27725_FusoPortal_Gene_863

Protein

27725_FusoPortal_Gene_863

Length

325 amino acids

Protein family membership

Delta-aminolevulinic acid dehydratase (IPR001731)

Homologous superfamilies

Homologous superfamily
1 - 322
Aldolase-type TIM barrel (IPR013785)

1 50 100 150 200 250 300 325

Domains and repeats

None predicted.

Detailed signature matches

IPR013785

Aldolase-type TIM barrel
1. G3DSA:3.20.20.70
  
  1 - 322
  
  GENE3D
  G3DSA:3.20.20.70 (G3DSA:3.20.20.70)
IPR001731

Delta-aminolevulinic acid dehydratase
1. PF00490 (ALAD)
  
  3 - 317
  
  Pfam
  PF00490 (ALAD)
2. PTHR11458 (PORPHOBI...)
  
  4 - 321
  
  PANTHER
  PTHR11458 (PORPHOBILINOGEN SYNTHASE)
3. PIRSF001415 (Porphb...)
  
  1 - 321
  
  PIRSF
  PIRSF001415 (Porphbilin_synth)
4. PR00144 (DALDHYDRTASE)
  
  118 - 132
  
  PRINTS
  PR00144 (DALDHYDRTASE)
  
  292 - 311
  
  PRINTS
  PR00144 (DALDHYDRTASE)
  
  238 - 254
  
  PRINTS
  PR00144 (DALDHYDRTASE)
  
  148 - 167
  
  PRINTS
  PR00144 (DALDHYDRTASE)
  
  186 - 205
  
  PRINTS
  PR00144 (DALDHYDRTASE)
IPR030656

Delta-aminolevulinic acid dehydratase, active site
1. PS00169 (D_ALA_DEHY...)
  
  238 - 250
  
  PROSITE patterns
  PS00169 (D_ALA_DEHYDRATASE)

no IPR

Unintegrated signatures

SSF51569 (Aldolase)

2 - 320

SUPERFAMILY
SSF51569 (Aldolase)
cd00384 (ALAD_PBGS)

6 - 317

CDD
cd00384 (ALAD_PBGS)

Residue annotation

dimer interface cd...

6R

dimer interface
6R, 9R, 10S, 21V, 45S, 48P, 137N, 138D, 165M, 166D, 195S, 196N, 197Y, 217Y, 220D, 226E, 229R, 230E, 248L, 249A, 250Y, 251L, 252D, 275M, 293E, 297A, 300R
CDD
cd00384 (ALAD_PBGS)

9R

dimer interface
6R, 9R, 10S, 21V, 45S, 48P, 137N, 138D, 165M, 166D, 195S, 196N, 197Y, 217Y, 220D, 226E, 229R, 230E, 248L, 249A, 250Y, 251L, 252D, 275M, 293E, 297A, 300R
CDD
cd00384 (ALAD_PBGS)

10S

dimer interface
6R, 9R, 10S, 21V, 45S, 48P, 137N, 138D, 165M, 166D, 195S, 196N, 197Y, 217Y, 220D, 226E, 229R, 230E, 248L, 249A, 250Y, 251L, 252D, 275M, 293E, 297A, 300R
CDD
cd00384 (ALAD_PBGS)

21V

dimer interface
6R, 9R, 10S, 21V, 45S, 48P, 137N, 138D, 165M, 166D, 195S, 196N, 197Y, 217Y, 220D, 226E, 229R, 230E, 248L, 249A, 250Y, 251L, 252D, 275M, 293E, 297A, 300R
CDD
cd00384 (ALAD_PBGS)

45S

dimer interface
6R, 9R, 10S, 21V, 45S, 48P, 137N, 138D, 165M, 166D, 195S, 196N, 197Y, 217Y, 220D, 226E, 229R, 230E, 248L, 249A, 250Y, 251L, 252D, 275M, 293E, 297A, 300R
CDD
cd00384 (ALAD_PBGS)

48P

dimer interface
6R, 9R, 10S, 21V, 45S, 48P, 137N, 138D, 165M, 166D, 195S, 196N, 197Y, 217Y, 220D, 226E, 229R, 230E, 248L, 249A, 250Y, 251L, 252D, 275M, 293E, 297A, 300R
CDD
cd00384 (ALAD_PBGS)

137N

dimer interface
6R, 9R, 10S, 21V, 45S, 48P, 137N, 138D, 165M, 166D, 195S, 196N, 197Y, 217Y, 220D, 226E, 229R, 230E, 248L, 249A, 250Y, 251L, 252D, 275M, 293E, 297A, 300R
CDD
cd00384 (ALAD_PBGS)

138D

dimer interface
6R, 9R, 10S, 21V, 45S, 48P, 137N, 138D, 165M, 166D, 195S, 196N, 197Y, 217Y, 220D, 226E, 229R, 230E, 248L, 249A, 250Y, 251L, 252D, 275M, 293E, 297A, 300R
CDD
cd00384 (ALAD_PBGS)

165M

dimer interface
6R, 9R, 10S, 21V, 45S, 48P, 137N, 138D, 165M, 166D, 195S, 196N, 197Y, 217Y, 220D, 226E, 229R, 230E, 248L, 249A, 250Y, 251L, 252D, 275M, 293E, 297A, 300R
CDD
cd00384 (ALAD_PBGS)

166D

dimer interface
6R, 9R, 10S, 21V, 45S, 48P, 137N, 138D, 165M, 166D, 195S, 196N, 197Y, 217Y, 220D, 226E, 229R, 230E, 248L, 249A, 250Y, 251L, 252D, 275M, 293E, 297A, 300R
CDD
cd00384 (ALAD_PBGS)

195S

dimer interface
6R, 9R, 10S, 21V, 45S, 48P, 137N, 138D, 165M, 166D, 195S, 196N, 197Y, 217Y, 220D, 226E, 229R, 230E, 248L, 249A, 250Y, 251L, 252D, 275M, 293E, 297A, 300R
CDD
cd00384 (ALAD_PBGS)

196N

dimer interface
6R, 9R, 10S, 21V, 45S, 48P, 137N, 138D, 165M, 166D, 195S, 196N, 197Y, 217Y, 220D, 226E, 229R, 230E, 248L, 249A, 250Y, 251L, 252D, 275M, 293E, 297A, 300R
CDD
cd00384 (ALAD_PBGS)

197Y

dimer interface
6R, 9R, 10S, 21V, 45S, 48P, 137N, 138D, 165M, 166D, 195S, 196N, 197Y, 217Y, 220D, 226E, 229R, 230E, 248L, 249A, 250Y, 251L, 252D, 275M, 293E, 297A, 300R
CDD
cd00384 (ALAD_PBGS)

217Y

dimer interface
6R, 9R, 10S, 21V, 45S, 48P, 137N, 138D, 165M, 166D, 195S, 196N, 197Y, 217Y, 220D, 226E, 229R, 230E, 248L, 249A, 250Y, 251L, 252D, 275M, 293E, 297A, 300R
CDD
cd00384 (ALAD_PBGS)

220D

dimer interface
6R, 9R, 10S, 21V, 45S, 48P, 137N, 138D, 165M, 166D, 195S, 196N, 197Y, 217Y, 220D, 226E, 229R, 230E, 248L, 249A, 250Y, 251L, 252D, 275M, 293E, 297A, 300R
CDD
cd00384 (ALAD_PBGS)

226E

dimer interface
6R, 9R, 10S, 21V, 45S, 48P, 137N, 138D, 165M, 166D, 195S, 196N, 197Y, 217Y, 220D, 226E, 229R, 230E, 248L, 249A, 250Y, 251L, 252D, 275M, 293E, 297A, 300R
CDD
cd00384 (ALAD_PBGS)

229R

dimer interface
6R, 9R, 10S, 21V, 45S, 48P, 137N, 138D, 165M, 166D, 195S, 196N, 197Y, 217Y, 220D, 226E, 229R, 230E, 248L, 249A, 250Y, 251L, 252D, 275M, 293E, 297A, 300R
CDD
cd00384 (ALAD_PBGS)

230E

dimer interface
6R, 9R, 10S, 21V, 45S, 48P, 137N, 138D, 165M, 166D, 195S, 196N, 197Y, 217Y, 220D, 226E, 229R, 230E, 248L, 249A, 250Y, 251L, 252D, 275M, 293E, 297A, 300R
CDD
cd00384 (ALAD_PBGS)

248L

dimer interface
6R, 9R, 10S, 21V, 45S, 48P, 137N, 138D, 165M, 166D, 195S, 196N, 197Y, 217Y, 220D, 226E, 229R, 230E, 248L, 249A, 250Y, 251L, 252D, 275M, 293E, 297A, 300R
CDD
cd00384 (ALAD_PBGS)

249A

dimer interface
6R, 9R, 10S, 21V, 45S, 48P, 137N, 138D, 165M, 166D, 195S, 196N, 197Y, 217Y, 220D, 226E, 229R, 230E, 248L, 249A, 250Y, 251L, 252D, 275M, 293E, 297A, 300R
CDD
cd00384 (ALAD_PBGS)

250Y

dimer interface
6R, 9R, 10S, 21V, 45S, 48P, 137N, 138D, 165M, 166D, 195S, 196N, 197Y, 217Y, 220D, 226E, 229R, 230E, 248L, 249A, 250Y, 251L, 252D, 275M, 293E, 297A, 300R
CDD
cd00384 (ALAD_PBGS)

251L

dimer interface
6R, 9R, 10S, 21V, 45S, 48P, 137N, 138D, 165M, 166D, 195S, 196N, 197Y, 217Y, 220D, 226E, 229R, 230E, 248L, 249A, 250Y, 251L, 252D, 275M, 293E, 297A, 300R
CDD
cd00384 (ALAD_PBGS)

252D

dimer interface
6R, 9R, 10S, 21V, 45S, 48P, 137N, 138D, 165M, 166D, 195S, 196N, 197Y, 217Y, 220D, 226E, 229R, 230E, 248L, 249A, 250Y, 251L, 252D, 275M, 293E, 297A, 300R
CDD
cd00384 (ALAD_PBGS)

275M

dimer interface
6R, 9R, 10S, 21V, 45S, 48P, 137N, 138D, 165M, 166D, 195S, 196N, 197Y, 217Y, 220D, 226E, 229R, 230E, 248L, 249A, 250Y, 251L, 252D, 275M, 293E, 297A, 300R
CDD
cd00384 (ALAD_PBGS)

293E

dimer interface
6R, 9R, 10S, 21V, 45S, 48P, 137N, 138D, 165M, 166D, 195S, 196N, 197Y, 217Y, 220D, 226E, 229R, 230E, 248L, 249A, 250Y, 251L, 252D, 275M, 293E, 297A, 300R
CDD
cd00384 (ALAD_PBGS)

297A

dimer interface
6R, 9R, 10S, 21V, 45S, 48P, 137N, 138D, 165M, 166D, 195S, 196N, 197Y, 217Y, 220D, 226E, 229R, 230E, 248L, 249A, 250Y, 251L, 252D, 275M, 293E, 297A, 300R
CDD
cd00384 (ALAD_PBGS)

300R

dimer interface
6R, 9R, 10S, 21V, 45S, 48P, 137N, 138D, 165M, 166D, 195S, 196N, 197Y, 217Y, 220D, 226E, 229R, 230E, 248L, 249A, 250Y, 251L, 252D, 275M, 293E, 297A, 300R
CDD
cd00384 (ALAD_PBGS)
active site cd00384

115D

active site
115D, 117C, 119C, 127C, 162S, 192K, 198Y, 201F, 202R, 207S, 214R, 218Q, 245K, 267Y, 270S, 309Y
CDD
cd00384 (ALAD_PBGS)

117C

active site
115D, 117C, 119C, 127C, 162S, 192K, 198Y, 201F, 202R, 207S, 214R, 218Q, 245K, 267Y, 270S, 309Y
CDD
cd00384 (ALAD_PBGS)

119C

active site
115D, 117C, 119C, 127C, 162S, 192K, 198Y, 201F, 202R, 207S, 214R, 218Q, 245K, 267Y, 270S, 309Y
CDD
cd00384 (ALAD_PBGS)

127C

active site
115D, 117C, 119C, 127C, 162S, 192K, 198Y, 201F, 202R, 207S, 214R, 218Q, 245K, 267Y, 270S, 309Y
CDD
cd00384 (ALAD_PBGS)

162S

active site
115D, 117C, 119C, 127C, 162S, 192K, 198Y, 201F, 202R, 207S, 214R, 218Q, 245K, 267Y, 270S, 309Y
CDD
cd00384 (ALAD_PBGS)

192K

active site
115D, 117C, 119C, 127C, 162S, 192K, 198Y, 201F, 202R, 207S, 214R, 218Q, 245K, 267Y, 270S, 309Y
CDD
cd00384 (ALAD_PBGS)

198Y

active site
115D, 117C, 119C, 127C, 162S, 192K, 198Y, 201F, 202R, 207S, 214R, 218Q, 245K, 267Y, 270S, 309Y
CDD
cd00384 (ALAD_PBGS)

201F

active site
115D, 117C, 119C, 127C, 162S, 192K, 198Y, 201F, 202R, 207S, 214R, 218Q, 245K, 267Y, 270S, 309Y
CDD
cd00384 (ALAD_PBGS)

202R

active site
115D, 117C, 119C, 127C, 162S, 192K, 198Y, 201F, 202R, 207S, 214R, 218Q, 245K, 267Y, 270S, 309Y
CDD
cd00384 (ALAD_PBGS)

207S

active site
115D, 117C, 119C, 127C, 162S, 192K, 198Y, 201F, 202R, 207S, 214R, 218Q, 245K, 267Y, 270S, 309Y
CDD
cd00384 (ALAD_PBGS)

214R

active site
115D, 117C, 119C, 127C, 162S, 192K, 198Y, 201F, 202R, 207S, 214R, 218Q, 245K, 267Y, 270S, 309Y
CDD
cd00384 (ALAD_PBGS)

218Q

active site
115D, 117C, 119C, 127C, 162S, 192K, 198Y, 201F, 202R, 207S, 214R, 218Q, 245K, 267Y, 270S, 309Y
CDD
cd00384 (ALAD_PBGS)

245K

active site
115D, 117C, 119C, 127C, 162S, 192K, 198Y, 201F, 202R, 207S, 214R, 218Q, 245K, 267Y, 270S, 309Y
CDD
cd00384 (ALAD_PBGS)

267Y

active site
115D, 117C, 119C, 127C, 162S, 192K, 198Y, 201F, 202R, 207S, 214R, 218Q, 245K, 267Y, 270S, 309Y
CDD
cd00384 (ALAD_PBGS)

270S

active site
115D, 117C, 119C, 127C, 162S, 192K, 198Y, 201F, 202R, 207S, 214R, 218Q, 245K, 267Y, 270S, 309Y
CDD
cd00384 (ALAD_PBGS)

309Y

active site
115D, 117C, 119C, 127C, 162S, 192K, 198Y, 201F, 202R, 207S, 214R, 218Q, 245K, 267Y, 270S, 309Y
CDD
cd00384 (ALAD_PBGS)
Schiff base residu...

192K

Schiff base residues
192K, 245K
CDD
cd00384 (ALAD_PBGS)

245K

Schiff base residues
192K, 245K
CDD
cd00384 (ALAD_PBGS)

GO term prediction

Biological Process

GO:0033014 tetrapyrrole biosynthetic process

Molecular Function

GO:0003824 catalytic activity
GO:0004655 porphobilinogen synthase activity
GO:0046872 metal ion binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

27725_FusoPortal_Gene_863

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component