27725_FusoPortal_Gene_157

Protein

27725_FusoPortal_Gene_157

Length

578 amino acids

Protein family membership

None predicted.

Homologous superfamilies

Homologous superfamily
1 - 176
Thiamin diphosphate-binding fold (IPR029061)
190 - 355
DHS-like NAD/FAD-binding domain superfamily (IPR029035)
369 - 554
Thiamin diphosphate-binding fold (IPR029061)

1 100 200 300 400 500 578

Domains and repeats

Domain
1 - 174
Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain (IPR012001)
197 - 328
Thiamine pyrophosphate enzyme, central domain (IPR012000)
389 - 523
Thiamine pyrophosphate enzyme, C-terminal TPP-binding (IPR011766)

1 100 200 300 400 500 578

Detailed signature matches

IPR029061

Thiamin diphosphate-binding fold
1. SSF52518 (Thiamin d...)
  
  1 - 176
  
  SUPERFAMILY
  SSF52518 (Thiamin diphosphate-binding fold (THDP-binding))
  
  369 - 554
  
  SUPERFAMILY
  SSF52518 (Thiamin diphosphate-binding fold (THDP-binding))
IPR029035

DHS-like NAD/FAD-binding domain superfamily
1. SSF52467 (DHS-like ...)
  
  190 - 355
  
  SUPERFAMILY
  SSF52467 (DHS-like NAD/FAD-binding domain)
2. G3DSA:3.40.50...
  
  195 - 344
  
  GENE3D
  G3DSA:3.40.50.1220 (G3DSA:3.40.50.1220)
IPR012001

Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain
1. PF02776 (TPP_enzyme_N)
  
  1 - 174
  
  Pfam
  PF02776 (TPP_enzyme_N)
IPR012000

Thiamine pyrophosphate enzyme, central domain
1. PF00205 (TPP_enzyme_M)
  
  197 - 328
  
  Pfam
  PF00205 (TPP_enzyme_M)
IPR011766

Thiamine pyrophosphate enzyme, C-terminal TPP-binding
1. PF02775 (TPP_enzyme_C)
  
  389 - 523
  
  Pfam
  PF02775 (TPP_enzyme_C)

no IPR

Unintegrated signatures

Coil

347 - 367

COILS
Coil (Coil)

289 - 316

COILS
Coil (Coil)
G3DSA:3.40.50...

1 - 194

GENE3D
G3DSA:3.40.50.970 (G3DSA:3.40.50.970)

345 - 538

GENE3D
G3DSA:3.40.50.970 (G3DSA:3.40.50.970)
PTHR18968 (THIAMINE...)

1 - 557

PANTHER
PTHR18968 (THIAMINE PYROPHOSPHATE ENZYMES)
PTHR18968:SF116 (AC...)

1 - 557

PANTHER
PTHR18968:SF116 (ACETOLACTATE SYNTHASE ISOZYME 3 LARGE SUBUNIT)
cd07035 (TPP_PYR_PO...)

5 - 166

CDD
cd07035 (TPP_PYR_POX_like)

Residue annotation

PYR/PP interface c...

18Y

PYR/PP interface
18Y, 23Q, 24G, 28T, 32D, 41K, 42F, 43I, 44Q, 45T, 46Y, 47H, 50S, 53L, 54A, 57G, 58Y, 60K, 61E, 62S, 74P, 81T, 85N, 88F, 89D
CDD
cd07035 (TPP_PYR_POX_like)

23Q

PYR/PP interface
18Y, 23Q, 24G, 28T, 32D, 41K, 42F, 43I, 44Q, 45T, 46Y, 47H, 50S, 53L, 54A, 57G, 58Y, 60K, 61E, 62S, 74P, 81T, 85N, 88F, 89D
CDD
cd07035 (TPP_PYR_POX_like)

24G

PYR/PP interface
18Y, 23Q, 24G, 28T, 32D, 41K, 42F, 43I, 44Q, 45T, 46Y, 47H, 50S, 53L, 54A, 57G, 58Y, 60K, 61E, 62S, 74P, 81T, 85N, 88F, 89D
CDD
cd07035 (TPP_PYR_POX_like)

28T

PYR/PP interface
18Y, 23Q, 24G, 28T, 32D, 41K, 42F, 43I, 44Q, 45T, 46Y, 47H, 50S, 53L, 54A, 57G, 58Y, 60K, 61E, 62S, 74P, 81T, 85N, 88F, 89D
CDD
cd07035 (TPP_PYR_POX_like)

32D

PYR/PP interface
18Y, 23Q, 24G, 28T, 32D, 41K, 42F, 43I, 44Q, 45T, 46Y, 47H, 50S, 53L, 54A, 57G, 58Y, 60K, 61E, 62S, 74P, 81T, 85N, 88F, 89D
CDD
cd07035 (TPP_PYR_POX_like)

41K

PYR/PP interface
18Y, 23Q, 24G, 28T, 32D, 41K, 42F, 43I, 44Q, 45T, 46Y, 47H, 50S, 53L, 54A, 57G, 58Y, 60K, 61E, 62S, 74P, 81T, 85N, 88F, 89D
CDD
cd07035 (TPP_PYR_POX_like)

42F

PYR/PP interface
18Y, 23Q, 24G, 28T, 32D, 41K, 42F, 43I, 44Q, 45T, 46Y, 47H, 50S, 53L, 54A, 57G, 58Y, 60K, 61E, 62S, 74P, 81T, 85N, 88F, 89D
CDD
cd07035 (TPP_PYR_POX_like)

43I

PYR/PP interface
18Y, 23Q, 24G, 28T, 32D, 41K, 42F, 43I, 44Q, 45T, 46Y, 47H, 50S, 53L, 54A, 57G, 58Y, 60K, 61E, 62S, 74P, 81T, 85N, 88F, 89D
CDD
cd07035 (TPP_PYR_POX_like)

44Q

PYR/PP interface
18Y, 23Q, 24G, 28T, 32D, 41K, 42F, 43I, 44Q, 45T, 46Y, 47H, 50S, 53L, 54A, 57G, 58Y, 60K, 61E, 62S, 74P, 81T, 85N, 88F, 89D
CDD
cd07035 (TPP_PYR_POX_like)

45T

PYR/PP interface
18Y, 23Q, 24G, 28T, 32D, 41K, 42F, 43I, 44Q, 45T, 46Y, 47H, 50S, 53L, 54A, 57G, 58Y, 60K, 61E, 62S, 74P, 81T, 85N, 88F, 89D
CDD
cd07035 (TPP_PYR_POX_like)

46Y

PYR/PP interface
18Y, 23Q, 24G, 28T, 32D, 41K, 42F, 43I, 44Q, 45T, 46Y, 47H, 50S, 53L, 54A, 57G, 58Y, 60K, 61E, 62S, 74P, 81T, 85N, 88F, 89D
CDD
cd07035 (TPP_PYR_POX_like)

47H

PYR/PP interface
18Y, 23Q, 24G, 28T, 32D, 41K, 42F, 43I, 44Q, 45T, 46Y, 47H, 50S, 53L, 54A, 57G, 58Y, 60K, 61E, 62S, 74P, 81T, 85N, 88F, 89D
CDD
cd07035 (TPP_PYR_POX_like)

50S

PYR/PP interface
18Y, 23Q, 24G, 28T, 32D, 41K, 42F, 43I, 44Q, 45T, 46Y, 47H, 50S, 53L, 54A, 57G, 58Y, 60K, 61E, 62S, 74P, 81T, 85N, 88F, 89D
CDD
cd07035 (TPP_PYR_POX_like)

53L

PYR/PP interface
18Y, 23Q, 24G, 28T, 32D, 41K, 42F, 43I, 44Q, 45T, 46Y, 47H, 50S, 53L, 54A, 57G, 58Y, 60K, 61E, 62S, 74P, 81T, 85N, 88F, 89D
CDD
cd07035 (TPP_PYR_POX_like)

54A

PYR/PP interface
18Y, 23Q, 24G, 28T, 32D, 41K, 42F, 43I, 44Q, 45T, 46Y, 47H, 50S, 53L, 54A, 57G, 58Y, 60K, 61E, 62S, 74P, 81T, 85N, 88F, 89D
CDD
cd07035 (TPP_PYR_POX_like)

57G

PYR/PP interface
18Y, 23Q, 24G, 28T, 32D, 41K, 42F, 43I, 44Q, 45T, 46Y, 47H, 50S, 53L, 54A, 57G, 58Y, 60K, 61E, 62S, 74P, 81T, 85N, 88F, 89D
CDD
cd07035 (TPP_PYR_POX_like)

58Y

PYR/PP interface
18Y, 23Q, 24G, 28T, 32D, 41K, 42F, 43I, 44Q, 45T, 46Y, 47H, 50S, 53L, 54A, 57G, 58Y, 60K, 61E, 62S, 74P, 81T, 85N, 88F, 89D
CDD
cd07035 (TPP_PYR_POX_like)

60K

PYR/PP interface
18Y, 23Q, 24G, 28T, 32D, 41K, 42F, 43I, 44Q, 45T, 46Y, 47H, 50S, 53L, 54A, 57G, 58Y, 60K, 61E, 62S, 74P, 81T, 85N, 88F, 89D
CDD
cd07035 (TPP_PYR_POX_like)

61E

PYR/PP interface
18Y, 23Q, 24G, 28T, 32D, 41K, 42F, 43I, 44Q, 45T, 46Y, 47H, 50S, 53L, 54A, 57G, 58Y, 60K, 61E, 62S, 74P, 81T, 85N, 88F, 89D
CDD
cd07035 (TPP_PYR_POX_like)

62S

PYR/PP interface
18Y, 23Q, 24G, 28T, 32D, 41K, 42F, 43I, 44Q, 45T, 46Y, 47H, 50S, 53L, 54A, 57G, 58Y, 60K, 61E, 62S, 74P, 81T, 85N, 88F, 89D
CDD
cd07035 (TPP_PYR_POX_like)

74P

PYR/PP interface
18Y, 23Q, 24G, 28T, 32D, 41K, 42F, 43I, 44Q, 45T, 46Y, 47H, 50S, 53L, 54A, 57G, 58Y, 60K, 61E, 62S, 74P, 81T, 85N, 88F, 89D
CDD
cd07035 (TPP_PYR_POX_like)

81T

PYR/PP interface
18Y, 23Q, 24G, 28T, 32D, 41K, 42F, 43I, 44Q, 45T, 46Y, 47H, 50S, 53L, 54A, 57G, 58Y, 60K, 61E, 62S, 74P, 81T, 85N, 88F, 89D
CDD
cd07035 (TPP_PYR_POX_like)

85N

PYR/PP interface
18Y, 23Q, 24G, 28T, 32D, 41K, 42F, 43I, 44Q, 45T, 46Y, 47H, 50S, 53L, 54A, 57G, 58Y, 60K, 61E, 62S, 74P, 81T, 85N, 88F, 89D
CDD
cd07035 (TPP_PYR_POX_like)

88F

PYR/PP interface
18Y, 23Q, 24G, 28T, 32D, 41K, 42F, 43I, 44Q, 45T, 46Y, 47H, 50S, 53L, 54A, 57G, 58Y, 60K, 61E, 62S, 74P, 81T, 85N, 88F, 89D
CDD
cd07035 (TPP_PYR_POX_like)

89D

PYR/PP interface
18Y, 23Q, 24G, 28T, 32D, 41K, 42F, 43I, 44Q, 45T, 46Y, 47H, 50S, 53L, 54A, 57G, 58Y, 60K, 61E, 62S, 74P, 81T, 85N, 88F, 89D
CDD
cd07035 (TPP_PYR_POX_like)
TPP binding site c...

23Q

TPP binding site
23Q, 48E, 74P, 78N
CDD
cd07035 (TPP_PYR_POX_like)

48E

TPP binding site
23Q, 48E, 74P, 78N
CDD
cd07035 (TPP_PYR_POX_like)

74P

TPP binding site
23Q, 48E, 74P, 78N
CDD
cd07035 (TPP_PYR_POX_like)

78N

TPP binding site
23Q, 48E, 74P, 78N
CDD
cd07035 (TPP_PYR_POX_like)
dimer interface cd...

23Q

dimer interface
23Q, 24G, 25G, 28T, 32D, 42F, 44Q, 45T, 46Y, 47H, 49Q, 74P, 77T, 78N, 80I, 81T, 84A, 124L, 127S
CDD
cd07035 (TPP_PYR_POX_like)

24G

dimer interface
23Q, 24G, 25G, 28T, 32D, 42F, 44Q, 45T, 46Y, 47H, 49Q, 74P, 77T, 78N, 80I, 81T, 84A, 124L, 127S
CDD
cd07035 (TPP_PYR_POX_like)

25G

dimer interface
23Q, 24G, 25G, 28T, 32D, 42F, 44Q, 45T, 46Y, 47H, 49Q, 74P, 77T, 78N, 80I, 81T, 84A, 124L, 127S
CDD
cd07035 (TPP_PYR_POX_like)

28T

dimer interface
23Q, 24G, 25G, 28T, 32D, 42F, 44Q, 45T, 46Y, 47H, 49Q, 74P, 77T, 78N, 80I, 81T, 84A, 124L, 127S
CDD
cd07035 (TPP_PYR_POX_like)

32D

dimer interface
23Q, 24G, 25G, 28T, 32D, 42F, 44Q, 45T, 46Y, 47H, 49Q, 74P, 77T, 78N, 80I, 81T, 84A, 124L, 127S
CDD
cd07035 (TPP_PYR_POX_like)

42F

dimer interface
23Q, 24G, 25G, 28T, 32D, 42F, 44Q, 45T, 46Y, 47H, 49Q, 74P, 77T, 78N, 80I, 81T, 84A, 124L, 127S
CDD
cd07035 (TPP_PYR_POX_like)

44Q

dimer interface
23Q, 24G, 25G, 28T, 32D, 42F, 44Q, 45T, 46Y, 47H, 49Q, 74P, 77T, 78N, 80I, 81T, 84A, 124L, 127S
CDD
cd07035 (TPP_PYR_POX_like)

45T

dimer interface
23Q, 24G, 25G, 28T, 32D, 42F, 44Q, 45T, 46Y, 47H, 49Q, 74P, 77T, 78N, 80I, 81T, 84A, 124L, 127S
CDD
cd07035 (TPP_PYR_POX_like)

46Y

dimer interface
23Q, 24G, 25G, 28T, 32D, 42F, 44Q, 45T, 46Y, 47H, 49Q, 74P, 77T, 78N, 80I, 81T, 84A, 124L, 127S
CDD
cd07035 (TPP_PYR_POX_like)

47H

dimer interface
23Q, 24G, 25G, 28T, 32D, 42F, 44Q, 45T, 46Y, 47H, 49Q, 74P, 77T, 78N, 80I, 81T, 84A, 124L, 127S
CDD
cd07035 (TPP_PYR_POX_like)

49Q

dimer interface
23Q, 24G, 25G, 28T, 32D, 42F, 44Q, 45T, 46Y, 47H, 49Q, 74P, 77T, 78N, 80I, 81T, 84A, 124L, 127S
CDD
cd07035 (TPP_PYR_POX_like)

74P

dimer interface
23Q, 24G, 25G, 28T, 32D, 42F, 44Q, 45T, 46Y, 47H, 49Q, 74P, 77T, 78N, 80I, 81T, 84A, 124L, 127S
CDD
cd07035 (TPP_PYR_POX_like)

77T

dimer interface
23Q, 24G, 25G, 28T, 32D, 42F, 44Q, 45T, 46Y, 47H, 49Q, 74P, 77T, 78N, 80I, 81T, 84A, 124L, 127S
CDD
cd07035 (TPP_PYR_POX_like)

78N

dimer interface
23Q, 24G, 25G, 28T, 32D, 42F, 44Q, 45T, 46Y, 47H, 49Q, 74P, 77T, 78N, 80I, 81T, 84A, 124L, 127S
CDD
cd07035 (TPP_PYR_POX_like)

80I

dimer interface
23Q, 24G, 25G, 28T, 32D, 42F, 44Q, 45T, 46Y, 47H, 49Q, 74P, 77T, 78N, 80I, 81T, 84A, 124L, 127S
CDD
cd07035 (TPP_PYR_POX_like)

81T

dimer interface
23Q, 24G, 25G, 28T, 32D, 42F, 44Q, 45T, 46Y, 47H, 49Q, 74P, 77T, 78N, 80I, 81T, 84A, 124L, 127S
CDD
cd07035 (TPP_PYR_POX_like)

84A

dimer interface
23Q, 24G, 25G, 28T, 32D, 42F, 44Q, 45T, 46Y, 47H, 49Q, 74P, 77T, 78N, 80I, 81T, 84A, 124L, 127S
CDD
cd07035 (TPP_PYR_POX_like)

124L

dimer interface
23Q, 24G, 25G, 28T, 32D, 42F, 44Q, 45T, 46Y, 47H, 49Q, 74P, 77T, 78N, 80I, 81T, 84A, 124L, 127S
CDD
cd07035 (TPP_PYR_POX_like)

127S

dimer interface
23Q, 24G, 25G, 28T, 32D, 42F, 44Q, 45T, 46Y, 47H, 49Q, 74P, 77T, 78N, 80I, 81T, 84A, 124L, 127S
CDD
cd07035 (TPP_PYR_POX_like)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0030976 thiamine pyrophosphate binding

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

27725_FusoPortal_Gene_157

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component