27725_FusoPortal_Gene_2578

Protein

27725_FusoPortal_Gene_2578

Length

755 amino acids

Protein family membership

Glutamate synthase (NADPH), homotetrameric (IPR006004)

Homologous superfamilies

Homologous superfamily
1 - 91
Riboflavin synthase-like beta-barrel (IPR017938)
221 - 256
Dihydroorotate dehydrogenase, electron transfer subunit, Fe-S binding domain superfamily (IPR037117)
286 - 443
Alpha-helical ferredoxin (IPR009051)
527 - 589
FAD/NAD(P)-binding domain superfamily (IPR036188)
590 - 755
FAD/NAD(P)-binding domain superfamily (IPR036188)

1 100 200 300 400 500 600 700 755

Domains and repeats

Domain
1 - 95
Ferredoxin reductase-type FAD-binding domain (IPR017927)
110 - 204
Oxidoreductase FAD/NAD(P)-binding (IPR001433)
220 - 255
Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain (IPR019480)
312 - 422
Dihydroprymidine dehydrogenase domain II (IPR028261)
433 - 741
FAD/NAD(P)-binding domain (IPR023753)

1 100 200 300 400 500 600 700 755

Detailed signature matches

IPR017938

Riboflavin synthase-like beta-barrel
1. SSF63380 (Riboflavi...)
  
  1 - 91
  
  SUPERFAMILY
  SSF63380 (Riboflavin synthase domain-like)
IPR037117

Dihydroorotate dehydrogenase, electron transfer subunit, Fe-S binding domain superfamily
1. G3DSA:2.10.24...
  
  221 - 256
  
  GENE3D
  G3DSA:2.10.240.10 (G3DSA:2.10.240.10)
IPR009051

Alpha-helical ferredoxin
1. SSF46548 (alpha-hel...)
  
  293 - 443
  
  SUPERFAMILY
  SSF46548 (alpha-helical ferredoxin)
2. G3DSA:1.10.10...
  
  286 - 431
  
  GENE3D
  G3DSA:1.10.1060.10 (G3DSA:1.10.1060.10)
IPR036188

FAD/NAD(P)-binding domain superfamily
1. G3DSA:3.50.50.60
  
  590 - 755
  
  GENE3D
  G3DSA:3.50.50.60 (G3DSA:3.50.50.60)
  
  527 - 589
  
  GENE3D
  G3DSA:3.50.50.60 (G3DSA:3.50.50.60)
IPR006004

Glutamate synthase (NADPH), homotetrameric
1. TIGR01316
  
  309 - 752
  
  TIGRFAMs
  TIGR01316 (TIGR01316)
IPR017927

Ferredoxin reductase-type FAD-binding domain
1. PS51384 (FAD_FR)
  
  1 - 95
  
  PROSITE profiles
  PS51384 (FAD_FR)
IPR001433

Oxidoreductase FAD/NAD(P)-binding
1. PF00175 (NAD_binding_1)
  
  110 - 204
  
  Pfam
  PF00175 (NAD_binding_1)
IPR019480

Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain
1. PF10418 (DHODB_Fe-S...)
  
  220 - 255
  
  Pfam
  PF10418 (DHODB_Fe-S_bind)
IPR028261

Dihydroprymidine dehydrogenase domain II
1. PF14691 (Fer4_20)
  
  312 - 422
  
  Pfam
  PF14691 (Fer4_20)
IPR023753

FAD/NAD(P)-binding domain
1. PF07992 (Pyr_redox_2)
  
  433 - 741
  
  Pfam
  PF07992 (Pyr_redox_2)

no IPR

Unintegrated signatures

G3DSA:2.40.30.10

1 - 91

GENE3D
G3DSA:2.40.30.10 (G3DSA:2.40.30.10)
G3DSA:3.40.50...

432 - 526

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
G3DSA:3.40.50.80

106 - 210

GENE3D
G3DSA:3.40.50.80 (G3DSA:3.40.50.80)
PR00419 (ADXRDTASE)

434 - 456

PRINTS
PR00419 (ADXRDTASE)

457 - 470

PRINTS
PR00419 (ADXRDTASE)

576 - 590

PRINTS
PR00419 (ADXRDTASE)

609 - 622

PRINTS
PR00419 (ADXRDTASE)
PTHR11938 (FAD NADP...)

187 - 754

PANTHER
PTHR11938 (FAD NADPH DEHYDROGENASE/OXIDOREDUCTASE)
PTHR11938:SF114 (SU...)

187 - 754

PANTHER
PTHR11938:SF114 (SUBFAMILY NOT NAMED)
SSF51971 (Nucleotid...)

432 - 685

SUPERFAMILY
SSF51971 (Nucleotide-binding domain)
SSF52343 (Ferredoxi...)

104 - 255

SUPERFAMILY
SSF52343 (Ferredoxin reductase-like, C-terminal NADP-linked domain)
cd06219 (DHOD_e_tra...)

2 - 256

CDD
cd06219 (DHOD_e_trans_like1)

Residue annotation

FAD binding pocket...

43E

FAD binding pocket
43E, 45I, 46P, 47L, 48T, 62V, 63F, 64Q, 68E, 69S, 70T, 115V, 220P, 221L
CDD
cd06219 (DHOD_e_trans_like1)

45I

FAD binding pocket
43E, 45I, 46P, 47L, 48T, 62V, 63F, 64Q, 68E, 69S, 70T, 115V, 220P, 221L
CDD
cd06219 (DHOD_e_trans_like1)

46P

FAD binding pocket
43E, 45I, 46P, 47L, 48T, 62V, 63F, 64Q, 68E, 69S, 70T, 115V, 220P, 221L
CDD
cd06219 (DHOD_e_trans_like1)

47L

FAD binding pocket
43E, 45I, 46P, 47L, 48T, 62V, 63F, 64Q, 68E, 69S, 70T, 115V, 220P, 221L
CDD
cd06219 (DHOD_e_trans_like1)

48T

FAD binding pocket
43E, 45I, 46P, 47L, 48T, 62V, 63F, 64Q, 68E, 69S, 70T, 115V, 220P, 221L
CDD
cd06219 (DHOD_e_trans_like1)

62V

FAD binding pocket
43E, 45I, 46P, 47L, 48T, 62V, 63F, 64Q, 68E, 69S, 70T, 115V, 220P, 221L
CDD
cd06219 (DHOD_e_trans_like1)

63F

FAD binding pocket
43E, 45I, 46P, 47L, 48T, 62V, 63F, 64Q, 68E, 69S, 70T, 115V, 220P, 221L
CDD
cd06219 (DHOD_e_trans_like1)

64Q

FAD binding pocket
43E, 45I, 46P, 47L, 48T, 62V, 63F, 64Q, 68E, 69S, 70T, 115V, 220P, 221L
CDD
cd06219 (DHOD_e_trans_like1)

68E

FAD binding pocket
43E, 45I, 46P, 47L, 48T, 62V, 63F, 64Q, 68E, 69S, 70T, 115V, 220P, 221L
CDD
cd06219 (DHOD_e_trans_like1)

69S

FAD binding pocket
43E, 45I, 46P, 47L, 48T, 62V, 63F, 64Q, 68E, 69S, 70T, 115V, 220P, 221L
CDD
cd06219 (DHOD_e_trans_like1)

70T

FAD binding pocket
43E, 45I, 46P, 47L, 48T, 62V, 63F, 64Q, 68E, 69S, 70T, 115V, 220P, 221L
CDD
cd06219 (DHOD_e_trans_like1)

115V

FAD binding pocket
43E, 45I, 46P, 47L, 48T, 62V, 63F, 64Q, 68E, 69S, 70T, 115V, 220P, 221L
CDD
cd06219 (DHOD_e_trans_like1)

220P

FAD binding pocket
43E, 45I, 46P, 47L, 48T, 62V, 63F, 64Q, 68E, 69S, 70T, 115V, 220P, 221L
CDD
cd06219 (DHOD_e_trans_like1)

221L

FAD binding pocket
43E, 45I, 46P, 47L, 48T, 62V, 63F, 64Q, 68E, 69S, 70T, 115V, 220P, 221L
CDD
cd06219 (DHOD_e_trans_like1)
FAD binding motif ...

45I

FAD binding motif
45I, 47L, 48T
CDD
cd06219 (DHOD_e_trans_like1)

47L

FAD binding motif
45I, 47L, 48T
CDD
cd06219 (DHOD_e_trans_like1)

48T

FAD binding motif
45I, 47L, 48T
CDD
cd06219 (DHOD_e_trans_like1)
phosphate binding ...

69S

phosphate binding motif
69S, 72K, 75E, 79G, 88P, 90G
CDD
cd06219 (DHOD_e_trans_like1)

72K

phosphate binding motif
69S, 72K, 75E, 79G, 88P, 90G
CDD
cd06219 (DHOD_e_trans_like1)

75E

phosphate binding motif
69S, 72K, 75E, 79G, 88P, 90G
CDD
cd06219 (DHOD_e_trans_like1)

79G

phosphate binding motif
69S, 72K, 75E, 79G, 88P, 90G
CDD
cd06219 (DHOD_e_trans_like1)

88P

phosphate binding motif
69S, 72K, 75E, 79G, 88P, 90G
CDD
cd06219 (DHOD_e_trans_like1)

90G

phosphate binding motif
69S, 72K, 75E, 79G, 88P, 90G
CDD
cd06219 (DHOD_e_trans_like1)
beta-alpha-beta st...

110F

beta-alpha-beta structure motif
110F, 114G, 115V, 116G, 117T, 119P
CDD
cd06219 (DHOD_e_trans_like1)

114G

beta-alpha-beta structure motif
110F, 114G, 115V, 116G, 117T, 119P
CDD
cd06219 (DHOD_e_trans_like1)

115V

beta-alpha-beta structure motif
110F, 114G, 115V, 116G, 117T, 119P
CDD
cd06219 (DHOD_e_trans_like1)

116G

beta-alpha-beta structure motif
110F, 114G, 115V, 116G, 117T, 119P
CDD
cd06219 (DHOD_e_trans_like1)

117T

beta-alpha-beta structure motif
110F, 114G, 115V, 116G, 117T, 119P
CDD
cd06219 (DHOD_e_trans_like1)

119P

beta-alpha-beta structure motif
110F, 114G, 115V, 116G, 117T, 119P
CDD
cd06219 (DHOD_e_trans_like1)
NAD binding pocket...

115V

NAD binding pocket
115V, 116G, 139G, 140T, 141R, 195G, 196P
CDD
cd06219 (DHOD_e_trans_like1)

116G

NAD binding pocket
115V, 116G, 139G, 140T, 141R, 195G, 196P
CDD
cd06219 (DHOD_e_trans_like1)

139G

NAD binding pocket
115V, 116G, 139G, 140T, 141R, 195G, 196P
CDD
cd06219 (DHOD_e_trans_like1)

140T

NAD binding pocket
115V, 116G, 139G, 140T, 141R, 195G, 196P
CDD
cd06219 (DHOD_e_trans_like1)

141R

NAD binding pocket
115V, 116G, 139G, 140T, 141R, 195G, 196P
CDD
cd06219 (DHOD_e_trans_like1)

195G

NAD binding pocket
115V, 116G, 139G, 140T, 141R, 195G, 196P
CDD
cd06219 (DHOD_e_trans_like1)

196P

NAD binding pocket
115V, 116G, 139G, 140T, 141R, 195G, 196P
CDD
cd06219 (DHOD_e_trans_like1)
Iron coordination ...

224D

Iron coordination center
224D, 229C, 232C, 244C
CDD
cd06219 (DHOD_e_trans_like1)

229C

Iron coordination center
224D, 229C, 232C, 244C
CDD
cd06219 (DHOD_e_trans_like1)

232C

Iron coordination center
224D, 229C, 232C, 244C
CDD
cd06219 (DHOD_e_trans_like1)

244C

Iron coordination center
224D, 229C, 232C, 244C
CDD
cd06219 (DHOD_e_trans_like1)

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016491 oxidoreductase activity
GO:0051536 iron-sulfur cluster binding

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

27725_FusoPortal_Gene_2578

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component