27725_FusoPortal_Gene_440

Protein

27725_FusoPortal_Gene_440

Length

289 amino acids

Protein family membership

Glycine-tRNA synthetase, heterodimeric (IPR006194)
- Glycine-tRNA ligase, alpha subunit (IPR002310)

Homologous superfamilies

None predicted.

Domains and repeats

None predicted.

Detailed signature matches

IPR006194

Glycine-tRNA synthetase, heterodimeric
1. PS50861 (AA_TRNA_LI...)
  
  2 - 276
  
  PROSITE profiles
  PS50861 (AA_TRNA_LIGASE_II_GLYAB)
IPR002310

Glycine-tRNA ligase, alpha subunit
1. PR01044 (TRNASYNTHGA)
  
  241 - 257
  
  PRINTS
  PR01044 (TRNASYNTHGA)
  
  156 - 171
  
  PRINTS
  PR01044 (TRNASYNTHGA)
  
  133 - 153
  
  PRINTS
  PR01044 (TRNASYNTHGA)
  
  76 - 96
  
  PRINTS
  PR01044 (TRNASYNTHGA)
  
  55 - 70
  
  PRINTS
  PR01044 (TRNASYNTHGA)
  
  107 - 131
  
  PRINTS
  PR01044 (TRNASYNTHGA)
2. PF02091 (tRNA-synt_2e)
  
  3 - 279
  
  Pfam
  PF02091 (tRNA-synt_2e)
3. TIGR00388
  
  1 - 289
  
  TIGRFAMs
  TIGR00388 (TIGR00388)
4. MF_00254 (Gly_tRNA_...)
  
  1 - 281
  
  HAMAP
  MF_00254 (Gly_tRNA_synth_alpha)
5. cd00733 (GlyRS_alph...)
  
  2 - 280
  
  CDD
  cd00733 (GlyRS_alpha_core)
6. PTHR44629 (FAMILY N...)
  
  1 - 289
  
  PANTHER
  PTHR44629 (FAMILY NOT NAMED)

no IPR

Unintegrated signatures

G3DSA:1.20.58...

206 - 282

GENE3D
G3DSA:1.20.58.180 (G3DSA:1.20.58.180)
G3DSA:3.30.93...

1 - 204

GENE3D
G3DSA:3.30.930.10 (G3DSA:3.30.930.10)
SSF55681 (Class II ...)

1 - 280

SUPERFAMILY
SSF55681 (Class II aaRS and biotin synthetases)

Residue annotation

dimer interface cd...

4Q

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

8F

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

12K

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

20V

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

21L

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

23N

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

25Y

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

26D

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

27I

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

28E

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

44G

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

53V

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

57R

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

73Q

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

179W

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

192F

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

195E

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

196N

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

203L

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

205D

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

208S

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

211K

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

212W

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

215E

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

216Y

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

219E

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

222K

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

226A

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

228L

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

229V

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

230L

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

231P

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

234D

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)

238K

dimer interface
4Q, 8F, 12K, 20V, 21L, 23N, 25Y, 26D, 27I, 28E, 44G, 53V, 57R, 73Q, 179W, 192F, 195E, 196N, 203L, 205D, 208S, 211K, 212W, 215E, 216Y, 219E, 222K, 226A, 228L, 229V, 230L, 231P, 234D, 238K
CDD
cd00733 (GlyRS_alpha_core)
motif 1 cd00733

19C

motif 1
19C, 20V, 21L, 22G, 23N, 24P, 25Y, 26D
CDD
cd00733 (GlyRS_alpha_core)

20V

motif 1
19C, 20V, 21L, 22G, 23N, 24P, 25Y, 26D
CDD
cd00733 (GlyRS_alpha_core)

21L

motif 1
19C, 20V, 21L, 22G, 23N, 24P, 25Y, 26D
CDD
cd00733 (GlyRS_alpha_core)

22G

motif 1
19C, 20V, 21L, 22G, 23N, 24P, 25Y, 26D
CDD
cd00733 (GlyRS_alpha_core)

23N

motif 1
19C, 20V, 21L, 22G, 23N, 24P, 25Y, 26D
CDD
cd00733 (GlyRS_alpha_core)

24P

motif 1
19C, 20V, 21L, 22G, 23N, 24P, 25Y, 26D
CDD
cd00733 (GlyRS_alpha_core)

25Y

motif 1
19C, 20V, 21L, 22G, 23N, 24P, 25Y, 26D
CDD
cd00733 (GlyRS_alpha_core)

26D

motif 1
19C, 20V, 21L, 22G, 23N, 24P, 25Y, 26D
CDD
cd00733 (GlyRS_alpha_core)
active site cd00733

31A

active site
31A, 33T, 58R, 74H, 76Q, 78Q, 79V, 80I, 135E, 136V, 140T, 156E, 157I, 159Y, 160G, 162E, 163R
CDD
cd00733 (GlyRS_alpha_core)

33T

active site
31A, 33T, 58R, 74H, 76Q, 78Q, 79V, 80I, 135E, 136V, 140T, 156E, 157I, 159Y, 160G, 162E, 163R
CDD
cd00733 (GlyRS_alpha_core)

58R

active site
31A, 33T, 58R, 74H, 76Q, 78Q, 79V, 80I, 135E, 136V, 140T, 156E, 157I, 159Y, 160G, 162E, 163R
CDD
cd00733 (GlyRS_alpha_core)

74H

active site
31A, 33T, 58R, 74H, 76Q, 78Q, 79V, 80I, 135E, 136V, 140T, 156E, 157I, 159Y, 160G, 162E, 163R
CDD
cd00733 (GlyRS_alpha_core)

76Q

active site
31A, 33T, 58R, 74H, 76Q, 78Q, 79V, 80I, 135E, 136V, 140T, 156E, 157I, 159Y, 160G, 162E, 163R
CDD
cd00733 (GlyRS_alpha_core)

78Q

active site
31A, 33T, 58R, 74H, 76Q, 78Q, 79V, 80I, 135E, 136V, 140T, 156E, 157I, 159Y, 160G, 162E, 163R
CDD
cd00733 (GlyRS_alpha_core)

79V

active site
31A, 33T, 58R, 74H, 76Q, 78Q, 79V, 80I, 135E, 136V, 140T, 156E, 157I, 159Y, 160G, 162E, 163R
CDD
cd00733 (GlyRS_alpha_core)

80I

active site
31A, 33T, 58R, 74H, 76Q, 78Q, 79V, 80I, 135E, 136V, 140T, 156E, 157I, 159Y, 160G, 162E, 163R
CDD
cd00733 (GlyRS_alpha_core)

135E

active site
31A, 33T, 58R, 74H, 76Q, 78Q, 79V, 80I, 135E, 136V, 140T, 156E, 157I, 159Y, 160G, 162E, 163R
CDD
cd00733 (GlyRS_alpha_core)

136V

active site
31A, 33T, 58R, 74H, 76Q, 78Q, 79V, 80I, 135E, 136V, 140T, 156E, 157I, 159Y, 160G, 162E, 163R
CDD
cd00733 (GlyRS_alpha_core)

140T

active site
31A, 33T, 58R, 74H, 76Q, 78Q, 79V, 80I, 135E, 136V, 140T, 156E, 157I, 159Y, 160G, 162E, 163R
CDD
cd00733 (GlyRS_alpha_core)

156E

active site
31A, 33T, 58R, 74H, 76Q, 78Q, 79V, 80I, 135E, 136V, 140T, 156E, 157I, 159Y, 160G, 162E, 163R
CDD
cd00733 (GlyRS_alpha_core)

157I

active site
31A, 33T, 58R, 74H, 76Q, 78Q, 79V, 80I, 135E, 136V, 140T, 156E, 157I, 159Y, 160G, 162E, 163R
CDD
cd00733 (GlyRS_alpha_core)

159Y

active site
31A, 33T, 58R, 74H, 76Q, 78Q, 79V, 80I, 135E, 136V, 140T, 156E, 157I, 159Y, 160G, 162E, 163R
CDD
cd00733 (GlyRS_alpha_core)

160G

active site
31A, 33T, 58R, 74H, 76Q, 78Q, 79V, 80I, 135E, 136V, 140T, 156E, 157I, 159Y, 160G, 162E, 163R
CDD
cd00733 (GlyRS_alpha_core)

162E

active site
31A, 33T, 58R, 74H, 76Q, 78Q, 79V, 80I, 135E, 136V, 140T, 156E, 157I, 159Y, 160G, 162E, 163R
CDD
cd00733 (GlyRS_alpha_core)

163R

active site
31A, 33T, 58R, 74H, 76Q, 78Q, 79V, 80I, 135E, 136V, 140T, 156E, 157I, 159Y, 160G, 162E, 163R
CDD
cd00733 (GlyRS_alpha_core)
motif 2 cd00733

57R

motif 2
57R, 58R, 59P, 60K
CDD
cd00733 (GlyRS_alpha_core)

58R

motif 2
57R, 58R, 59P, 60K
CDD
cd00733 (GlyRS_alpha_core)

59P

motif 2
57R, 58R, 59P, 60K
CDD
cd00733 (GlyRS_alpha_core)

60K

motif 2
57R, 58R, 59P, 60K
CDD
cd00733 (GlyRS_alpha_core)
motif 3 cd00733

160G

motif 3
160G, 161L, 162E, 163R
CDD
cd00733 (GlyRS_alpha_core)

161L

motif 3
160G, 161L, 162E, 163R
CDD
cd00733 (GlyRS_alpha_core)

162E

motif 3
160G, 161L, 162E, 163R
CDD
cd00733 (GlyRS_alpha_core)

163R

motif 3
160G, 161L, 162E, 163R
CDD
cd00733 (GlyRS_alpha_core)

GO term prediction

Biological Process

GO:0006426 glycyl-tRNA aminoacylation

Molecular Function

GO:0000166 nucleotide binding
GO:0004820 glycine-tRNA ligase activity
GO:0005524 ATP binding

Cellular Component

GO:0005737 cytoplasm

Filter view on

Entry type

Status

Per-residue features

27725_FusoPortal_Gene_440

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component