27725_FusoPortal_Gene_349

Protein

27725_FusoPortal_Gene_349

Length

312 amino acids

Protein family membership

None predicted.

Homologous superfamilies

Homologous superfamily
9 - 308
Thiamin diphosphate-binding fold (IPR029061)

1 50 100 150 200 250 312

Domains and repeats

Domain
59 - 218
Thiamine pyrophosphate enzyme, C-terminal TPP-binding (IPR011766)

1 50 100 150 200 250 312

Detailed signature matches

IPR029061

Thiamin diphosphate-binding fold
1. SSF52518 (Thiamin d...)
  
  9 - 308
  
  SUPERFAMILY
  SSF52518 (Thiamin diphosphate-binding fold (THDP-binding))
IPR011766

Thiamine pyrophosphate enzyme, C-terminal TPP-binding
1. PF02775 (TPP_enzyme_C)
  
  59 - 218
  
  Pfam
  PF02775 (TPP_enzyme_C)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

98 - 311

GENE3D
G3DSA:3.40.50.970 (G3DSA:3.40.50.970)

1 - 97

GENE3D
G3DSA:3.40.50.970 (G3DSA:3.40.50.970)
PTHR42897 (FAMILY N...)

6 - 306

PANTHER
PTHR42897 (FAMILY NOT NAMED)
PTHR42897:SF2 (SUBF...)

6 - 306

PANTHER
PTHR42897:SF2 (SUBFAMILY NOT NAMED)
cd03376 (TPP_PFOR_p...)

15 - 255

CDD
cd03376 (TPP_PFOR_porB_like)
mobidb-lite (disord...)

151 - 173

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

TPP-binding site c...

27A

TPP-binding site
27A, 52C, 74F, 75E, 108G, 109D, 110G, 111G, 137N, 139A, 141M, 142N, 143T
CDD
cd03376 (TPP_PFOR_porB_like)

52C

TPP-binding site
27A, 52C, 74F, 75E, 108G, 109D, 110G, 111G, 137N, 139A, 141M, 142N, 143T
CDD
cd03376 (TPP_PFOR_porB_like)

74F

TPP-binding site
27A, 52C, 74F, 75E, 108G, 109D, 110G, 111G, 137N, 139A, 141M, 142N, 143T
CDD
cd03376 (TPP_PFOR_porB_like)

75E

TPP-binding site
27A, 52C, 74F, 75E, 108G, 109D, 110G, 111G, 137N, 139A, 141M, 142N, 143T
CDD
cd03376 (TPP_PFOR_porB_like)

108G

TPP-binding site
27A, 52C, 74F, 75E, 108G, 109D, 110G, 111G, 137N, 139A, 141M, 142N, 143T
CDD
cd03376 (TPP_PFOR_porB_like)

109D

TPP-binding site
27A, 52C, 74F, 75E, 108G, 109D, 110G, 111G, 137N, 139A, 141M, 142N, 143T
CDD
cd03376 (TPP_PFOR_porB_like)

110G

TPP-binding site
27A, 52C, 74F, 75E, 108G, 109D, 110G, 111G, 137N, 139A, 141M, 142N, 143T
CDD
cd03376 (TPP_PFOR_porB_like)

111G

TPP-binding site
27A, 52C, 74F, 75E, 108G, 109D, 110G, 111G, 137N, 139A, 141M, 142N, 143T
CDD
cd03376 (TPP_PFOR_porB_like)

137N

TPP-binding site
27A, 52C, 74F, 75E, 108G, 109D, 110G, 111G, 137N, 139A, 141M, 142N, 143T
CDD
cd03376 (TPP_PFOR_porB_like)

139A

TPP-binding site
27A, 52C, 74F, 75E, 108G, 109D, 110G, 111G, 137N, 139A, 141M, 142N, 143T
CDD
cd03376 (TPP_PFOR_porB_like)

141M

TPP-binding site
27A, 52C, 74F, 75E, 108G, 109D, 110G, 111G, 137N, 139A, 141M, 142N, 143T
CDD
cd03376 (TPP_PFOR_porB_like)

142N

TPP-binding site
27A, 52C, 74F, 75E, 108G, 109D, 110G, 111G, 137N, 139A, 141M, 142N, 143T
CDD
cd03376 (TPP_PFOR_porB_like)

143T

TPP-binding site
27A, 52C, 74F, 75E, 108G, 109D, 110G, 111G, 137N, 139A, 141M, 142N, 143T
CDD
cd03376 (TPP_PFOR_porB_like)
putative dimer int...

41E

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

44A

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

58F

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

68S

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

69F

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

70I

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

71H

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

72S

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

73A

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

76N

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

79A

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

80T

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

83G

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

84A

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

86T

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

87A

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

90V

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

101Y

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

117F

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

121S

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

122G

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

128H

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

143T

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

144G

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

149S

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

156D

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

158T

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

161P

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

170P

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

174K

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

178D

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

179V

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

182A

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

223P

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

224R

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

229E

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

230G

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

231E

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

232D

putative dimer interface
41E, 44A, 58F, 68S, 69F, 70I, 71H, 72S, 73A, 76N, 79A, 80T, 83G, 84A, 86T, 87A, 90V, 101Y, 117F, 121S, 122G, 128H, 143T, 144G, 149S, 156D, 158T, 161P, 170P, 174K, 178D, 179V, 182A, 223P, 224R, 229E, 230G, 231E, 232D
CDD
cd03376 (TPP_PFOR_porB_like)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003824 catalytic activity
GO:0030976 thiamine pyrophosphate binding

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

27725_FusoPortal_Gene_349

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component