2_1_31_FusoPortal_Gene_609

Protein

2_1_31_FusoPortal_Gene_609

Length

753 amino acids

Protein family membership

DNA topoisomerase I, type IA (IPR028612)
- DNA topoisomerase I, bacterial-type (IPR005733)

Homologous superfamilies

Homologous superfamily
9 - 559
DNA topoisomerase, type IA, core domain (IPR023405)
716 - 725
DNA topoisomerase, type IA, core domain (IPR023405)
Homologous superfamily
327 - 445
DNA topoisomerase, type IA, central region, subdomain 2 (IPR013825)

1 100 200 300 400 500 600 700 753

Domains and repeats

Domain
8 - 130
TOPRIM domain (IPR006171)
DNA topoisomerase 1, TOPRIM domain (IPR034149)
Domain
82 - 95
DNA topoisomerase, type IA, central (IPR013497)
133 - 555
DNA topoisomerase, type IA, central (IPR013497)
716 - 753
DNA topoisomerase, type IA, zn finger (IPR013498)

1 100 200 300 400 500 600 700 753

Detailed signature matches

IPR023405

DNA topoisomerase, type IA, core domain
1. SSF56712 (Prokaryot...)
  
  9 - 559
  
  SUPERFAMILY
  SSF56712 (Prokaryotic type I DNA topoisomerase)
  
  716 - 725
  
  SUPERFAMILY
  SSF56712 (Prokaryotic type I DNA topoisomerase)
IPR013825

DNA topoisomerase, type IA, central region, subdomain 2
1. G3DSA:2.70.20.10
  
  327 - 445
  
  GENE3D
  G3DSA:2.70.20.10 (G3DSA:2.70.20.10)
IPR028612

DNA topoisomerase I, type IA
1. MF_00952 (Topoisom_...)
  
  8 - 730
  
  HAMAP
  MF_00952 (Topoisom_1_prok)
IPR005733

DNA topoisomerase I, bacterial-type
1. TIGR01051
  
  10 - 601
  
  TIGRFAMs
  TIGR01051 (TIGR01051)
IPR006171

TOPRIM domain
1. PF01751 (Toprim)
  
  10 - 118
  
  Pfam
  PF01751 (Toprim)
2. PS50880 (TOPRIM)
  
  8 - 118
  
  PROSITE profiles
  PS50880 (TOPRIM)
IPR034149

DNA topoisomerase 1, TOPRIM domain
1. cd03363 (TOPRIM_Top...)
  
  9 - 130
  
  CDD
  cd03363 (TOPRIM_TopoIA_TopoI)
IPR013497

DNA topoisomerase, type IA, central
1. PR00417 (PRTPISMRASEI)
  
  167 - 185
  
  PRINTS
  PR00417 (PRTPISMRASEI)
  
  372 - 388
  
  PRINTS
  PR00417 (PRTPISMRASEI)
  
  82 - 95
  
  PRINTS
  PR00417 (PRTPISMRASEI)
  
  471 - 485
  
  PRINTS
  PR00417 (PRTPISMRASEI)
  
  294 - 303
  
  PRINTS
  PR00417 (PRTPISMRASEI)
2. PF01131 (Topoisom_bac)
  
  133 - 545
  
  Pfam
  PF01131 (Topoisom_bac)
3. cd00186 (TOP1Ac)
  
  137 - 555
  
  CDD
  cd00186 (TOP1Ac)
IPR013498

DNA topoisomerase, type IA, zn finger
1. PF01396 (zf-C4_Topo...)
  
  716 - 753
  
  Pfam
  PF01396 (zf-C4_Topoisom)
IPR023406

DNA topoisomerase, type IA, active site
1. PS00396 (TOPOISOMER...)
  
  281 - 303
  
  PROSITE patterns
  PS00396 (TOPOISOMERASE_I_PROK)

no IPR

Unintegrated signatures

G3DSA:1.10.46...

446 - 568

GENE3D
G3DSA:1.10.460.10 (G3DSA:1.10.460.10)

140 - 326

GENE3D
G3DSA:1.10.460.10 (G3DSA:1.10.460.10)
G3DSA:3.30.65.10

701 - 753

GENE3D
G3DSA:3.30.65.10 (G3DSA:3.30.65.10)
G3DSA:3.40.50...

7 - 134

GENE3D
G3DSA:3.40.50.140 (G3DSA:3.40.50.140)
SSF57783 (Zinc beta...)

715 - 750

SUPERFAMILY
SSF57783 (Zinc beta-ribbon)

Residue annotation

active site cd03363

14E

active site
14E, 15S, 18K, 87D, 89D, 91E
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

15S

active site
14E, 15S, 18K, 87D, 89D, 91E
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

18K

active site
14E, 15S, 18K, 87D, 89D, 91E
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

87D

active site
14E, 15S, 18K, 87D, 89D, 91E
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

89D

active site
14E, 15S, 18K, 87D, 89D, 91E
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

91E

active site
14E, 15S, 18K, 87D, 89D, 91E
CDD
cd03363 (TOPRIM_TopoIA_TopoI)
interdomain intera...

21T

interdomain interaction site
21T, 88P, 90R, 97W, 98H, 100A, 101N
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

88P

interdomain interaction site
21T, 88P, 90R, 97W, 98H, 100A, 101N
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

90R

interdomain interaction site
21T, 88P, 90R, 97W, 98H, 100A, 101N
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

97W

interdomain interaction site
21T, 88P, 90R, 97W, 98H, 100A, 101N
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

98H

interdomain interaction site
21T, 88P, 90R, 97W, 98H, 100A, 101N
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

100A

interdomain interaction site
21T, 88P, 90R, 97W, 98H, 100A, 101N
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

101N

interdomain interaction site
21T, 88P, 90R, 97W, 98H, 100A, 101N
CDD
cd03363 (TOPRIM_TopoIA_TopoI)
putative metal-bin...

87D

putative metal-binding site
87D, 89D
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

89D

putative metal-binding site
87D, 89D
CDD
cd03363 (TOPRIM_TopoIA_TopoI)
nucleotide binding...

90R

nucleotide binding site
90R
CDD
cd03363 (TOPRIM_TopoIA_TopoI)
domain I cd00186

137R

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

138V

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

139N

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

140S

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

141Q

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

142Q

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

143A

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

144R

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

145R

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

146I

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

147L

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

148D

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

149R

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

150L

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

151V

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

152G

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

153Y

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

154E

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

155I

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

156S

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

157P

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

158F

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

159L

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

160W

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

161K

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

162L

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

167T

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

168S

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

169A

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

170G

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

171R

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

172V

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

173Q

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

174S

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

175V

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

176A

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

177L

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

178K

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

179I

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

180I

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

181C

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

182E

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

183L

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

184E

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

185D

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

186K

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)

187I

domain I
137R, 138V, 139N, 140S, 141Q, 142Q, 143A, 144R, 145R, 146I, 147L, 148D, 149R, 150L, 151V, 152G, 153Y, 154E, 155I, 156S, 157P, 158F, 159L, 160W, 161K, 162L, 167T, 168S, 169A, 170G, 171R, 172V, 173Q, 174S, 175V, 176A, 177L, 178K, 179I, 180I, 181C, 182E, 183L, 184E, 185D, 186K, 187I
CDD
cd00186 (TOP1Ac)
DNA binding groove...

144R

DNA binding groove
144R, 145R, 148D, 152G, 156S, 281Q, 285E, 301R, 476S, 477T, 480S, 481I, 483D, 487K, 488R
CDD
cd00186 (TOP1Ac)

145R

DNA binding groove
144R, 145R, 148D, 152G, 156S, 281Q, 285E, 301R, 476S, 477T, 480S, 481I, 483D, 487K, 488R
CDD
cd00186 (TOP1Ac)

148D

DNA binding groove
144R, 145R, 148D, 152G, 156S, 281Q, 285E, 301R, 476S, 477T, 480S, 481I, 483D, 487K, 488R
CDD
cd00186 (TOP1Ac)

152G

DNA binding groove
144R, 145R, 148D, 152G, 156S, 281Q, 285E, 301R, 476S, 477T, 480S, 481I, 483D, 487K, 488R
CDD
cd00186 (TOP1Ac)

156S

DNA binding groove
144R, 145R, 148D, 152G, 156S, 281Q, 285E, 301R, 476S, 477T, 480S, 481I, 483D, 487K, 488R
CDD
cd00186 (TOP1Ac)

281Q

DNA binding groove
144R, 145R, 148D, 152G, 156S, 281Q, 285E, 301R, 476S, 477T, 480S, 481I, 483D, 487K, 488R
CDD
cd00186 (TOP1Ac)

285E

DNA binding groove
144R, 145R, 148D, 152G, 156S, 281Q, 285E, 301R, 476S, 477T, 480S, 481I, 483D, 487K, 488R
CDD
cd00186 (TOP1Ac)

301R

DNA binding groove
144R, 145R, 148D, 152G, 156S, 281Q, 285E, 301R, 476S, 477T, 480S, 481I, 483D, 487K, 488R
CDD
cd00186 (TOP1Ac)

476S

DNA binding groove
144R, 145R, 148D, 152G, 156S, 281Q, 285E, 301R, 476S, 477T, 480S, 481I, 483D, 487K, 488R
CDD
cd00186 (TOP1Ac)

477T

DNA binding groove
144R, 145R, 148D, 152G, 156S, 281Q, 285E, 301R, 476S, 477T, 480S, 481I, 483D, 487K, 488R
CDD
cd00186 (TOP1Ac)

480S

DNA binding groove
144R, 145R, 148D, 152G, 156S, 281Q, 285E, 301R, 476S, 477T, 480S, 481I, 483D, 487K, 488R
CDD
cd00186 (TOP1Ac)

481I

DNA binding groove
144R, 145R, 148D, 152G, 156S, 281Q, 285E, 301R, 476S, 477T, 480S, 481I, 483D, 487K, 488R
CDD
cd00186 (TOP1Ac)

483D

DNA binding groove
144R, 145R, 148D, 152G, 156S, 281Q, 285E, 301R, 476S, 477T, 480S, 481I, 483D, 487K, 488R
CDD
cd00186 (TOP1Ac)

487K

DNA binding groove
144R, 145R, 148D, 152G, 156S, 281Q, 285E, 301R, 476S, 477T, 480S, 481I, 483D, 487K, 488R
CDD
cd00186 (TOP1Ac)

488R

DNA binding groove
144R, 145R, 148D, 152G, 156S, 281Q, 285E, 301R, 476S, 477T, 480S, 481I, 483D, 487K, 488R
CDD
cd00186 (TOP1Ac)
phosphate binding ...

178K

phosphate binding site
178K, 182E, 512D
CDD
cd00186 (TOP1Ac)

182E

phosphate binding site
178K, 182E, 512D
CDD
cd00186 (TOP1Ac)

512D

phosphate binding site
178K, 182E, 512D
CDD
cd00186 (TOP1Ac)
domain II cd00186

192P

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

193E

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

194K

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

195Y

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

196W

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

197D

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

198V

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

199K

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

237K

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

238Y

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

239E

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

240V

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

241V

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

242S

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

243S

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

244K

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

245I

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

246S

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

247N

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

248K

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

249I

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

250K

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

251N

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

386A

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

387A

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

388M

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

389K

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

390Y

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

391E

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

392Q

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

393F

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

394E

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

395Y

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

396I

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

397L

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

398E

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

399K

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

400D

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

402I

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

403Q

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

404Y

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

405R

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

406G

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

407S

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

408I

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

409N

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

410K

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

411I

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

412I

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

413F

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

414D

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

415G

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

416Y

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

417Y

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

418K

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

419V

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

420F

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

443D

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

444K

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

445L

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

446D

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

447I

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

448K

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

449E

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

450D

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

451Y

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

452T

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)

453K

domain II
192P, 193E, 194K, 195Y, 196W, 197D, 198V, 199K, 237K, 238Y, 239E, 240V, 241V, 242S, 243S, 244K, 245I, 246S, 247N, 248K, 249I, 250K, 251N, 386A, 387A, 388M, 389K, 390Y, 391E, 392Q, 393F, 394E, 395Y, 396I, 397L, 398E, 399K, 400D, 402I, 403Q, 404Y, 405R, 406G, 407S, 408I, 409N, 410K, 411I, 412I, 413F, 414D, 415G, 416Y, 417Y, 418K, 419V, 420F, 443D, 444K, 445L, 446D, 447I, 448K, 449E, 450D, 451Y, 452T, 453K
CDD
cd00186 (TOP1Ac)
domain III cd00186

252P

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

253P

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

254L

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

255P

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

256L

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

257K

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

258T

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

260T

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

261L

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

262Q

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

263Q

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

264L

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

265A

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

266S

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

267S

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

268Y

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

269L

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

270G

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

271F

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

272S

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

273A

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

274S

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

275K

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

276T

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

277M

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

278M

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

279V

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

280A

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

281Q

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

282K

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

283L

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

284Y

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

285E

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

294K

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

295G

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

296L

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

297I

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

298T

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

299Y

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

300M

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

301R

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

302T

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

303D

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

304S

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

305T

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

306R

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

307I

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

308S

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

309E

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

310E

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

311A

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

312K

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

313E

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

314M

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

315A

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

316R

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

317K

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

318Y

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

319I

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

320T

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

321K

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

322E

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

323Y

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

345A

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

346H

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

347E

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

348G

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

349V

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

350R

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

351P

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

352T

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

353D

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

365L

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

366D

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

367K

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

368D

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

369Q

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

370F

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

371K

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

372L

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

373Y

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

374N

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

375L

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

376I

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

377W

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

378Q

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

379R

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

380F

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

381L

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

382I

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

383S

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

384Q

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)

385L

domain III
252P, 253P, 254L, 255P, 256L, 257K, 258T, 260T, 261L, 262Q, 263Q, 264L, 265A, 266S, 267S, 268Y, 269L, 270G, 271F, 272S, 273A, 274S, 275K, 276T, 277M, 278M, 279V, 280A, 281Q, 282K, 283L, 284Y, 285E, 294K, 295G, 296L, 297I, 298T, 299Y, 300M, 301R, 302T, 303D, 304S, 305T, 306R, 307I, 308S, 309E, 310E, 311A, 312K, 313E, 314M, 315A, 316R, 317K, 318Y, 319I, 320T, 321K, 322E, 323Y, 345A, 346H, 347E, 348G, 349V, 350R, 351P, 352T, 353D, 365L, 366D, 367K, 368D, 369Q, 370F, 371K, 372L, 373Y, 374N, 375L, 376I, 377W, 378Q, 379R, 380F, 381L, 382I, 383S, 384Q, 385L
CDD
cd00186 (TOP1Ac)
nucleotide binding...

263Q

nucleotide binding site
263Q, 267S, 268Y, 269L, 346H, 371K, 374N, 378Q, 474R, 476S, 498F
CDD
cd00186 (TOP1Ac)

267S

nucleotide binding site
263Q, 267S, 268Y, 269L, 346H, 371K, 374N, 378Q, 474R, 476S, 498F
CDD
cd00186 (TOP1Ac)

268Y

nucleotide binding site
263Q, 267S, 268Y, 269L, 346H, 371K, 374N, 378Q, 474R, 476S, 498F
CDD
cd00186 (TOP1Ac)

269L

nucleotide binding site
263Q, 267S, 268Y, 269L, 346H, 371K, 374N, 378Q, 474R, 476S, 498F
CDD
cd00186 (TOP1Ac)

346H

nucleotide binding site
263Q, 267S, 268Y, 269L, 346H, 371K, 374N, 378Q, 474R, 476S, 498F
CDD
cd00186 (TOP1Ac)

371K

nucleotide binding site
263Q, 267S, 268Y, 269L, 346H, 371K, 374N, 378Q, 474R, 476S, 498F
CDD
cd00186 (TOP1Ac)

374N

nucleotide binding site
263Q, 267S, 268Y, 269L, 346H, 371K, 374N, 378Q, 474R, 476S, 498F
CDD
cd00186 (TOP1Ac)

378Q

nucleotide binding site
263Q, 267S, 268Y, 269L, 346H, 371K, 374N, 378Q, 474R, 476S, 498F
CDD
cd00186 (TOP1Ac)

474R

nucleotide binding site
263Q, 267S, 268Y, 269L, 346H, 371K, 374N, 378Q, 474R, 476S, 498F
CDD
cd00186 (TOP1Ac)

476S

nucleotide binding site
263Q, 267S, 268Y, 269L, 346H, 371K, 374N, 378Q, 474R, 476S, 498F
CDD
cd00186 (TOP1Ac)

498F

nucleotide binding site
263Q, 267S, 268Y, 269L, 346H, 371K, 374N, 378Q, 474R, 476S, 498F
CDD
cd00186 (TOP1Ac)
catalytic site cd0...

299Y

catalytic site
299Y, 301R, 346H
CDD
cd00186 (TOP1Ac)

301R

catalytic site
299Y, 301R, 346H
CDD
cd00186 (TOP1Ac)

346H

catalytic site
299Y, 301R, 346H
CDD
cd00186 (TOP1Ac)
domain IV cd00186

454P

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

455P

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

456A

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

457R

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

458L

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

459T

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

460E

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

461S

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

462S

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

463L

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

464V

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

465K

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

466T

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

467L

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

468E

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

469S

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

470E

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

471G

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

472I

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

473G

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

474R

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

475P

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

476S

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

477T

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

478Y

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

479A

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

480S

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

481I

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

482I

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

483D

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

484T

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

485L

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

486K

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

487K

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

488R

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

489E

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

490Y

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

491V

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

492E

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

493L

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

494Q

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

498F

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

499V

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

500P

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

501T

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

502E

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

503I

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

504G

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

505Y

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

506E

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

507V

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

508K

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

509T

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

510Q

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

511L

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

512D

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

518I

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

519M

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

520N

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

521I

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

522K

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

523F

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

524T

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

525A

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

526K

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

527L

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

528E

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

529D

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

530E

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

531L

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

532D

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

533E

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

534V

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

535D

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

536S

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

537G

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

538D

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

539K

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

540D

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

541W

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

542I

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

543D

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

544L

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

545L

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

546K

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

547T

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

548F

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

549Y

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

550T

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

551E

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

552L

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

553Q

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

554K

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

555Y

domain IV
454P, 455P, 456A, 457R, 458L, 459T, 460E, 461S, 462S, 463L, 464V, 465K, 466T, 467L, 468E, 469S, 470E, 471G, 472I, 473G, 474R, 475P, 476S, 477T, 478Y, 479A, 480S, 481I, 482I, 483D, 484T, 485L, 486K, 487K, 488R, 489E, 490Y, 491V, 492E, 493L, 494Q, 498F, 499V, 500P, 501T, 502E, 503I, 504G, 505Y, 506E, 507V, 508K, 509T, 510Q, 511L, 512D, 518I, 519M, 520N, 521I, 522K, 523F, 524T, 525A, 526K, 527L, 528E, 529D, 530E, 531L, 532D, 533E, 534V, 535D, 536S, 537G, 538D, 539K, 540D, 541W, 542I, 543D, 544L, 545L, 546K, 547T, 548F, 549Y, 550T, 551E, 552L, 553Q, 554K, 555Y
CDD
cd00186 (TOP1Ac)

GO term prediction

Biological Process

GO:0006265 DNA topological change

Molecular Function

GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003917 DNA topoisomerase type I activity

Cellular Component

GO:0005694 chromosome

Filter view on

Entry type

Status

Per-residue features

2_1_31_FusoPortal_Gene_609

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component