49185_FusoPortal_Gene_1492

Protein

49185_FusoPortal_Gene_1492

Length

420 amino acids

Protein family membership

Hydroxymethylglutaryl-CoA reductase, class I/II (IPR002202)
- Hydroxymethylglutaryl-CoA reductase, bacterial-type (IPR004553)

Homologous superfamilies

Homologous superfamily
3 - 132
Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily (IPR023074)
133 - 367
Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily (IPR023074)
Homologous superfamily
5 - 118
Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily (IPR009029)
221 - 418
Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily (IPR009029)
Homologous superfamily
110 - 216
Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily (IPR009023)

1 50 100 150 200 250 300 350 420

Domains and repeats

None predicted.

Detailed signature matches

IPR023074

Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily
1. G3DSA:3.90.77...
  
  133 - 367
  
  GENE3D
  G3DSA:3.90.770.10 (G3DSA:3.90.770.10)
  
  3 - 132
  
  GENE3D
  G3DSA:3.90.770.10 (G3DSA:3.90.770.10)
IPR009029

Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily
1. SSF56542 (Substrate...)
  
  221 - 418
  
  SUPERFAMILY
  SSF56542 (Substrate-binding domain of HMG-CoA reductase)
  
  5 - 118
  
  SUPERFAMILY
  SSF56542 (Substrate-binding domain of HMG-CoA reductase)
IPR009023

Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily
1. SSF55035 (NAD-bindi...)
  
  110 - 216
  
  SUPERFAMILY
  SSF55035 (NAD-binding domain of HMG-CoA reductase)
IPR002202

Hydroxymethylglutaryl-CoA reductase, class I/II
1. PF00368 (HMG-CoA_red)
  
  15 - 378
  
  Pfam
  PF00368 (HMG-CoA_red)
2. PS50065 (HMG_COA_RE...)
  
  51 - 377
  
  PROSITE profiles
  PS50065 (HMG_COA_REDUCTASE_4)
3. PR00071 (HMGCOARDTASE)
  
  76 - 96
  
  PRINTS
  PR00071 (HMGCOARDTASE)
  
  305 - 326
  
  PRINTS
  PR00071 (HMGCOARDTASE)
  
  49 - 70
  
  PRINTS
  PR00071 (HMGCOARDTASE)
  
  172 - 190
  
  PRINTS
  PR00071 (HMGCOARDTASE)
4. PTHR10572 (3-HYDROX...)
  
  2 - 417
  
  PANTHER
  PTHR10572 (3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE)
IPR004553

Hydroxymethylglutaryl-CoA reductase, bacterial-type
1. cd00644 (HMG-CoA_re...)
  
  7 - 416
  
  CDD
  cd00644 (HMG-CoA_reductase_classII)
2. PTHR10572:SF13 (SUB...)
  
  2 - 417
  
  PANTHER
  PTHR10572:SF13 (SUBFAMILY NOT NAMED)
3. TIGR00532
  
  1 - 378
  
  TIGRFAMs
  TIGR00532 (TIGR00532)
IPR023076

Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
1. PS00318 (HMG_COA_RE...)
  
  317 - 324
  
  PROSITE patterns
  PS00318 (HMG_COA_REDUCTASE_2)
2. PS01192 (HMG_COA_RE...)
  
  363 - 376
  
  PROSITE patterns
  PS01192 (HMG_COA_REDUCTASE_3)

Residue annotation

homodimer interfac...

9F

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

14P

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

17R

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

18L

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

35L

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

43M

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

46A

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

47D

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

49M

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

50I

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

51E

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

52N

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

53V

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

54I

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

55G

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

56R

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

57F

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

58A

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

59L

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

60P

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

61L

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

62G

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

63V

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

79V

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

80S

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

81E

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

82E

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

83P

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

84S

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

85V

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

86V

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

87A

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

112I

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

114Q

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

116Q

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

163I

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

172I

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

174H

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

208F

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

209L

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

210R

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

211I

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

212L

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

213S

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

214N

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

238D

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

241I

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

242T

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

243A

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

245A

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

246F

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

249A

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

250D

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

252F

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

253R

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

255V

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

256T

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

259K

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

262M

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

263N

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

266I

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

270L

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

271A

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

275D

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

276T

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

277R

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

278A

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

280E

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

281S

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

284H

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

288S

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

291G

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

293Y

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

323A

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

327H

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

329T

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

330A

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

364L

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

367E

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

368G

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

369I

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

370Q

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

374M

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

376L

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

377H

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

379R

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

380N

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

383T

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

384V

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)

408E

homodimer interface
9F, 14P, 17R, 18L, 35L, 43M, 46A, 47D, 49M, 50I, 51E, 52N, 53V, 54I, 55G, 56R, 57F, 58A, 59L, 60P, 61L, 62G, 63V, 79V, 80S, 81E, 82E, 83P, 84S, 85V, 86V, 87A, 112I, 114Q, 116Q, 163I, 172I, 174H, 208F, 209L, 210R, 211I, 212L, 213S, 214N, 238D, 241I, 242T, 243A, 245A, 246F, 249A, 250D, 252F, 253R, 255V, 256T, 259K, 262M, 263N, 266I, 270L, 271A, 275D, 276T, 277R, 278A, 280E, 281S, 284H, 288S, 291G, 293Y, 323A, 327H, 329T, 330A, 364L, 367E, 368G, 369I, 370Q, 374M, 376L, 377H, 379R, 380N, 383T, 384V, 408E
CDD
cd00644 (HMG-CoA_reductase_classII)
substrate binding ...

82E

substrate binding pocket
82E, 253R, 256T, 257H, 259K, 260G, 263N, 360A, 364L, 369I
CDD
cd00644 (HMG-CoA_reductase_classII)

253R

substrate binding pocket
82E, 253R, 256T, 257H, 259K, 260G, 263N, 360A, 364L, 369I
CDD
cd00644 (HMG-CoA_reductase_classII)

256T

substrate binding pocket
82E, 253R, 256T, 257H, 259K, 260G, 263N, 360A, 364L, 369I
CDD
cd00644 (HMG-CoA_reductase_classII)

257H

substrate binding pocket
82E, 253R, 256T, 257H, 259K, 260G, 263N, 360A, 364L, 369I
CDD
cd00644 (HMG-CoA_reductase_classII)

259K

substrate binding pocket
82E, 253R, 256T, 257H, 259K, 260G, 263N, 360A, 364L, 369I
CDD
cd00644 (HMG-CoA_reductase_classII)

260G

substrate binding pocket
82E, 253R, 256T, 257H, 259K, 260G, 263N, 360A, 364L, 369I
CDD
cd00644 (HMG-CoA_reductase_classII)

263N

substrate binding pocket
82E, 253R, 256T, 257H, 259K, 260G, 263N, 360A, 364L, 369I
CDD
cd00644 (HMG-CoA_reductase_classII)

360A

substrate binding pocket
82E, 253R, 256T, 257H, 259K, 260G, 263N, 360A, 364L, 369I
CDD
cd00644 (HMG-CoA_reductase_classII)

364L

substrate binding pocket
82E, 253R, 256T, 257H, 259K, 260G, 263N, 360A, 364L, 369I
CDD
cd00644 (HMG-CoA_reductase_classII)

369I

substrate binding pocket
82E, 253R, 256T, 257H, 259K, 260G, 263N, 360A, 364L, 369I
CDD
cd00644 (HMG-CoA_reductase_classII)
catalytic residues...

82E

catalytic residues
82E, 259K, 275D, 373H
CDD
cd00644 (HMG-CoA_reductase_classII)

259K

catalytic residues
82E, 259K, 275D, 373H
CDD
cd00644 (HMG-CoA_reductase_classII)

275D

catalytic residues
82E, 259K, 275D, 373H
CDD
cd00644 (HMG-CoA_reductase_classII)

373H

catalytic residues
82E, 259K, 275D, 373H
CDD
cd00644 (HMG-CoA_reductase_classII)
NAD binding site c...

82E

NAD binding site
82E, 148L, 151F, 180L, 181D, 182A, 183M, 184G, 185A, 186N, 187A, 189N, 212L, 214N, 256T, 259K, 275D, 278A, 320V, 321G, 322G, 373H
CDD
cd00644 (HMG-CoA_reductase_classII)

148L

NAD binding site
82E, 148L, 151F, 180L, 181D, 182A, 183M, 184G, 185A, 186N, 187A, 189N, 212L, 214N, 256T, 259K, 275D, 278A, 320V, 321G, 322G, 373H
CDD
cd00644 (HMG-CoA_reductase_classII)

151F

NAD binding site
82E, 148L, 151F, 180L, 181D, 182A, 183M, 184G, 185A, 186N, 187A, 189N, 212L, 214N, 256T, 259K, 275D, 278A, 320V, 321G, 322G, 373H
CDD
cd00644 (HMG-CoA_reductase_classII)

180L

NAD binding site
82E, 148L, 151F, 180L, 181D, 182A, 183M, 184G, 185A, 186N, 187A, 189N, 212L, 214N, 256T, 259K, 275D, 278A, 320V, 321G, 322G, 373H
CDD
cd00644 (HMG-CoA_reductase_classII)

181D

NAD binding site
82E, 148L, 151F, 180L, 181D, 182A, 183M, 184G, 185A, 186N, 187A, 189N, 212L, 214N, 256T, 259K, 275D, 278A, 320V, 321G, 322G, 373H
CDD
cd00644 (HMG-CoA_reductase_classII)

182A

NAD binding site
82E, 148L, 151F, 180L, 181D, 182A, 183M, 184G, 185A, 186N, 187A, 189N, 212L, 214N, 256T, 259K, 275D, 278A, 320V, 321G, 322G, 373H
CDD
cd00644 (HMG-CoA_reductase_classII)

183M

NAD binding site
82E, 148L, 151F, 180L, 181D, 182A, 183M, 184G, 185A, 186N, 187A, 189N, 212L, 214N, 256T, 259K, 275D, 278A, 320V, 321G, 322G, 373H
CDD
cd00644 (HMG-CoA_reductase_classII)

184G

NAD binding site
82E, 148L, 151F, 180L, 181D, 182A, 183M, 184G, 185A, 186N, 187A, 189N, 212L, 214N, 256T, 259K, 275D, 278A, 320V, 321G, 322G, 373H
CDD
cd00644 (HMG-CoA_reductase_classII)

185A

NAD binding site
82E, 148L, 151F, 180L, 181D, 182A, 183M, 184G, 185A, 186N, 187A, 189N, 212L, 214N, 256T, 259K, 275D, 278A, 320V, 321G, 322G, 373H
CDD
cd00644 (HMG-CoA_reductase_classII)

186N

NAD binding site
82E, 148L, 151F, 180L, 181D, 182A, 183M, 184G, 185A, 186N, 187A, 189N, 212L, 214N, 256T, 259K, 275D, 278A, 320V, 321G, 322G, 373H
CDD
cd00644 (HMG-CoA_reductase_classII)

187A

NAD binding site
82E, 148L, 151F, 180L, 181D, 182A, 183M, 184G, 185A, 186N, 187A, 189N, 212L, 214N, 256T, 259K, 275D, 278A, 320V, 321G, 322G, 373H
CDD
cd00644 (HMG-CoA_reductase_classII)

189N

NAD binding site
82E, 148L, 151F, 180L, 181D, 182A, 183M, 184G, 185A, 186N, 187A, 189N, 212L, 214N, 256T, 259K, 275D, 278A, 320V, 321G, 322G, 373H
CDD
cd00644 (HMG-CoA_reductase_classII)

212L

NAD binding site
82E, 148L, 151F, 180L, 181D, 182A, 183M, 184G, 185A, 186N, 187A, 189N, 212L, 214N, 256T, 259K, 275D, 278A, 320V, 321G, 322G, 373H
CDD
cd00644 (HMG-CoA_reductase_classII)

214N

NAD binding site
82E, 148L, 151F, 180L, 181D, 182A, 183M, 184G, 185A, 186N, 187A, 189N, 212L, 214N, 256T, 259K, 275D, 278A, 320V, 321G, 322G, 373H
CDD
cd00644 (HMG-CoA_reductase_classII)

256T

NAD binding site
82E, 148L, 151F, 180L, 181D, 182A, 183M, 184G, 185A, 186N, 187A, 189N, 212L, 214N, 256T, 259K, 275D, 278A, 320V, 321G, 322G, 373H
CDD
cd00644 (HMG-CoA_reductase_classII)

259K

NAD binding site
82E, 148L, 151F, 180L, 181D, 182A, 183M, 184G, 185A, 186N, 187A, 189N, 212L, 214N, 256T, 259K, 275D, 278A, 320V, 321G, 322G, 373H
CDD
cd00644 (HMG-CoA_reductase_classII)

275D

NAD binding site
82E, 148L, 151F, 180L, 181D, 182A, 183M, 184G, 185A, 186N, 187A, 189N, 212L, 214N, 256T, 259K, 275D, 278A, 320V, 321G, 322G, 373H
CDD
cd00644 (HMG-CoA_reductase_classII)

278A

NAD binding site
82E, 148L, 151F, 180L, 181D, 182A, 183M, 184G, 185A, 186N, 187A, 189N, 212L, 214N, 256T, 259K, 275D, 278A, 320V, 321G, 322G, 373H
CDD
cd00644 (HMG-CoA_reductase_classII)

320V

NAD binding site
82E, 148L, 151F, 180L, 181D, 182A, 183M, 184G, 185A, 186N, 187A, 189N, 212L, 214N, 256T, 259K, 275D, 278A, 320V, 321G, 322G, 373H
CDD
cd00644 (HMG-CoA_reductase_classII)

321G

NAD binding site
82E, 148L, 151F, 180L, 181D, 182A, 183M, 184G, 185A, 186N, 187A, 189N, 212L, 214N, 256T, 259K, 275D, 278A, 320V, 321G, 322G, 373H
CDD
cd00644 (HMG-CoA_reductase_classII)

322G

NAD binding site
82E, 148L, 151F, 180L, 181D, 182A, 183M, 184G, 185A, 186N, 187A, 189N, 212L, 214N, 256T, 259K, 275D, 278A, 320V, 321G, 322G, 373H
CDD
cd00644 (HMG-CoA_reductase_classII)

373H

NAD binding site
82E, 148L, 151F, 180L, 181D, 182A, 183M, 184G, 185A, 186N, 187A, 189N, 212L, 214N, 256T, 259K, 275D, 278A, 320V, 321G, 322G, 373H
CDD
cd00644 (HMG-CoA_reductase_classII)
flexible flap cd00...

370Q

flexible flap
370Q, 371R, 372G, 373H, 374M, 375S, 376L, 377H, 378A, 379R, 380N, 381L, 382A, 383T, 384V, 385A
CDD
cd00644 (HMG-CoA_reductase_classII)

371R

flexible flap
370Q, 371R, 372G, 373H, 374M, 375S, 376L, 377H, 378A, 379R, 380N, 381L, 382A, 383T, 384V, 385A
CDD
cd00644 (HMG-CoA_reductase_classII)

372G

flexible flap
370Q, 371R, 372G, 373H, 374M, 375S, 376L, 377H, 378A, 379R, 380N, 381L, 382A, 383T, 384V, 385A
CDD
cd00644 (HMG-CoA_reductase_classII)

373H

flexible flap
370Q, 371R, 372G, 373H, 374M, 375S, 376L, 377H, 378A, 379R, 380N, 381L, 382A, 383T, 384V, 385A
CDD
cd00644 (HMG-CoA_reductase_classII)

374M

flexible flap
370Q, 371R, 372G, 373H, 374M, 375S, 376L, 377H, 378A, 379R, 380N, 381L, 382A, 383T, 384V, 385A
CDD
cd00644 (HMG-CoA_reductase_classII)

375S

flexible flap
370Q, 371R, 372G, 373H, 374M, 375S, 376L, 377H, 378A, 379R, 380N, 381L, 382A, 383T, 384V, 385A
CDD
cd00644 (HMG-CoA_reductase_classII)

376L

flexible flap
370Q, 371R, 372G, 373H, 374M, 375S, 376L, 377H, 378A, 379R, 380N, 381L, 382A, 383T, 384V, 385A
CDD
cd00644 (HMG-CoA_reductase_classII)

377H

flexible flap
370Q, 371R, 372G, 373H, 374M, 375S, 376L, 377H, 378A, 379R, 380N, 381L, 382A, 383T, 384V, 385A
CDD
cd00644 (HMG-CoA_reductase_classII)

378A

flexible flap
370Q, 371R, 372G, 373H, 374M, 375S, 376L, 377H, 378A, 379R, 380N, 381L, 382A, 383T, 384V, 385A
CDD
cd00644 (HMG-CoA_reductase_classII)

379R

flexible flap
370Q, 371R, 372G, 373H, 374M, 375S, 376L, 377H, 378A, 379R, 380N, 381L, 382A, 383T, 384V, 385A
CDD
cd00644 (HMG-CoA_reductase_classII)

380N

flexible flap
370Q, 371R, 372G, 373H, 374M, 375S, 376L, 377H, 378A, 379R, 380N, 381L, 382A, 383T, 384V, 385A
CDD
cd00644 (HMG-CoA_reductase_classII)

381L

flexible flap
370Q, 371R, 372G, 373H, 374M, 375S, 376L, 377H, 378A, 379R, 380N, 381L, 382A, 383T, 384V, 385A
CDD
cd00644 (HMG-CoA_reductase_classII)

382A

flexible flap
370Q, 371R, 372G, 373H, 374M, 375S, 376L, 377H, 378A, 379R, 380N, 381L, 382A, 383T, 384V, 385A
CDD
cd00644 (HMG-CoA_reductase_classII)

383T

flexible flap
370Q, 371R, 372G, 373H, 374M, 375S, 376L, 377H, 378A, 379R, 380N, 381L, 382A, 383T, 384V, 385A
CDD
cd00644 (HMG-CoA_reductase_classII)

384V

flexible flap
370Q, 371R, 372G, 373H, 374M, 375S, 376L, 377H, 378A, 379R, 380N, 381L, 382A, 383T, 384V, 385A
CDD
cd00644 (HMG-CoA_reductase_classII)

385A

flexible flap
370Q, 371R, 372G, 373H, 374M, 375S, 376L, 377H, 378A, 379R, 380N, 381L, 382A, 383T, 384V, 385A
CDD
cd00644 (HMG-CoA_reductase_classII)

GO term prediction

Biological Process

GO:0015936 coenzyme A metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0050662 coenzyme binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

49185_FusoPortal_Gene_1492

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component