49185_FusoPortal_Gene_1095

Protein

49185_FusoPortal_Gene_1095

Length

319 amino acids

Protein family membership

L-lactate/malate dehydrogenase (IPR001557)
- L-lactate dehydrogenase (IPR011304)

Homologous superfamilies

Homologous superfamily
2 - 146
NAD(P)-binding domain superfamily (IPR036291)
Homologous superfamily
145 - 319
Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal (IPR015955)

1 50 100 150 200 250 319

Domains and repeats

Domain
6 - 144
Lactate/malate dehydrogenase, N-terminal (IPR001236)
147 - 315
Lactate/malate dehydrogenase, C-terminal (IPR022383)

1 50 100 150 200 250 319

Detailed signature matches

IPR036291

NAD(P)-binding domain superfamily
1. SSF51735 (NAD(P)-bi...)
  
  2 - 146
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR015955

Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
1. G3DSA:3.90.11...
  
  145 - 319
  
  GENE3D
  G3DSA:3.90.110.10 (G3DSA:3.90.110.10)
2. SSF56327 (LDH C-ter...)
  
  145 - 311
  
  SUPERFAMILY
  SSF56327 (LDH C-terminal domain-like)
IPR001557

L-lactate/malate dehydrogenase
1. PR00086 (LLDHDRGNASE)
  
  142 - 160
  
  PRINTS
  PR00086 (LLDHDRGNASE)
  
  118 - 138
  
  PRINTS
  PR00086 (LLDHDRGNASE)
  
  31 - 55
  
  PRINTS
  PR00086 (LLDHDRGNASE)
  
  6 - 30
  
  PRINTS
  PR00086 (LLDHDRGNASE)
  
  172 - 185
  
  PRINTS
  PR00086 (LLDHDRGNASE)
2. PIRSF000102 (Lac_ma...)
  
  1 - 319
  
  PIRSF
  PIRSF000102 (Lac_mal_DH)
IPR011304

L-lactate dehydrogenase
1. MF_00488 (Lactate_d...)
  
  4 - 314
  
  HAMAP
  MF_00488 (Lactate_dehydrog)
2. TIGR01771
  
  9 - 307
  
  TIGRFAMs
  TIGR01771 (TIGR01771)
IPR001236

Lactate/malate dehydrogenase, N-terminal
1. PF00056 (Ldh_1_N)
  
  6 - 144
  
  Pfam
  PF00056 (Ldh_1_N)
IPR022383

Lactate/malate dehydrogenase, C-terminal
1. PF02866 (Ldh_1_C)
  
  147 - 315
  
  Pfam
  PF02866 (Ldh_1_C)
IPR018177

L-lactate dehydrogenase, active site
1. PS00064 (L_LDH)
  
  174 - 180
  
  PROSITE patterns
  PS00064 (L_LDH)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

5 - 144

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
PTHR43128 (FAMILY N...)

3 - 310

PANTHER
PTHR43128 (FAMILY NOT NAMED)
PTHR43128:SF4 (SUBF...)

3 - 310

PANTHER
PTHR43128:SF4 (SUBFAMILY NOT NAMED)
cd05291 (HicDH_like)

5 - 311

CDD
cd05291 (HicDH_like)

Residue annotation

tetramer (dimer of...

5R

tetramer (dimer of dimers) interface
5R, 30D, 59R, 163E, 165D, 168S, 187C, 192G, 193K, 248F, 249H, 250D, 251E, 252K, 254V, 280K, 288E, 289L
CDD
cd05291 (HicDH_like)

30D

tetramer (dimer of dimers) interface
5R, 30D, 59R, 163E, 165D, 168S, 187C, 192G, 193K, 248F, 249H, 250D, 251E, 252K, 254V, 280K, 288E, 289L
CDD
cd05291 (HicDH_like)

59R

tetramer (dimer of dimers) interface
5R, 30D, 59R, 163E, 165D, 168S, 187C, 192G, 193K, 248F, 249H, 250D, 251E, 252K, 254V, 280K, 288E, 289L
CDD
cd05291 (HicDH_like)

163E

tetramer (dimer of dimers) interface
5R, 30D, 59R, 163E, 165D, 168S, 187C, 192G, 193K, 248F, 249H, 250D, 251E, 252K, 254V, 280K, 288E, 289L
CDD
cd05291 (HicDH_like)

165D

tetramer (dimer of dimers) interface
5R, 30D, 59R, 163E, 165D, 168S, 187C, 192G, 193K, 248F, 249H, 250D, 251E, 252K, 254V, 280K, 288E, 289L
CDD
cd05291 (HicDH_like)

168S

tetramer (dimer of dimers) interface
5R, 30D, 59R, 163E, 165D, 168S, 187C, 192G, 193K, 248F, 249H, 250D, 251E, 252K, 254V, 280K, 288E, 289L
CDD
cd05291 (HicDH_like)

187C

tetramer (dimer of dimers) interface
5R, 30D, 59R, 163E, 165D, 168S, 187C, 192G, 193K, 248F, 249H, 250D, 251E, 252K, 254V, 280K, 288E, 289L
CDD
cd05291 (HicDH_like)

192G

tetramer (dimer of dimers) interface
5R, 30D, 59R, 163E, 165D, 168S, 187C, 192G, 193K, 248F, 249H, 250D, 251E, 252K, 254V, 280K, 288E, 289L
CDD
cd05291 (HicDH_like)

193K

tetramer (dimer of dimers) interface
5R, 30D, 59R, 163E, 165D, 168S, 187C, 192G, 193K, 248F, 249H, 250D, 251E, 252K, 254V, 280K, 288E, 289L
CDD
cd05291 (HicDH_like)

248F

tetramer (dimer of dimers) interface
5R, 30D, 59R, 163E, 165D, 168S, 187C, 192G, 193K, 248F, 249H, 250D, 251E, 252K, 254V, 280K, 288E, 289L
CDD
cd05291 (HicDH_like)

249H

tetramer (dimer of dimers) interface
5R, 30D, 59R, 163E, 165D, 168S, 187C, 192G, 193K, 248F, 249H, 250D, 251E, 252K, 254V, 280K, 288E, 289L
CDD
cd05291 (HicDH_like)

250D

tetramer (dimer of dimers) interface
5R, 30D, 59R, 163E, 165D, 168S, 187C, 192G, 193K, 248F, 249H, 250D, 251E, 252K, 254V, 280K, 288E, 289L
CDD
cd05291 (HicDH_like)

251E

tetramer (dimer of dimers) interface
5R, 30D, 59R, 163E, 165D, 168S, 187C, 192G, 193K, 248F, 249H, 250D, 251E, 252K, 254V, 280K, 288E, 289L
CDD
cd05291 (HicDH_like)

252K

tetramer (dimer of dimers) interface
5R, 30D, 59R, 163E, 165D, 168S, 187C, 192G, 193K, 248F, 249H, 250D, 251E, 252K, 254V, 280K, 288E, 289L
CDD
cd05291 (HicDH_like)

254V

tetramer (dimer of dimers) interface
5R, 30D, 59R, 163E, 165D, 168S, 187C, 192G, 193K, 248F, 249H, 250D, 251E, 252K, 254V, 280K, 288E, 289L
CDD
cd05291 (HicDH_like)

280K

tetramer (dimer of dimers) interface
5R, 30D, 59R, 163E, 165D, 168S, 187C, 192G, 193K, 248F, 249H, 250D, 251E, 252K, 254V, 280K, 288E, 289L
CDD
cd05291 (HicDH_like)

288E

tetramer (dimer of dimers) interface
5R, 30D, 59R, 163E, 165D, 168S, 187C, 192G, 193K, 248F, 249H, 250D, 251E, 252K, 254V, 280K, 288E, 289L
CDD
cd05291 (HicDH_like)

289L

tetramer (dimer of dimers) interface
5R, 30D, 59R, 163E, 165D, 168S, 187C, 192G, 193K, 248F, 249H, 250D, 251E, 252K, 254V, 280K, 288E, 289L
CDD
cd05291 (HicDH_like)
NAD binding site c...

13G

NAD binding site
13G, 14H, 15V, 36D, 37V, 79C, 80V, 81G, 82T, 120I, 121T, 122N, 145T, 177H
CDD
cd05291 (HicDH_like)

14H

NAD binding site
13G, 14H, 15V, 36D, 37V, 79C, 80V, 81G, 82T, 120I, 121T, 122N, 145T, 177H
CDD
cd05291 (HicDH_like)

15V

NAD binding site
13G, 14H, 15V, 36D, 37V, 79C, 80V, 81G, 82T, 120I, 121T, 122N, 145T, 177H
CDD
cd05291 (HicDH_like)

36D

NAD binding site
13G, 14H, 15V, 36D, 37V, 79C, 80V, 81G, 82T, 120I, 121T, 122N, 145T, 177H
CDD
cd05291 (HicDH_like)

37V

NAD binding site
13G, 14H, 15V, 36D, 37V, 79C, 80V, 81G, 82T, 120I, 121T, 122N, 145T, 177H
CDD
cd05291 (HicDH_like)

79C

NAD binding site
13G, 14H, 15V, 36D, 37V, 79C, 80V, 81G, 82T, 120I, 121T, 122N, 145T, 177H
CDD
cd05291 (HicDH_like)

80V

NAD binding site
13G, 14H, 15V, 36D, 37V, 79C, 80V, 81G, 82T, 120I, 121T, 122N, 145T, 177H
CDD
cd05291 (HicDH_like)

81G

NAD binding site
13G, 14H, 15V, 36D, 37V, 79C, 80V, 81G, 82T, 120I, 121T, 122N, 145T, 177H
CDD
cd05291 (HicDH_like)

82T

NAD binding site
13G, 14H, 15V, 36D, 37V, 79C, 80V, 81G, 82T, 120I, 121T, 122N, 145T, 177H
CDD
cd05291 (HicDH_like)

120I

NAD binding site
13G, 14H, 15V, 36D, 37V, 79C, 80V, 81G, 82T, 120I, 121T, 122N, 145T, 177H
CDD
cd05291 (HicDH_like)

121T

NAD binding site
13G, 14H, 15V, 36D, 37V, 79C, 80V, 81G, 82T, 120I, 121T, 122N, 145T, 177H
CDD
cd05291 (HicDH_like)

122N

NAD binding site
13G, 14H, 15V, 36D, 37V, 79C, 80V, 81G, 82T, 120I, 121T, 122N, 145T, 177H
CDD
cd05291 (HicDH_like)

145T

NAD binding site
13G, 14H, 15V, 36D, 37V, 79C, 80V, 81G, 82T, 120I, 121T, 122N, 145T, 177H
CDD
cd05291 (HicDH_like)

177H

NAD binding site
13G, 14H, 15V, 36D, 37V, 79C, 80V, 81G, 82T, 120I, 121T, 122N, 145T, 177H
CDD
cd05291 (HicDH_like)
dimer interface cd...

17S

dimer interface
17S, 18H, 21F, 25L, 26Q, 45Q, 47F, 48D, 49C, 50M, 51D, 54A, 55F, 152A, 153R, 155R, 167R, 228G, 229K, 233E, 234F, 235G, 238C, 242E
CDD
cd05291 (HicDH_like)

18H

dimer interface
17S, 18H, 21F, 25L, 26Q, 45Q, 47F, 48D, 49C, 50M, 51D, 54A, 55F, 152A, 153R, 155R, 167R, 228G, 229K, 233E, 234F, 235G, 238C, 242E
CDD
cd05291 (HicDH_like)

21F

dimer interface
17S, 18H, 21F, 25L, 26Q, 45Q, 47F, 48D, 49C, 50M, 51D, 54A, 55F, 152A, 153R, 155R, 167R, 228G, 229K, 233E, 234F, 235G, 238C, 242E
CDD
cd05291 (HicDH_like)

25L

dimer interface
17S, 18H, 21F, 25L, 26Q, 45Q, 47F, 48D, 49C, 50M, 51D, 54A, 55F, 152A, 153R, 155R, 167R, 228G, 229K, 233E, 234F, 235G, 238C, 242E
CDD
cd05291 (HicDH_like)

26Q

dimer interface
17S, 18H, 21F, 25L, 26Q, 45Q, 47F, 48D, 49C, 50M, 51D, 54A, 55F, 152A, 153R, 155R, 167R, 228G, 229K, 233E, 234F, 235G, 238C, 242E
CDD
cd05291 (HicDH_like)

45Q

dimer interface
17S, 18H, 21F, 25L, 26Q, 45Q, 47F, 48D, 49C, 50M, 51D, 54A, 55F, 152A, 153R, 155R, 167R, 228G, 229K, 233E, 234F, 235G, 238C, 242E
CDD
cd05291 (HicDH_like)

47F

dimer interface
17S, 18H, 21F, 25L, 26Q, 45Q, 47F, 48D, 49C, 50M, 51D, 54A, 55F, 152A, 153R, 155R, 167R, 228G, 229K, 233E, 234F, 235G, 238C, 242E
CDD
cd05291 (HicDH_like)

48D

dimer interface
17S, 18H, 21F, 25L, 26Q, 45Q, 47F, 48D, 49C, 50M, 51D, 54A, 55F, 152A, 153R, 155R, 167R, 228G, 229K, 233E, 234F, 235G, 238C, 242E
CDD
cd05291 (HicDH_like)

49C

dimer interface
17S, 18H, 21F, 25L, 26Q, 45Q, 47F, 48D, 49C, 50M, 51D, 54A, 55F, 152A, 153R, 155R, 167R, 228G, 229K, 233E, 234F, 235G, 238C, 242E
CDD
cd05291 (HicDH_like)

50M

dimer interface
17S, 18H, 21F, 25L, 26Q, 45Q, 47F, 48D, 49C, 50M, 51D, 54A, 55F, 152A, 153R, 155R, 167R, 228G, 229K, 233E, 234F, 235G, 238C, 242E
CDD
cd05291 (HicDH_like)

51D

dimer interface
17S, 18H, 21F, 25L, 26Q, 45Q, 47F, 48D, 49C, 50M, 51D, 54A, 55F, 152A, 153R, 155R, 167R, 228G, 229K, 233E, 234F, 235G, 238C, 242E
CDD
cd05291 (HicDH_like)

54A

dimer interface
17S, 18H, 21F, 25L, 26Q, 45Q, 47F, 48D, 49C, 50M, 51D, 54A, 55F, 152A, 153R, 155R, 167R, 228G, 229K, 233E, 234F, 235G, 238C, 242E
CDD
cd05291 (HicDH_like)

55F

dimer interface
17S, 18H, 21F, 25L, 26Q, 45Q, 47F, 48D, 49C, 50M, 51D, 54A, 55F, 152A, 153R, 155R, 167R, 228G, 229K, 233E, 234F, 235G, 238C, 242E
CDD
cd05291 (HicDH_like)

152A

dimer interface
17S, 18H, 21F, 25L, 26Q, 45Q, 47F, 48D, 49C, 50M, 51D, 54A, 55F, 152A, 153R, 155R, 167R, 228G, 229K, 233E, 234F, 235G, 238C, 242E
CDD
cd05291 (HicDH_like)

153R

dimer interface
17S, 18H, 21F, 25L, 26Q, 45Q, 47F, 48D, 49C, 50M, 51D, 54A, 55F, 152A, 153R, 155R, 167R, 228G, 229K, 233E, 234F, 235G, 238C, 242E
CDD
cd05291 (HicDH_like)

155R

dimer interface
17S, 18H, 21F, 25L, 26Q, 45Q, 47F, 48D, 49C, 50M, 51D, 54A, 55F, 152A, 153R, 155R, 167R, 228G, 229K, 233E, 234F, 235G, 238C, 242E
CDD
cd05291 (HicDH_like)

167R

dimer interface
17S, 18H, 21F, 25L, 26Q, 45Q, 47F, 48D, 49C, 50M, 51D, 54A, 55F, 152A, 153R, 155R, 167R, 228G, 229K, 233E, 234F, 235G, 238C, 242E
CDD
cd05291 (HicDH_like)

228G

dimer interface
17S, 18H, 21F, 25L, 26Q, 45Q, 47F, 48D, 49C, 50M, 51D, 54A, 55F, 152A, 153R, 155R, 167R, 228G, 229K, 233E, 234F, 235G, 238C, 242E
CDD
cd05291 (HicDH_like)

229K

dimer interface
17S, 18H, 21F, 25L, 26Q, 45Q, 47F, 48D, 49C, 50M, 51D, 54A, 55F, 152A, 153R, 155R, 167R, 228G, 229K, 233E, 234F, 235G, 238C, 242E
CDD
cd05291 (HicDH_like)

233E

dimer interface
17S, 18H, 21F, 25L, 26Q, 45Q, 47F, 48D, 49C, 50M, 51D, 54A, 55F, 152A, 153R, 155R, 167R, 228G, 229K, 233E, 234F, 235G, 238C, 242E
CDD
cd05291 (HicDH_like)

234F

dimer interface
17S, 18H, 21F, 25L, 26Q, 45Q, 47F, 48D, 49C, 50M, 51D, 54A, 55F, 152A, 153R, 155R, 167R, 228G, 229K, 233E, 234F, 235G, 238C, 242E
CDD
cd05291 (HicDH_like)

235G

dimer interface
17S, 18H, 21F, 25L, 26Q, 45Q, 47F, 48D, 49C, 50M, 51D, 54A, 55F, 152A, 153R, 155R, 167R, 228G, 229K, 233E, 234F, 235G, 238C, 242E
CDD
cd05291 (HicDH_like)

238C

dimer interface
17S, 18H, 21F, 25L, 26Q, 45Q, 47F, 48D, 49C, 50M, 51D, 54A, 55F, 152A, 153R, 155R, 167R, 228G, 229K, 233E, 234F, 235G, 238C, 242E
CDD
cd05291 (HicDH_like)

242E

dimer interface
17S, 18H, 21F, 25L, 26Q, 45Q, 47F, 48D, 49C, 50M, 51D, 54A, 55F, 152A, 153R, 155R, 167R, 228G, 229K, 233E, 234F, 235G, 238C, 242E
CDD
cd05291 (HicDH_like)
substrate binding ...

90R

substrate binding site
90R, 122N, 153R, 177H, 222G, 232T
CDD
cd05291 (HicDH_like)

122N

substrate binding site
90R, 122N, 153R, 177H, 222G, 232T
CDD
cd05291 (HicDH_like)

153R

substrate binding site
90R, 122N, 153R, 177H, 222G, 232T
CDD
cd05291 (HicDH_like)

177H

substrate binding site
90R, 122N, 153R, 177H, 222G, 232T
CDD
cd05291 (HicDH_like)

222G

substrate binding site
90R, 122N, 153R, 177H, 222G, 232T
CDD
cd05291 (HicDH_like)

232T

substrate binding site
90R, 122N, 153R, 177H, 222G, 232T
CDD
cd05291 (HicDH_like)

GO term prediction

Biological Process

GO:0005975 carbohydrate metabolic process
GO:0019752 carboxylic acid metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0003824 catalytic activity
GO:0004459 L-lactate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Cellular Component

GO:0005737 cytoplasm

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Entry type

Status

Per-residue features

49185_FusoPortal_Gene_1095

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component