27725_FusoPortal_Gene_862

Protein

27725_FusoPortal_Gene_862

Length

488 amino acids

Protein family membership

Sirohaem synthase (IPR012409)

Homologous superfamilies

Homologous superfamily
4 - 255
Tetrapyrrole methylase superfamily (IPR035996)
Homologous superfamily
4 - 129
Tetrapyrrole methylase, subdomain 1 (IPR014777)
130 - 260
Tetrapyrrole methylase, subdomain 2 (IPR014776)
Homologous superfamily
253 - 487
Tetrapyrrole biosynthesis, uroporphyrinogen III synthase superfamily (IPR036108)

1 50 100 150 200 250 300 350 400 450 488

Domains and repeats

Domain
5 - 240
Tetrapyrrole methylase (IPR000878)
Uroporphyrin-III C-methyltransferase (IPR006366)
256 - 487
Tetrapyrrole biosynthesis, uroporphyrinogen III synthase (IPR003754)

1 50 100 150 200 250 300 350 400 450 488

Detailed signature matches

IPR014777

Tetrapyrrole methylase, subdomain 1
1. G3DSA:3.40.10...
  
  4 - 129
  
  GENE3D
  G3DSA:3.40.1010.10 (G3DSA:3.40.1010.10)
IPR035996

Tetrapyrrole methylase superfamily
1. SSF53790 (Tetrapyrr...)
  
  4 - 255
  
  SUPERFAMILY
  SSF53790 (Tetrapyrrole methylase)
IPR014776

Tetrapyrrole methylase, subdomain 2
1. G3DSA:3.30.95...
  
  130 - 260
  
  GENE3D
  G3DSA:3.30.950.10 (G3DSA:3.30.950.10)
IPR036108

Tetrapyrrole biosynthesis, uroporphyrinogen III synthase superfamily
1. SSF69618 (HemD-like)
  
  253 - 487
  
  SUPERFAMILY
  SSF69618 (HemD-like)
IPR012409

Sirohaem synthase
1. PIRSF036426 (Siroha...)
  
  1 - 256
  
  PIRSF
  PIRSF036426 (Sirohaem_synth)
IPR000878

Tetrapyrrole methylase
1. PF00590 (TP_methylase)
  
  6 - 215
  
  Pfam
  PF00590 (TP_methylase)
IPR006366

Uroporphyrin-III C-methyltransferase
1. TIGR01469
  
  5 - 240
  
  TIGRFAMs
  TIGR01469 (TIGR01469)
IPR003754

Tetrapyrrole biosynthesis, uroporphyrinogen III synthase
1. cd06578 (HemD)
  
  256 - 487
  
  CDD
  cd06578 (HemD)
2. PF02602 (HEM4)
  
  267 - 484
  
  Pfam
  PF02602 (HEM4)
IPR003043

Uroporphiryn-III C-methyltransferase, conserved site
1. PS00839 (SUMT_1)
  
  10 - 24
  
  PROSITE patterns
  PS00839 (SUMT_1)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

261 - 364

GENE3D
G3DSA:3.40.50.10090 (G3DSA:3.40.50.10090)

394 - 488

GENE3D
G3DSA:3.40.50.10090 (G3DSA:3.40.50.10090)
PTHR21091 (METHYLTE...)

4 - 347

PANTHER
PTHR21091 (METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED)

402 - 447

PANTHER
PTHR21091 (METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED)
PTHR21091:SF138 (SU...)

402 - 447

PANTHER
PTHR21091:SF138 (SUBFAMILY NOT NAMED)

4 - 347

PANTHER
PTHR21091:SF138 (SUBFAMILY NOT NAMED)
cd11642 (SUMT)

6 - 238

CDD
cd11642 (SUMT)

Residue annotation

active site cd11642

14P

active site
14P, 37D, 38R, 39L, 90G, 91G, 92D, 95V, 96F, 97G, 98R, 120T, 121S, 125V, 146T, 148H, 170F, 171L, 172M, 173G, 174I, 198I, 200K, 201G, 203T, 227P, 228P, 229A, 230I
CDD
cd11642 (SUMT)

37D

active site
14P, 37D, 38R, 39L, 90G, 91G, 92D, 95V, 96F, 97G, 98R, 120T, 121S, 125V, 146T, 148H, 170F, 171L, 172M, 173G, 174I, 198I, 200K, 201G, 203T, 227P, 228P, 229A, 230I
CDD
cd11642 (SUMT)

38R

active site
14P, 37D, 38R, 39L, 90G, 91G, 92D, 95V, 96F, 97G, 98R, 120T, 121S, 125V, 146T, 148H, 170F, 171L, 172M, 173G, 174I, 198I, 200K, 201G, 203T, 227P, 228P, 229A, 230I
CDD
cd11642 (SUMT)

39L

active site
14P, 37D, 38R, 39L, 90G, 91G, 92D, 95V, 96F, 97G, 98R, 120T, 121S, 125V, 146T, 148H, 170F, 171L, 172M, 173G, 174I, 198I, 200K, 201G, 203T, 227P, 228P, 229A, 230I
CDD
cd11642 (SUMT)

90G

active site
14P, 37D, 38R, 39L, 90G, 91G, 92D, 95V, 96F, 97G, 98R, 120T, 121S, 125V, 146T, 148H, 170F, 171L, 172M, 173G, 174I, 198I, 200K, 201G, 203T, 227P, 228P, 229A, 230I
CDD
cd11642 (SUMT)

91G

active site
14P, 37D, 38R, 39L, 90G, 91G, 92D, 95V, 96F, 97G, 98R, 120T, 121S, 125V, 146T, 148H, 170F, 171L, 172M, 173G, 174I, 198I, 200K, 201G, 203T, 227P, 228P, 229A, 230I
CDD
cd11642 (SUMT)

92D

active site
14P, 37D, 38R, 39L, 90G, 91G, 92D, 95V, 96F, 97G, 98R, 120T, 121S, 125V, 146T, 148H, 170F, 171L, 172M, 173G, 174I, 198I, 200K, 201G, 203T, 227P, 228P, 229A, 230I
CDD
cd11642 (SUMT)

95V

active site
14P, 37D, 38R, 39L, 90G, 91G, 92D, 95V, 96F, 97G, 98R, 120T, 121S, 125V, 146T, 148H, 170F, 171L, 172M, 173G, 174I, 198I, 200K, 201G, 203T, 227P, 228P, 229A, 230I
CDD
cd11642 (SUMT)

96F

active site
14P, 37D, 38R, 39L, 90G, 91G, 92D, 95V, 96F, 97G, 98R, 120T, 121S, 125V, 146T, 148H, 170F, 171L, 172M, 173G, 174I, 198I, 200K, 201G, 203T, 227P, 228P, 229A, 230I
CDD
cd11642 (SUMT)

97G

active site
14P, 37D, 38R, 39L, 90G, 91G, 92D, 95V, 96F, 97G, 98R, 120T, 121S, 125V, 146T, 148H, 170F, 171L, 172M, 173G, 174I, 198I, 200K, 201G, 203T, 227P, 228P, 229A, 230I
CDD
cd11642 (SUMT)

98R

active site
14P, 37D, 38R, 39L, 90G, 91G, 92D, 95V, 96F, 97G, 98R, 120T, 121S, 125V, 146T, 148H, 170F, 171L, 172M, 173G, 174I, 198I, 200K, 201G, 203T, 227P, 228P, 229A, 230I
CDD
cd11642 (SUMT)

120T

active site
14P, 37D, 38R, 39L, 90G, 91G, 92D, 95V, 96F, 97G, 98R, 120T, 121S, 125V, 146T, 148H, 170F, 171L, 172M, 173G, 174I, 198I, 200K, 201G, 203T, 227P, 228P, 229A, 230I
CDD
cd11642 (SUMT)

121S

active site
14P, 37D, 38R, 39L, 90G, 91G, 92D, 95V, 96F, 97G, 98R, 120T, 121S, 125V, 146T, 148H, 170F, 171L, 172M, 173G, 174I, 198I, 200K, 201G, 203T, 227P, 228P, 229A, 230I
CDD
cd11642 (SUMT)

125V

active site
14P, 37D, 38R, 39L, 90G, 91G, 92D, 95V, 96F, 97G, 98R, 120T, 121S, 125V, 146T, 148H, 170F, 171L, 172M, 173G, 174I, 198I, 200K, 201G, 203T, 227P, 228P, 229A, 230I
CDD
cd11642 (SUMT)

146T

active site
14P, 37D, 38R, 39L, 90G, 91G, 92D, 95V, 96F, 97G, 98R, 120T, 121S, 125V, 146T, 148H, 170F, 171L, 172M, 173G, 174I, 198I, 200K, 201G, 203T, 227P, 228P, 229A, 230I
CDD
cd11642 (SUMT)

148H

active site
14P, 37D, 38R, 39L, 90G, 91G, 92D, 95V, 96F, 97G, 98R, 120T, 121S, 125V, 146T, 148H, 170F, 171L, 172M, 173G, 174I, 198I, 200K, 201G, 203T, 227P, 228P, 229A, 230I
CDD
cd11642 (SUMT)

170F

active site
14P, 37D, 38R, 39L, 90G, 91G, 92D, 95V, 96F, 97G, 98R, 120T, 121S, 125V, 146T, 148H, 170F, 171L, 172M, 173G, 174I, 198I, 200K, 201G, 203T, 227P, 228P, 229A, 230I
CDD
cd11642 (SUMT)

171L

active site
14P, 37D, 38R, 39L, 90G, 91G, 92D, 95V, 96F, 97G, 98R, 120T, 121S, 125V, 146T, 148H, 170F, 171L, 172M, 173G, 174I, 198I, 200K, 201G, 203T, 227P, 228P, 229A, 230I
CDD
cd11642 (SUMT)

172M

active site
14P, 37D, 38R, 39L, 90G, 91G, 92D, 95V, 96F, 97G, 98R, 120T, 121S, 125V, 146T, 148H, 170F, 171L, 172M, 173G, 174I, 198I, 200K, 201G, 203T, 227P, 228P, 229A, 230I
CDD
cd11642 (SUMT)

173G

active site
14P, 37D, 38R, 39L, 90G, 91G, 92D, 95V, 96F, 97G, 98R, 120T, 121S, 125V, 146T, 148H, 170F, 171L, 172M, 173G, 174I, 198I, 200K, 201G, 203T, 227P, 228P, 229A, 230I
CDD
cd11642 (SUMT)

174I

active site
14P, 37D, 38R, 39L, 90G, 91G, 92D, 95V, 96F, 97G, 98R, 120T, 121S, 125V, 146T, 148H, 170F, 171L, 172M, 173G, 174I, 198I, 200K, 201G, 203T, 227P, 228P, 229A, 230I
CDD
cd11642 (SUMT)

198I

active site
14P, 37D, 38R, 39L, 90G, 91G, 92D, 95V, 96F, 97G, 98R, 120T, 121S, 125V, 146T, 148H, 170F, 171L, 172M, 173G, 174I, 198I, 200K, 201G, 203T, 227P, 228P, 229A, 230I
CDD
cd11642 (SUMT)

200K

active site
14P, 37D, 38R, 39L, 90G, 91G, 92D, 95V, 96F, 97G, 98R, 120T, 121S, 125V, 146T, 148H, 170F, 171L, 172M, 173G, 174I, 198I, 200K, 201G, 203T, 227P, 228P, 229A, 230I
CDD
cd11642 (SUMT)

201G

active site
14P, 37D, 38R, 39L, 90G, 91G, 92D, 95V, 96F, 97G, 98R, 120T, 121S, 125V, 146T, 148H, 170F, 171L, 172M, 173G, 174I, 198I, 200K, 201G, 203T, 227P, 228P, 229A, 230I
CDD
cd11642 (SUMT)

203T

active site
14P, 37D, 38R, 39L, 90G, 91G, 92D, 95V, 96F, 97G, 98R, 120T, 121S, 125V, 146T, 148H, 170F, 171L, 172M, 173G, 174I, 198I, 200K, 201G, 203T, 227P, 228P, 229A, 230I
CDD
cd11642 (SUMT)

227P

active site
14P, 37D, 38R, 39L, 90G, 91G, 92D, 95V, 96F, 97G, 98R, 120T, 121S, 125V, 146T, 148H, 170F, 171L, 172M, 173G, 174I, 198I, 200K, 201G, 203T, 227P, 228P, 229A, 230I
CDD
cd11642 (SUMT)

228P

active site
14P, 37D, 38R, 39L, 90G, 91G, 92D, 95V, 96F, 97G, 98R, 120T, 121S, 125V, 146T, 148H, 170F, 171L, 172M, 173G, 174I, 198I, 200K, 201G, 203T, 227P, 228P, 229A, 230I
CDD
cd11642 (SUMT)

229A

active site
14P, 37D, 38R, 39L, 90G, 91G, 92D, 95V, 96F, 97G, 98R, 120T, 121S, 125V, 146T, 148H, 170F, 171L, 172M, 173G, 174I, 198I, 200K, 201G, 203T, 227P, 228P, 229A, 230I
CDD
cd11642 (SUMT)

230I

active site
14P, 37D, 38R, 39L, 90G, 91G, 92D, 95V, 96F, 97G, 98R, 120T, 121S, 125V, 146T, 148H, 170F, 171L, 172M, 173G, 174I, 198I, 200K, 201G, 203T, 227P, 228P, 229A, 230I
CDD
cd11642 (SUMT)
SAM binding site c...

14P

SAM binding site
14P, 90G, 91G, 92D, 95V, 96F, 120T, 121S, 171L, 198I, 200K, 201G, 228P, 229A, 230I
CDD
cd11642 (SUMT)

90G

SAM binding site
14P, 90G, 91G, 92D, 95V, 96F, 120T, 121S, 171L, 198I, 200K, 201G, 228P, 229A, 230I
CDD
cd11642 (SUMT)

91G

SAM binding site
14P, 90G, 91G, 92D, 95V, 96F, 120T, 121S, 171L, 198I, 200K, 201G, 228P, 229A, 230I
CDD
cd11642 (SUMT)

92D

SAM binding site
14P, 90G, 91G, 92D, 95V, 96F, 120T, 121S, 171L, 198I, 200K, 201G, 228P, 229A, 230I
CDD
cd11642 (SUMT)

95V

SAM binding site
14P, 90G, 91G, 92D, 95V, 96F, 120T, 121S, 171L, 198I, 200K, 201G, 228P, 229A, 230I
CDD
cd11642 (SUMT)

96F

SAM binding site
14P, 90G, 91G, 92D, 95V, 96F, 120T, 121S, 171L, 198I, 200K, 201G, 228P, 229A, 230I
CDD
cd11642 (SUMT)

120T

SAM binding site
14P, 90G, 91G, 92D, 95V, 96F, 120T, 121S, 171L, 198I, 200K, 201G, 228P, 229A, 230I
CDD
cd11642 (SUMT)

121S

SAM binding site
14P, 90G, 91G, 92D, 95V, 96F, 120T, 121S, 171L, 198I, 200K, 201G, 228P, 229A, 230I
CDD
cd11642 (SUMT)

171L

SAM binding site
14P, 90G, 91G, 92D, 95V, 96F, 120T, 121S, 171L, 198I, 200K, 201G, 228P, 229A, 230I
CDD
cd11642 (SUMT)

198I

SAM binding site
14P, 90G, 91G, 92D, 95V, 96F, 120T, 121S, 171L, 198I, 200K, 201G, 228P, 229A, 230I
CDD
cd11642 (SUMT)

200K

SAM binding site
14P, 90G, 91G, 92D, 95V, 96F, 120T, 121S, 171L, 198I, 200K, 201G, 228P, 229A, 230I
CDD
cd11642 (SUMT)

201G

SAM binding site
14P, 90G, 91G, 92D, 95V, 96F, 120T, 121S, 171L, 198I, 200K, 201G, 228P, 229A, 230I
CDD
cd11642 (SUMT)

228P

SAM binding site
14P, 90G, 91G, 92D, 95V, 96F, 120T, 121S, 171L, 198I, 200K, 201G, 228P, 229A, 230I
CDD
cd11642 (SUMT)

229A

SAM binding site
14P, 90G, 91G, 92D, 95V, 96F, 120T, 121S, 171L, 198I, 200K, 201G, 228P, 229A, 230I
CDD
cd11642 (SUMT)

230I

SAM binding site
14P, 90G, 91G, 92D, 95V, 96F, 120T, 121S, 171L, 198I, 200K, 201G, 228P, 229A, 230I
CDD
cd11642 (SUMT)
homodimer interfac...

18E

homodimer interface
18E, 19L, 20L, 21T, 22L, 23K, 25K, 92D, 94F, 95V, 96F, 100G, 101E, 103I, 107Y, 108D, 115I, 117P, 119I, 123I, 124S, 132P, 134T, 135H, 136R, 140R, 141S, 142F, 143H, 144V
CDD
cd11642 (SUMT)

19L

homodimer interface
18E, 19L, 20L, 21T, 22L, 23K, 25K, 92D, 94F, 95V, 96F, 100G, 101E, 103I, 107Y, 108D, 115I, 117P, 119I, 123I, 124S, 132P, 134T, 135H, 136R, 140R, 141S, 142F, 143H, 144V
CDD
cd11642 (SUMT)

20L

homodimer interface
18E, 19L, 20L, 21T, 22L, 23K, 25K, 92D, 94F, 95V, 96F, 100G, 101E, 103I, 107Y, 108D, 115I, 117P, 119I, 123I, 124S, 132P, 134T, 135H, 136R, 140R, 141S, 142F, 143H, 144V
CDD
cd11642 (SUMT)

21T

homodimer interface
18E, 19L, 20L, 21T, 22L, 23K, 25K, 92D, 94F, 95V, 96F, 100G, 101E, 103I, 107Y, 108D, 115I, 117P, 119I, 123I, 124S, 132P, 134T, 135H, 136R, 140R, 141S, 142F, 143H, 144V
CDD
cd11642 (SUMT)

22L

homodimer interface
18E, 19L, 20L, 21T, 22L, 23K, 25K, 92D, 94F, 95V, 96F, 100G, 101E, 103I, 107Y, 108D, 115I, 117P, 119I, 123I, 124S, 132P, 134T, 135H, 136R, 140R, 141S, 142F, 143H, 144V
CDD
cd11642 (SUMT)

23K

homodimer interface
18E, 19L, 20L, 21T, 22L, 23K, 25K, 92D, 94F, 95V, 96F, 100G, 101E, 103I, 107Y, 108D, 115I, 117P, 119I, 123I, 124S, 132P, 134T, 135H, 136R, 140R, 141S, 142F, 143H, 144V
CDD
cd11642 (SUMT)

25K

homodimer interface
18E, 19L, 20L, 21T, 22L, 23K, 25K, 92D, 94F, 95V, 96F, 100G, 101E, 103I, 107Y, 108D, 115I, 117P, 119I, 123I, 124S, 132P, 134T, 135H, 136R, 140R, 141S, 142F, 143H, 144V
CDD
cd11642 (SUMT)

92D

homodimer interface
18E, 19L, 20L, 21T, 22L, 23K, 25K, 92D, 94F, 95V, 96F, 100G, 101E, 103I, 107Y, 108D, 115I, 117P, 119I, 123I, 124S, 132P, 134T, 135H, 136R, 140R, 141S, 142F, 143H, 144V
CDD
cd11642 (SUMT)

94F

homodimer interface
18E, 19L, 20L, 21T, 22L, 23K, 25K, 92D, 94F, 95V, 96F, 100G, 101E, 103I, 107Y, 108D, 115I, 117P, 119I, 123I, 124S, 132P, 134T, 135H, 136R, 140R, 141S, 142F, 143H, 144V
CDD
cd11642 (SUMT)

95V

homodimer interface
18E, 19L, 20L, 21T, 22L, 23K, 25K, 92D, 94F, 95V, 96F, 100G, 101E, 103I, 107Y, 108D, 115I, 117P, 119I, 123I, 124S, 132P, 134T, 135H, 136R, 140R, 141S, 142F, 143H, 144V
CDD
cd11642 (SUMT)

96F

homodimer interface
18E, 19L, 20L, 21T, 22L, 23K, 25K, 92D, 94F, 95V, 96F, 100G, 101E, 103I, 107Y, 108D, 115I, 117P, 119I, 123I, 124S, 132P, 134T, 135H, 136R, 140R, 141S, 142F, 143H, 144V
CDD
cd11642 (SUMT)

100G

homodimer interface
18E, 19L, 20L, 21T, 22L, 23K, 25K, 92D, 94F, 95V, 96F, 100G, 101E, 103I, 107Y, 108D, 115I, 117P, 119I, 123I, 124S, 132P, 134T, 135H, 136R, 140R, 141S, 142F, 143H, 144V
CDD
cd11642 (SUMT)

101E

homodimer interface
18E, 19L, 20L, 21T, 22L, 23K, 25K, 92D, 94F, 95V, 96F, 100G, 101E, 103I, 107Y, 108D, 115I, 117P, 119I, 123I, 124S, 132P, 134T, 135H, 136R, 140R, 141S, 142F, 143H, 144V
CDD
cd11642 (SUMT)

103I

homodimer interface
18E, 19L, 20L, 21T, 22L, 23K, 25K, 92D, 94F, 95V, 96F, 100G, 101E, 103I, 107Y, 108D, 115I, 117P, 119I, 123I, 124S, 132P, 134T, 135H, 136R, 140R, 141S, 142F, 143H, 144V
CDD
cd11642 (SUMT)

107Y

homodimer interface
18E, 19L, 20L, 21T, 22L, 23K, 25K, 92D, 94F, 95V, 96F, 100G, 101E, 103I, 107Y, 108D, 115I, 117P, 119I, 123I, 124S, 132P, 134T, 135H, 136R, 140R, 141S, 142F, 143H, 144V
CDD
cd11642 (SUMT)

108D

homodimer interface
18E, 19L, 20L, 21T, 22L, 23K, 25K, 92D, 94F, 95V, 96F, 100G, 101E, 103I, 107Y, 108D, 115I, 117P, 119I, 123I, 124S, 132P, 134T, 135H, 136R, 140R, 141S, 142F, 143H, 144V
CDD
cd11642 (SUMT)

115I

homodimer interface
18E, 19L, 20L, 21T, 22L, 23K, 25K, 92D, 94F, 95V, 96F, 100G, 101E, 103I, 107Y, 108D, 115I, 117P, 119I, 123I, 124S, 132P, 134T, 135H, 136R, 140R, 141S, 142F, 143H, 144V
CDD
cd11642 (SUMT)

117P

homodimer interface
18E, 19L, 20L, 21T, 22L, 23K, 25K, 92D, 94F, 95V, 96F, 100G, 101E, 103I, 107Y, 108D, 115I, 117P, 119I, 123I, 124S, 132P, 134T, 135H, 136R, 140R, 141S, 142F, 143H, 144V
CDD
cd11642 (SUMT)

119I

homodimer interface
18E, 19L, 20L, 21T, 22L, 23K, 25K, 92D, 94F, 95V, 96F, 100G, 101E, 103I, 107Y, 108D, 115I, 117P, 119I, 123I, 124S, 132P, 134T, 135H, 136R, 140R, 141S, 142F, 143H, 144V
CDD
cd11642 (SUMT)

123I

homodimer interface
18E, 19L, 20L, 21T, 22L, 23K, 25K, 92D, 94F, 95V, 96F, 100G, 101E, 103I, 107Y, 108D, 115I, 117P, 119I, 123I, 124S, 132P, 134T, 135H, 136R, 140R, 141S, 142F, 143H, 144V
CDD
cd11642 (SUMT)

124S

homodimer interface
18E, 19L, 20L, 21T, 22L, 23K, 25K, 92D, 94F, 95V, 96F, 100G, 101E, 103I, 107Y, 108D, 115I, 117P, 119I, 123I, 124S, 132P, 134T, 135H, 136R, 140R, 141S, 142F, 143H, 144V
CDD
cd11642 (SUMT)

132P

homodimer interface
18E, 19L, 20L, 21T, 22L, 23K, 25K, 92D, 94F, 95V, 96F, 100G, 101E, 103I, 107Y, 108D, 115I, 117P, 119I, 123I, 124S, 132P, 134T, 135H, 136R, 140R, 141S, 142F, 143H, 144V
CDD
cd11642 (SUMT)

134T

homodimer interface
18E, 19L, 20L, 21T, 22L, 23K, 25K, 92D, 94F, 95V, 96F, 100G, 101E, 103I, 107Y, 108D, 115I, 117P, 119I, 123I, 124S, 132P, 134T, 135H, 136R, 140R, 141S, 142F, 143H, 144V
CDD
cd11642 (SUMT)

135H

homodimer interface
18E, 19L, 20L, 21T, 22L, 23K, 25K, 92D, 94F, 95V, 96F, 100G, 101E, 103I, 107Y, 108D, 115I, 117P, 119I, 123I, 124S, 132P, 134T, 135H, 136R, 140R, 141S, 142F, 143H, 144V
CDD
cd11642 (SUMT)

136R

homodimer interface
18E, 19L, 20L, 21T, 22L, 23K, 25K, 92D, 94F, 95V, 96F, 100G, 101E, 103I, 107Y, 108D, 115I, 117P, 119I, 123I, 124S, 132P, 134T, 135H, 136R, 140R, 141S, 142F, 143H, 144V
CDD
cd11642 (SUMT)

140R

homodimer interface
18E, 19L, 20L, 21T, 22L, 23K, 25K, 92D, 94F, 95V, 96F, 100G, 101E, 103I, 107Y, 108D, 115I, 117P, 119I, 123I, 124S, 132P, 134T, 135H, 136R, 140R, 141S, 142F, 143H, 144V
CDD
cd11642 (SUMT)

141S

homodimer interface
18E, 19L, 20L, 21T, 22L, 23K, 25K, 92D, 94F, 95V, 96F, 100G, 101E, 103I, 107Y, 108D, 115I, 117P, 119I, 123I, 124S, 132P, 134T, 135H, 136R, 140R, 141S, 142F, 143H, 144V
CDD
cd11642 (SUMT)

142F

homodimer interface
18E, 19L, 20L, 21T, 22L, 23K, 25K, 92D, 94F, 95V, 96F, 100G, 101E, 103I, 107Y, 108D, 115I, 117P, 119I, 123I, 124S, 132P, 134T, 135H, 136R, 140R, 141S, 142F, 143H, 144V
CDD
cd11642 (SUMT)

143H

homodimer interface
18E, 19L, 20L, 21T, 22L, 23K, 25K, 92D, 94F, 95V, 96F, 100G, 101E, 103I, 107Y, 108D, 115I, 117P, 119I, 123I, 124S, 132P, 134T, 135H, 136R, 140R, 141S, 142F, 143H, 144V
CDD
cd11642 (SUMT)

144V

homodimer interface
18E, 19L, 20L, 21T, 22L, 23K, 25K, 92D, 94F, 95V, 96F, 100G, 101E, 103I, 107Y, 108D, 115I, 117P, 119I, 123I, 124S, 132P, 134T, 135H, 136R, 140R, 141S, 142F, 143H, 144V
CDD
cd11642 (SUMT)
active site cd06578

260R

active site
260R, 309S, 310P, 311N, 337K, 380S, 404Y, 406T, 429L, 430S, 431S, 432S, 433T
CDD
cd06578 (HemD)

309S

active site
260R, 309S, 310P, 311N, 337K, 380S, 404Y, 406T, 429L, 430S, 431S, 432S, 433T
CDD
cd06578 (HemD)

310P

active site
260R, 309S, 310P, 311N, 337K, 380S, 404Y, 406T, 429L, 430S, 431S, 432S, 433T
CDD
cd06578 (HemD)

311N

active site
260R, 309S, 310P, 311N, 337K, 380S, 404Y, 406T, 429L, 430S, 431S, 432S, 433T
CDD
cd06578 (HemD)

337K

active site
260R, 309S, 310P, 311N, 337K, 380S, 404Y, 406T, 429L, 430S, 431S, 432S, 433T
CDD
cd06578 (HemD)

380S

active site
260R, 309S, 310P, 311N, 337K, 380S, 404Y, 406T, 429L, 430S, 431S, 432S, 433T
CDD
cd06578 (HemD)

404Y

active site
260R, 309S, 310P, 311N, 337K, 380S, 404Y, 406T, 429L, 430S, 431S, 432S, 433T
CDD
cd06578 (HemD)

406T

active site
260R, 309S, 310P, 311N, 337K, 380S, 404Y, 406T, 429L, 430S, 431S, 432S, 433T
CDD
cd06578 (HemD)

429L

active site
260R, 309S, 310P, 311N, 337K, 380S, 404Y, 406T, 429L, 430S, 431S, 432S, 433T
CDD
cd06578 (HemD)

430S

active site
260R, 309S, 310P, 311N, 337K, 380S, 404Y, 406T, 429L, 430S, 431S, 432S, 433T
CDD
cd06578 (HemD)

431S

active site
260R, 309S, 310P, 311N, 337K, 380S, 404Y, 406T, 429L, 430S, 431S, 432S, 433T
CDD
cd06578 (HemD)

432S

active site
260R, 309S, 310P, 311N, 337K, 380S, 404Y, 406T, 429L, 430S, 431S, 432S, 433T
CDD
cd06578 (HemD)

433T

active site
260R, 309S, 310P, 311N, 337K, 380S, 404Y, 406T, 429L, 430S, 431S, 432S, 433T
CDD
cd06578 (HemD)

GO term prediction

Biological Process

GO:0006779 porphyrin-containing compound biosynthetic process
GO:0008152 metabolic process
GO:0009236 cobalamin biosynthetic process
GO:0019354 siroheme biosynthetic process
GO:0033014 tetrapyrrole biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004851 uroporphyrin-III C-methyltransferase activity
GO:0004852 uroporphyrinogen-III synthase activity
GO:0008168 methyltransferase activity
GO:0043115 precorrin-2 dehydrogenase activity
GO:0051266 sirohydrochlorin ferrochelatase activity
GO:0051287 NAD binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features