49185_FusoPortal_Gene_1809

Protein

49185_FusoPortal_Gene_1809

Length

1,141 amino acids

Protein family membership

DNA polymerase III, alpha subunit (IPR004805)

Homologous superfamilies

Homologous superfamily
5 - 231
Polymerase/histidinol phosphatase-like (IPR016195)

1 200 400 600 800 1000 1141

Domains and repeats

Domain
7 - 175
PHP domain (IPR004013)
297 - 720
Bacterial DNA polymerase III, alpha subunit (IPR011708)
796 - 882
DNA polymerase, helix-hairpin-helix motif (IPR029460)

1 200 400 600 800 1000 1141

Detailed signature matches

IPR016195

Polymerase/histidinol phosphatase-like
1. SSF89550 (PHP domai...)
  
  5 - 231
  
  SUPERFAMILY
  SSF89550 (PHP domain-like)
IPR004805

DNA polymerase III, alpha subunit
1. TIGR00594
  
  5 - 1,017
  
  TIGRFAMs
  TIGR00594 (TIGR00594)
2. PTHR32294 (FAMILY N...)
  
  1 - 1,136
  
  PANTHER
  PTHR32294 (FAMILY NOT NAMED)
IPR004013

PHP domain
1. PF02811 (PHP)
  
  7 - 175
  
  Pfam
  PF02811 (PHP)
IPR011708

Bacterial DNA polymerase III, alpha subunit
1. PF07733 (DNA_pol3_a...)
  
  297 - 720
  
  Pfam
  PF07733 (DNA_pol3_alpha)
IPR029460

DNA polymerase, helix-hairpin-helix motif
1. PF14579 (HHH_6)
  
  796 - 882
  
  Pfam
  PF14579 (HHH_6)

no IPR

Unintegrated signatures

G3DSA:1.10.15...

795 - 879

GENE3D
G3DSA:1.10.150.280 (G3DSA:1.10.150.280)
G3DSA:2.40.50...

957 - 1,061

GENE3D
G3DSA:2.40.50.140 (G3DSA:2.40.50.140)
G3DSA:3.20.20...

3 - 250

GENE3D
G3DSA:3.20.20.140 (G3DSA:3.20.20.140)
PTHR32294:SF0 (DNA ...)

1 - 1,136

PANTHER
PTHR32294:SF0 (DNA POLYMERASE III SUBUNIT ALPHA)
cd04485 (DnaE_OBF)

980 - 1,064

CDD
cd04485 (DnaE_OBF)
cd12113 (PHP_PolIII...)

4 - 283

CDD
cd12113 (PHP_PolIIIA_DnaE3)

Residue annotation

active site cd12113

9H

active site
9H, 11H, 18D, 43H, 68E, 204D, 206H
CDD
cd12113 (PHP_PolIIIA_DnaE3)

11H

active site
9H, 11H, 18D, 43H, 68E, 204D, 206H
CDD
cd12113 (PHP_PolIIIA_DnaE3)

18D

active site
9H, 11H, 18D, 43H, 68E, 204D, 206H
CDD
cd12113 (PHP_PolIIIA_DnaE3)

43H

active site
9H, 11H, 18D, 43H, 68E, 204D, 206H
CDD
cd12113 (PHP_PolIIIA_DnaE3)

68E

active site
9H, 11H, 18D, 43H, 68E, 204D, 206H
CDD
cd12113 (PHP_PolIIIA_DnaE3)

204D

active site
9H, 11H, 18D, 43H, 68E, 204D, 206H
CDD
cd12113 (PHP_PolIIIA_DnaE3)

206H

active site
9H, 11H, 18D, 43H, 68E, 204D, 206H
CDD
cd12113 (PHP_PolIIIA_DnaE3)
PHP Thumb interfac...

61I

PHP Thumb interface
61I, 62K, 63P
CDD
cd12113 (PHP_PolIIIA_DnaE3)

62K

PHP Thumb interface
61I, 62K, 63P
CDD
cd12113 (PHP_PolIIIA_DnaE3)

63P

PHP Thumb interface
61I, 62K, 63P
CDD
cd12113 (PHP_PolIIIA_DnaE3)
metal binding site...

139E

metal binding site
139E, 160Y
CDD
cd12113 (PHP_PolIIIA_DnaE3)

160Y

metal binding site
139E, 160Y
CDD
cd12113 (PHP_PolIIIA_DnaE3)
generic binding su...

980R

generic binding surface II
980R, 1,033T, 1,035Y, 1,037E, 1,059K
CDD
cd04485 (DnaE_OBF)

1,033T

generic binding surface II
980R, 1,033T, 1,035Y, 1,037E, 1,059K
CDD
cd04485 (DnaE_OBF)

1,035Y

generic binding surface II
980R, 1,033T, 1,035Y, 1,037E, 1,059K
CDD
cd04485 (DnaE_OBF)

1,037E

generic binding surface II
980R, 1,033T, 1,035Y, 1,037E, 1,059K
CDD
cd04485 (DnaE_OBF)

1,059K

generic binding surface II
980R, 1,033T, 1,035Y, 1,037E, 1,059K
CDD
cd04485 (DnaE_OBF)
generic binding su...

985L

generic binding surface I
985L, 986R, 987E, 1,002L, 1,003F, 1,004E, 1,005L, 1,007D, 1,013N, 1,014C, 1,015V, 1,017F, 1,032K, 1,039T, 1,040I, 1,041Q, 1,052K, 1,053L, 1,054I
CDD
cd04485 (DnaE_OBF)

986R

generic binding surface I
985L, 986R, 987E, 1,002L, 1,003F, 1,004E, 1,005L, 1,007D, 1,013N, 1,014C, 1,015V, 1,017F, 1,032K, 1,039T, 1,040I, 1,041Q, 1,052K, 1,053L, 1,054I
CDD
cd04485 (DnaE_OBF)

987E

generic binding surface I
985L, 986R, 987E, 1,002L, 1,003F, 1,004E, 1,005L, 1,007D, 1,013N, 1,014C, 1,015V, 1,017F, 1,032K, 1,039T, 1,040I, 1,041Q, 1,052K, 1,053L, 1,054I
CDD
cd04485 (DnaE_OBF)

1,002L

generic binding surface I
985L, 986R, 987E, 1,002L, 1,003F, 1,004E, 1,005L, 1,007D, 1,013N, 1,014C, 1,015V, 1,017F, 1,032K, 1,039T, 1,040I, 1,041Q, 1,052K, 1,053L, 1,054I
CDD
cd04485 (DnaE_OBF)

1,003F

generic binding surface I
985L, 986R, 987E, 1,002L, 1,003F, 1,004E, 1,005L, 1,007D, 1,013N, 1,014C, 1,015V, 1,017F, 1,032K, 1,039T, 1,040I, 1,041Q, 1,052K, 1,053L, 1,054I
CDD
cd04485 (DnaE_OBF)

1,004E

generic binding surface I
985L, 986R, 987E, 1,002L, 1,003F, 1,004E, 1,005L, 1,007D, 1,013N, 1,014C, 1,015V, 1,017F, 1,032K, 1,039T, 1,040I, 1,041Q, 1,052K, 1,053L, 1,054I
CDD
cd04485 (DnaE_OBF)

1,005L

generic binding surface I
985L, 986R, 987E, 1,002L, 1,003F, 1,004E, 1,005L, 1,007D, 1,013N, 1,014C, 1,015V, 1,017F, 1,032K, 1,039T, 1,040I, 1,041Q, 1,052K, 1,053L, 1,054I
CDD
cd04485 (DnaE_OBF)

1,007D

generic binding surface I
985L, 986R, 987E, 1,002L, 1,003F, 1,004E, 1,005L, 1,007D, 1,013N, 1,014C, 1,015V, 1,017F, 1,032K, 1,039T, 1,040I, 1,041Q, 1,052K, 1,053L, 1,054I
CDD
cd04485 (DnaE_OBF)

1,013N

generic binding surface I
985L, 986R, 987E, 1,002L, 1,003F, 1,004E, 1,005L, 1,007D, 1,013N, 1,014C, 1,015V, 1,017F, 1,032K, 1,039T, 1,040I, 1,041Q, 1,052K, 1,053L, 1,054I
CDD
cd04485 (DnaE_OBF)

1,014C

generic binding surface I
985L, 986R, 987E, 1,002L, 1,003F, 1,004E, 1,005L, 1,007D, 1,013N, 1,014C, 1,015V, 1,017F, 1,032K, 1,039T, 1,040I, 1,041Q, 1,052K, 1,053L, 1,054I
CDD
cd04485 (DnaE_OBF)

1,015V

generic binding surface I
985L, 986R, 987E, 1,002L, 1,003F, 1,004E, 1,005L, 1,007D, 1,013N, 1,014C, 1,015V, 1,017F, 1,032K, 1,039T, 1,040I, 1,041Q, 1,052K, 1,053L, 1,054I
CDD
cd04485 (DnaE_OBF)

1,017F

generic binding surface I
985L, 986R, 987E, 1,002L, 1,003F, 1,004E, 1,005L, 1,007D, 1,013N, 1,014C, 1,015V, 1,017F, 1,032K, 1,039T, 1,040I, 1,041Q, 1,052K, 1,053L, 1,054I
CDD
cd04485 (DnaE_OBF)

1,032K

generic binding surface I
985L, 986R, 987E, 1,002L, 1,003F, 1,004E, 1,005L, 1,007D, 1,013N, 1,014C, 1,015V, 1,017F, 1,032K, 1,039T, 1,040I, 1,041Q, 1,052K, 1,053L, 1,054I
CDD
cd04485 (DnaE_OBF)

1,039T

generic binding surface I
985L, 986R, 987E, 1,002L, 1,003F, 1,004E, 1,005L, 1,007D, 1,013N, 1,014C, 1,015V, 1,017F, 1,032K, 1,039T, 1,040I, 1,041Q, 1,052K, 1,053L, 1,054I
CDD
cd04485 (DnaE_OBF)

1,040I

generic binding surface I
985L, 986R, 987E, 1,002L, 1,003F, 1,004E, 1,005L, 1,007D, 1,013N, 1,014C, 1,015V, 1,017F, 1,032K, 1,039T, 1,040I, 1,041Q, 1,052K, 1,053L, 1,054I
CDD
cd04485 (DnaE_OBF)

1,041Q

generic binding surface I
985L, 986R, 987E, 1,002L, 1,003F, 1,004E, 1,005L, 1,007D, 1,013N, 1,014C, 1,015V, 1,017F, 1,032K, 1,039T, 1,040I, 1,041Q, 1,052K, 1,053L, 1,054I
CDD
cd04485 (DnaE_OBF)

1,052K

generic binding surface I
985L, 986R, 987E, 1,002L, 1,003F, 1,004E, 1,005L, 1,007D, 1,013N, 1,014C, 1,015V, 1,017F, 1,032K, 1,039T, 1,040I, 1,041Q, 1,052K, 1,053L, 1,054I
CDD
cd04485 (DnaE_OBF)

1,053L

generic binding surface I
985L, 986R, 987E, 1,002L, 1,003F, 1,004E, 1,005L, 1,007D, 1,013N, 1,014C, 1,015V, 1,017F, 1,032K, 1,039T, 1,040I, 1,041Q, 1,052K, 1,053L, 1,054I
CDD
cd04485 (DnaE_OBF)

1,054I

generic binding surface I
985L, 986R, 987E, 1,002L, 1,003F, 1,004E, 1,005L, 1,007D, 1,013N, 1,014C, 1,015V, 1,017F, 1,032K, 1,039T, 1,040I, 1,041Q, 1,052K, 1,053L, 1,054I
CDD
cd04485 (DnaE_OBF)

GO term prediction

Biological Process

GO:0006260 DNA replication

Molecular Function

GO:0003824 catalytic activity
GO:0008408 3'-5' exonuclease activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

49185_FusoPortal_Gene_1809

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component