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Protein

27725_FusoPortal_Gene_2980

Length

310 amino acids

Protein family membership

Methionyl-tRNA formyltransferase (IPR005794)

Homologous superfamilies

Homologous superfamily
1 - 203
Formyl transferase, N-terminal domain superfamily (IPR036477)
205 - 310
Formyl transferase, C-terminal domain superfamily (IPR037022)
Homologous superfamily
204 - 307
Formyl transferase-like, C-terminal domain superfamily (IPR011034)

1 50 100 150 200 250 310

Domains and repeats

Domain
1 - 179
Formyl transferase, N-terminal (IPR002376)
204 - 300
Formyl transferase, C-terminal (IPR005793)

1 50 100 150 200 250 310

Detailed signature matches

IPR036477

Formyl transferase, N-terminal domain superfamily

G3DSA:3.40.50...

1 - 203

GENE3D
G3DSA:3.40.50.170 (G3DSA:3.40.50.170)
SSF53328 (Formyltra...)

1 - 203

SUPERFAMILY
SSF53328 (Formyltransferase)

IPR011034

Formyl transferase-like, C-terminal domain superfamily

SSF50486 (FMT C-ter...)

204 - 307

SUPERFAMILY
SSF50486 (FMT C-terminal domain-like)

IPR037022

Formyl transferase, C-terminal domain superfamily

G3DSA:3.10.25.10

205 - 310

GENE3D
G3DSA:3.10.25.10 (G3DSA:3.10.25.10)

IPR005794

Methionyl-tRNA formyltransferase

TIGR00460

1 - 302

TIGRFAMs
TIGR00460 (TIGR00460)
MF_00182 (Formyl_trans)

1 - 304

HAMAP
MF_00182 (Formyl_trans)

IPR002376

Formyl transferase, N-terminal

PF00551 (Formyl_tra...)

1 - 179

Pfam
PF00551 (Formyl_trans_N)

IPR005793

Formyl transferase, C-terminal

PF02911 (Formyl_tra...)

204 - 300

Pfam
PF02911 (Formyl_trans_C)

no IPR

Unintegrated signatures

PTHR11138 (METHIONY...)

1 - 303

PANTHER
PTHR11138 (METHIONYL-TRNA FORMYLTRANSFERASE)
PTHR11138:SF4 (TRAN...)

1 - 303

PANTHER
PTHR11138:SF4 (TRANSFERASE, PUTATIVE-RELATED)
cd08646 (FMT_core_M...)

1 - 199

CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)
cd08704 (Met_tRNA_F...)

206 - 290

CDD
cd08704 (Met_tRNA_FMT_C)

Residue annotation

putative active si...

7G

putative active site
7G, 11F, 12A, 83V, 84V, 85A, 86Y, 87G, 88K, 89L, 90L, 95I, 104N, 105V, 106H, 107S, 115G, 135M, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

11F

putative active site
7G, 11F, 12A, 83V, 84V, 85A, 86Y, 87G, 88K, 89L, 90L, 95I, 104N, 105V, 106H, 107S, 115G, 135M, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

12A

putative active site
7G, 11F, 12A, 83V, 84V, 85A, 86Y, 87G, 88K, 89L, 90L, 95I, 104N, 105V, 106H, 107S, 115G, 135M, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

83V

putative active site
7G, 11F, 12A, 83V, 84V, 85A, 86Y, 87G, 88K, 89L, 90L, 95I, 104N, 105V, 106H, 107S, 115G, 135M, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

84V

putative active site
7G, 11F, 12A, 83V, 84V, 85A, 86Y, 87G, 88K, 89L, 90L, 95I, 104N, 105V, 106H, 107S, 115G, 135M, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

85A

putative active site
7G, 11F, 12A, 83V, 84V, 85A, 86Y, 87G, 88K, 89L, 90L, 95I, 104N, 105V, 106H, 107S, 115G, 135M, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

86Y

putative active site
7G, 11F, 12A, 83V, 84V, 85A, 86Y, 87G, 88K, 89L, 90L, 95I, 104N, 105V, 106H, 107S, 115G, 135M, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

87G

putative active site
7G, 11F, 12A, 83V, 84V, 85A, 86Y, 87G, 88K, 89L, 90L, 95I, 104N, 105V, 106H, 107S, 115G, 135M, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

88K

putative active site
7G, 11F, 12A, 83V, 84V, 85A, 86Y, 87G, 88K, 89L, 90L, 95I, 104N, 105V, 106H, 107S, 115G, 135M, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

89L

putative active site
7G, 11F, 12A, 83V, 84V, 85A, 86Y, 87G, 88K, 89L, 90L, 95I, 104N, 105V, 106H, 107S, 115G, 135M, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

90L

putative active site
7G, 11F, 12A, 83V, 84V, 85A, 86Y, 87G, 88K, 89L, 90L, 95I, 104N, 105V, 106H, 107S, 115G, 135M, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

95I

putative active site
7G, 11F, 12A, 83V, 84V, 85A, 86Y, 87G, 88K, 89L, 90L, 95I, 104N, 105V, 106H, 107S, 115G, 135M, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

104N

putative active site
7G, 11F, 12A, 83V, 84V, 85A, 86Y, 87G, 88K, 89L, 90L, 95I, 104N, 105V, 106H, 107S, 115G, 135M, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

105V

putative active site
7G, 11F, 12A, 83V, 84V, 85A, 86Y, 87G, 88K, 89L, 90L, 95I, 104N, 105V, 106H, 107S, 115G, 135M, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

106H

putative active site
7G, 11F, 12A, 83V, 84V, 85A, 86Y, 87G, 88K, 89L, 90L, 95I, 104N, 105V, 106H, 107S, 115G, 135M, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

107S

putative active site
7G, 11F, 12A, 83V, 84V, 85A, 86Y, 87G, 88K, 89L, 90L, 95I, 104N, 105V, 106H, 107S, 115G, 135M, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

115G

putative active site
7G, 11F, 12A, 83V, 84V, 85A, 86Y, 87G, 88K, 89L, 90L, 95I, 104N, 105V, 106H, 107S, 115G, 135M, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

135M

putative active site
7G, 11F, 12A, 83V, 84V, 85A, 86Y, 87G, 88K, 89L, 90L, 95I, 104N, 105V, 106H, 107S, 115G, 135M, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

137I

putative active site
7G, 11F, 12A, 83V, 84V, 85A, 86Y, 87G, 88K, 89L, 90L, 95I, 104N, 105V, 106H, 107S, 115G, 135M, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

138A

putative active site
7G, 11F, 12A, 83V, 84V, 85A, 86Y, 87G, 88K, 89L, 90L, 95I, 104N, 105V, 106H, 107S, 115G, 135M, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

141L

putative active site
7G, 11F, 12A, 83V, 84V, 85A, 86Y, 87G, 88K, 89L, 90L, 95I, 104N, 105V, 106H, 107S, 115G, 135M, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

142D

putative active site
7G, 11F, 12A, 83V, 84V, 85A, 86Y, 87G, 88K, 89L, 90L, 95I, 104N, 105V, 106H, 107S, 115G, 135M, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)
substrate binding ...

8T

substrate binding site
8T, 9P, 11F, 31K, 35P, 37M, 38R, 39G, 40K, 84V, 85A, 86Y, 87G, 104N, 106H, 107S, 115G, 116A, 117A
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

9P

substrate binding site
8T, 9P, 11F, 31K, 35P, 37M, 38R, 39G, 40K, 84V, 85A, 86Y, 87G, 104N, 106H, 107S, 115G, 116A, 117A
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

11F

substrate binding site
8T, 9P, 11F, 31K, 35P, 37M, 38R, 39G, 40K, 84V, 85A, 86Y, 87G, 104N, 106H, 107S, 115G, 116A, 117A
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

31K

substrate binding site
8T, 9P, 11F, 31K, 35P, 37M, 38R, 39G, 40K, 84V, 85A, 86Y, 87G, 104N, 106H, 107S, 115G, 116A, 117A
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

35P

substrate binding site
8T, 9P, 11F, 31K, 35P, 37M, 38R, 39G, 40K, 84V, 85A, 86Y, 87G, 104N, 106H, 107S, 115G, 116A, 117A
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

37M

substrate binding site
8T, 9P, 11F, 31K, 35P, 37M, 38R, 39G, 40K, 84V, 85A, 86Y, 87G, 104N, 106H, 107S, 115G, 116A, 117A
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

38R

substrate binding site
8T, 9P, 11F, 31K, 35P, 37M, 38R, 39G, 40K, 84V, 85A, 86Y, 87G, 104N, 106H, 107S, 115G, 116A, 117A
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

39G

substrate binding site
8T, 9P, 11F, 31K, 35P, 37M, 38R, 39G, 40K, 84V, 85A, 86Y, 87G, 104N, 106H, 107S, 115G, 116A, 117A
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

40K

substrate binding site
8T, 9P, 11F, 31K, 35P, 37M, 38R, 39G, 40K, 84V, 85A, 86Y, 87G, 104N, 106H, 107S, 115G, 116A, 117A
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

84V

substrate binding site
8T, 9P, 11F, 31K, 35P, 37M, 38R, 39G, 40K, 84V, 85A, 86Y, 87G, 104N, 106H, 107S, 115G, 116A, 117A
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

85A

substrate binding site
8T, 9P, 11F, 31K, 35P, 37M, 38R, 39G, 40K, 84V, 85A, 86Y, 87G, 104N, 106H, 107S, 115G, 116A, 117A
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

86Y

substrate binding site
8T, 9P, 11F, 31K, 35P, 37M, 38R, 39G, 40K, 84V, 85A, 86Y, 87G, 104N, 106H, 107S, 115G, 116A, 117A
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

87G

substrate binding site
8T, 9P, 11F, 31K, 35P, 37M, 38R, 39G, 40K, 84V, 85A, 86Y, 87G, 104N, 106H, 107S, 115G, 116A, 117A
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

104N

substrate binding site
8T, 9P, 11F, 31K, 35P, 37M, 38R, 39G, 40K, 84V, 85A, 86Y, 87G, 104N, 106H, 107S, 115G, 116A, 117A
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

106H

substrate binding site
8T, 9P, 11F, 31K, 35P, 37M, 38R, 39G, 40K, 84V, 85A, 86Y, 87G, 104N, 106H, 107S, 115G, 116A, 117A
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

107S

substrate binding site
8T, 9P, 11F, 31K, 35P, 37M, 38R, 39G, 40K, 84V, 85A, 86Y, 87G, 104N, 106H, 107S, 115G, 116A, 117A
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

115G

substrate binding site
8T, 9P, 11F, 31K, 35P, 37M, 38R, 39G, 40K, 84V, 85A, 86Y, 87G, 104N, 106H, 107S, 115G, 116A, 117A
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

116A

substrate binding site
8T, 9P, 11F, 31K, 35P, 37M, 38R, 39G, 40K, 84V, 85A, 86Y, 87G, 104N, 106H, 107S, 115G, 116A, 117A
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

117A

substrate binding site
8T, 9P, 11F, 31K, 35P, 37M, 38R, 39G, 40K, 84V, 85A, 86Y, 87G, 104N, 106H, 107S, 115G, 116A, 117A
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)
putative cosubstra...

83V

putative cosubstrate binding site
83V, 86Y, 88K, 89L, 90L, 95I, 104N, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

86Y

putative cosubstrate binding site
83V, 86Y, 88K, 89L, 90L, 95I, 104N, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

88K

putative cosubstrate binding site
83V, 86Y, 88K, 89L, 90L, 95I, 104N, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

89L

putative cosubstrate binding site
83V, 86Y, 88K, 89L, 90L, 95I, 104N, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

90L

putative cosubstrate binding site
83V, 86Y, 88K, 89L, 90L, 95I, 104N, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

95I

putative cosubstrate binding site
83V, 86Y, 88K, 89L, 90L, 95I, 104N, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

104N

putative cosubstrate binding site
83V, 86Y, 88K, 89L, 90L, 95I, 104N, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

137I

putative cosubstrate binding site
83V, 86Y, 88K, 89L, 90L, 95I, 104N, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

138A

putative cosubstrate binding site
83V, 86Y, 88K, 89L, 90L, 95I, 104N, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

141L

putative cosubstrate binding site
83V, 86Y, 88K, 89L, 90L, 95I, 104N, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

142D

putative cosubstrate binding site
83V, 86Y, 88K, 89L, 90L, 95I, 104N, 137I, 138A, 141L, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)
catalytic site cd0...

104N

catalytic site
104N, 106H, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

106H

catalytic site
104N, 106H, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)

142D

catalytic site
104N, 106H, 142D
CDD
cd08646 (FMT_core_Met-tRNA-FMT_N)
substrate binding ...

229F

substrate binding site
229F, 240I, 242K, 285K, 287E, 289K, 290K
CDD
cd08704 (Met_tRNA_FMT_C)

240I

substrate binding site
229F, 240I, 242K, 285K, 287E, 289K, 290K
CDD
cd08704 (Met_tRNA_FMT_C)

242K

substrate binding site
229F, 240I, 242K, 285K, 287E, 289K, 290K
CDD
cd08704 (Met_tRNA_FMT_C)

285K

substrate binding site
229F, 240I, 242K, 285K, 287E, 289K, 290K
CDD
cd08704 (Met_tRNA_FMT_C)

287E

substrate binding site
229F, 240I, 242K, 285K, 287E, 289K, 290K
CDD
cd08704 (Met_tRNA_FMT_C)

289K

substrate binding site
229F, 240I, 242K, 285K, 287E, 289K, 290K
CDD
cd08704 (Met_tRNA_FMT_C)

290K

substrate binding site
229F, 240I, 242K, 285K, 287E, 289K, 290K
CDD
cd08704 (Met_tRNA_FMT_C)

GO term prediction

Biological Process

GO:0009058 biosynthetic process
GO:0071951 conversion of methionyl-tRNA to N-formyl-methionyl-tRNA

Molecular Function

GO:0003824 catalytic activity
GO:0004479 methionyl-tRNA formyltransferase activity
GO:0016742 hydroxymethyl-, formyl- and related transferase activity

Cellular Component

None predicted.