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Protein

27725_FusoPortal_Gene_2236

Length

321 amino acids

Protein family membership

None predicted.

Homologous superfamilies

Homologous superfamily
2 - 55
Lambda repressor-like, DNA-binding domain superfamily (IPR010982)
60 - 302
Periplasmic binding protein-like I (IPR028082)

1 50 100 150 200 250 321

Domains and repeats

Domain
1 - 55
LacI-type HTH domain (IPR000843)
59 - 259
Periplasmic binding protein/LacI sugar binding domain (IPR001761)

1 50 100 150 200 250 321

Detailed signature matches

IPR010982

Lambda repressor-like, DNA-binding domain superfamily

SSF47413 (lambda re...)

2 - 55

SUPERFAMILY
SSF47413 (lambda repressor-like DNA-binding domains)

IPR028082

Periplasmic binding protein-like I

SSF53822 (Periplasm...)

60 - 302

SUPERFAMILY
SSF53822 (Periplasmic binding protein-like I)

IPR000843

LacI-type HTH domain

PF00356 (LacI)

2 - 47

Pfam
PF00356 (LacI)
PS50932 (HTH_LACI_2)

1 - 55

PROSITE profiles
PS50932 (HTH_LACI_2)
cd01392 (HTH_LacI)

4 - 55

CDD
cd01392 (HTH_LacI)

IPR001761

Periplasmic binding protein/LacI sugar binding domain

PF00532 (Peripla_BP_1)

59 - 259

Pfam
PF00532 (Peripla_BP_1)

no IPR

Unintegrated signatures

G3DSA:1.10.26...

1 - 53

GENE3D
G3DSA:1.10.260.40 (G3DSA:1.10.260.40)
G3DSA:3.40.50...

54 - 175

GENE3D
G3DSA:3.40.50.2300 (G3DSA:3.40.50.2300)

176 - 298

GENE3D
G3DSA:3.40.50.2300 (G3DSA:3.40.50.2300)
PTHR30146 (LACI-REL...)

2 - 307

PANTHER
PTHR30146 (LACI-RELATED TRANSCRIPTIONAL REPRESSOR)
PTHR30146:SF94 (SUB...)

2 - 307

PANTHER
PTHR30146:SF94 (SUBFAMILY NOT NAMED)
cd06267 (PBP1_LacI_...)

60 - 262

CDD
cd06267 (PBP1_LacI_sugar_binding_like)

Residue annotation

DNA binding site c...

4K

DNA binding site
4K, 12I, 13S, 14V, 15A, 16T, 18S, 19R, 22N, 27I, 28N, 31T, 44Y, 47N, 50A, 51R, 53L, 54S
CDD
cd01392 (HTH_LacI)

12I

DNA binding site
4K, 12I, 13S, 14V, 15A, 16T, 18S, 19R, 22N, 27I, 28N, 31T, 44Y, 47N, 50A, 51R, 53L, 54S
CDD
cd01392 (HTH_LacI)

13S

DNA binding site
4K, 12I, 13S, 14V, 15A, 16T, 18S, 19R, 22N, 27I, 28N, 31T, 44Y, 47N, 50A, 51R, 53L, 54S
CDD
cd01392 (HTH_LacI)

14V

DNA binding site
4K, 12I, 13S, 14V, 15A, 16T, 18S, 19R, 22N, 27I, 28N, 31T, 44Y, 47N, 50A, 51R, 53L, 54S
CDD
cd01392 (HTH_LacI)

15A

DNA binding site
4K, 12I, 13S, 14V, 15A, 16T, 18S, 19R, 22N, 27I, 28N, 31T, 44Y, 47N, 50A, 51R, 53L, 54S
CDD
cd01392 (HTH_LacI)

16T

DNA binding site
4K, 12I, 13S, 14V, 15A, 16T, 18S, 19R, 22N, 27I, 28N, 31T, 44Y, 47N, 50A, 51R, 53L, 54S
CDD
cd01392 (HTH_LacI)

18S

DNA binding site
4K, 12I, 13S, 14V, 15A, 16T, 18S, 19R, 22N, 27I, 28N, 31T, 44Y, 47N, 50A, 51R, 53L, 54S
CDD
cd01392 (HTH_LacI)

19R

DNA binding site
4K, 12I, 13S, 14V, 15A, 16T, 18S, 19R, 22N, 27I, 28N, 31T, 44Y, 47N, 50A, 51R, 53L, 54S
CDD
cd01392 (HTH_LacI)

22N

DNA binding site
4K, 12I, 13S, 14V, 15A, 16T, 18S, 19R, 22N, 27I, 28N, 31T, 44Y, 47N, 50A, 51R, 53L, 54S
CDD
cd01392 (HTH_LacI)

27I

DNA binding site
4K, 12I, 13S, 14V, 15A, 16T, 18S, 19R, 22N, 27I, 28N, 31T, 44Y, 47N, 50A, 51R, 53L, 54S
CDD
cd01392 (HTH_LacI)

28N

DNA binding site
4K, 12I, 13S, 14V, 15A, 16T, 18S, 19R, 22N, 27I, 28N, 31T, 44Y, 47N, 50A, 51R, 53L, 54S
CDD
cd01392 (HTH_LacI)

31T

DNA binding site
4K, 12I, 13S, 14V, 15A, 16T, 18S, 19R, 22N, 27I, 28N, 31T, 44Y, 47N, 50A, 51R, 53L, 54S
CDD
cd01392 (HTH_LacI)

44Y

DNA binding site
4K, 12I, 13S, 14V, 15A, 16T, 18S, 19R, 22N, 27I, 28N, 31T, 44Y, 47N, 50A, 51R, 53L, 54S
CDD
cd01392 (HTH_LacI)

47N

DNA binding site
4K, 12I, 13S, 14V, 15A, 16T, 18S, 19R, 22N, 27I, 28N, 31T, 44Y, 47N, 50A, 51R, 53L, 54S
CDD
cd01392 (HTH_LacI)

50A

DNA binding site
4K, 12I, 13S, 14V, 15A, 16T, 18S, 19R, 22N, 27I, 28N, 31T, 44Y, 47N, 50A, 51R, 53L, 54S
CDD
cd01392 (HTH_LacI)

51R

DNA binding site
4K, 12I, 13S, 14V, 15A, 16T, 18S, 19R, 22N, 27I, 28N, 31T, 44Y, 47N, 50A, 51R, 53L, 54S
CDD
cd01392 (HTH_LacI)

53L

DNA binding site
4K, 12I, 13S, 14V, 15A, 16T, 18S, 19R, 22N, 27I, 28N, 31T, 44Y, 47N, 50A, 51R, 53L, 54S
CDD
cd01392 (HTH_LacI)

54S

DNA binding site
4K, 12I, 13S, 14V, 15A, 16T, 18S, 19R, 22N, 27I, 28N, 31T, 44Y, 47N, 50A, 51R, 53L, 54S
CDD
cd01392 (HTH_LacI)
domain linker moti...

44Y

domain linker motif
44Y, 45T, 46P, 47N, 48V, 49I, 50A, 51R, 52N, 53L
CDD
cd01392 (HTH_LacI)

45T

domain linker motif
44Y, 45T, 46P, 47N, 48V, 49I, 50A, 51R, 52N, 53L
CDD
cd01392 (HTH_LacI)

46P

domain linker motif
44Y, 45T, 46P, 47N, 48V, 49I, 50A, 51R, 52N, 53L
CDD
cd01392 (HTH_LacI)

47N

domain linker motif
44Y, 45T, 46P, 47N, 48V, 49I, 50A, 51R, 52N, 53L
CDD
cd01392 (HTH_LacI)

48V

domain linker motif
44Y, 45T, 46P, 47N, 48V, 49I, 50A, 51R, 52N, 53L
CDD
cd01392 (HTH_LacI)

49I

domain linker motif
44Y, 45T, 46P, 47N, 48V, 49I, 50A, 51R, 52N, 53L
CDD
cd01392 (HTH_LacI)

50A

domain linker motif
44Y, 45T, 46P, 47N, 48V, 49I, 50A, 51R, 52N, 53L
CDD
cd01392 (HTH_LacI)

51R

domain linker motif
44Y, 45T, 46P, 47N, 48V, 49I, 50A, 51R, 52N, 53L
CDD
cd01392 (HTH_LacI)

52N

domain linker motif
44Y, 45T, 46P, 47N, 48V, 49I, 50A, 51R, 52N, 53L
CDD
cd01392 (HTH_LacI)

53L

domain linker motif
44Y, 45T, 46P, 47N, 48V, 49I, 50A, 51R, 52N, 53L
CDD
cd01392 (HTH_LacI)
dimerization inter...

60T

dimerization interface
60T, 73F, 74A, 75S, 78N, 79N, 81C, 82A, 89Y, 90Q, 91I, 92A, 93L, 95N, 106A, 109N, 112G, 113Q, 114R, 223E, 249L, 253K, 256K, 257V
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

73F

dimerization interface
60T, 73F, 74A, 75S, 78N, 79N, 81C, 82A, 89Y, 90Q, 91I, 92A, 93L, 95N, 106A, 109N, 112G, 113Q, 114R, 223E, 249L, 253K, 256K, 257V
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

74A

dimerization interface
60T, 73F, 74A, 75S, 78N, 79N, 81C, 82A, 89Y, 90Q, 91I, 92A, 93L, 95N, 106A, 109N, 112G, 113Q, 114R, 223E, 249L, 253K, 256K, 257V
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

75S

dimerization interface
60T, 73F, 74A, 75S, 78N, 79N, 81C, 82A, 89Y, 90Q, 91I, 92A, 93L, 95N, 106A, 109N, 112G, 113Q, 114R, 223E, 249L, 253K, 256K, 257V
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

78N

dimerization interface
60T, 73F, 74A, 75S, 78N, 79N, 81C, 82A, 89Y, 90Q, 91I, 92A, 93L, 95N, 106A, 109N, 112G, 113Q, 114R, 223E, 249L, 253K, 256K, 257V
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

79N

dimerization interface
60T, 73F, 74A, 75S, 78N, 79N, 81C, 82A, 89Y, 90Q, 91I, 92A, 93L, 95N, 106A, 109N, 112G, 113Q, 114R, 223E, 249L, 253K, 256K, 257V
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

81C

dimerization interface
60T, 73F, 74A, 75S, 78N, 79N, 81C, 82A, 89Y, 90Q, 91I, 92A, 93L, 95N, 106A, 109N, 112G, 113Q, 114R, 223E, 249L, 253K, 256K, 257V
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

82A

dimerization interface
60T, 73F, 74A, 75S, 78N, 79N, 81C, 82A, 89Y, 90Q, 91I, 92A, 93L, 95N, 106A, 109N, 112G, 113Q, 114R, 223E, 249L, 253K, 256K, 257V
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

89Y

dimerization interface
60T, 73F, 74A, 75S, 78N, 79N, 81C, 82A, 89Y, 90Q, 91I, 92A, 93L, 95N, 106A, 109N, 112G, 113Q, 114R, 223E, 249L, 253K, 256K, 257V
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

90Q

dimerization interface
60T, 73F, 74A, 75S, 78N, 79N, 81C, 82A, 89Y, 90Q, 91I, 92A, 93L, 95N, 106A, 109N, 112G, 113Q, 114R, 223E, 249L, 253K, 256K, 257V
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

91I

dimerization interface
60T, 73F, 74A, 75S, 78N, 79N, 81C, 82A, 89Y, 90Q, 91I, 92A, 93L, 95N, 106A, 109N, 112G, 113Q, 114R, 223E, 249L, 253K, 256K, 257V
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

92A

dimerization interface
60T, 73F, 74A, 75S, 78N, 79N, 81C, 82A, 89Y, 90Q, 91I, 92A, 93L, 95N, 106A, 109N, 112G, 113Q, 114R, 223E, 249L, 253K, 256K, 257V
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

93L

dimerization interface
60T, 73F, 74A, 75S, 78N, 79N, 81C, 82A, 89Y, 90Q, 91I, 92A, 93L, 95N, 106A, 109N, 112G, 113Q, 114R, 223E, 249L, 253K, 256K, 257V
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

95N

dimerization interface
60T, 73F, 74A, 75S, 78N, 79N, 81C, 82A, 89Y, 90Q, 91I, 92A, 93L, 95N, 106A, 109N, 112G, 113Q, 114R, 223E, 249L, 253K, 256K, 257V
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

106A

dimerization interface
60T, 73F, 74A, 75S, 78N, 79N, 81C, 82A, 89Y, 90Q, 91I, 92A, 93L, 95N, 106A, 109N, 112G, 113Q, 114R, 223E, 249L, 253K, 256K, 257V
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

109N

dimerization interface
60T, 73F, 74A, 75S, 78N, 79N, 81C, 82A, 89Y, 90Q, 91I, 92A, 93L, 95N, 106A, 109N, 112G, 113Q, 114R, 223E, 249L, 253K, 256K, 257V
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

112G

dimerization interface
60T, 73F, 74A, 75S, 78N, 79N, 81C, 82A, 89Y, 90Q, 91I, 92A, 93L, 95N, 106A, 109N, 112G, 113Q, 114R, 223E, 249L, 253K, 256K, 257V
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

113Q

dimerization interface
60T, 73F, 74A, 75S, 78N, 79N, 81C, 82A, 89Y, 90Q, 91I, 92A, 93L, 95N, 106A, 109N, 112G, 113Q, 114R, 223E, 249L, 253K, 256K, 257V
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

114R

dimerization interface
60T, 73F, 74A, 75S, 78N, 79N, 81C, 82A, 89Y, 90Q, 91I, 92A, 93L, 95N, 106A, 109N, 112G, 113Q, 114R, 223E, 249L, 253K, 256K, 257V
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

223E

dimerization interface
60T, 73F, 74A, 75S, 78N, 79N, 81C, 82A, 89Y, 90Q, 91I, 92A, 93L, 95N, 106A, 109N, 112G, 113Q, 114R, 223E, 249L, 253K, 256K, 257V
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

249L

dimerization interface
60T, 73F, 74A, 75S, 78N, 79N, 81C, 82A, 89Y, 90Q, 91I, 92A, 93L, 95N, 106A, 109N, 112G, 113Q, 114R, 223E, 249L, 253K, 256K, 257V
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

253K

dimerization interface
60T, 73F, 74A, 75S, 78N, 79N, 81C, 82A, 89Y, 90Q, 91I, 92A, 93L, 95N, 106A, 109N, 112G, 113Q, 114R, 223E, 249L, 253K, 256K, 257V
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

256K

dimerization interface
60T, 73F, 74A, 75S, 78N, 79N, 81C, 82A, 89Y, 90Q, 91I, 92A, 93L, 95N, 106A, 109N, 112G, 113Q, 114R, 223E, 249L, 253K, 256K, 257V
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

257V

dimerization interface
60T, 73F, 74A, 75S, 78N, 79N, 81C, 82A, 89Y, 90Q, 91I, 92A, 93L, 95N, 106A, 109N, 112G, 113Q, 114R, 223E, 249L, 253K, 256K, 257V
CDD
cd06267 (PBP1_LacI_sugar_binding_like)
ligand binding sit...

72F

ligand binding site
72F, 73F, 76L, 123I, 146D, 159L, 195R, 220F
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

73F

ligand binding site
72F, 73F, 76L, 123I, 146D, 159L, 195R, 220F
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

76L

ligand binding site
72F, 73F, 76L, 123I, 146D, 159L, 195R, 220F
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

123I

ligand binding site
72F, 73F, 76L, 123I, 146D, 159L, 195R, 220F
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

146D

ligand binding site
72F, 73F, 76L, 123I, 146D, 159L, 195R, 220F
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

159L

ligand binding site
72F, 73F, 76L, 123I, 146D, 159L, 195R, 220F
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

195R

ligand binding site
72F, 73F, 76L, 123I, 146D, 159L, 195R, 220F
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

220F

ligand binding site
72F, 73F, 76L, 123I, 146D, 159L, 195R, 220F
CDD
cd06267 (PBP1_LacI_sugar_binding_like)

GO term prediction

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003677 DNA binding

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

27725_FusoPortal_Gene_2236

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component