, 294M, 297L, 301L
CDD
cd00082 (HisKA)

301L

dimer interface
248F, 252V, 256L, 259P, 263I, 266Y, 283Y, 287I, 290E, 294M, 297L, 301L
CDD
cd00082 (HisKA)
phosphorylation si...

254H

phosphorylation site
254H
CDD
cd00082 (HisKA)
ATP binding site c...

362N

ATP binding site
362N, 366N, 369K, 392V, 394N, 396T, 398R, 399L, 424G, 425L, 426G, 427L, 443V, 445F, 450I, 451V, 453F
CDD
cd00075 (HATPase_c)

366N

ATP binding site
362N, 366N, 369K, 392V, 394N, 396T, 398R, 399L, 424G, 425L, 426G, 427L, 443V, 445F, 450I, 451V, 453F
CDD
cd00075 (HATPase_c)

369K

ATP binding site
362N, 366N, 369K, 392V, 394N, 396T, 398R, 399L, 424G, 425L, 426G, 427L, 443V, 445F, 450I, 451V, 453F
CDD
cd00075 (HATPase_c)

392V

ATP binding site
362N, 366N, 369K, 392V, 394N, 396T, 398R, 399L, 424G, 425L, 426G, 427L, 443V, 445F, 450I, 451V, 453F
CDD
cd00075 (HATPase_c)

394N

ATP binding site
362N, 366N, 369K, 392V, 394N, 396T, 398R, 399L, 424G, 425L, 426G, 427L, 443V, 445F, 450I, 451V, 453F
CDD
cd00075 (HATPase_c)

396T

ATP binding site
362N, 366N, 369K, 392V, 394N, 396T, 398R, 399L, 424G, 425L, 426G, 427L, 443V, 445F, 450I, 451V, 453F
CDD
cd00075 (HATPase_c)

398R

ATP binding site
362N, 366N, 369K, 392V, 394N, 396T, 398R, 399L, 424G, 425L, 426G, 427L, 443V, 445F, 450I, 451V, 453F
CDD
cd00075 (HATPase_c)

399L

ATP binding site
362N, 366N, 369K, 392V, 394N, 396T, 398R, 399L, 424G, 425L, 426G, 427L, 443V, 445F, 450I, 451V, 453F
CDD
cd00075 (HATPase_c)

424G

ATP binding site
362N, 366N, 369K, 392V, 394N, 396T, 398R, 399L, 424G, 425L, 426G, 427L, 443V, 445F, 450I, 451V, 453F
CDD
cd00075 (HATPase_c)

425L

ATP binding site
362N, 366N, 369K, 392V, 394N, 396T, 398R, 399L, 424G, 425L, 426G, 427L, 443V, 445F, 450I, 451V, 453F
CDD
cd00075 (HATPase_c)

426G

ATP binding site
362N, 366N, 369K, 392V, 394N, 396T, 398R, 399L, 424G, 425L, 426G, 427L, 443V, 445F, 450I, 451V, 453F
CDD
cd00075 (HATPase_c)

427L

ATP binding site
362N, 366N, 369K, 392V, 394N, 396T, 398R, 399L, 424G, 425L, 426G, 427L, 443V, 445F, 450I, 451V, 453F
CDD
cd00075 (HATPase_c)

443V

ATP binding site
362N, 366N, 369K, 392V, 394N, 396T, 398R, 399L, 424G, 425L, 426G, 427L, 443V, 445F, 450I, 451V, 453F
CDD
cd00075 (HATPase_c)

445F

ATP binding site
362N, 366N, 369K, 392V, 394N, 396T, 398R, 399L, 424G, 425L, 426G, 427L, 443V, 445F, 450I, 451V, 453F
CDD
cd00075 (HATPase_c)

450I

ATP binding site
362N, 366N, 369K, 392V, 394N, 396T, 398R, 399L, 424G, 425L, 426G, 427L, 443V, 445F, 450I, 451V, 453F
CDD
cd00075 (HATPase_c)

451V

ATP binding site
362N, 366N, 369K, 392V, 394N, 396T, 398R, 399L, 424G, 425L, 426G, 427L, 443V, 445F, 450I, 451V, 453F
CDD
cd00075 (HATPase_c)

453F

ATP binding site
362N, 366N, 369K, 392V, 394N, 396T, 398R, 399L, 424G, 425L, 426G, 427L, 443V, 445F, 450I, 451V, 453F
CDD
cd00075 (HATPase_c)
Mg2+ binding site ...

366N

Mg2+ binding site
366N
CDD
cd00075 (HATPase_c)
G-X-G motif cd00075

396T

G-X-G motif
396T, 398R, 424G, 426G
CDD
cd00075 (HATPase_c)

398R

G-X-G motif
396T, 398R, 424G, 426G
CDD
cd00075 (HATPase_c)

424G

G-X-G motif
396T, 398R, 424G, 426G
CDD
cd00075 (HATPase_c)

426G

G-X-G motif
396T, 398R, 424G, 426G
CDD
cd00075 (HATPase_c)

GO term prediction

Biological Process

GO:0007165 signal transduction

Molecular Function

GO:0000155 phosphorelay sensor kinase activity
GO:0004871 signal transducer activity

Cellular Component

GO:0016021 integral component of membrane

Filter view on

Entry type

Status

Per-residue features

27725_FusoPortal_Gene_1536

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component