2_1_31_FusoPortal_Gene_138

Protein

2_1_31_FusoPortal_Gene_138

Length

382 amino acids

Protein family membership

Cys/Met metabolism, pyridoxal phosphate-dependent enzyme (IPR000277)

Homologous superfamilies

Homologous superfamily
3 - 249
Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (IPR015421)
250 - 382
Pyridoxal phosphate-dependent transferase, subdomain 2 (IPR015422)
Homologous superfamily
19 - 381
Pyridoxal phosphate-dependent transferase (IPR015424)

1 50 100 150 200 250 300 350 382

Domains and repeats

None predicted.

Detailed signature matches

IPR015421

Pyridoxal phosphate-dependent transferase, major region, subdomain 1
1. G3DSA:3.40.64...
  
  3 - 249
  
  GENE3D
  G3DSA:3.40.640.10 (G3DSA:3.40.640.10)
IPR015424

Pyridoxal phosphate-dependent transferase
1. SSF53383 (PLP-depen...)
  
  19 - 381
  
  SUPERFAMILY
  SSF53383 (PLP-dependent transferases)
IPR015422

Pyridoxal phosphate-dependent transferase, subdomain 2
1. G3DSA:3.90.11...
  
  250 - 382
  
  GENE3D
  G3DSA:3.90.1150.10 (G3DSA:3.90.1150.10)
IPR000277

Cys/Met metabolism, pyridoxal phosphate-dependent enzyme
1. cd00614 (CGS_like)
  
  23 - 381
  
  CDD
  cd00614 (CGS_like)
2. PTHR11808 (TRANS-SU...)
  
  4 - 381
  
  PANTHER
  PTHR11808 (TRANS-SULFURATION ENZYME FAMILY MEMBER)
3. PIRSF001434 (CGS)
  
  1 - 382
  
  PIRSF
  PIRSF001434 (CGS)
4. PS00868 (CYS_MET_ME...)
  
  191 - 205
  
  PROSITE patterns
  PS00868 (CYS_MET_METAB_PP)
5. PF01053 (Cys_Met_Me...)
  
  7 - 380
  
  Pfam
  PF01053 (Cys_Met_Meta_PP)

no IPR

Unintegrated signatures

Coil

366 - 382

COILS
Coil (Coil)

Residue annotation

homodimer interfac...

31Q

homodimer interface
31Q, 32S, 33A, 34T, 36V, 37H, 48Y, 50R, 76S, 77T, 79M, 80T, 102Y, 107R, 110E, 198T, 206D, 208L, 225F, 235S, 237F, 238D, 316K
CDD
cd00614 (CGS_like)

32S

homodimer interface
31Q, 32S, 33A, 34T, 36V, 37H, 48Y, 50R, 76S, 77T, 79M, 80T, 102Y, 107R, 110E, 198T, 206D, 208L, 225F, 235S, 237F, 238D, 316K
CDD
cd00614 (CGS_like)

33A

homodimer interface
31Q, 32S, 33A, 34T, 36V, 37H, 48Y, 50R, 76S, 77T, 79M, 80T, 102Y, 107R, 110E, 198T, 206D, 208L, 225F, 235S, 237F, 238D, 316K
CDD
cd00614 (CGS_like)

34T

homodimer interface
31Q, 32S, 33A, 34T, 36V, 37H, 48Y, 50R, 76S, 77T, 79M, 80T, 102Y, 107R, 110E, 198T, 206D, 208L, 225F, 235S, 237F, 238D, 316K
CDD
cd00614 (CGS_like)

36V

homodimer interface
31Q, 32S, 33A, 34T, 36V, 37H, 48Y, 50R, 76S, 77T, 79M, 80T, 102Y, 107R, 110E, 198T, 206D, 208L, 225F, 235S, 237F, 238D, 316K
CDD
cd00614 (CGS_like)

37H

homodimer interface
31Q, 32S, 33A, 34T, 36V, 37H, 48Y, 50R, 76S, 77T, 79M, 80T, 102Y, 107R, 110E, 198T, 206D, 208L, 225F, 235S, 237F, 238D, 316K
CDD
cd00614 (CGS_like)

48Y

homodimer interface
31Q, 32S, 33A, 34T, 36V, 37H, 48Y, 50R, 76S, 77T, 79M, 80T, 102Y, 107R, 110E, 198T, 206D, 208L, 225F, 235S, 237F, 238D, 316K
CDD
cd00614 (CGS_like)

50R

homodimer interface
31Q, 32S, 33A, 34T, 36V, 37H, 48Y, 50R, 76S, 77T, 79M, 80T, 102Y, 107R, 110E, 198T, 206D, 208L, 225F, 235S, 237F, 238D, 316K
CDD
cd00614 (CGS_like)

76S

homodimer interface
31Q, 32S, 33A, 34T, 36V, 37H, 48Y, 50R, 76S, 77T, 79M, 80T, 102Y, 107R, 110E, 198T, 206D, 208L, 225F, 235S, 237F, 238D, 316K
CDD
cd00614 (CGS_like)

77T

homodimer interface
31Q, 32S, 33A, 34T, 36V, 37H, 48Y, 50R, 76S, 77T, 79M, 80T, 102Y, 107R, 110E, 198T, 206D, 208L, 225F, 235S, 237F, 238D, 316K
CDD
cd00614 (CGS_like)

79M

homodimer interface
31Q, 32S, 33A, 34T, 36V, 37H, 48Y, 50R, 76S, 77T, 79M, 80T, 102Y, 107R, 110E, 198T, 206D, 208L, 225F, 235S, 237F, 238D, 316K
CDD
cd00614 (CGS_like)

80T

homodimer interface
31Q, 32S, 33A, 34T, 36V, 37H, 48Y, 50R, 76S, 77T, 79M, 80T, 102Y, 107R, 110E, 198T, 206D, 208L, 225F, 235S, 237F, 238D, 316K
CDD
cd00614 (CGS_like)

102Y

homodimer interface
31Q, 32S, 33A, 34T, 36V, 37H, 48Y, 50R, 76S, 77T, 79M, 80T, 102Y, 107R, 110E, 198T, 206D, 208L, 225F, 235S, 237F, 238D, 316K
CDD
cd00614 (CGS_like)

107R

homodimer interface
31Q, 32S, 33A, 34T, 36V, 37H, 48Y, 50R, 76S, 77T, 79M, 80T, 102Y, 107R, 110E, 198T, 206D, 208L, 225F, 235S, 237F, 238D, 316K
CDD
cd00614 (CGS_like)

110E

homodimer interface
31Q, 32S, 33A, 34T, 36V, 37H, 48Y, 50R, 76S, 77T, 79M, 80T, 102Y, 107R, 110E, 198T, 206D, 208L, 225F, 235S, 237F, 238D, 316K
CDD
cd00614 (CGS_like)

198T

homodimer interface
31Q, 32S, 33A, 34T, 36V, 37H, 48Y, 50R, 76S, 77T, 79M, 80T, 102Y, 107R, 110E, 198T, 206D, 208L, 225F, 235S, 237F, 238D, 316K
CDD
cd00614 (CGS_like)

206D

homodimer interface
31Q, 32S, 33A, 34T, 36V, 37H, 48Y, 50R, 76S, 77T, 79M, 80T, 102Y, 107R, 110E, 198T, 206D, 208L, 225F, 235S, 237F, 238D, 316K
CDD
cd00614 (CGS_like)

208L

homodimer interface
31Q, 32S, 33A, 34T, 36V, 37H, 48Y, 50R, 76S, 77T, 79M, 80T, 102Y, 107R, 110E, 198T, 206D, 208L, 225F, 235S, 237F, 238D, 316K
CDD
cd00614 (CGS_like)

225F

homodimer interface
31Q, 32S, 33A, 34T, 36V, 37H, 48Y, 50R, 76S, 77T, 79M, 80T, 102Y, 107R, 110E, 198T, 206D, 208L, 225F, 235S, 237F, 238D, 316K
CDD
cd00614 (CGS_like)

235S

homodimer interface
31Q, 32S, 33A, 34T, 36V, 37H, 48Y, 50R, 76S, 77T, 79M, 80T, 102Y, 107R, 110E, 198T, 206D, 208L, 225F, 235S, 237F, 238D, 316K
CDD
cd00614 (CGS_like)

237F

homodimer interface
31Q, 32S, 33A, 34T, 36V, 37H, 48Y, 50R, 76S, 77T, 79M, 80T, 102Y, 107R, 110E, 198T, 206D, 208L, 225F, 235S, 237F, 238D, 316K
CDD
cd00614 (CGS_like)

238D

homodimer interface
31Q, 32S, 33A, 34T, 36V, 37H, 48Y, 50R, 76S, 77T, 79M, 80T, 102Y, 107R, 110E, 198T, 206D, 208L, 225F, 235S, 237F, 238D, 316K
CDD
cd00614 (CGS_like)

316K

homodimer interface
31Q, 32S, 33A, 34T, 36V, 37H, 48Y, 50R, 76S, 77T, 79M, 80T, 102Y, 107R, 110E, 198T, 206D, 208L, 225F, 235S, 237F, 238D, 316K
CDD
cd00614 (CGS_like)
pyridoxal 5'-phosp...

77T

pyridoxal 5'-phosphate binding site
77T, 78G, 79M, 102Y, 174D, 177F, 196S, 198T, 199K
CDD
cd00614 (CGS_like)

78G

pyridoxal 5'-phosphate binding site
77T, 78G, 79M, 102Y, 174D, 177F, 196S, 198T, 199K
CDD
cd00614 (CGS_like)

79M

pyridoxal 5'-phosphate binding site
77T, 78G, 79M, 102Y, 174D, 177F, 196S, 198T, 199K
CDD
cd00614 (CGS_like)

102Y

pyridoxal 5'-phosphate binding site
77T, 78G, 79M, 102Y, 174D, 177F, 196S, 198T, 199K
CDD
cd00614 (CGS_like)

174D

pyridoxal 5'-phosphate binding site
77T, 78G, 79M, 102Y, 174D, 177F, 196S, 198T, 199K
CDD
cd00614 (CGS_like)

177F

pyridoxal 5'-phosphate binding site
77T, 78G, 79M, 102Y, 174D, 177F, 196S, 198T, 199K
CDD
cd00614 (CGS_like)

196S

pyridoxal 5'-phosphate binding site
77T, 78G, 79M, 102Y, 174D, 177F, 196S, 198T, 199K
CDD
cd00614 (CGS_like)

198T

pyridoxal 5'-phosphate binding site
77T, 78G, 79M, 102Y, 174D, 177F, 196S, 198T, 199K
CDD
cd00614 (CGS_like)

199K

pyridoxal 5'-phosphate binding site
77T, 78G, 79M, 102Y, 174D, 177F, 196S, 198T, 199K
CDD
cd00614 (CGS_like)
substrate-cofactor...

77T

substrate-cofactor binding pocket
77T, 78G, 79M, 102Y, 145E, 174D, 196S, 198T, 199K, 208L
CDD
cd00614 (CGS_like)

78G

substrate-cofactor binding pocket
77T, 78G, 79M, 102Y, 145E, 174D, 196S, 198T, 199K, 208L
CDD
cd00614 (CGS_like)

79M

substrate-cofactor binding pocket
77T, 78G, 79M, 102Y, 145E, 174D, 196S, 198T, 199K, 208L
CDD
cd00614 (CGS_like)

102Y

substrate-cofactor binding pocket
77T, 78G, 79M, 102Y, 145E, 174D, 196S, 198T, 199K, 208L
CDD
cd00614 (CGS_like)

145E

substrate-cofactor binding pocket
77T, 78G, 79M, 102Y, 145E, 174D, 196S, 198T, 199K, 208L
CDD
cd00614 (CGS_like)

174D

substrate-cofactor binding pocket
77T, 78G, 79M, 102Y, 145E, 174D, 196S, 198T, 199K, 208L
CDD
cd00614 (CGS_like)

196S

substrate-cofactor binding pocket
77T, 78G, 79M, 102Y, 145E, 174D, 196S, 198T, 199K, 208L
CDD
cd00614 (CGS_like)

198T

substrate-cofactor binding pocket
77T, 78G, 79M, 102Y, 145E, 174D, 196S, 198T, 199K, 208L
CDD
cd00614 (CGS_like)

199K

substrate-cofactor binding pocket
77T, 78G, 79M, 102Y, 145E, 174D, 196S, 198T, 199K, 208L
CDD
cd00614 (CGS_like)

208L

substrate-cofactor binding pocket
77T, 78G, 79M, 102Y, 145E, 174D, 196S, 198T, 199K, 208L
CDD
cd00614 (CGS_like)
catalytic residue ...

199K

catalytic residue
199K
CDD
cd00614 (CGS_like)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003824 catalytic activity
GO:0030170 pyridoxal phosphate binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

2_1_31_FusoPortal_Gene_138

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component