2_1_31_FusoPortal_Gene_155

Protein

2_1_31_FusoPortal_Gene_155

Length

323 amino acids

Protein family membership

Delta-aminolevulinic acid dehydratase (IPR001731)

Homologous superfamilies

Homologous superfamily
1 - 323
Aldolase-type TIM barrel (IPR013785)

1 50 100 150 200 250 323

Domains and repeats

None predicted.

Detailed signature matches

IPR013785

Aldolase-type TIM barrel
1. G3DSA:3.20.20.70
  
  1 - 323
  
  GENE3D
  G3DSA:3.20.20.70 (G3DSA:3.20.20.70)
IPR001731

Delta-aminolevulinic acid dehydratase
1. PF00490 (ALAD)
  
  4 - 319
  
  Pfam
  PF00490 (ALAD)
2. PTHR11458 (PORPHOBI...)
  
  4 - 321
  
  PANTHER
  PTHR11458 (PORPHOBILINOGEN SYNTHASE)
3. PIRSF001415 (Porphb...)
  
  1 - 323
  
  PIRSF
  PIRSF001415 (Porphbilin_synth)
4. PR00144 (DALDHYDRTASE)
  
  119 - 133
  
  PRINTS
  PR00144 (DALDHYDRTASE)
  
  239 - 255
  
  PRINTS
  PR00144 (DALDHYDRTASE)
  
  187 - 206
  
  PRINTS
  PR00144 (DALDHYDRTASE)
  
  294 - 313
  
  PRINTS
  PR00144 (DALDHYDRTASE)
  
  149 - 168
  
  PRINTS
  PR00144 (DALDHYDRTASE)
  
  264 - 279
  
  PRINTS
  PR00144 (DALDHYDRTASE)
IPR030656

Delta-aminolevulinic acid dehydratase, active site
1. PS00169 (D_ALA_DEHY...)
  
  239 - 251
  
  PROSITE patterns
  PS00169 (D_ALA_DEHYDRATASE)

no IPR

Unintegrated signatures

SSF51569 (Aldolase)

2 - 320

SUPERFAMILY
SSF51569 (Aldolase)
cd00384 (ALAD_PBGS)

6 - 320

CDD
cd00384 (ALAD_PBGS)

Residue annotation

dimer interface cd...

6R

dimer interface
6R, 9R, 10R, 21I, 45E, 48P, 138N, 139D, 166M, 167D, 196S, 197A, 198Y, 218Y, 221D, 227N, 230A, 231E, 249M, 250A, 251Y, 252L, 253D, 277M, 295E, 299A, 302R
CDD
cd00384 (ALAD_PBGS)

9R

dimer interface
6R, 9R, 10R, 21I, 45E, 48P, 138N, 139D, 166M, 167D, 196S, 197A, 198Y, 218Y, 221D, 227N, 230A, 231E, 249M, 250A, 251Y, 252L, 253D, 277M, 295E, 299A, 302R
CDD
cd00384 (ALAD_PBGS)

10R

dimer interface
6R, 9R, 10R, 21I, 45E, 48P, 138N, 139D, 166M, 167D, 196S, 197A, 198Y, 218Y, 221D, 227N, 230A, 231E, 249M, 250A, 251Y, 252L, 253D, 277M, 295E, 299A, 302R
CDD
cd00384 (ALAD_PBGS)

21I

dimer interface
6R, 9R, 10R, 21I, 45E, 48P, 138N, 139D, 166M, 167D, 196S, 197A, 198Y, 218Y, 221D, 227N, 230A, 231E, 249M, 250A, 251Y, 252L, 253D, 277M, 295E, 299A, 302R
CDD
cd00384 (ALAD_PBGS)

45E

dimer interface
6R, 9R, 10R, 21I, 45E, 48P, 138N, 139D, 166M, 167D, 196S, 197A, 198Y, 218Y, 221D, 227N, 230A, 231E, 249M, 250A, 251Y, 252L, 253D, 277M, 295E, 299A, 302R
CDD
cd00384 (ALAD_PBGS)

48P

dimer interface
6R, 9R, 10R, 21I, 45E, 48P, 138N, 139D, 166M, 167D, 196S, 197A, 198Y, 218Y, 221D, 227N, 230A, 231E, 249M, 250A, 251Y, 252L, 253D, 277M, 295E, 299A, 302R
CDD
cd00384 (ALAD_PBGS)

138N

dimer interface
6R, 9R, 10R, 21I, 45E, 48P, 138N, 139D, 166M, 167D, 196S, 197A, 198Y, 218Y, 221D, 227N, 230A, 231E, 249M, 250A, 251Y, 252L, 253D, 277M, 295E, 299A, 302R
CDD
cd00384 (ALAD_PBGS)

139D

dimer interface
6R, 9R, 10R, 21I, 45E, 48P, 138N, 139D, 166M, 167D, 196S, 197A, 198Y, 218Y, 221D, 227N, 230A, 231E, 249M, 250A, 251Y, 252L, 253D, 277M, 295E, 299A, 302R
CDD
cd00384 (ALAD_PBGS)

166M

dimer interface
6R, 9R, 10R, 21I, 45E, 48P, 138N, 139D, 166M, 167D, 196S, 197A, 198Y, 218Y, 221D, 227N, 230A, 231E, 249M, 250A, 251Y, 252L, 253D, 277M, 295E, 299A, 302R
CDD
cd00384 (ALAD_PBGS)

167D

dimer interface
6R, 9R, 10R, 21I, 45E, 48P, 138N, 139D, 166M, 167D, 196S, 197A, 198Y, 218Y, 221D, 227N, 230A, 231E, 249M, 250A, 251Y, 252L, 253D, 277M, 295E, 299A, 302R
CDD
cd00384 (ALAD_PBGS)

196S

dimer interface
6R, 9R, 10R, 21I, 45E, 48P, 138N, 139D, 166M, 167D, 196S, 197A, 198Y, 218Y, 221D, 227N, 230A, 231E, 249M, 250A, 251Y, 252L, 253D, 277M, 295E, 299A, 302R
CDD
cd00384 (ALAD_PBGS)

197A

dimer interface
6R, 9R, 10R, 21I, 45E, 48P, 138N, 139D, 166M, 167D, 196S, 197A, 198Y, 218Y, 221D, 227N, 230A, 231E, 249M, 250A, 251Y, 252L, 253D, 277M, 295E, 299A, 302R
CDD
cd00384 (ALAD_PBGS)

198Y

dimer interface
6R, 9R, 10R, 21I, 45E, 48P, 138N, 139D, 166M, 167D, 196S, 197A, 198Y, 218Y, 221D, 227N, 230A, 231E, 249M, 250A, 251Y, 252L, 253D, 277M, 295E, 299A, 302R
CDD
cd00384 (ALAD_PBGS)

218Y

dimer interface
6R, 9R, 10R, 21I, 45E, 48P, 138N, 139D, 166M, 167D, 196S, 197A, 198Y, 218Y, 221D, 227N, 230A, 231E, 249M, 250A, 251Y, 252L, 253D, 277M, 295E, 299A, 302R
CDD
cd00384 (ALAD_PBGS)

221D

dimer interface
6R, 9R, 10R, 21I, 45E, 48P, 138N, 139D, 166M, 167D, 196S, 197A, 198Y, 218Y, 221D, 227N, 230A, 231E, 249M, 250A, 251Y, 252L, 253D, 277M, 295E, 299A, 302R
CDD
cd00384 (ALAD_PBGS)

227N

dimer interface
6R, 9R, 10R, 21I, 45E, 48P, 138N, 139D, 166M, 167D, 196S, 197A, 198Y, 218Y, 221D, 227N, 230A, 231E, 249M, 250A, 251Y, 252L, 253D, 277M, 295E, 299A, 302R
CDD
cd00384 (ALAD_PBGS)

230A

dimer interface
6R, 9R, 10R, 21I, 45E, 48P, 138N, 139D, 166M, 167D, 196S, 197A, 198Y, 218Y, 221D, 227N, 230A, 231E, 249M, 250A, 251Y, 252L, 253D, 277M, 295E, 299A, 302R
CDD
cd00384 (ALAD_PBGS)

231E

dimer interface
6R, 9R, 10R, 21I, 45E, 48P, 138N, 139D, 166M, 167D, 196S, 197A, 198Y, 218Y, 221D, 227N, 230A, 231E, 249M, 250A, 251Y, 252L, 253D, 277M, 295E, 299A, 302R
CDD
cd00384 (ALAD_PBGS)

249M

dimer interface
6R, 9R, 10R, 21I, 45E, 48P, 138N, 139D, 166M, 167D, 196S, 197A, 198Y, 218Y, 221D, 227N, 230A, 231E, 249M, 250A, 251Y, 252L, 253D, 277M, 295E, 299A, 302R
CDD
cd00384 (ALAD_PBGS)

250A

dimer interface
6R, 9R, 10R, 21I, 45E, 48P, 138N, 139D, 166M, 167D, 196S, 197A, 198Y, 218Y, 221D, 227N, 230A, 231E, 249M, 250A, 251Y, 252L, 253D, 277M, 295E, 299A, 302R
CDD
cd00384 (ALAD_PBGS)

251Y

dimer interface
6R, 9R, 10R, 21I, 45E, 48P, 138N, 139D, 166M, 167D, 196S, 197A, 198Y, 218Y, 221D, 227N, 230A, 231E, 249M, 250A, 251Y, 252L, 253D, 277M, 295E, 299A, 302R
CDD
cd00384 (ALAD_PBGS)

252L

dimer interface
6R, 9R, 10R, 21I, 45E, 48P, 138N, 139D, 166M, 167D, 196S, 197A, 198Y, 218Y, 221D, 227N, 230A, 231E, 249M, 250A, 251Y, 252L, 253D, 277M, 295E, 299A, 302R
CDD
cd00384 (ALAD_PBGS)

253D

dimer interface
6R, 9R, 10R, 21I, 45E, 48P, 138N, 139D, 166M, 167D, 196S, 197A, 198Y, 218Y, 221D, 227N, 230A, 231E, 249M, 250A, 251Y, 252L, 253D, 277M, 295E, 299A, 302R
CDD
cd00384 (ALAD_PBGS)

277M

dimer interface
6R, 9R, 10R, 21I, 45E, 48P, 138N, 139D, 166M, 167D, 196S, 197A, 198Y, 218Y, 221D, 227N, 230A, 231E, 249M, 250A, 251Y, 252L, 253D, 277M, 295E, 299A, 302R
CDD
cd00384 (ALAD_PBGS)

295E

dimer interface
6R, 9R, 10R, 21I, 45E, 48P, 138N, 139D, 166M, 167D, 196S, 197A, 198Y, 218Y, 221D, 227N, 230A, 231E, 249M, 250A, 251Y, 252L, 253D, 277M, 295E, 299A, 302R
CDD
cd00384 (ALAD_PBGS)

299A

dimer interface
6R, 9R, 10R, 21I, 45E, 48P, 138N, 139D, 166M, 167D, 196S, 197A, 198Y, 218Y, 221D, 227N, 230A, 231E, 249M, 250A, 251Y, 252L, 253D, 277M, 295E, 299A, 302R
CDD
cd00384 (ALAD_PBGS)

302R

dimer interface
6R, 9R, 10R, 21I, 45E, 48P, 138N, 139D, 166M, 167D, 196S, 197A, 198Y, 218Y, 221D, 227N, 230A, 231E, 249M, 250A, 251Y, 252L, 253D, 277M, 295E, 299A, 302R
CDD
cd00384 (ALAD_PBGS)
active site cd00384

116D

active site
116D, 118C, 120C, 128C, 163S, 193K, 199Y, 202F, 203R, 208S, 215R, 219Q, 246K, 269Y, 272S, 311Y
CDD
cd00384 (ALAD_PBGS)

118C

active site
116D, 118C, 120C, 128C, 163S, 193K, 199Y, 202F, 203R, 208S, 215R, 219Q, 246K, 269Y, 272S, 311Y
CDD
cd00384 (ALAD_PBGS)

120C

active site
116D, 118C, 120C, 128C, 163S, 193K, 199Y, 202F, 203R, 208S, 215R, 219Q, 246K, 269Y, 272S, 311Y
CDD
cd00384 (ALAD_PBGS)

128C

active site
116D, 118C, 120C, 128C, 163S, 193K, 199Y, 202F, 203R, 208S, 215R, 219Q, 246K, 269Y, 272S, 311Y
CDD
cd00384 (ALAD_PBGS)

163S

active site
116D, 118C, 120C, 128C, 163S, 193K, 199Y, 202F, 203R, 208S, 215R, 219Q, 246K, 269Y, 272S, 311Y
CDD
cd00384 (ALAD_PBGS)

193K

active site
116D, 118C, 120C, 128C, 163S, 193K, 199Y, 202F, 203R, 208S, 215R, 219Q, 246K, 269Y, 272S, 311Y
CDD
cd00384 (ALAD_PBGS)

199Y

active site
116D, 118C, 120C, 128C, 163S, 193K, 199Y, 202F, 203R, 208S, 215R, 219Q, 246K, 269Y, 272S, 311Y
CDD
cd00384 (ALAD_PBGS)

202F

active site
116D, 118C, 120C, 128C, 163S, 193K, 199Y, 202F, 203R, 208S, 215R, 219Q, 246K, 269Y, 272S, 311Y
CDD
cd00384 (ALAD_PBGS)

203R

active site
116D, 118C, 120C, 128C, 163S, 193K, 199Y, 202F, 203R, 208S, 215R, 219Q, 246K, 269Y, 272S, 311Y
CDD
cd00384 (ALAD_PBGS)

208S

active site
116D, 118C, 120C, 128C, 163S, 193K, 199Y, 202F, 203R, 208S, 215R, 219Q, 246K, 269Y, 272S, 311Y
CDD
cd00384 (ALAD_PBGS)

215R

active site
116D, 118C, 120C, 128C, 163S, 193K, 199Y, 202F, 203R, 208S, 215R, 219Q, 246K, 269Y, 272S, 311Y
CDD
cd00384 (ALAD_PBGS)

219Q

active site
116D, 118C, 120C, 128C, 163S, 193K, 199Y, 202F, 203R, 208S, 215R, 219Q, 246K, 269Y, 272S, 311Y
CDD
cd00384 (ALAD_PBGS)

246K

active site
116D, 118C, 120C, 128C, 163S, 193K, 199Y, 202F, 203R, 208S, 215R, 219Q, 246K, 269Y, 272S, 311Y
CDD
cd00384 (ALAD_PBGS)

269Y

active site
116D, 118C, 120C, 128C, 163S, 193K, 199Y, 202F, 203R, 208S, 215R, 219Q, 246K, 269Y, 272S, 311Y
CDD
cd00384 (ALAD_PBGS)

272S

active site
116D, 118C, 120C, 128C, 163S, 193K, 199Y, 202F, 203R, 208S, 215R, 219Q, 246K, 269Y, 272S, 311Y
CDD
cd00384 (ALAD_PBGS)

311Y

active site
116D, 118C, 120C, 128C, 163S, 193K, 199Y, 202F, 203R, 208S, 215R, 219Q, 246K, 269Y, 272S, 311Y
CDD
cd00384 (ALAD_PBGS)
Schiff base residu...

193K

Schiff base residues
193K, 246K
CDD
cd00384 (ALAD_PBGS)

246K

Schiff base residues
193K, 246K
CDD
cd00384 (ALAD_PBGS)

GO term prediction

Biological Process

GO:0033014 tetrapyrrole biosynthetic process

Molecular Function

GO:0003824 catalytic activity
GO:0004655 porphobilinogen synthase activity
GO:0046872 metal ion binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

2_1_31_FusoPortal_Gene_155

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component