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Protein

49185_FusoPortal_Gene_1862

Length

282 amino acids

Protein family membership

Dihydroneopterin aldolase (IPR006156)

Homologous superfamilies

Homologous superfamily
119 - 282
7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK superfamily (IPR035907)

1 50 100 150 200 250 282

Domains and repeats

Domain
1 - 120
Dihydroneopterin aldolase/epimerase domain (IPR006157)
122 - 251
7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK (IPR000550)

1 50 100 150 200 250 282

Detailed signature matches

IPR035907

7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK superfamily

G3DSA:3.30.70...

119 - 282

GENE3D
G3DSA:3.30.70.560 (G3DSA:3.30.70.560)
SSF55083 (6-hydroxy...)

120 - 270

SUPERFAMILY
SSF55083 (6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK)

IPR006156

Dihydroneopterin aldolase

TIGR00525

2 - 117

TIGRFAMs
TIGR00525 (TIGR00525)

IPR006157

Dihydroneopterin aldolase/epimerase domain

TIGR00526

1 - 120

TIGRFAMs
TIGR00526 (TIGR00526)
cd00534 (DHNA_DHNTPE)

1 - 118

CDD
cd00534 (DHNA_DHNTPE)
PF02152 (FolB)

4 - 116

Pfam
PF02152 (FolB)

IPR000550

7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK

cd00483 (HPPK)

122 - 249

CDD
cd00483 (HPPK)
TIGR01498

122 - 251

TIGRFAMs
TIGR01498 (TIGR01498)
PS00794 (HPPK)

206 - 217

PROSITE patterns
PS00794 (HPPK)
PF01288 (HPPK)

123 - 251

Pfam
PF01288 (HPPK)

no IPR

Unintegrated signatures

Coil

130 - 150

COILS
Coil (Coil)
G3DSA:3.30.11...

1 - 118

GENE3D
G3DSA:3.30.1130.10 (G3DSA:3.30.1130.10)
PTHR43071 (FAMILY N...)

111 - 276

PANTHER
PTHR43071 (FAMILY NOT NAMED)
PTHR43071:SF1 (2-AM...)

111 - 276

PANTHER
PTHR43071:SF1 (2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE)
SSF55620 (Tetrahydr...)

2 - 119

SUPERFAMILY
SSF55620 (Tetrahydrobiopterin biosynthesis enzymes-like)

Residue annotation

homooctamer interf...

2D

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)

3K

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)

4I

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)

5Y

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)

6I

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)

7N

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)

8N

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)

9L

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)

10E

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)

11F

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)

12I

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)

18F

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)

19P

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)

20E

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)

21E

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)

22K

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)

23K

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)

24L

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)

25G

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)

26Q

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)

101W

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)

102A

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)

107H

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)

108F

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)

109E

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)

110N

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)

111V

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)

112A

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)

113V

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)

114E

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)

115I

homooctamer interface
2D, 3K, 4I, 5Y, 6I, 7N, 8N, 9L, 10E, 11F, 12I, 18F, 19P, 20E, 21E, 22K, 23K, 24L, 25G, 26Q, 101W, 102A, 107H, 108F, 109E, 110N, 111V, 112A, 113V, 114E, 115I
CDD
cd00534 (DHNA_DHNTPE)
active site cd00534

16G

active site
16G, 17V, 18F, 21E, 70D, 71L, 72I, 73E, 99K, 113V
CDD
cd00534 (DHNA_DHNTPE)

17V

active site
16G, 17V, 18F, 21E, 70D, 71L, 72I, 73E, 99K, 113V
CDD
cd00534 (DHNA_DHNTPE)

18F

active site
16G, 17V, 18F, 21E, 70D, 71L, 72I, 73E, 99K, 113V
CDD
cd00534 (DHNA_DHNTPE)

21E

active site
16G, 17V, 18F, 21E, 70D, 71L, 72I, 73E, 99K, 113V
CDD
cd00534 (DHNA_DHNTPE)

70D

active site
16G, 17V, 18F, 21E, 70D, 71L, 72I, 73E, 99K, 113V
CDD
cd00534 (DHNA_DHNTPE)

71L

active site
16G, 17V, 18F, 21E, 70D, 71L, 72I, 73E, 99K, 113V
CDD
cd00534 (DHNA_DHNTPE)

72I

active site
16G, 17V, 18F, 21E, 70D, 71L, 72I, 73E, 99K, 113V
CDD
cd00534 (DHNA_DHNTPE)

73E

active site
16G, 17V, 18F, 21E, 70D, 71L, 72I, 73E, 99K, 113V
CDD
cd00534 (DHNA_DHNTPE)

99K

active site
16G, 17V, 18F, 21E, 70D, 71L, 72I, 73E, 99K, 113V
CDD
cd00534 (DHNA_DHNTPE)

113V

active site
16G, 17V, 18F, 21E, 70D, 71L, 72I, 73E, 99K, 113V
CDD
cd00534 (DHNA_DHNTPE)
catalytic center b...

127G

catalytic center binding site
127G, 161T, 162E, 164F, 172F, 174N, 189L, 193L, 196E, 201R, 203R, 207W, 210R, 213D, 215D, 216I, 230A, 233H, 234P, 239R, 241F
CDD
cd00483 (HPPK)

161T

catalytic center binding site
127G, 161T, 162E, 164F, 172F, 174N, 189L, 193L, 196E, 201R, 203R, 207W, 210R, 213D, 215D, 216I, 230A, 233H, 234P, 239R, 241F
CDD
cd00483 (HPPK)

162E

catalytic center binding site
127G, 161T, 162E, 164F, 172F, 174N, 189L, 193L, 196E, 201R, 203R, 207W, 210R, 213D, 215D, 216I, 230A, 233H, 234P, 239R, 241F
CDD
cd00483 (HPPK)

164F

catalytic center binding site
127G, 161T, 162E, 164F, 172F, 174N, 189L, 193L, 196E, 201R, 203R, 207W, 210R, 213D, 215D, 216I, 230A, 233H, 234P, 239R, 241F
CDD
cd00483 (HPPK)

172F

catalytic center binding site
127G, 161T, 162E, 164F, 172F, 174N, 189L, 193L, 196E, 201R, 203R, 207W, 210R, 213D, 215D, 216I, 230A, 233H, 234P, 239R, 241F
CDD
cd00483 (HPPK)

174N

catalytic center binding site
127G, 161T, 162E, 164F, 172F, 174N, 189L, 193L, 196E, 201R, 203R, 207W, 210R, 213D, 215D, 216I, 230A, 233H, 234P, 239R, 241F
CDD
cd00483 (HPPK)

189L

catalytic center binding site
127G, 161T, 162E, 164F, 172F, 174N, 189L, 193L, 196E, 201R, 203R, 207W, 210R, 213D, 215D, 216I, 230A, 233H, 234P, 239R, 241F
CDD
cd00483 (HPPK)

193L

catalytic center binding site
127G, 161T, 162E, 164F, 172F, 174N, 189L, 193L, 196E, 201R, 203R, 207W, 210R, 213D, 215D, 216I, 230A, 233H, 234P, 239R, 241F
CDD
cd00483 (HPPK)

196E

catalytic center binding site
127G, 161T, 162E, 164F, 172F, 174N, 189L, 193L, 196E, 201R, 203R, 207W, 210R, 213D, 215D, 216I, 230A, 233H, 234P, 239R, 241F
CDD
cd00483 (HPPK)

201R

catalytic center binding site
127G, 161T, 162E, 164F, 172F, 174N, 189L, 193L, 196E, 201R, 203R, 207W, 210R, 213D, 215D, 216I, 230A, 233H, 234P, 239R, 241F
CDD
cd00483 (HPPK)

203R

catalytic center binding site
127G, 161T, 162E, 164F, 172F, 174N, 189L, 193L, 196E, 201R, 203R, 207W, 210R, 213D, 215D, 216I, 230A, 233H, 234P, 239R, 241F
CDD
cd00483 (HPPK)

207W

catalytic center binding site
127G, 161T, 162E, 164F, 172F, 174N, 189L, 193L, 196E, 201R, 203R, 207W, 210R, 213D, 215D, 216I, 230A, 233H, 234P, 239R, 241F
CDD
cd00483 (HPPK)

210R

catalytic center binding site
127G, 161T, 162E, 164F, 172F, 174N, 189L, 193L, 196E, 201R, 203R, 207W, 210R, 213D, 215D, 216I, 230A, 233H, 234P, 239R, 241F
CDD
cd00483 (HPPK)

213D

catalytic center binding site
127G, 161T, 162E, 164F, 172F, 174N, 189L, 193L, 196E, 201R, 203R, 207W, 210R, 213D, 215D, 216I, 230A, 233H, 234P, 239R, 241F
CDD
cd00483 (HPPK)

215D

catalytic center binding site
127G, 161T, 162E, 164F, 172F, 174N, 189L, 193L, 196E, 201R, 203R, 207W, 210R, 213D, 215D, 216I, 230A, 233H, 234P, 239R, 241F
CDD
cd00483 (HPPK)

216I

catalytic center binding site
127G, 161T, 162E, 164F, 172F, 174N, 189L, 193L, 196E, 201R, 203R, 207W, 210R, 213D, 215D, 216I, 230A, 233H, 234P, 239R, 241F
CDD
cd00483 (HPPK)

230A

catalytic center binding site
127G, 161T, 162E, 164F, 172F, 174N, 189L, 193L, 196E, 201R, 203R, 207W, 210R, 213D, 215D, 216I, 230A, 233H, 234P, 239R, 241F
CDD
cd00483 (HPPK)

233H

catalytic center binding site
127G, 161T, 162E, 164F, 172F, 174N, 189L, 193L, 196E, 201R, 203R, 207W, 210R, 213D, 215D, 216I, 230A, 233H, 234P, 239R, 241F
CDD
cd00483 (HPPK)

234P

catalytic center binding site
127G, 161T, 162E, 164F, 172F, 174N, 189L, 193L, 196E, 201R, 203R, 207W, 210R, 213D, 215D, 216I, 230A, 233H, 234P, 239R, 241F
CDD
cd00483 (HPPK)

239R

catalytic center binding site
127G, 161T, 162E, 164F, 172F, 174N, 189L, 193L, 196E, 201R, 203R, 207W, 210R, 213D, 215D, 216I, 230A, 233H, 234P, 239R, 241F
CDD
cd00483 (HPPK)

241F

catalytic center binding site
127G, 161T, 162E, 164F, 172F, 174N, 189L, 193L, 196E, 201R, 203R, 207W, 210R, 213D, 215D, 216I, 230A, 233H, 234P, 239R, 241F
CDD
cd00483 (HPPK)
ATP binding site c...

189L

ATP binding site
189L, 193L, 196E, 201R, 203R, 210R, 215D, 216I, 230A, 233H, 234P, 239R
CDD
cd00483 (HPPK)

193L

ATP binding site
189L, 193L, 196E, 201R, 203R, 210R, 215D, 216I, 230A, 233H, 234P, 239R
CDD
cd00483 (HPPK)

196E

ATP binding site
189L, 193L, 196E, 201R, 203R, 210R, 215D, 216I, 230A, 233H, 234P, 239R
CDD
cd00483 (HPPK)

201R

ATP binding site
189L, 193L, 196E, 201R, 203R, 210R, 215D, 216I, 230A, 233H, 234P, 239R
CDD
cd00483 (HPPK)

203R

ATP binding site
189L, 193L, 196E, 201R, 203R, 210R, 215D, 216I, 230A, 233H, 234P, 239R
CDD
cd00483 (HPPK)

210R

ATP binding site
189L, 193L, 196E, 201R, 203R, 210R, 215D, 216I, 230A, 233H, 234P, 239R
CDD
cd00483 (HPPK)

215D

ATP binding site
189L, 193L, 196E, 201R, 203R, 210R, 215D, 216I, 230A, 233H, 234P, 239R
CDD
cd00483 (HPPK)

216I

ATP binding site
189L, 193L, 196E, 201R, 203R, 210R, 215D, 216I, 230A, 233H, 234P, 239R
CDD
cd00483 (HPPK)

230A

ATP binding site
189L, 193L, 196E, 201R, 203R, 210R, 215D, 216I, 230A, 233H, 234P, 239R
CDD
cd00483 (HPPK)

233H

ATP binding site
189L, 193L, 196E, 201R, 203R, 210R, 215D, 216I, 230A, 233H, 234P, 239R
CDD
cd00483 (HPPK)

234P

ATP binding site
189L, 193L, 196E, 201R, 203R, 210R, 215D, 216I, 230A, 233H, 234P, 239R
CDD
cd00483 (HPPK)

239R

ATP binding site
189L, 193L, 196E, 201R, 203R, 210R, 215D, 216I, 230A, 233H, 234P, 239R
CDD
cd00483 (HPPK)

GO term prediction

Biological Process

GO:0006760 folic acid-containing compound metabolic process
GO:0009396 folic acid-containing compound biosynthetic process

Molecular Function

GO:0003848 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
GO:0004150 dihydroneopterin aldolase activity

Cellular Component

None predicted.