27725_FusoPortal_Gene_1871

Protein

27725_FusoPortal_Gene_1871

Length

325 amino acids

Protein family membership

UDP-glucose 4-epimerase (IPR005886)

Homologous superfamilies

Homologous superfamily
1 - 323
NAD(P)-binding domain superfamily (IPR036291)

1 50 100 150 200 250 300 325

Domains and repeats

Domain
4 - 253
NAD-dependent epimerase/dehydratase (IPR001509)

1 50 100 150 200 250 300 325

Detailed signature matches

IPR036291

NAD(P)-binding domain superfamily
1. SSF51735 (NAD(P)-bi...)
  
  1 - 323
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR005886

UDP-glucose 4-epimerase
1. TIGR01179
  
  3 - 323
  
  TIGRFAMs
  TIGR01179 (TIGR01179)
2. cd05247 (UDP_G4E_1_...)
  
  3 - 320
  
  CDD
  cd05247 (UDP_G4E_1_SDR_e)
IPR001509

NAD-dependent epimerase/dehydratase
1. PF01370 (Epimerase)
  
  4 - 253
  
  Pfam
  PF01370 (Epimerase)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

1 - 166

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
G3DSA:3.90.25.10

167 - 325

GENE3D
G3DSA:3.90.25.10 (G3DSA:3.90.25.10)
PTHR43725 (FAMILY N...)

1 - 322

PANTHER
PTHR43725 (FAMILY NOT NAMED)
PTHR43725:SF8 (UDP-...)

1 - 322

PANTHER
PTHR43725:SF8 (UDP-GLUCOSE 4-EPIMERASE)

Residue annotation

NAD binding site c...

8G

NAD binding site
8G, 10A, 11G, 12Y, 13I, 32D, 33S, 34L, 35E, 36N, 37G, 51G, 52N, 53V, 74F, 75A, 76G, 78I, 93N, 116S, 117S, 118T, 143Y, 147K, 170Y, 171F, 173V
CDD
cd05247 (UDP_G4E_1_SDR_e)

10A

NAD binding site
8G, 10A, 11G, 12Y, 13I, 32D, 33S, 34L, 35E, 36N, 37G, 51G, 52N, 53V, 74F, 75A, 76G, 78I, 93N, 116S, 117S, 118T, 143Y, 147K, 170Y, 171F, 173V
CDD
cd05247 (UDP_G4E_1_SDR_e)

11G

NAD binding site
8G, 10A, 11G, 12Y, 13I, 32D, 33S, 34L, 35E, 36N, 37G, 51G, 52N, 53V, 74F, 75A, 76G, 78I, 93N, 116S, 117S, 118T, 143Y, 147K, 170Y, 171F, 173V
CDD
cd05247 (UDP_G4E_1_SDR_e)

12Y

NAD binding site
8G, 10A, 11G, 12Y, 13I, 32D, 33S, 34L, 35E, 36N, 37G, 51G, 52N, 53V, 74F, 75A, 76G, 78I, 93N, 116S, 117S, 118T, 143Y, 147K, 170Y, 171F, 173V
CDD
cd05247 (UDP_G4E_1_SDR_e)

13I

NAD binding site
8G, 10A, 11G, 12Y, 13I, 32D, 33S, 34L, 35E, 36N, 37G, 51G, 52N, 53V, 74F, 75A, 76G, 78I, 93N, 116S, 117S, 118T, 143Y, 147K, 170Y, 171F, 173V
CDD
cd05247 (UDP_G4E_1_SDR_e)

32D

NAD binding site
8G, 10A, 11G, 12Y, 13I, 32D, 33S, 34L, 35E, 36N, 37G, 51G, 52N, 53V, 74F, 75A, 76G, 78I, 93N, 116S, 117S, 118T, 143Y, 147K, 170Y, 171F, 173V
CDD
cd05247 (UDP_G4E_1_SDR_e)

33S

NAD binding site
8G, 10A, 11G, 12Y, 13I, 32D, 33S, 34L, 35E, 36N, 37G, 51G, 52N, 53V, 74F, 75A, 76G, 78I, 93N, 116S, 117S, 118T, 143Y, 147K, 170Y, 171F, 173V
CDD
cd05247 (UDP_G4E_1_SDR_e)

34L

NAD binding site
8G, 10A, 11G, 12Y, 13I, 32D, 33S, 34L, 35E, 36N, 37G, 51G, 52N, 53V, 74F, 75A, 76G, 78I, 93N, 116S, 117S, 118T, 143Y, 147K, 170Y, 171F, 173V
CDD
cd05247 (UDP_G4E_1_SDR_e)

35E

NAD binding site
8G, 10A, 11G, 12Y, 13I, 32D, 33S, 34L, 35E, 36N, 37G, 51G, 52N, 53V, 74F, 75A, 76G, 78I, 93N, 116S, 117S, 118T, 143Y, 147K, 170Y, 171F, 173V
CDD
cd05247 (UDP_G4E_1_SDR_e)

36N

NAD binding site
8G, 10A, 11G, 12Y, 13I, 32D, 33S, 34L, 35E, 36N, 37G, 51G, 52N, 53V, 74F, 75A, 76G, 78I, 93N, 116S, 117S, 118T, 143Y, 147K, 170Y, 171F, 173V
CDD
cd05247 (UDP_G4E_1_SDR_e)

37G

NAD binding site
8G, 10A, 11G, 12Y, 13I, 32D, 33S, 34L, 35E, 36N, 37G, 51G, 52N, 53V, 74F, 75A, 76G, 78I, 93N, 116S, 117S, 118T, 143Y, 147K, 170Y, 171F, 173V
CDD
cd05247 (UDP_G4E_1_SDR_e)

51G

NAD binding site
8G, 10A, 11G, 12Y, 13I, 32D, 33S, 34L, 35E, 36N, 37G, 51G, 52N, 53V, 74F, 75A, 76G, 78I, 93N, 116S, 117S, 118T, 143Y, 147K, 170Y, 171F, 173V
CDD
cd05247 (UDP_G4E_1_SDR_e)

52N

NAD binding site
8G, 10A, 11G, 12Y, 13I, 32D, 33S, 34L, 35E, 36N, 37G, 51G, 52N, 53V, 74F, 75A, 76G, 78I, 93N, 116S, 117S, 118T, 143Y, 147K, 170Y, 171F, 173V
CDD
cd05247 (UDP_G4E_1_SDR_e)

53V

NAD binding site
8G, 10A, 11G, 12Y, 13I, 32D, 33S, 34L, 35E, 36N, 37G, 51G, 52N, 53V, 74F, 75A, 76G, 78I, 93N, 116S, 117S, 118T, 143Y, 147K, 170Y, 171F, 173V
CDD
cd05247 (UDP_G4E_1_SDR_e)

74F

NAD binding site
8G, 10A, 11G, 12Y, 13I, 32D, 33S, 34L, 35E, 36N, 37G, 51G, 52N, 53V, 74F, 75A, 76G, 78I, 93N, 116S, 117S, 118T, 143Y, 147K, 170Y, 171F, 173V
CDD
cd05247 (UDP_G4E_1_SDR_e)

75A

NAD binding site
8G, 10A, 11G, 12Y, 13I, 32D, 33S, 34L, 35E, 36N, 37G, 51G, 52N, 53V, 74F, 75A, 76G, 78I, 93N, 116S, 117S, 118T, 143Y, 147K, 170Y, 171F, 173V
CDD
cd05247 (UDP_G4E_1_SDR_e)

76G

NAD binding site
8G, 10A, 11G, 12Y, 13I, 32D, 33S, 34L, 35E, 36N, 37G, 51G, 52N, 53V, 74F, 75A, 76G, 78I, 93N, 116S, 117S, 118T, 143Y, 147K, 170Y, 171F, 173V
CDD
cd05247 (UDP_G4E_1_SDR_e)

78I

NAD binding site
8G, 10A, 11G, 12Y, 13I, 32D, 33S, 34L, 35E, 36N, 37G, 51G, 52N, 53V, 74F, 75A, 76G, 78I, 93N, 116S, 117S, 118T, 143Y, 147K, 170Y, 171F, 173V
CDD
cd05247 (UDP_G4E_1_SDR_e)

93N

NAD binding site
8G, 10A, 11G, 12Y, 13I, 32D, 33S, 34L, 35E, 36N, 37G, 51G, 52N, 53V, 74F, 75A, 76G, 78I, 93N, 116S, 117S, 118T, 143Y, 147K, 170Y, 171F, 173V
CDD
cd05247 (UDP_G4E_1_SDR_e)

116S

NAD binding site
8G, 10A, 11G, 12Y, 13I, 32D, 33S, 34L, 35E, 36N, 37G, 51G, 52N, 53V, 74F, 75A, 76G, 78I, 93N, 116S, 117S, 118T, 143Y, 147K, 170Y, 171F, 173V
CDD
cd05247 (UDP_G4E_1_SDR_e)

117S

NAD binding site
8G, 10A, 11G, 12Y, 13I, 32D, 33S, 34L, 35E, 36N, 37G, 51G, 52N, 53V, 74F, 75A, 76G, 78I, 93N, 116S, 117S, 118T, 143Y, 147K, 170Y, 171F, 173V
CDD
cd05247 (UDP_G4E_1_SDR_e)

118T

NAD binding site
8G, 10A, 11G, 12Y, 13I, 32D, 33S, 34L, 35E, 36N, 37G, 51G, 52N, 53V, 74F, 75A, 76G, 78I, 93N, 116S, 117S, 118T, 143Y, 147K, 170Y, 171F, 173V
CDD
cd05247 (UDP_G4E_1_SDR_e)

143Y

NAD binding site
8G, 10A, 11G, 12Y, 13I, 32D, 33S, 34L, 35E, 36N, 37G, 51G, 52N, 53V, 74F, 75A, 76G, 78I, 93N, 116S, 117S, 118T, 143Y, 147K, 170Y, 171F, 173V
CDD
cd05247 (UDP_G4E_1_SDR_e)

147K

NAD binding site
8G, 10A, 11G, 12Y, 13I, 32D, 33S, 34L, 35E, 36N, 37G, 51G, 52N, 53V, 74F, 75A, 76G, 78I, 93N, 116S, 117S, 118T, 143Y, 147K, 170Y, 171F, 173V
CDD
cd05247 (UDP_G4E_1_SDR_e)

170Y

NAD binding site
8G, 10A, 11G, 12Y, 13I, 32D, 33S, 34L, 35E, 36N, 37G, 51G, 52N, 53V, 74F, 75A, 76G, 78I, 93N, 116S, 117S, 118T, 143Y, 147K, 170Y, 171F, 173V
CDD
cd05247 (UDP_G4E_1_SDR_e)

171F

NAD binding site
8G, 10A, 11G, 12Y, 13I, 32D, 33S, 34L, 35E, 36N, 37G, 51G, 52N, 53V, 74F, 75A, 76G, 78I, 93N, 116S, 117S, 118T, 143Y, 147K, 170Y, 171F, 173V
CDD
cd05247 (UDP_G4E_1_SDR_e)

173V

NAD binding site
8G, 10A, 11G, 12Y, 13I, 32D, 33S, 34L, 35E, 36N, 37G, 51G, 52N, 53V, 74F, 75A, 76G, 78I, 93N, 116S, 117S, 118T, 143Y, 147K, 170Y, 171F, 173V
CDD
cd05247 (UDP_G4E_1_SDR_e)
homodimer interfac...

84V

homodimer interface
84V, 86E, 87P, 88N, 91Y, 92L, 95T, 96Y, 99M, 100C, 102L, 103E, 106K, 142P, 145M, 149M, 152R, 153I, 155M, 156D, 157C
CDD
cd05247 (UDP_G4E_1_SDR_e)

86E

homodimer interface
84V, 86E, 87P, 88N, 91Y, 92L, 95T, 96Y, 99M, 100C, 102L, 103E, 106K, 142P, 145M, 149M, 152R, 153I, 155M, 156D, 157C
CDD
cd05247 (UDP_G4E_1_SDR_e)

87P

homodimer interface
84V, 86E, 87P, 88N, 91Y, 92L, 95T, 96Y, 99M, 100C, 102L, 103E, 106K, 142P, 145M, 149M, 152R, 153I, 155M, 156D, 157C
CDD
cd05247 (UDP_G4E_1_SDR_e)

88N

homodimer interface
84V, 86E, 87P, 88N, 91Y, 92L, 95T, 96Y, 99M, 100C, 102L, 103E, 106K, 142P, 145M, 149M, 152R, 153I, 155M, 156D, 157C
CDD
cd05247 (UDP_G4E_1_SDR_e)

91Y

homodimer interface
84V, 86E, 87P, 88N, 91Y, 92L, 95T, 96Y, 99M, 100C, 102L, 103E, 106K, 142P, 145M, 149M, 152R, 153I, 155M, 156D, 157C
CDD
cd05247 (UDP_G4E_1_SDR_e)

92L

homodimer interface
84V, 86E, 87P, 88N, 91Y, 92L, 95T, 96Y, 99M, 100C, 102L, 103E, 106K, 142P, 145M, 149M, 152R, 153I, 155M, 156D, 157C
CDD
cd05247 (UDP_G4E_1_SDR_e)

95T

homodimer interface
84V, 86E, 87P, 88N, 91Y, 92L, 95T, 96Y, 99M, 100C, 102L, 103E, 106K, 142P, 145M, 149M, 152R, 153I, 155M, 156D, 157C
CDD
cd05247 (UDP_G4E_1_SDR_e)

96Y

homodimer interface
84V, 86E, 87P, 88N, 91Y, 92L, 95T, 96Y, 99M, 100C, 102L, 103E, 106K, 142P, 145M, 149M, 152R, 153I, 155M, 156D, 157C
CDD
cd05247 (UDP_G4E_1_SDR_e)

99M

homodimer interface
84V, 86E, 87P, 88N, 91Y, 92L, 95T, 96Y, 99M, 100C, 102L, 103E, 106K, 142P, 145M, 149M, 152R, 153I, 155M, 156D, 157C
CDD
cd05247 (UDP_G4E_1_SDR_e)

100C

homodimer interface
84V, 86E, 87P, 88N, 91Y, 92L, 95T, 96Y, 99M, 100C, 102L, 103E, 106K, 142P, 145M, 149M, 152R, 153I, 155M, 156D, 157C
CDD
cd05247 (UDP_G4E_1_SDR_e)

102L

homodimer interface
84V, 86E, 87P, 88N, 91Y, 92L, 95T, 96Y, 99M, 100C, 102L, 103E, 106K, 142P, 145M, 149M, 152R, 153I, 155M, 156D, 157C
CDD
cd05247 (UDP_G4E_1_SDR_e)

103E

homodimer interface
84V, 86E, 87P, 88N, 91Y, 92L, 95T, 96Y, 99M, 100C, 102L, 103E, 106K, 142P, 145M, 149M, 152R, 153I, 155M, 156D, 157C
CDD
cd05247 (UDP_G4E_1_SDR_e)

106K

homodimer interface
84V, 86E, 87P, 88N, 91Y, 92L, 95T, 96Y, 99M, 100C, 102L, 103E, 106K, 142P, 145M, 149M, 152R, 153I, 155M, 156D, 157C
CDD
cd05247 (UDP_G4E_1_SDR_e)

142P

homodimer interface
84V, 86E, 87P, 88N, 91Y, 92L, 95T, 96Y, 99M, 100C, 102L, 103E, 106K, 142P, 145M, 149M, 152R, 153I, 155M, 156D, 157C
CDD
cd05247 (UDP_G4E_1_SDR_e)

145M

homodimer interface
84V, 86E, 87P, 88N, 91Y, 92L, 95T, 96Y, 99M, 100C, 102L, 103E, 106K, 142P, 145M, 149M, 152R, 153I, 155M, 156D, 157C
CDD
cd05247 (UDP_G4E_1_SDR_e)

149M

homodimer interface
84V, 86E, 87P, 88N, 91Y, 92L, 95T, 96Y, 99M, 100C, 102L, 103E, 106K, 142P, 145M, 149M, 152R, 153I, 155M, 156D, 157C
CDD
cd05247 (UDP_G4E_1_SDR_e)

152R

homodimer interface
84V, 86E, 87P, 88N, 91Y, 92L, 95T, 96Y, 99M, 100C, 102L, 103E, 106K, 142P, 145M, 149M, 152R, 153I, 155M, 156D, 157C
CDD
cd05247 (UDP_G4E_1_SDR_e)

153I

homodimer interface
84V, 86E, 87P, 88N, 91Y, 92L, 95T, 96Y, 99M, 100C, 102L, 103E, 106K, 142P, 145M, 149M, 152R, 153I, 155M, 156D, 157C
CDD
cd05247 (UDP_G4E_1_SDR_e)

155M

homodimer interface
84V, 86E, 87P, 88N, 91Y, 92L, 95T, 96Y, 99M, 100C, 102L, 103E, 106K, 142P, 145M, 149M, 152R, 153I, 155M, 156D, 157C
CDD
cd05247 (UDP_G4E_1_SDR_e)

156D

homodimer interface
84V, 86E, 87P, 88N, 91Y, 92L, 95T, 96Y, 99M, 100C, 102L, 103E, 106K, 142P, 145M, 149M, 152R, 153I, 155M, 156D, 157C
CDD
cd05247 (UDP_G4E_1_SDR_e)

157C

homodimer interface
84V, 86E, 87P, 88N, 91Y, 92L, 95T, 96Y, 99M, 100C, 102L, 103E, 106K, 142P, 145M, 149M, 152R, 153I, 155M, 156D, 157C
CDD
cd05247 (UDP_G4E_1_SDR_e)
active site cd05247

94N

active site
94N, 118T, 143Y, 147K
CDD
cd05247 (UDP_G4E_1_SDR_e)

118T

active site
94N, 118T, 143Y, 147K
CDD
cd05247 (UDP_G4E_1_SDR_e)

143Y

active site
94N, 118T, 143Y, 147K
CDD
cd05247 (UDP_G4E_1_SDR_e)

147K

active site
94N, 118T, 143Y, 147K
CDD
cd05247 (UDP_G4E_1_SDR_e)
substrate binding ...

118T

substrate binding site
118T, 119A, 120A, 143Y, 170Y, 171F, 172N, 190T, 191A, 192L, 207L, 208S, 209I, 210Y, 221G, 223R, 225Y, 260V, 283R, 286D
CDD
cd05247 (UDP_G4E_1_SDR_e)

119A

substrate binding site
118T, 119A, 120A, 143Y, 170Y, 171F, 172N, 190T, 191A, 192L, 207L, 208S, 209I, 210Y, 221G, 223R, 225Y, 260V, 283R, 286D
CDD
cd05247 (UDP_G4E_1_SDR_e)

120A

substrate binding site
118T, 119A, 120A, 143Y, 170Y, 171F, 172N, 190T, 191A, 192L, 207L, 208S, 209I, 210Y, 221G, 223R, 225Y, 260V, 283R, 286D
CDD
cd05247 (UDP_G4E_1_SDR_e)

143Y

substrate binding site
118T, 119A, 120A, 143Y, 170Y, 171F, 172N, 190T, 191A, 192L, 207L, 208S, 209I, 210Y, 221G, 223R, 225Y, 260V, 283R, 286D
CDD
cd05247 (UDP_G4E_1_SDR_e)

170Y

substrate binding site
118T, 119A, 120A, 143Y, 170Y, 171F, 172N, 190T, 191A, 192L, 207L, 208S, 209I, 210Y, 221G, 223R, 225Y, 260V, 283R, 286D
CDD
cd05247 (UDP_G4E_1_SDR_e)

171F

substrate binding site
118T, 119A, 120A, 143Y, 170Y, 171F, 172N, 190T, 191A, 192L, 207L, 208S, 209I, 210Y, 221G, 223R, 225Y, 260V, 283R, 286D
CDD
cd05247 (UDP_G4E_1_SDR_e)

172N

substrate binding site
118T, 119A, 120A, 143Y, 170Y, 171F, 172N, 190T, 191A, 192L, 207L, 208S, 209I, 210Y, 221G, 223R, 225Y, 260V, 283R, 286D
CDD
cd05247 (UDP_G4E_1_SDR_e)

190T

substrate binding site
118T, 119A, 120A, 143Y, 170Y, 171F, 172N, 190T, 191A, 192L, 207L, 208S, 209I, 210Y, 221G, 223R, 225Y, 260V, 283R, 286D
CDD
cd05247 (UDP_G4E_1_SDR_e)

191A

substrate binding site
118T, 119A, 120A, 143Y, 170Y, 171F, 172N, 190T, 191A, 192L, 207L, 208S, 209I, 210Y, 221G, 223R, 225Y, 260V, 283R, 286D
CDD
cd05247 (UDP_G4E_1_SDR_e)

192L

substrate binding site
118T, 119A, 120A, 143Y, 170Y, 171F, 172N, 190T, 191A, 192L, 207L, 208S, 209I, 210Y, 221G, 223R, 225Y, 260V, 283R, 286D
CDD
cd05247 (UDP_G4E_1_SDR_e)

207L

substrate binding site
118T, 119A, 120A, 143Y, 170Y, 171F, 172N, 190T, 191A, 192L, 207L, 208S, 209I, 210Y, 221G, 223R, 225Y, 260V, 283R, 286D
CDD
cd05247 (UDP_G4E_1_SDR_e)

208S

substrate binding site
118T, 119A, 120A, 143Y, 170Y, 171F, 172N, 190T, 191A, 192L, 207L, 208S, 209I, 210Y, 221G, 223R, 225Y, 260V, 283R, 286D
CDD
cd05247 (UDP_G4E_1_SDR_e)

209I

substrate binding site
118T, 119A, 120A, 143Y, 170Y, 171F, 172N, 190T, 191A, 192L, 207L, 208S, 209I, 210Y, 221G, 223R, 225Y, 260V, 283R, 286D
CDD
cd05247 (UDP_G4E_1_SDR_e)

210Y

substrate binding site
118T, 119A, 120A, 143Y, 170Y, 171F, 172N, 190T, 191A, 192L, 207L, 208S, 209I, 210Y, 221G, 223R, 225Y, 260V, 283R, 286D
CDD
cd05247 (UDP_G4E_1_SDR_e)

221G

substrate binding site
118T, 119A, 120A, 143Y, 170Y, 171F, 172N, 190T, 191A, 192L, 207L, 208S, 209I, 210Y, 221G, 223R, 225Y, 260V, 283R, 286D
CDD
cd05247 (UDP_G4E_1_SDR_e)

223R

substrate binding site
118T, 119A, 120A, 143Y, 170Y, 171F, 172N, 190T, 191A, 192L, 207L, 208S, 209I, 210Y, 221G, 223R, 225Y, 260V, 283R, 286D
CDD
cd05247 (UDP_G4E_1_SDR_e)

225Y

substrate binding site
118T, 119A, 120A, 143Y, 170Y, 171F, 172N, 190T, 191A, 192L, 207L, 208S, 209I, 210Y, 221G, 223R, 225Y, 260V, 283R, 286D
CDD
cd05247 (UDP_G4E_1_SDR_e)

260V

substrate binding site
118T, 119A, 120A, 143Y, 170Y, 171F, 172N, 190T, 191A, 192L, 207L, 208S, 209I, 210Y, 221G, 223R, 225Y, 260V, 283R, 286D
CDD
cd05247 (UDP_G4E_1_SDR_e)

283R

substrate binding site
118T, 119A, 120A, 143Y, 170Y, 171F, 172N, 190T, 191A, 192L, 207L, 208S, 209I, 210Y, 221G, 223R, 225Y, 260V, 283R, 286D
CDD
cd05247 (UDP_G4E_1_SDR_e)

286D

substrate binding site
118T, 119A, 120A, 143Y, 170Y, 171F, 172N, 190T, 191A, 192L, 207L, 208S, 209I, 210Y, 221G, 223R, 225Y, 260V, 283R, 286D
CDD
cd05247 (UDP_G4E_1_SDR_e)

GO term prediction

Biological Process

GO:0006012 galactose metabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0003978 UDP-glucose 4-epimerase activity
GO:0050662 coenzyme binding

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

27725_FusoPortal_Gene_1871

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component