27725_FusoPortal_Gene_1971

Protein

27725_FusoPortal_Gene_1971

Length

751 amino acids

Protein family membership

DNA topoisomerase I, type IA (IPR028612)
- DNA topoisomerase I, bacterial-type (IPR005733)

Homologous superfamilies

Homologous superfamily
4 - 580
DNA topoisomerase, type IA, core domain (IPR023405)
Homologous superfamily
323 - 439
DNA topoisomerase, type IA, central region, subdomain 2 (IPR013825)

1 100 200 300 400 500 600 700 751

Domains and repeats

Domain
4 - 125
TOPRIM domain (IPR006171)
DNA topoisomerase 1, TOPRIM domain (IPR034149)
Domain
78 - 91
DNA topoisomerase, type IA, central (IPR013497)
128 - 550
DNA topoisomerase, type IA, central (IPR013497)
571 - 594
DNA topoisomerase, type IA, zn finger (IPR013498)
713 - 749
DNA topoisomerase, type IA, zn finger (IPR013498)

1 100 200 300 400 500 600 700 751

Detailed signature matches

IPR023405

DNA topoisomerase, type IA, core domain
1. SSF56712 (Prokaryot...)
  
  4 - 580
  
  SUPERFAMILY
  SSF56712 (Prokaryotic type I DNA topoisomerase)
IPR013825

DNA topoisomerase, type IA, central region, subdomain 2
1. G3DSA:2.70.20.10
  
  323 - 439
  
  GENE3D
  G3DSA:2.70.20.10 (G3DSA:2.70.20.10)
IPR028612

DNA topoisomerase I, type IA
1. MF_00952 (Topoisom_...)
  
  4 - 727
  
  HAMAP
  MF_00952 (Topoisom_1_prok)
IPR005733

DNA topoisomerase I, bacterial-type
1. TIGR01051
  
  6 - 603
  
  TIGRFAMs
  TIGR01051 (TIGR01051)
IPR006171

TOPRIM domain
1. PF01751 (Toprim)
  
  6 - 114
  
  Pfam
  PF01751 (Toprim)
2. PS50880 (TOPRIM)
  
  4 - 114
  
  PROSITE profiles
  PS50880 (TOPRIM)
IPR034149

DNA topoisomerase 1, TOPRIM domain
1. cd03363 (TOPRIM_Top...)
  
  4 - 125
  
  CDD
  cd03363 (TOPRIM_TopoIA_TopoI)
IPR013497

DNA topoisomerase, type IA, central
1. PR00417 (PRTPISMRASEI)
  
  465 - 479
  
  PRINTS
  PR00417 (PRTPISMRASEI)
  
  78 - 91
  
  PRINTS
  PR00417 (PRTPISMRASEI)
  
  163 - 181
  
  PRINTS
  PR00417 (PRTPISMRASEI)
  
  290 - 299
  
  PRINTS
  PR00417 (PRTPISMRASEI)
  
  366 - 382
  
  PRINTS
  PR00417 (PRTPISMRASEI)
2. PF01131 (Topoisom_bac)
  
  128 - 538
  
  Pfam
  PF01131 (Topoisom_bac)
3. cd00186 (TOP1Ac)
  
  131 - 550
  
  CDD
  cd00186 (TOP1Ac)
IPR013498

DNA topoisomerase, type IA, zn finger
1. PF01396 (zf-C4_Topo...)
  
  571 - 594
  
  Pfam
  PF01396 (zf-C4_Topoisom)
  
  713 - 749
  
  Pfam
  PF01396 (zf-C4_Topoisom)
IPR023406

DNA topoisomerase, type IA, active site
1. PS00396 (TOPOISOMER...)
  
  277 - 299
  
  PROSITE patterns
  PS00396 (TOPOISOMERASE_I_PROK)

no IPR

Unintegrated signatures

Coil

691 - 711

COILS
Coil (Coil)
G3DSA:1.10.46...

440 - 558

GENE3D
G3DSA:1.10.460.10 (G3DSA:1.10.460.10)

136 - 322

GENE3D
G3DSA:1.10.460.10 (G3DSA:1.10.460.10)
G3DSA:3.30.65.10

559 - 613

GENE3D
G3DSA:3.30.65.10 (G3DSA:3.30.65.10)

695 - 751

GENE3D
G3DSA:3.30.65.10 (G3DSA:3.30.65.10)
G3DSA:3.40.50...

3 - 130

GENE3D
G3DSA:3.40.50.140 (G3DSA:3.40.50.140)
SSF57783 (Zinc beta...)

708 - 747

SUPERFAMILY
SSF57783 (Zinc beta-ribbon)

Residue annotation

active site cd03363

10E

active site
10E, 11S, 14K, 83D, 85D, 87E
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

11S

active site
10E, 11S, 14K, 83D, 85D, 87E
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

14K

active site
10E, 11S, 14K, 83D, 85D, 87E
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

83D

active site
10E, 11S, 14K, 83D, 85D, 87E
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

85D

active site
10E, 11S, 14K, 83D, 85D, 87E
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

87E

active site
10E, 11S, 14K, 83D, 85D, 87E
CDD
cd03363 (TOPRIM_TopoIA_TopoI)
interdomain intera...

17T

interdomain interaction site
17T, 84P, 86R, 93W, 94H, 96A, 97H
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

84P

interdomain interaction site
17T, 84P, 86R, 93W, 94H, 96A, 97H
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

86R

interdomain interaction site
17T, 84P, 86R, 93W, 94H, 96A, 97H
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

93W

interdomain interaction site
17T, 84P, 86R, 93W, 94H, 96A, 97H
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

94H

interdomain interaction site
17T, 84P, 86R, 93W, 94H, 96A, 97H
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

96A

interdomain interaction site
17T, 84P, 86R, 93W, 94H, 96A, 97H
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

97H

interdomain interaction site
17T, 84P, 86R, 93W, 94H, 96A, 97H
CDD
cd03363 (TOPRIM_TopoIA_TopoI)
putative metal-bin...

83D

putative metal-binding site
83D, 85D
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

85D

putative metal-binding site
83D, 85D
CDD
cd03363 (TOPRIM_TopoIA_TopoI)
nucleotide binding...

86R

nucleotide binding site
86R
CDD
cd03363 (TOPRIM_TopoIA_TopoI)
domain I cd00186

131M

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

132D

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

133K

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

134V

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

135N

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

136A

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

137Q

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

138Q

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

139A

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

140R

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

141R

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

142I

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

143L

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

144D

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

145R

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

146L

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

147V

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

148G

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

149Y

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

150G

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

151I

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

152S

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

153S

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

154L

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

155L

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

156W

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

157K

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

158S

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

163T

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

164S

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

165A

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

166G

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

167R

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

168V

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

169Q

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

170S

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

171V

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

172A

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

173L

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

174K

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

175L

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

176I

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

177C

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

178D

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

179L

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

180E

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

181D

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

182E

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)

183I

domain I
131M, 132D, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142I, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150G, 151I, 152S, 153S, 154L, 155L, 156W, 157K, 158S, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182E, 183I
CDD
cd00186 (TOP1Ac)
DNA binding groove...

140R

DNA binding groove
140R, 141R, 144D, 148G, 152S, 277Q, 281E, 297R, 470S, 471T, 474T, 475I, 477E, 481K, 482R
CDD
cd00186 (TOP1Ac)

141R

DNA binding groove
140R, 141R, 144D, 148G, 152S, 277Q, 281E, 297R, 470S, 471T, 474T, 475I, 477E, 481K, 482R
CDD
cd00186 (TOP1Ac)

144D

DNA binding groove
140R, 141R, 144D, 148G, 152S, 277Q, 281E, 297R, 470S, 471T, 474T, 475I, 477E, 481K, 482R
CDD
cd00186 (TOP1Ac)

148G

DNA binding groove
140R, 141R, 144D, 148G, 152S, 277Q, 281E, 297R, 470S, 471T, 474T, 475I, 477E, 481K, 482R
CDD
cd00186 (TOP1Ac)

152S

DNA binding groove
140R, 141R, 144D, 148G, 152S, 277Q, 281E, 297R, 470S, 471T, 474T, 475I, 477E, 481K, 482R
CDD
cd00186 (TOP1Ac)

277Q

DNA binding groove
140R, 141R, 144D, 148G, 152S, 277Q, 281E, 297R, 470S, 471T, 474T, 475I, 477E, 481K, 482R
CDD
cd00186 (TOP1Ac)

281E

DNA binding groove
140R, 141R, 144D, 148G, 152S, 277Q, 281E, 297R, 470S, 471T, 474T, 475I, 477E, 481K, 482R
CDD
cd00186 (TOP1Ac)

297R

DNA binding groove
140R, 141R, 144D, 148G, 152S, 277Q, 281E, 297R, 470S, 471T, 474T, 475I, 477E, 481K, 482R
CDD
cd00186 (TOP1Ac)

470S

DNA binding groove
140R, 141R, 144D, 148G, 152S, 277Q, 281E, 297R, 470S, 471T, 474T, 475I, 477E, 481K, 482R
CDD
cd00186 (TOP1Ac)

471T

DNA binding groove
140R, 141R, 144D, 148G, 152S, 277Q, 281E, 297R, 470S, 471T, 474T, 475I, 477E, 481K, 482R
CDD
cd00186 (TOP1Ac)

474T

DNA binding groove
140R, 141R, 144D, 148G, 152S, 277Q, 281E, 297R, 470S, 471T, 474T, 475I, 477E, 481K, 482R
CDD
cd00186 (TOP1Ac)

475I

DNA binding groove
140R, 141R, 144D, 148G, 152S, 277Q, 281E, 297R, 470S, 471T, 474T, 475I, 477E, 481K, 482R
CDD
cd00186 (TOP1Ac)

477E

DNA binding groove
140R, 141R, 144D, 148G, 152S, 277Q, 281E, 297R, 470S, 471T, 474T, 475I, 477E, 481K, 482R
CDD
cd00186 (TOP1Ac)

481K

DNA binding groove
140R, 141R, 144D, 148G, 152S, 277Q, 281E, 297R, 470S, 471T, 474T, 475I, 477E, 481K, 482R
CDD
cd00186 (TOP1Ac)

482R

DNA binding groove
140R, 141R, 144D, 148G, 152S, 277Q, 281E, 297R, 470S, 471T, 474T, 475I, 477E, 481K, 482R
CDD
cd00186 (TOP1Ac)
phosphate binding ...

174K

phosphate binding site
174K, 178D, 506D
CDD
cd00186 (TOP1Ac)

178D

phosphate binding site
174K, 178D, 506D
CDD
cd00186 (TOP1Ac)

506D

phosphate binding site
174K, 178D, 506D
CDD
cd00186 (TOP1Ac)
domain II cd00186

188P

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

189V

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

190K

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

191F

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

192W

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

193E

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

194V

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

195K

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

233D

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

234F

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

235T

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

236V

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

237I

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

238E

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

239A

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

240K

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

241V

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

242S

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

243K

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

244K

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

245S

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

246K

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

247N

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

380A

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

381P

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

382M

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

383K

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

384Y

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

385E

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

386Q

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

387F

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

388E

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

389I

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

390I

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

391C

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

392N

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

393Y

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

394E

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

396F

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

397D

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

398F

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

399R

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

400G

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

401T

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

402I

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

403N

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

404K

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

405I

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

406I

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

407F

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

408D

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

409G

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

410Y

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

411Y

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

412K

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

413I

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

414F

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

437E

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

438K

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

439L

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

440L

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

441I

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

442K

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

443E

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

444D

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

445F

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

446T

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)

447K

domain II
188P, 189V, 190K, 191F, 192W, 193E, 194V, 195K, 233D, 234F, 235T, 236V, 237I, 238E, 239A, 240K, 241V, 242S, 243K, 244K, 245S, 246K, 247N, 380A, 381P, 382M, 383K, 384Y, 385E, 386Q, 387F, 388E, 389I, 390I, 391C, 392N, 393Y, 394E, 396F, 397D, 398F, 399R, 400G, 401T, 402I, 403N, 404K, 405I, 406I, 407F, 408D, 409G, 410Y, 411Y, 412K, 413I, 414F, 437E, 438K, 439L, 440L, 441I, 442K, 443E, 444D, 445F, 446T, 447K
CDD
cd00186 (TOP1Ac)
domain III cd00186

248S

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

249P

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

250L

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

251P

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

252L

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

253K

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

254T

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

256T

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

257L

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

258Q

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

259Q

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

260L

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

261A

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

262S

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

263S

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

264Y

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

265L

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

266G

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

267F

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

268S

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

269A

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

270S

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

271K

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

272T

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

273M

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

274R

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

275V

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

276A

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

277Q

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

278G

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

279L

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

280Y

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

281E

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

290K

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

291G

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

292L

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

293I

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

294T

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

295Y

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

296M

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

297R

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

298T

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

299D

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

300S

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

301T

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

302R

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

303I

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

304S

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

305E

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

306D

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

307A

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

308I

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

309E

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

310M

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

311A

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

312K

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

313K

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

314Y

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

315I

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

316L

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

317E

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

318N

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

319F

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

339A

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

340H

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

341E

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

342A

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

343I

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

344R

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

345P

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

346T

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

347D

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

359L

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

360D

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

361K

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

362D

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

363Q

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

364Y

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

365K

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

366L

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

367Y

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

368K

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

369L

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

370I

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

371W

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

372D

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

373R

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

374F

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

375L

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

376I

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

377S

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

378Q

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)

379L

domain III
248S, 249P, 250L, 251P, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261A, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271K, 272T, 273M, 274R, 275V, 276A, 277Q, 278G, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305E, 306D, 307A, 308I, 309E, 310M, 311A, 312K, 313K, 314Y, 315I, 316L, 317E, 318N, 319F, 339A, 340H, 341E, 342A, 343I, 344R, 345P, 346T, 347D, 359L, 360D, 361K, 362D, 363Q, 364Y, 365K, 366L, 367Y, 368K, 369L, 370I, 371W, 372D, 373R, 374F, 375L, 376I, 377S, 378Q, 379L
CDD
cd00186 (TOP1Ac)
nucleotide binding...

259Q

nucleotide binding site
259Q, 263S, 264Y, 265L, 340H, 365K, 368K, 372D, 468R, 470S, 492F
CDD
cd00186 (TOP1Ac)

263S

nucleotide binding site
259Q, 263S, 264Y, 265L, 340H, 365K, 368K, 372D, 468R, 470S, 492F
CDD
cd00186 (TOP1Ac)

264Y

nucleotide binding site
259Q, 263S, 264Y, 265L, 340H, 365K, 368K, 372D, 468R, 470S, 492F
CDD
cd00186 (TOP1Ac)

265L

nucleotide binding site
259Q, 263S, 264Y, 265L, 340H, 365K, 368K, 372D, 468R, 470S, 492F
CDD
cd00186 (TOP1Ac)

340H

nucleotide binding site
259Q, 263S, 264Y, 265L, 340H, 365K, 368K, 372D, 468R, 470S, 492F
CDD
cd00186 (TOP1Ac)

365K

nucleotide binding site
259Q, 263S, 264Y, 265L, 340H, 365K, 368K, 372D, 468R, 470S, 492F
CDD
cd00186 (TOP1Ac)

368K

nucleotide binding site
259Q, 263S, 264Y, 265L, 340H, 365K, 368K, 372D, 468R, 470S, 492F
CDD
cd00186 (TOP1Ac)

372D

nucleotide binding site
259Q, 263S, 264Y, 265L, 340H, 365K, 368K, 372D, 468R, 470S, 492F
CDD
cd00186 (TOP1Ac)

468R

nucleotide binding site
259Q, 263S, 264Y, 265L, 340H, 365K, 368K, 372D, 468R, 470S, 492F
CDD
cd00186 (TOP1Ac)

470S

nucleotide binding site
259Q, 263S, 264Y, 265L, 340H, 365K, 368K, 372D, 468R, 470S, 492F
CDD
cd00186 (TOP1Ac)

492F

nucleotide binding site
259Q, 263S, 264Y, 265L, 340H, 365K, 368K, 372D, 468R, 470S, 492F
CDD
cd00186 (TOP1Ac)
catalytic site cd0...

295Y

catalytic site
295Y, 297R, 340H
CDD
cd00186 (TOP1Ac)

297R

catalytic site
295Y, 297R, 340H
CDD
cd00186 (TOP1Ac)

340H

catalytic site
295Y, 297R, 340H
CDD
cd00186 (TOP1Ac)
domain IV cd00186

448P

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

449P

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

450S

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

451R

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

452F

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

453T

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

454E

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

455S

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

456S

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

457L

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

458V

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

459K

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

460K

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

461L

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

462E

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

463A

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

464E

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

465G

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

466I

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

467G

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

468R

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

469P

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

470S

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

471T

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

472Y

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

473A

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

474T

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

475I

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

476I

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

477E

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

478T

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

479L

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

480K

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

481K

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

482R

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

483E

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

484Y

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

485V

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

486V

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

487V

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

488E

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

492F

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

493S

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

494P

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

495T

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

496A

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

497L

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

498G

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

499Y

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

500E

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

501I

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

502K

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

503D

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

504K

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

505L

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

506D

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

512I

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

513M

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

514N

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

515V

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

516K

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

517F

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

518T

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

519A

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

520E

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

521L

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

522E

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

523N

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

524Q

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

525L

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

526D

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

527K

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

528V

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

529A

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

530E

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

531G

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

532E

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

533K

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

534D

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

535W

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

536I

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

537N

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

538L

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

539L

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

540S

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

541V

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

542F

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

543Y

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

544K

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

545E

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

546L

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

547K

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

548H

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

549Y

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

550I

domain IV
448P, 449P, 450S, 451R, 452F, 453T, 454E, 455S, 456S, 457L, 458V, 459K, 460K, 461L, 462E, 463A, 464E, 465G, 466I, 467G, 468R, 469P, 470S, 471T, 472Y, 473A, 474T, 475I, 476I, 477E, 478T, 479L, 480K, 481K, 482R, 483E, 484Y, 485V, 486V, 487V, 488E, 492F, 493S, 494P, 495T, 496A, 497L, 498G, 499Y, 500E, 501I, 502K, 503D, 504K, 505L, 506D, 512I, 513M, 514N, 515V, 516K, 517F, 518T, 519A, 520E, 521L, 522E, 523N, 524Q, 525L, 526D, 527K, 528V, 529A, 530E, 531G, 532E, 533K, 534D, 535W, 536I, 537N, 538L, 539L, 540S, 541V, 542F, 543Y, 544K, 545E, 546L, 547K, 548H, 549Y, 550I
CDD
cd00186 (TOP1Ac)

GO term prediction

Biological Process

GO:0006265 DNA topological change

Molecular Function

GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003917 DNA topoisomerase type I activity

Cellular Component

GO:0005694 chromosome

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Entry type

Status

Per-residue features

27725_FusoPortal_Gene_1971

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component