27725_FusoPortal_Gene_1953

Protein

27725_FusoPortal_Gene_1953

Length

388 amino acids

Protein family membership

Alanine dehydrogenase (IPR008141)

Homologous superfamilies

Homologous superfamily
131 - 296
NAD(P)-binding domain superfamily (IPR036291)

1 50 100 150 200 250 300 350 388

Domains and repeats

Domain
4 - 119
Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal (IPR007886)
137 - 345
Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain (IPR007698)

1 50 100 150 200 250 300 350 388

Detailed signature matches

IPR036291

NAD(P)-binding domain superfamily
1. SSF51735 (NAD(P)-bi...)
  
  131 - 296
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR008141

Alanine dehydrogenase
1. cd05305 (L-AlaDH)
  
  1 - 347
  
  CDD
  cd05305 (L-AlaDH)
2. PTHR42795 (FAMILY N...)
  
  1 - 360
  
  PANTHER
  PTHR42795 (FAMILY NOT NAMED)
IPR007886

Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal
1. PF05222 (AlaDh_PNT_N)
  
  4 - 119
  
  Pfam
  PF05222 (AlaDh_PNT_N)
IPR007698

Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain
1. PF01262 (AlaDh_PNT_C)
  
  137 - 345
  
  Pfam
  PF01262 (AlaDh_PNT_C)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

188 - 364

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)

1 - 187

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
SSF52283 (Formate/g...)

298 - 348

SUPERFAMILY
SSF52283 (Formate/glycerate dehydrogenase catalytic domain-like)

1 - 131

SUPERFAMILY
SSF52283 (Formate/glycerate dehydrogenase catalytic domain-like)

Residue annotation

hexamer interface ...

12G

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

14F

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

20P

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

21N

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

42G

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

44S

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

129E

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

130I

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

133K

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

134L

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

137L

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

140A

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

141E

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

142H

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

144L

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

150S

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

151G

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

152Q

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

153L

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

154I

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

155C

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

156G

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

157A

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

158G

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

159G

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

160A

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

162A

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

175T

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

179Q

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

180L

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

183G

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

184L

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

187N

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

195V

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

198L

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

199R

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

202I

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

203E

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

204K

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

205Y

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

206P

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

209N

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

210T

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

211M

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

212I

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

276H

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

297A

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

298A

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

299S

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

300K

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

301T

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

304I

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

305A

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

308A

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

311I

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)

312E

hexamer interface
12G, 14F, 20P, 21N, 42G, 44S, 129E, 130I, 133K, 134L, 137L, 140A, 141E, 142H, 144L, 150S, 151G, 152Q, 153L, 154I, 155C, 156G, 157A, 158G, 159G, 160A, 162A, 175T, 179Q, 180L, 183G, 184L, 187N, 195V, 198L, 199R, 202I, 203E, 204K, 205Y, 206P, 209N, 210T, 211M, 212I, 276H, 297A, 298A, 299S, 300K, 301T, 304I, 305A, 308A, 311I, 312E
CDD
cd05305 (L-AlaDH)
ligand binding sit...

15R

ligand binding site
15R, 75K, 94C, 293N
CDD
cd05305 (L-AlaDH)

75K

ligand binding site
15R, 75K, 94C, 293N
CDD
cd05305 (L-AlaDH)

94C

ligand binding site
15R, 75K, 94C, 293N
CDD
cd05305 (L-AlaDH)

293N

ligand binding site
15R, 75K, 94C, 293N
CDD
cd05305 (L-AlaDH)
putative active si...

96H

putative active site
96H, 263D
CDD
cd05305 (L-AlaDH)

263D

putative active site
96H, 263D
CDD
cd05305 (L-AlaDH)
NAD(P) binding sit...

127N

NAD(P) binding site
127N, 128C, 131A, 168I, 169G, 171G, 172L, 173A, 191M, 192D, 193I, 197I, 213S, 231C, 232V, 233K, 242L, 260V, 263D, 264V, 291V, 292D, 293N, 294I, 295P
CDD
cd05305 (L-AlaDH)

128C

NAD(P) binding site
127N, 128C, 131A, 168I, 169G, 171G, 172L, 173A, 191M, 192D, 193I, 197I, 213S, 231C, 232V, 233K, 242L, 260V, 263D, 264V, 291V, 292D, 293N, 294I, 295P
CDD
cd05305 (L-AlaDH)

131A

NAD(P) binding site
127N, 128C, 131A, 168I, 169G, 171G, 172L, 173A, 191M, 192D, 193I, 197I, 213S, 231C, 232V, 233K, 242L, 260V, 263D, 264V, 291V, 292D, 293N, 294I, 295P
CDD
cd05305 (L-AlaDH)

168I

NAD(P) binding site
127N, 128C, 131A, 168I, 169G, 171G, 172L, 173A, 191M, 192D, 193I, 197I, 213S, 231C, 232V, 233K, 242L, 260V, 263D, 264V, 291V, 292D, 293N, 294I, 295P
CDD
cd05305 (L-AlaDH)

169G

NAD(P) binding site
127N, 128C, 131A, 168I, 169G, 171G, 172L, 173A, 191M, 192D, 193I, 197I, 213S, 231C, 232V, 233K, 242L, 260V, 263D, 264V, 291V, 292D, 293N, 294I, 295P
CDD
cd05305 (L-AlaDH)

171G

NAD(P) binding site
127N, 128C, 131A, 168I, 169G, 171G, 172L, 173A, 191M, 192D, 193I, 197I, 213S, 231C, 232V, 233K, 242L, 260V, 263D, 264V, 291V, 292D, 293N, 294I, 295P
CDD
cd05305 (L-AlaDH)

172L

NAD(P) binding site
127N, 128C, 131A, 168I, 169G, 171G, 172L, 173A, 191M, 192D, 193I, 197I, 213S, 231C, 232V, 233K, 242L, 260V, 263D, 264V, 291V, 292D, 293N, 294I, 295P
CDD
cd05305 (L-AlaDH)

173A

NAD(P) binding site
127N, 128C, 131A, 168I, 169G, 171G, 172L, 173A, 191M, 192D, 193I, 197I, 213S, 231C, 232V, 233K, 242L, 260V, 263D, 264V, 291V, 292D, 293N, 294I, 295P
CDD
cd05305 (L-AlaDH)

191M

NAD(P) binding site
127N, 128C, 131A, 168I, 169G, 171G, 172L, 173A, 191M, 192D, 193I, 197I, 213S, 231C, 232V, 233K, 242L, 260V, 263D, 264V, 291V, 292D, 293N, 294I, 295P
CDD
cd05305 (L-AlaDH)

192D

NAD(P) binding site
127N, 128C, 131A, 168I, 169G, 171G, 172L, 173A, 191M, 192D, 193I, 197I, 213S, 231C, 232V, 233K, 242L, 260V, 263D, 264V, 291V, 292D, 293N, 294I, 295P
CDD
cd05305 (L-AlaDH)

193I

NAD(P) binding site
127N, 128C, 131A, 168I, 169G, 171G, 172L, 173A, 191M, 192D, 193I, 197I, 213S, 231C, 232V, 233K, 242L, 260V, 263D, 264V, 291V, 292D, 293N, 294I, 295P
CDD
cd05305 (L-AlaDH)

197I

NAD(P) binding site
127N, 128C, 131A, 168I, 169G, 171G, 172L, 173A, 191M, 192D, 193I, 197I, 213S, 231C, 232V, 233K, 242L, 260V, 263D, 264V, 291V, 292D, 293N, 294I, 295P
CDD
cd05305 (L-AlaDH)

213S

NAD(P) binding site
127N, 128C, 131A, 168I, 169G, 171G, 172L, 173A, 191M, 192D, 193I, 197I, 213S, 231C, 232V, 233K, 242L, 260V, 263D, 264V, 291V, 292D, 293N, 294I, 295P
CDD
cd05305 (L-AlaDH)

231C

NAD(P) binding site
127N, 128C, 131A, 168I, 169G, 171G, 172L, 173A, 191M, 192D, 193I, 197I, 213S, 231C, 232V, 233K, 242L, 260V, 263D, 264V, 291V, 292D, 293N, 294I, 295P
CDD
cd05305 (L-AlaDH)

232V

NAD(P) binding site
127N, 128C, 131A, 168I, 169G, 171G, 172L, 173A, 191M, 192D, 193I, 197I, 213S, 231C, 232V, 233K, 242L, 260V, 263D, 264V, 291V, 292D, 293N, 294I, 295P
CDD
cd05305 (L-AlaDH)

233K

NAD(P) binding site
127N, 128C, 131A, 168I, 169G, 171G, 172L, 173A, 191M, 192D, 193I, 197I, 213S, 231C, 232V, 233K, 242L, 260V, 263D, 264V, 291V, 292D, 293N, 294I, 295P
CDD
cd05305 (L-AlaDH)

242L

NAD(P) binding site
127N, 128C, 131A, 168I, 169G, 171G, 172L, 173A, 191M, 192D, 193I, 197I, 213S, 231C, 232V, 233K, 242L, 260V, 263D, 264V, 291V, 292D, 293N, 294I, 295P
CDD
cd05305 (L-AlaDH)

260V

NAD(P) binding site
127N, 128C, 131A, 168I, 169G, 171G, 172L, 173A, 191M, 192D, 193I, 197I, 213S, 231C, 232V, 233K, 242L, 260V, 263D, 264V, 291V, 292D, 293N, 294I, 295P
CDD
cd05305 (L-AlaDH)

263D

NAD(P) binding site
127N, 128C, 131A, 168I, 169G, 171G, 172L, 173A, 191M, 192D, 193I, 197I, 213S, 231C, 232V, 233K, 242L, 260V, 263D, 264V, 291V, 292D, 293N, 294I, 295P
CDD
cd05305 (L-AlaDH)

264V

NAD(P) binding site
127N, 128C, 131A, 168I, 169G, 171G, 172L, 173A, 191M, 192D, 193I, 197I, 213S, 231C, 232V, 233K, 242L, 260V, 263D, 264V, 291V, 292D, 293N, 294I, 295P
CDD
cd05305 (L-AlaDH)

291V

NAD(P) binding site
127N, 128C, 131A, 168I, 169G, 171G, 172L, 173A, 191M, 192D, 193I, 197I, 213S, 231C, 232V, 233K, 242L, 260V, 263D, 264V, 291V, 292D, 293N, 294I, 295P
CDD
cd05305 (L-AlaDH)

292D

NAD(P) binding site
127N, 128C, 131A, 168I, 169G, 171G, 172L, 173A, 191M, 192D, 193I, 197I, 213S, 231C, 232V, 233K, 242L, 260V, 263D, 264V, 291V, 292D, 293N, 294I, 295P
CDD
cd05305 (L-AlaDH)

293N

NAD(P) binding site
127N, 128C, 131A, 168I, 169G, 171G, 172L, 173A, 191M, 192D, 193I, 197I, 213S, 231C, 232V, 233K, 242L, 260V, 263D, 264V, 291V, 292D, 293N, 294I, 295P
CDD
cd05305 (L-AlaDH)

294I

NAD(P) binding site
127N, 128C, 131A, 168I, 169G, 171G, 172L, 173A, 191M, 192D, 193I, 197I, 213S, 231C, 232V, 233K, 242L, 260V, 263D, 264V, 291V, 292D, 293N, 294I, 295P
CDD
cd05305 (L-AlaDH)

295P

NAD(P) binding site
127N, 128C, 131A, 168I, 169G, 171G, 172L, 173A, 191M, 192D, 193I, 197I, 213S, 231C, 232V, 233K, 242L, 260V, 263D, 264V, 291V, 292D, 293N, 294I, 295P
CDD
cd05305 (L-AlaDH)

GO term prediction

Biological Process

GO:0042853 L-alanine catabolic process

Molecular Function

GO:0000286 alanine dehydrogenase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

27725_FusoPortal_Gene_1953

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component