49185_FusoPortal_Gene_1215

Protein

49185_FusoPortal_Gene_1215

Length

834 amino acids

Protein family membership

DNA gyrase, subunit A (IPR005743)

Homologous superfamilies

Homologous superfamily
26 - 482
DNA topoisomerase, type IIA-like domain superfamily (IPR013760)
Homologous superfamily
30 - 211
DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta (IPR013758)
232 - 327
Arginine repressor-like, C-terminal (IPR024946)
340 - 482
Type IIA DNA topoisomerase subunit A, alpha-helical domain superfamily (IPR013757)
494 - 821
DNA gyrase/topoisomerase IV, subunit A, C-terminal (IPR035516)

1 100 200 300 400 500 600 700 834

Domains and repeats

Domain
28 - 467
DNA topoisomerase, type IIA, subunit A/C-terminal (IPR002205)
Repeat
501 - 544
DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat (IPR006691)
549 - 597
DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat (IPR006691)
606 - 647
DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat (IPR006691)
656 - 701
DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat (IPR006691)
707 - 753
DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat (IPR006691)
757 - 803
DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat (IPR006691)

1 100 200 300 400 500 600 700 834

Detailed signature matches

IPR013760

DNA topoisomerase, type IIA-like domain superfamily
1. SSF56719 (Type II D...)
  
  26 - 482
  
  SUPERFAMILY
  SSF56719 (Type II DNA topoisomerase)
IPR013758

DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta
1. G3DSA:3.90.19...
  
  30 - 211
  
  GENE3D
  G3DSA:3.90.199.10 (G3DSA:3.90.199.10)
IPR024946

Arginine repressor-like, C-terminal
1. G3DSA:3.30.13...
  
  232 - 327
  
  GENE3D
  G3DSA:3.30.1360.40 (G3DSA:3.30.1360.40)
IPR013757

Type IIA DNA topoisomerase subunit A, alpha-helical domain superfamily
1. G3DSA:1.10.26...
  
  340 - 482
  
  GENE3D
  G3DSA:1.10.268.10 (G3DSA:1.10.268.10)
IPR035516

DNA gyrase/topoisomerase IV, subunit A, C-terminal
1. SSF101904 (GyrA/Par...)
  
  494 - 818
  
  SUPERFAMILY
  SSF101904 (GyrA/ParC C-terminal domain-like)
2. G3DSA:2.120.1...
  
  494 - 821
  
  GENE3D
  G3DSA:2.120.10.90 (G3DSA:2.120.10.90)
IPR005743

DNA gyrase, subunit A
1. MF_01897 (GyrA)
  
  1 - 805
  
  HAMAP
  MF_01897 (GyrA)
IPR002205

DNA topoisomerase, type IIA, subunit A/C-terminal
1. PF00521 (DNA_topoisoIV)
  
  28 - 467
  
  Pfam
  PF00521 (DNA_topoisoIV)
IPR006691

DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat
1. PF03989 (DNA_gyraseA_C)
  
  549 - 597
  
  Pfam
  PF03989 (DNA_gyraseA_C)
  
  501 - 544
  
  Pfam
  PF03989 (DNA_gyraseA_C)
  
  757 - 803
  
  Pfam
  PF03989 (DNA_gyraseA_C)
  
  606 - 647
  
  Pfam
  PF03989 (DNA_gyraseA_C)
  
  656 - 701
  
  Pfam
  PF03989 (DNA_gyraseA_C)
  
  707 - 753
  
  Pfam
  PF03989 (DNA_gyraseA_C)

no IPR

Unintegrated signatures

Coil

800 - 824

COILS
Coil (Coil)
PTHR43493 (FAMILY N...)

2 - 814

PANTHER
PTHR43493 (FAMILY NOT NAMED)
PTHR43493:SF5 (DNA ...)

2 - 814

PANTHER
PTHR43493:SF5 (DNA GYRASE SUBUNIT A)
TIGR01063

6 - 804

TIGRFAMs
TIGR01063 (TIGR01063)
cd00187 (TOP4c)

26 - 467

CDD
cd00187 (TOP4c)

Residue annotation

CAP-like domain cd...

26V

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

27S

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

28R

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

29A

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

30L

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

31P

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

32D

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

33V

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

34R

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

35D

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

36G

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

37M

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

38K

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

39P

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

40V

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

41H

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

42R

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

43R

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

44I

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

45L

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

46F

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

47A

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

48M

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

49S

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

50E

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

51L

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

52G

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

53M

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

58A

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

59Y

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

60K

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

61K

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

62S

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

63A

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

64R

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

65I

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

66V

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

67G

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

68E

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

69V

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

70L

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

71G

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

72K

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

73Y

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

74H

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

75P

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

76H

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

77G

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

78D

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

79S

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

80A

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

81V

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

82Y

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

83G

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

84T

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

85M

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

86V

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

87R

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

88M

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

89A

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

90Q

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

91D

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

92F

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

93N

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

94Y

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

95R

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

96Y

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

97L

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

98L

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

99V

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

100D

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

101G

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

102H

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

103G

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

104N

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

105F

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

106G

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

107S

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

109D

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

110G

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

111D

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

112S

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

113A

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

114A

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

115A

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

116M

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

117R

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

118Y

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

119T

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

120E

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

121A

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

122R

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

123M

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

124A

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

125K

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

126I

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

127S

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

129E

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

130L

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

131I

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

132D

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

133D

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

134I

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

135D

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

136K

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

137N

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

138T

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

139I

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

140D

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

141F

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

142R

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

143K

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

144N

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

145F

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

146D

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

147D

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

148S

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

149L

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

150D

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

151E

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

152P

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

155L

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37M, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49S, 50E, 51L, 52G, 53M, 58A, 59Y, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79S, 80A, 81V, 82Y, 83G, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91D, 92F, 93N, 94Y, 95R, 96Y, 97L, 98L, 99V, 100D, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124A, 125K, 126I, 127S, 129E, 130L, 131I, 132D, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)
Active site cd00187

118Y

Active site
118Y
CDD
cd00187 (TOP4c)
primary dimer inte...

383D

primary dimer interface
383D, 384N, 385I, 388I, 389I, 390E, 391I, 402R, 403E, 417R, 418A, 419I, 420L, 421D, 422M, 423K, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433G
CDD
cd00187 (TOP4c)

384N

primary dimer interface
383D, 384N, 385I, 388I, 389I, 390E, 391I, 402R, 403E, 417R, 418A, 419I, 420L, 421D, 422M, 423K, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433G
CDD
cd00187 (TOP4c)

385I

primary dimer interface
383D, 384N, 385I, 388I, 389I, 390E, 391I, 402R, 403E, 417R, 418A, 419I, 420L, 421D, 422M, 423K, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433G
CDD
cd00187 (TOP4c)

388I

primary dimer interface
383D, 384N, 385I, 388I, 389I, 390E, 391I, 402R, 403E, 417R, 418A, 419I, 420L, 421D, 422M, 423K, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433G
CDD
cd00187 (TOP4c)

389I

primary dimer interface
383D, 384N, 385I, 388I, 389I, 390E, 391I, 402R, 403E, 417R, 418A, 419I, 420L, 421D, 422M, 423K, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433G
CDD
cd00187 (TOP4c)

390E

primary dimer interface
383D, 384N, 385I, 388I, 389I, 390E, 391I, 402R, 403E, 417R, 418A, 419I, 420L, 421D, 422M, 423K, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433G
CDD
cd00187 (TOP4c)

391I

primary dimer interface
383D, 384N, 385I, 388I, 389I, 390E, 391I, 402R, 403E, 417R, 418A, 419I, 420L, 421D, 422M, 423K, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433G
CDD
cd00187 (TOP4c)

402R

primary dimer interface
383D, 384N, 385I, 388I, 389I, 390E, 391I, 402R, 403E, 417R, 418A, 419I, 420L, 421D, 422M, 423K, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433G
CDD
cd00187 (TOP4c)

403E

primary dimer interface
383D, 384N, 385I, 388I, 389I, 390E, 391I, 402R, 403E, 417R, 418A, 419I, 420L, 421D, 422M, 423K, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433G
CDD
cd00187 (TOP4c)

417R

primary dimer interface
383D, 384N, 385I, 388I, 389I, 390E, 391I, 402R, 403E, 417R, 418A, 419I, 420L, 421D, 422M, 423K, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433G
CDD
cd00187 (TOP4c)

418A

primary dimer interface
383D, 384N, 385I, 388I, 389I, 390E, 391I, 402R, 403E, 417R, 418A, 419I, 420L, 421D, 422M, 423K, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433G
CDD
cd00187 (TOP4c)

419I

primary dimer interface
383D, 384N, 385I, 388I, 389I, 390E, 391I, 402R, 403E, 417R, 418A, 419I, 420L, 421D, 422M, 423K, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433G
CDD
cd00187 (TOP4c)

420L

primary dimer interface
383D, 384N, 385I, 388I, 389I, 390E, 391I, 402R, 403E, 417R, 418A, 419I, 420L, 421D, 422M, 423K, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433G
CDD
cd00187 (TOP4c)

421D

primary dimer interface
383D, 384N, 385I, 388I, 389I, 390E, 391I, 402R, 403E, 417R, 418A, 419I, 420L, 421D, 422M, 423K, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433G
CDD
cd00187 (TOP4c)

422M

primary dimer interface
383D, 384N, 385I, 388I, 389I, 390E, 391I, 402R, 403E, 417R, 418A, 419I, 420L, 421D, 422M, 423K, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433G
CDD
cd00187 (TOP4c)

423K

primary dimer interface
383D, 384N, 385I, 388I, 389I, 390E, 391I, 402R, 403E, 417R, 418A, 419I, 420L, 421D, 422M, 423K, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433G
CDD
cd00187 (TOP4c)

424L

primary dimer interface
383D, 384N, 385I, 388I, 389I, 390E, 391I, 402R, 403E, 417R, 418A, 419I, 420L, 421D, 422M, 423K, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433G
CDD
cd00187 (TOP4c)

425Q

primary dimer interface
383D, 384N, 385I, 388I, 389I, 390E, 391I, 402R, 403E, 417R, 418A, 419I, 420L, 421D, 422M, 423K, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433G
CDD
cd00187 (TOP4c)

426R

primary dimer interface
383D, 384N, 385I, 388I, 389I, 390E, 391I, 402R, 403E, 417R, 418A, 419I, 420L, 421D, 422M, 423K, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433G
CDD
cd00187 (TOP4c)

427L

primary dimer interface
383D, 384N, 385I, 388I, 389I, 390E, 391I, 402R, 403E, 417R, 418A, 419I, 420L, 421D, 422M, 423K, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433G
CDD
cd00187 (TOP4c)

428T

primary dimer interface
383D, 384N, 385I, 388I, 389I, 390E, 391I, 402R, 403E, 417R, 418A, 419I, 420L, 421D, 422M, 423K, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433G
CDD
cd00187 (TOP4c)

429G

primary dimer interface
383D, 384N, 385I, 388I, 389I, 390E, 391I, 402R, 403E, 417R, 418A, 419I, 420L, 421D, 422M, 423K, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433G
CDD
cd00187 (TOP4c)

430L

primary dimer interface
383D, 384N, 385I, 388I, 389I, 390E, 391I, 402R, 403E, 417R, 418A, 419I, 420L, 421D, 422M, 423K, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433G
CDD
cd00187 (TOP4c)

431E

primary dimer interface
383D, 384N, 385I, 388I, 389I, 390E, 391I, 402R, 403E, 417R, 418A, 419I, 420L, 421D, 422M, 423K, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433G
CDD
cd00187 (TOP4c)

432R

primary dimer interface
383D, 384N, 385I, 388I, 389I, 390E, 391I, 402R, 403E, 417R, 418A, 419I, 420L, 421D, 422M, 423K, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433G
CDD
cd00187 (TOP4c)

433G

primary dimer interface
383D, 384N, 385I, 388I, 389I, 390E, 391I, 402R, 403E, 417R, 418A, 419I, 420L, 421D, 422M, 423K, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433G
CDD
cd00187 (TOP4c)

GO term prediction

Biological Process

GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

Molecular Function

GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005524 ATP binding

Cellular Component

GO:0005694 chromosome

Filter view on

Entry type

Status

Per-residue features

49185_FusoPortal_Gene_1215

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component