27725_FusoPortal_Gene_237

Protein

27725_FusoPortal_Gene_237

Length

752 amino acids

Protein family membership

Ornithine/lysine/arginine decarboxylase (IPR011193)

Homologous superfamilies

Homologous superfamily
150 - 604
Pyridoxal phosphate-dependent transferase (IPR015424)
Homologous superfamily
150 - 441
Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (IPR015421)
607 - 752
Orn/Lys/Arg decarboxylase, C-terminal domain superfamily (IPR036633)
Homologous superfamily
443 - 635
Pyridoxal phosphate-dependent transferase, subdomain 2 (IPR015422)

1 100 200 300 400 500 600 700 752

Domains and repeats

Domain
27 - 144
Orn/Lys/Arg decarboxylase, N-terminal (IPR005308)
150 - 585
Orn/Lys/Arg decarboxylase, major domain (IPR000310)
611 - 739
Orn/Lys/Arg decarboxylase, C-terminal (IPR008286)

1 100 200 300 400 500 600 700 752

Detailed signature matches

IPR015421

Pyridoxal phosphate-dependent transferase, major region, subdomain 1
1. G3DSA:3.40.64...
  
  150 - 441
  
  GENE3D
  G3DSA:3.40.640.10 (G3DSA:3.40.640.10)
IPR015424

Pyridoxal phosphate-dependent transferase
1. SSF53383 (PLP-depen...)
  
  150 - 604
  
  SUPERFAMILY
  SSF53383 (PLP-dependent transferases)
IPR015422

Pyridoxal phosphate-dependent transferase, subdomain 2
1. G3DSA:3.90.11...
  
  443 - 635
  
  GENE3D
  G3DSA:3.90.1150.10 (G3DSA:3.90.1150.10)
IPR036633

Orn/Lys/Arg decarboxylase, C-terminal domain superfamily
1. G3DSA:3.90.10...
  
  636 - 752
  
  GENE3D
  G3DSA:3.90.100.10 (G3DSA:3.90.100.10)
2. SSF55904 (Ornithine...)
  
  607 - 751
  
  SUPERFAMILY
  SSF55904 (Ornithine decarboxylase C-terminal domain)
IPR011193

Ornithine/lysine/arginine decarboxylase
1. PIRSF009393 (Orn_de...)
  
  6 - 752
  
  PIRSF
  PIRSF009393 (Orn_decarb)
IPR005308

Orn/Lys/Arg decarboxylase, N-terminal
1. PF03709 (OKR_DC_1_N)
  
  27 - 144
  
  Pfam
  PF03709 (OKR_DC_1_N)
IPR000310

Orn/Lys/Arg decarboxylase, major domain
1. PS00703 (OKR_DC_1)
  
  377 - 391
  
  PROSITE patterns
  PS00703 (OKR_DC_1)
2. cd00615 (Orn_deC_like)
  
  151 - 459
  
  CDD
  cd00615 (Orn_deC_like)
3. PF01276 (OKR_DC_1)
  
  150 - 585
  
  Pfam
  PF01276 (OKR_DC_1)
IPR008286

Orn/Lys/Arg decarboxylase, C-terminal
1. PF03711 (OKR_DC_1_C)
  
  611 - 739
  
  Pfam
  PF03711 (OKR_DC_1_C)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

10 - 149

GENE3D
G3DSA:3.40.50.2300 (G3DSA:3.40.50.2300)
PTHR45229 (FAMILY N...)

12 - 750

PANTHER
PTHR45229 (FAMILY NOT NAMED)
PTHR45229:SF2 (BIOD...)

12 - 750

PANTHER
PTHR45229:SF2 (BIODEGRADATIVE ARGININE DECARBOXYLASE)

Residue annotation

homodimer interfac...

199D

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

204R

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

212D

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

237L

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

238V

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

239G

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

241S

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

242G

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

245R

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

249Q

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

250A

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

251C

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

253T

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

254D

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

265H

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

266K

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

381H

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

382K

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

385N

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

386A

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

387L

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

388S

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

389Q

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

409Q

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

410S

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

412M

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

413M

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

414H

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

416T

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

423I

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

426S

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

429I

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

442L

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)

443I

homodimer interface
199D, 204R, 212D, 237L, 238V, 239G, 241S, 242G, 245R, 249Q, 250A, 251C, 253T, 254D, 265H, 266K, 381H, 382K, 385N, 386A, 387L, 388S, 389Q, 409Q, 410S, 412M, 413M, 414H, 416T, 423I, 426S, 429I, 442L, 443I
CDD
cd00615 (Orn_deC_like)
pyridoxal 5'-phosp...

239G

pyridoxal 5'-phosphate binding site
239G, 240T, 241S, 265H, 267S, 314T, 342D, 344A, 345W, 379S, 381H, 382K
CDD
cd00615 (Orn_deC_like)

240T

pyridoxal 5'-phosphate binding site
239G, 240T, 241S, 265H, 267S, 314T, 342D, 344A, 345W, 379S, 381H, 382K
CDD
cd00615 (Orn_deC_like)

241S

pyridoxal 5'-phosphate binding site
239G, 240T, 241S, 265H, 267S, 314T, 342D, 344A, 345W, 379S, 381H, 382K
CDD
cd00615 (Orn_deC_like)

265H

pyridoxal 5'-phosphate binding site
239G, 240T, 241S, 265H, 267S, 314T, 342D, 344A, 345W, 379S, 381H, 382K
CDD
cd00615 (Orn_deC_like)

267S

pyridoxal 5'-phosphate binding site
239G, 240T, 241S, 265H, 267S, 314T, 342D, 344A, 345W, 379S, 381H, 382K
CDD
cd00615 (Orn_deC_like)

314T

pyridoxal 5'-phosphate binding site
239G, 240T, 241S, 265H, 267S, 314T, 342D, 344A, 345W, 379S, 381H, 382K
CDD
cd00615 (Orn_deC_like)

342D

pyridoxal 5'-phosphate binding site
239G, 240T, 241S, 265H, 267S, 314T, 342D, 344A, 345W, 379S, 381H, 382K
CDD
cd00615 (Orn_deC_like)

344A

pyridoxal 5'-phosphate binding site
239G, 240T, 241S, 265H, 267S, 314T, 342D, 344A, 345W, 379S, 381H, 382K
CDD
cd00615 (Orn_deC_like)

345W

pyridoxal 5'-phosphate binding site
239G, 240T, 241S, 265H, 267S, 314T, 342D, 344A, 345W, 379S, 381H, 382K
CDD
cd00615 (Orn_deC_like)

379S

pyridoxal 5'-phosphate binding site
239G, 240T, 241S, 265H, 267S, 314T, 342D, 344A, 345W, 379S, 381H, 382K
CDD
cd00615 (Orn_deC_like)

381H

pyridoxal 5'-phosphate binding site
239G, 240T, 241S, 265H, 267S, 314T, 342D, 344A, 345W, 379S, 381H, 382K
CDD
cd00615 (Orn_deC_like)

382K

pyridoxal 5'-phosphate binding site
239G, 240T, 241S, 265H, 267S, 314T, 342D, 344A, 345W, 379S, 381H, 382K
CDD
cd00615 (Orn_deC_like)
catalytic residue ...

382K

catalytic residue
382K
CDD
cd00615 (Orn_deC_like)

GO term prediction

Biological Process

GO:0006520 cellular amino acid metabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0016831 carboxy-lyase activity

Cellular Component

GO:0005737 cytoplasm

Filter view on

Entry type

Status

Per-residue features

27725_FusoPortal_Gene_237

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component