Filter view on
Entry type
Status
Per-residue features
Colour by
27725_FusoPortal_Gene_2979
Length
282 amino acids
Protein family membership
- Tetrahydrofolate dehydrogenase/cyclohydrolase (IPR000672)
Homologous superfamilies
-
Homologous superfamily120 - 277
- NAD(P)-binding domain superfamily (IPR036291)
1
50
100
150
200
250
282
Domains and repeats
-
Domain2 - 118122 - 279
1
50
100
150
200
250
282
Detailed signature matches

Unintegrated signatures
-
8 - 137
-
138 - 261
-
PTHR10025:SF46 (BIF...)2 - 280PANTHER
PTHR10025:SF46 (BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL) -
SSF53223 (Aminoacid...)1 - 119
-
cd01080 (NAD_bind_m...)114 - 277
Residue annotation
-
homodimer interfac...122Phomodimer interface
122P, 123E, 126G, 157G, 159D, 165R, 174A, 175G, 178I, 181G, 182A, 183T, 184V, 185T, 186V, 188N, 190K, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)123Ehomodimer interface
122P, 123E, 126G, 157G, 159D, 165R, 174A, 175G, 178I, 181G, 182A, 183T, 184V, 185T, 186V, 188N, 190K, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)126Ghomodimer interface
122P, 123E, 126G, 157G, 159D, 165R, 174A, 175G, 178I, 181G, 182A, 183T, 184V, 185T, 186V, 188N, 190K, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)157Ghomodimer interface
122P, 123E, 126G, 157G, 159D, 165R, 174A, 175G, 178I, 181G, 182A, 183T, 184V, 185T, 186V, 188N, 190K, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)159Dhomodimer interface
122P, 123E, 126G, 157G, 159D, 165R, 174A, 175G, 178I, 181G, 182A, 183T, 184V, 185T, 186V, 188N, 190K, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)165Rhomodimer interface
122P, 123E, 126G, 157G, 159D, 165R, 174A, 175G, 178I, 181G, 182A, 183T, 184V, 185T, 186V, 188N, 190K, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)174Ahomodimer interface
122P, 123E, 126G, 157G, 159D, 165R, 174A, 175G, 178I, 181G, 182A, 183T, 184V, 185T, 186V, 188N, 190K, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)175Ghomodimer interface
122P, 123E, 126G, 157G, 159D, 165R, 174A, 175G, 178I, 181G, 182A, 183T, 184V, 185T, 186V, 188N, 190K, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)178Ihomodimer interface
122P, 123E, 126G, 157G, 159D, 165R, 174A, 175G, 178I, 181G, 182A, 183T, 184V, 185T, 186V, 188N, 190K, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)181Ghomodimer interface
122P, 123E, 126G, 157G, 159D, 165R, 174A, 175G, 178I, 181G, 182A, 183T, 184V, 185T, 186V, 188N, 190K, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)182Ahomodimer interface
122P, 123E, 126G, 157G, 159D, 165R, 174A, 175G, 178I, 181G, 182A, 183T, 184V, 185T, 186V, 188N, 190K, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)183Thomodimer interface
122P, 123E, 126G, 157G, 159D, 165R, 174A, 175G, 178I, 181G, 182A, 183T, 184V, 185T, 186V, 188N, 190K, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)184Vhomodimer interface
122P, 123E, 126G, 157G, 159D, 165R, 174A, 175G, 178I, 181G, 182A, 183T, 184V, 185T, 186V, 188N, 190K, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)185Thomodimer interface
122P, 123E, 126G, 157G, 159D, 165R, 174A, 175G, 178I, 181G, 182A, 183T, 184V, 185T, 186V, 188N, 190K, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)186Vhomodimer interface
122P, 123E, 126G, 157G, 159D, 165R, 174A, 175G, 178I, 181G, 182A, 183T, 184V, 185T, 186V, 188N, 190K, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)188Nhomodimer interface
122P, 123E, 126G, 157G, 159D, 165R, 174A, 175G, 178I, 181G, 182A, 183T, 184V, 185T, 186V, 188N, 190K, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)190Khomodimer interface
122P, 123E, 126G, 157G, 159D, 165R, 174A, 175G, 178I, 181G, 182A, 183T, 184V, 185T, 186V, 188N, 190K, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)191Thomodimer interface
122P, 123E, 126G, 157G, 159D, 165R, 174A, 175G, 178I, 181G, 182A, 183T, 184V, 185T, 186V, 188N, 190K, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)200Nhomodimer interface
122P, 123E, 126G, 157G, 159D, 165R, 174A, 175G, 178I, 181G, 182A, 183T, 184V, 185T, 186V, 188N, 190K, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd) -
NADP binding site ...140TNADP binding site
140T, 165R, 166S, 188N, 189S, 208I, 210V, 213F, 228V, 230I, 261G, 264T
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)165RNADP binding site
140T, 165R, 166S, 188N, 189S, 208I, 210V, 213F, 228V, 230I, 261G, 264T
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)166SNADP binding site
140T, 165R, 166S, 188N, 189S, 208I, 210V, 213F, 228V, 230I, 261G, 264T
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)188NNADP binding site
140T, 165R, 166S, 188N, 189S, 208I, 210V, 213F, 228V, 230I, 261G, 264T
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)189SNADP binding site
140T, 165R, 166S, 188N, 189S, 208I, 210V, 213F, 228V, 230I, 261G, 264T
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)208INADP binding site
140T, 165R, 166S, 188N, 189S, 208I, 210V, 213F, 228V, 230I, 261G, 264T
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)210VNADP binding site
140T, 165R, 166S, 188N, 189S, 208I, 210V, 213F, 228V, 230I, 261G, 264T
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)213FNADP binding site
140T, 165R, 166S, 188N, 189S, 208I, 210V, 213F, 228V, 230I, 261G, 264T
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)228VNADP binding site
140T, 165R, 166S, 188N, 189S, 208I, 210V, 213F, 228V, 230I, 261G, 264T
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)230INADP binding site
140T, 165R, 166S, 188N, 189S, 208I, 210V, 213F, 228V, 230I, 261G, 264T
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)261GNADP binding site
140T, 165R, 166S, 188N, 189S, 208I, 210V, 213F, 228V, 230I, 261G, 264T
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)264TNADP binding site
140T, 165R, 166S, 188N, 189S, 208I, 210V, 213F, 228V, 230I, 261G, 264T
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd) -
substrate binding ...
GO term prediction
Biological Process
GO:0055114 oxidation-reduction process
Molecular Function
GO:0003824 catalytic activity
GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity
Cellular Component
None predicted.