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Protein

49185_FusoPortal_Gene_1263

Length

457 amino acids

Protein family membership

Alkaline phosphatase (IPR001952)

Homologous superfamilies

Homologous superfamily
7 - 456
Alkaline phosphatase-like, alpha/beta/alpha (IPR017849)
Homologous superfamily
11 - 354
Alkaline-phosphatase-like, core domain superfamily (IPR017850)
396 - 453
Alkaline-phosphatase-like, core domain superfamily (IPR017850)

1 50 100 150 200 250 300 350 400 457

Domains and repeats

None predicted.

Detailed signature matches

IPR017849

Alkaline phosphatase-like, alpha/beta/alpha

G3DSA:3.40.72...

7 - 456

GENE3D
G3DSA:3.40.720.10 (G3DSA:3.40.720.10)

IPR017850

Alkaline-phosphatase-like, core domain superfamily

SSF53649 (Alkaline ...)

11 - 354

SUPERFAMILY
SSF53649 (Alkaline phosphatase-like)

396 - 453

SUPERFAMILY
SSF53649 (Alkaline phosphatase-like)

IPR001952

Alkaline phosphatase

PF00245 (Alk_phosph...)

22 - 449

Pfam
PF00245 (Alk_phosphatase)
cd16012 (ALP)

23 - 453

CDD
cd16012 (ALP)
PTHR11596 (ALKALINE...)

21 - 453

PANTHER
PTHR11596 (ALKALINE PHOSPHATASE)
PR00113 (ALKPHPHTASE)

22 - 42

PRINTS
PR00113 (ALKPHPHTASE)

75 - 90

PRINTS
PR00113 (ALKPHPHTASE)

156 - 166

PRINTS
PR00113 (ALKPHPHTASE)

112 - 132

PRINTS
PR00113 (ALKPHPHTASE)

238 - 267

PRINTS
PR00113 (ALKPHPHTASE)

IPR018299

Alkaline phosphatase, active site

PS00123 (ALKALINE_P...)

75 - 83

PROSITE patterns
PS00123 (ALKALINE_PHOSPHATASE)

no IPR

Unintegrated signatures

PTHR11596:SF5 (REPR...)

21 - 453

PANTHER
PTHR11596:SF5 (REPRESSIBLE ALKALINE PHOSPHATASE)

Residue annotation

active site cd16012

31D

active site
31D, 77D, 78S, 131T, 142R, 262E, 267D, 271H, 310D, 311H, 418H
CDD
cd16012 (ALP)

77D

active site
31D, 77D, 78S, 131T, 142R, 262E, 267D, 271H, 310D, 311H, 418H
CDD
cd16012 (ALP)

78S

active site
31D, 77D, 78S, 131T, 142R, 262E, 267D, 271H, 310D, 311H, 418H
CDD
cd16012 (ALP)

131T

active site
31D, 77D, 78S, 131T, 142R, 262E, 267D, 271H, 310D, 311H, 418H
CDD
cd16012 (ALP)

142R

active site
31D, 77D, 78S, 131T, 142R, 262E, 267D, 271H, 310D, 311H, 418H
CDD
cd16012 (ALP)

262E

active site
31D, 77D, 78S, 131T, 142R, 262E, 267D, 271H, 310D, 311H, 418H
CDD
cd16012 (ALP)

267D

active site
31D, 77D, 78S, 131T, 142R, 262E, 267D, 271H, 310D, 311H, 418H
CDD
cd16012 (ALP)

271H

active site
31D, 77D, 78S, 131T, 142R, 262E, 267D, 271H, 310D, 311H, 418H
CDD
cd16012 (ALP)

310D

active site
31D, 77D, 78S, 131T, 142R, 262E, 267D, 271H, 310D, 311H, 418H
CDD
cd16012 (ALP)

311H

active site
31D, 77D, 78S, 131T, 142R, 262E, 267D, 271H, 310D, 311H, 418H
CDD
cd16012 (ALP)

418H

active site
31D, 77D, 78S, 131T, 142R, 262E, 267D, 271H, 310D, 311H, 418H
CDD
cd16012 (ALP)
metal binding site...

31D

metal binding site
31D, 78S, 131T, 262E, 267D, 271H, 310D, 311H, 418H
CDD
cd16012 (ALP)

78S

metal binding site
31D, 78S, 131T, 262E, 267D, 271H, 310D, 311H, 418H
CDD
cd16012 (ALP)

131T

metal binding site
31D, 78S, 131T, 262E, 267D, 271H, 310D, 311H, 418H
CDD
cd16012 (ALP)

262E

metal binding site
31D, 78S, 131T, 262E, 267D, 271H, 310D, 311H, 418H
CDD
cd16012 (ALP)

267D

metal binding site
31D, 78S, 131T, 262E, 267D, 271H, 310D, 311H, 418H
CDD
cd16012 (ALP)

271H

metal binding site
31D, 78S, 131T, 262E, 267D, 271H, 310D, 311H, 418H
CDD
cd16012 (ALP)

310D

metal binding site
31D, 78S, 131T, 262E, 267D, 271H, 310D, 311H, 418H
CDD
cd16012 (ALP)

311H

metal binding site
31D, 78S, 131T, 262E, 267D, 271H, 310D, 311H, 418H
CDD
cd16012 (ALP)

418H

metal binding site
31D, 78S, 131T, 262E, 267D, 271H, 310D, 311H, 418H
CDD
cd16012 (ALP)
substrate binding ...

31D

substrate binding site
31D, 77D, 78S, 142R, 267D, 271H, 311H, 418H
CDD
cd16012 (ALP)

77D

substrate binding site
31D, 77D, 78S, 142R, 267D, 271H, 311H, 418H
CDD
cd16012 (ALP)

78S

substrate binding site
31D, 77D, 78S, 142R, 267D, 271H, 311H, 418H
CDD
cd16012 (ALP)

142R

substrate binding site
31D, 77D, 78S, 142R, 267D, 271H, 311H, 418H
CDD
cd16012 (ALP)

267D

substrate binding site
31D, 77D, 78S, 142R, 267D, 271H, 311H, 418H
CDD
cd16012 (ALP)

271H

substrate binding site
31D, 77D, 78S, 142R, 267D, 271H, 311H, 418H
CDD
cd16012 (ALP)

311H

substrate binding site
31D, 77D, 78S, 142R, 267D, 271H, 311H, 418H
CDD
cd16012 (ALP)

418H

substrate binding site
31D, 77D, 78S, 142R, 267D, 271H, 311H, 418H
CDD
cd16012 (ALP)
homodimer interfac...

35A

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

36A

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

39Q

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

42E

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

43E

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

63S

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

64A

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

65I

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

67T

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

69Y

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

71A

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

75I

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

88G

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

89H

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

90K

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

105L

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

314G

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

419T

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

420A

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

421V

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

422Q

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

424P

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

434K

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

436I

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

437G

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

438F

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

439K

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

440D

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

442T

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

443E

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

446K

homodimer interface
35A, 36A, 39Q, 42E, 43E, 63S, 64A, 65I, 67T, 69Y, 71A, 75I, 88G, 89H, 90K, 105L, 314G, 419T, 420A, 421V, 422Q, 424P, 434K, 436I, 437G, 438F, 439K, 440D, 442T, 443E, 446K
CDD
cd16012 (ALP)

GO term prediction

Biological Process

GO:0008152 metabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0016791 phosphatase activity

Cellular Component