27725_FusoPortal_Gene_2225

Protein

27725_FusoPortal_Gene_2225

Length

458 amino acids

Protein family membership

Fumarate lyase family (IPR000362)

Homologous superfamilies

Homologous superfamily
2 - 108
Fumarase/histidase, N-terminal (IPR024083)
Homologous superfamily
17 - 448
L-Aspartase-like (IPR008948)

1 50 100 150 200 250 300 350 400 458

Domains and repeats

Domain
21 - 290
Fumarate lyase, N-terminal (IPR022761)
368 - 443
Adenylosuccinate lyase C-terminal (IPR019468)

1 50 100 150 200 250 300 350 400 458

Detailed signature matches

IPR024083

Fumarase/histidase, N-terminal
1. G3DSA:1.10.27...
  
  2 - 108
  
  GENE3D
  G3DSA:1.10.275.10 (G3DSA:1.10.275.10)
IPR008948

L-Aspartase-like
1. SSF48557 (L-asparta...)
  
  17 - 448
  
  SUPERFAMILY
  SSF48557 (L-aspartase-like)
IPR000362

Fumarate lyase family
1. PR00149 (FUMRATELYASE)
  
  234 - 261
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  104 - 122
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  149 - 167
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  279 - 295
  
  PRINTS
  PR00149 (FUMRATELYASE)
IPR022761

Fumarate lyase, N-terminal
1. PF00206 (Lyase_1)
  
  21 - 290
  
  Pfam
  PF00206 (Lyase_1)
IPR019468

Adenylosuccinate lyase C-terminal
1. PF10397 (ADSL_C)
  
  368 - 443
  
  Pfam
  PF10397 (ADSL_C)
IPR020557

Fumarate lyase, conserved site
1. PS00163 (FUMARATE_L...)
  
  279 - 288
  
  PROSITE patterns
  PS00163 (FUMARATE_LYASES)

no IPR

Unintegrated signatures

Coil

439 - 458

COILS
Coil (Coil)
G3DSA:1.10.40.30

367 - 445

GENE3D
G3DSA:1.10.40.30 (G3DSA:1.10.40.30)
G3DSA:1.20.20...

109 - 366

GENE3D
G3DSA:1.20.200.10 (G3DSA:1.20.200.10)
PR00145 (ARGSUCLYASE)

234 - 258

PRINTS
PR00145 (ARGSUCLYASE)

279 - 295

PRINTS
PR00145 (ARGSUCLYASE)

144 - 164

PRINTS
PR00145 (ARGSUCLYASE)
PTHR43093 (FAMILY N...)

17 - 448

PANTHER
PTHR43093 (FAMILY NOT NAMED)
cd01597 (pCLME)

4 - 448

CDD
cd01597 (pCLME)

Residue annotation

tetramer interface...

21V

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

22S

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

23K

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

26K

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

27Y

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

70D

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

73Y

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

74K

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

97E

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

103Y

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

155R

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

156T

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

157H

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

159K

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

160H

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

162T

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

163P

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

169K

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

171S

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

176D

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

179A

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

182E

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

183R

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

186E

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

200V

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

201G

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

202A

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

205T

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

210G

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

211R

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

226M

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

227E

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

232N

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

233I

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

235S

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

236H

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

238E

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

239E

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

242M

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

245A

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

246L

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

253K

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

256E

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

257E

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

262S

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

263I

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

265E

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

287I

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

288N

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

293K

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

300Q

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

301K

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

306V

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

310L

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

315R

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

316P

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

317F

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

318E

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

319A

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

325M

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

326L

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

328D

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

330A

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

369L

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

436G

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

437L

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

441L

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)

444E

tetramer interface
21V, 22S, 23K, 26K, 27Y, 70D, 73Y, 74K, 97E, 103Y, 155R, 156T, 157H, 159K, 160H, 162T, 163P, 169K, 171S, 176D, 179A, 182E, 183R, 186E, 200V, 201G, 202A, 205T, 210G, 211R, 226M, 227E, 232N, 233I, 235S, 236H, 238E, 239E, 242M, 245A, 246L, 253K, 256E, 257E, 262S, 263I, 265E, 287I, 288N, 293K, 300Q, 301K, 306V, 310L, 315R, 316P, 317F, 318E, 319A, 325M, 326L, 328D, 330A, 369L, 436G, 437L, 441L, 444E
CDD
cd01597 (pCLME)
active site cd01597

78H

active site
78H, 79G, 109T, 110T, 111Q, 156T, 157H, 199A, 285Q, 286K, 288N, 319A
CDD
cd01597 (pCLME)

79G

active site
78H, 79G, 109T, 110T, 111Q, 156T, 157H, 199A, 285Q, 286K, 288N, 319A
CDD
cd01597 (pCLME)

109T

active site
78H, 79G, 109T, 110T, 111Q, 156T, 157H, 199A, 285Q, 286K, 288N, 319A
CDD
cd01597 (pCLME)

110T

active site
78H, 79G, 109T, 110T, 111Q, 156T, 157H, 199A, 285Q, 286K, 288N, 319A
CDD
cd01597 (pCLME)

111Q

active site
78H, 79G, 109T, 110T, 111Q, 156T, 157H, 199A, 285Q, 286K, 288N, 319A
CDD
cd01597 (pCLME)

156T

active site
78H, 79G, 109T, 110T, 111Q, 156T, 157H, 199A, 285Q, 286K, 288N, 319A
CDD
cd01597 (pCLME)

157H

active site
78H, 79G, 109T, 110T, 111Q, 156T, 157H, 199A, 285Q, 286K, 288N, 319A
CDD
cd01597 (pCLME)

199A

active site
78H, 79G, 109T, 110T, 111Q, 156T, 157H, 199A, 285Q, 286K, 288N, 319A
CDD
cd01597 (pCLME)

285Q

active site
78H, 79G, 109T, 110T, 111Q, 156T, 157H, 199A, 285Q, 286K, 288N, 319A
CDD
cd01597 (pCLME)

286K

active site
78H, 79G, 109T, 110T, 111Q, 156T, 157H, 199A, 285Q, 286K, 288N, 319A
CDD
cd01597 (pCLME)

288N

active site
78H, 79G, 109T, 110T, 111Q, 156T, 157H, 199A, 285Q, 286K, 288N, 319A
CDD
cd01597 (pCLME)

319A

active site
78H, 79G, 109T, 110T, 111Q, 156T, 157H, 199A, 285Q, 286K, 288N, 319A
CDD
cd01597 (pCLME)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003824 catalytic activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

27725_FusoPortal_Gene_2225

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component