27725_FusoPortal_Gene_750

Protein

27725_FusoPortal_Gene_750

Length

309 amino acids

Protein family membership

None predicted.

Homologous superfamilies

Homologous superfamily
3 - 170
Thiamin diphosphate-binding fold (IPR029061)
178 - 309
Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II (IPR009014)

1 50 100 150 200 250 309

Domains and repeats

Domain
3 - 166
Transketolase-like, pyrimidine-binding domain (IPR005475)
183 - 300
Transketolase, C-terminal domain (IPR033248)

1 50 100 150 200 250 309

Detailed signature matches

IPR029061

Thiamin diphosphate-binding fold
1. SSF52518 (Thiamin d...)
  
  3 - 170
  
  SUPERFAMILY
  SSF52518 (Thiamin diphosphate-binding fold (THDP-binding))
IPR009014

Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II
1. G3DSA:3.40.50...
  
  181 - 309
  
  GENE3D
  G3DSA:3.40.50.920 (G3DSA:3.40.50.920)
2. SSF52922 (TK C-term...)
  
  178 - 308
  
  SUPERFAMILY
  SSF52922 (TK C-terminal domain-like)
IPR005475

Transketolase-like, pyrimidine-binding domain
1. PF02779 (Transket_pyr)
  
  3 - 166
  
  Pfam
  PF02779 (Transket_pyr)
IPR033248

Transketolase, C-terminal domain
1. PF02780 (Transketol...)
  
  183 - 300
  
  Pfam
  PF02780 (Transketolase_C)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

1 - 180

GENE3D
G3DSA:3.40.50.970 (G3DSA:3.40.50.970)
PTHR43825 (FAMILY N...)

2 - 308

PANTHER
PTHR43825 (FAMILY NOT NAMED)
PTHR43825:SF1 (SUBF...)

2 - 308

PANTHER
PTHR43825:SF1 (SUBFAMILY NOT NAMED)
cd07033 (TPP_PYR_DX...)

8 - 164

CDD
cd07033 (TPP_PYR_DXS_TK_like)

Residue annotation

PYR/PP interface c...

22K

PYR/PP interface
22K, 24I, 30D, 47R, 50N, 52G, 53I, 54A, 55E, 56A, 57D, 60G, 61T, 63A, 64G, 65F, 84R, 87E, 88Q, 114D, 117S, 133M, 134V, 155E
CDD
cd07033 (TPP_PYR_DXS_TK_like)

24I

PYR/PP interface
22K, 24I, 30D, 47R, 50N, 52G, 53I, 54A, 55E, 56A, 57D, 60G, 61T, 63A, 64G, 65F, 84R, 87E, 88Q, 114D, 117S, 133M, 134V, 155E
CDD
cd07033 (TPP_PYR_DXS_TK_like)

30D

PYR/PP interface
22K, 24I, 30D, 47R, 50N, 52G, 53I, 54A, 55E, 56A, 57D, 60G, 61T, 63A, 64G, 65F, 84R, 87E, 88Q, 114D, 117S, 133M, 134V, 155E
CDD
cd07033 (TPP_PYR_DXS_TK_like)

47R

PYR/PP interface
22K, 24I, 30D, 47R, 50N, 52G, 53I, 54A, 55E, 56A, 57D, 60G, 61T, 63A, 64G, 65F, 84R, 87E, 88Q, 114D, 117S, 133M, 134V, 155E
CDD
cd07033 (TPP_PYR_DXS_TK_like)

50N

PYR/PP interface
22K, 24I, 30D, 47R, 50N, 52G, 53I, 54A, 55E, 56A, 57D, 60G, 61T, 63A, 64G, 65F, 84R, 87E, 88Q, 114D, 117S, 133M, 134V, 155E
CDD
cd07033 (TPP_PYR_DXS_TK_like)

52G

PYR/PP interface
22K, 24I, 30D, 47R, 50N, 52G, 53I, 54A, 55E, 56A, 57D, 60G, 61T, 63A, 64G, 65F, 84R, 87E, 88Q, 114D, 117S, 133M, 134V, 155E
CDD
cd07033 (TPP_PYR_DXS_TK_like)

53I

PYR/PP interface
22K, 24I, 30D, 47R, 50N, 52G, 53I, 54A, 55E, 56A, 57D, 60G, 61T, 63A, 64G, 65F, 84R, 87E, 88Q, 114D, 117S, 133M, 134V, 155E
CDD
cd07033 (TPP_PYR_DXS_TK_like)

54A

PYR/PP interface
22K, 24I, 30D, 47R, 50N, 52G, 53I, 54A, 55E, 56A, 57D, 60G, 61T, 63A, 64G, 65F, 84R, 87E, 88Q, 114D, 117S, 133M, 134V, 155E
CDD
cd07033 (TPP_PYR_DXS_TK_like)

55E

PYR/PP interface
22K, 24I, 30D, 47R, 50N, 52G, 53I, 54A, 55E, 56A, 57D, 60G, 61T, 63A, 64G, 65F, 84R, 87E, 88Q, 114D, 117S, 133M, 134V, 155E
CDD
cd07033 (TPP_PYR_DXS_TK_like)

56A

PYR/PP interface
22K, 24I, 30D, 47R, 50N, 52G, 53I, 54A, 55E, 56A, 57D, 60G, 61T, 63A, 64G, 65F, 84R, 87E, 88Q, 114D, 117S, 133M, 134V, 155E
CDD
cd07033 (TPP_PYR_DXS_TK_like)

57D

PYR/PP interface
22K, 24I, 30D, 47R, 50N, 52G, 53I, 54A, 55E, 56A, 57D, 60G, 61T, 63A, 64G, 65F, 84R, 87E, 88Q, 114D, 117S, 133M, 134V, 155E
CDD
cd07033 (TPP_PYR_DXS_TK_like)

60G

PYR/PP interface
22K, 24I, 30D, 47R, 50N, 52G, 53I, 54A, 55E, 56A, 57D, 60G, 61T, 63A, 64G, 65F, 84R, 87E, 88Q, 114D, 117S, 133M, 134V, 155E
CDD
cd07033 (TPP_PYR_DXS_TK_like)

61T

PYR/PP interface
22K, 24I, 30D, 47R, 50N, 52G, 53I, 54A, 55E, 56A, 57D, 60G, 61T, 63A, 64G, 65F, 84R, 87E, 88Q, 114D, 117S, 133M, 134V, 155E
CDD
cd07033 (TPP_PYR_DXS_TK_like)

63A

PYR/PP interface
22K, 24I, 30D, 47R, 50N, 52G, 53I, 54A, 55E, 56A, 57D, 60G, 61T, 63A, 64G, 65F, 84R, 87E, 88Q, 114D, 117S, 133M, 134V, 155E
CDD
cd07033 (TPP_PYR_DXS_TK_like)

64G

PYR/PP interface
22K, 24I, 30D, 47R, 50N, 52G, 53I, 54A, 55E, 56A, 57D, 60G, 61T, 63A, 64G, 65F, 84R, 87E, 88Q, 114D, 117S, 133M, 134V, 155E
CDD
cd07033 (TPP_PYR_DXS_TK_like)

65F

PYR/PP interface
22K, 24I, 30D, 47R, 50N, 52G, 53I, 54A, 55E, 56A, 57D, 60G, 61T, 63A, 64G, 65F, 84R, 87E, 88Q, 114D, 117S, 133M, 134V, 155E
CDD
cd07033 (TPP_PYR_DXS_TK_like)

84R

PYR/PP interface
22K, 24I, 30D, 47R, 50N, 52G, 53I, 54A, 55E, 56A, 57D, 60G, 61T, 63A, 64G, 65F, 84R, 87E, 88Q, 114D, 117S, 133M, 134V, 155E
CDD
cd07033 (TPP_PYR_DXS_TK_like)

87E

PYR/PP interface
22K, 24I, 30D, 47R, 50N, 52G, 53I, 54A, 55E, 56A, 57D, 60G, 61T, 63A, 64G, 65F, 84R, 87E, 88Q, 114D, 117S, 133M, 134V, 155E
CDD
cd07033 (TPP_PYR_DXS_TK_like)

88Q

PYR/PP interface
22K, 24I, 30D, 47R, 50N, 52G, 53I, 54A, 55E, 56A, 57D, 60G, 61T, 63A, 64G, 65F, 84R, 87E, 88Q, 114D, 117S, 133M, 134V, 155E
CDD
cd07033 (TPP_PYR_DXS_TK_like)

114D

PYR/PP interface
22K, 24I, 30D, 47R, 50N, 52G, 53I, 54A, 55E, 56A, 57D, 60G, 61T, 63A, 64G, 65F, 84R, 87E, 88Q, 114D, 117S, 133M, 134V, 155E
CDD
cd07033 (TPP_PYR_DXS_TK_like)

117S

PYR/PP interface
22K, 24I, 30D, 47R, 50N, 52G, 53I, 54A, 55E, 56A, 57D, 60G, 61T, 63A, 64G, 65F, 84R, 87E, 88Q, 114D, 117S, 133M, 134V, 155E
CDD
cd07033 (TPP_PYR_DXS_TK_like)

133M

PYR/PP interface
22K, 24I, 30D, 47R, 50N, 52G, 53I, 54A, 55E, 56A, 57D, 60G, 61T, 63A, 64G, 65F, 84R, 87E, 88Q, 114D, 117S, 133M, 134V, 155E
CDD
cd07033 (TPP_PYR_DXS_TK_like)

134V

PYR/PP interface
22K, 24I, 30D, 47R, 50N, 52G, 53I, 54A, 55E, 56A, 57D, 60G, 61T, 63A, 64G, 65F, 84R, 87E, 88Q, 114D, 117S, 133M, 134V, 155E
CDD
cd07033 (TPP_PYR_DXS_TK_like)

155E

PYR/PP interface
22K, 24I, 30D, 47R, 50N, 52G, 53I, 54A, 55E, 56A, 57D, 60G, 61T, 63A, 64G, 65F, 84R, 87E, 88Q, 114D, 117S, 133M, 134V, 155E
CDD
cd07033 (TPP_PYR_DXS_TK_like)
dimer interface cd...

30D

dimer interface
30D, 50N, 53I, 54A, 55E, 83G, 84R, 86F, 114D, 116G, 125A, 126L, 128R, 129S, 131P
CDD
cd07033 (TPP_PYR_DXS_TK_like)

50N

dimer interface
30D, 50N, 53I, 54A, 55E, 83G, 84R, 86F, 114D, 116G, 125A, 126L, 128R, 129S, 131P
CDD
cd07033 (TPP_PYR_DXS_TK_like)

53I

dimer interface
30D, 50N, 53I, 54A, 55E, 83G, 84R, 86F, 114D, 116G, 125A, 126L, 128R, 129S, 131P
CDD
cd07033 (TPP_PYR_DXS_TK_like)

54A

dimer interface
30D, 50N, 53I, 54A, 55E, 83G, 84R, 86F, 114D, 116G, 125A, 126L, 128R, 129S, 131P
CDD
cd07033 (TPP_PYR_DXS_TK_like)

55E

dimer interface
30D, 50N, 53I, 54A, 55E, 83G, 84R, 86F, 114D, 116G, 125A, 126L, 128R, 129S, 131P
CDD
cd07033 (TPP_PYR_DXS_TK_like)

83G

dimer interface
30D, 50N, 53I, 54A, 55E, 83G, 84R, 86F, 114D, 116G, 125A, 126L, 128R, 129S, 131P
CDD
cd07033 (TPP_PYR_DXS_TK_like)

84R

dimer interface
30D, 50N, 53I, 54A, 55E, 83G, 84R, 86F, 114D, 116G, 125A, 126L, 128R, 129S, 131P
CDD
cd07033 (TPP_PYR_DXS_TK_like)

86F

dimer interface
30D, 50N, 53I, 54A, 55E, 83G, 84R, 86F, 114D, 116G, 125A, 126L, 128R, 129S, 131P
CDD
cd07033 (TPP_PYR_DXS_TK_like)

114D

dimer interface
30D, 50N, 53I, 54A, 55E, 83G, 84R, 86F, 114D, 116G, 125A, 126L, 128R, 129S, 131P
CDD
cd07033 (TPP_PYR_DXS_TK_like)

116G

dimer interface
30D, 50N, 53I, 54A, 55E, 83G, 84R, 86F, 114D, 116G, 125A, 126L, 128R, 129S, 131P
CDD
cd07033 (TPP_PYR_DXS_TK_like)

125A

dimer interface
30D, 50N, 53I, 54A, 55E, 83G, 84R, 86F, 114D, 116G, 125A, 126L, 128R, 129S, 131P
CDD
cd07033 (TPP_PYR_DXS_TK_like)

126L

dimer interface
30D, 50N, 53I, 54A, 55E, 83G, 84R, 86F, 114D, 116G, 125A, 126L, 128R, 129S, 131P
CDD
cd07033 (TPP_PYR_DXS_TK_like)

128R

dimer interface
30D, 50N, 53I, 54A, 55E, 83G, 84R, 86F, 114D, 116G, 125A, 126L, 128R, 129S, 131P
CDD
cd07033 (TPP_PYR_DXS_TK_like)

129S

dimer interface
30D, 50N, 53I, 54A, 55E, 83G, 84R, 86F, 114D, 116G, 125A, 126L, 128R, 129S, 131P
CDD
cd07033 (TPP_PYR_DXS_TK_like)

131P

dimer interface
30D, 50N, 53I, 54A, 55E, 83G, 84R, 86F, 114D, 116G, 125A, 126L, 128R, 129S, 131P
CDD
cd07033 (TPP_PYR_DXS_TK_like)
TPP binding site c...

53I

TPP binding site
53I, 55E, 80F, 84R
CDD
cd07033 (TPP_PYR_DXS_TK_like)

55E

TPP binding site
53I, 55E, 80F, 84R
CDD
cd07033 (TPP_PYR_DXS_TK_like)

80F

TPP binding site
53I, 55E, 80F, 84R
CDD
cd07033 (TPP_PYR_DXS_TK_like)

84R

TPP binding site
53I, 55E, 80F, 84R
CDD
cd07033 (TPP_PYR_DXS_TK_like)

GO term prediction

Biological Process

GO:0008152 metabolic process

Molecular Function

GO:0003824 catalytic activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

27725_FusoPortal_Gene_750

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component