49185_FusoPortal_Gene_1895

Protein

49185_FusoPortal_Gene_1895

Length

319 amino acids

Protein family membership

None predicted.

Homologous superfamilies

Homologous superfamily
100 - 283
NAD(P)-binding domain superfamily (IPR036291)

1 50 100 150 200 250 319

Domains and repeats

Domain
5 - 314
D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain (IPR006139)
Domain
107 - 282
D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain (IPR006140)

1 50 100 150 200 250 319

Detailed signature matches

IPR036291

NAD(P)-binding domain superfamily
1. SSF51735 (NAD(P)-bi...)
  
  100 - 283
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR006139

D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
1. PF00389 (2-Hacid_dh)
  
  5 - 314
  
  Pfam
  PF00389 (2-Hacid_dh)
IPR006140

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
1. PF02826 (2-Hacid_dh_C)
  
  107 - 282
  
  Pfam
  PF02826 (2-Hacid_dh_C)
IPR029752

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1
1. PS00065 (D_2_HYDROX...)
  
  144 - 172
  
  PROSITE patterns
  PS00065 (D_2_HYDROXYACID_DH_1)

no IPR

Unintegrated signatures

Coil

228 - 248

COILS
Coil (Coil)
G3DSA:3.40.50...

2 - 108

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)

109 - 285

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
PTHR42938 (FAMILY N...)

1 - 317

PANTHER
PTHR42938 (FAMILY NOT NAMED)
PTHR42938:SF9 (FORM...)

1 - 317

PANTHER
PTHR42938:SF9 (FORMATE DEHYDROGENASE 1-RELATED)
SSF52283 (Formate/g...)

1 - 128

SUPERFAMILY
SSF52283 (Formate/glycerate dehydrogenase catalytic domain-like)
cd12173 (PGDH_4)

4 - 307

CDD
cd12173 (PGDH_4)

Residue annotation

ligand binding sit...

50R

ligand binding site
50R, 51T, 70R, 72G, 73A, 97T, 232R, 280H, 283S, 289M
CDD
cd12173 (PGDH_4)

51T

ligand binding site
50R, 51T, 70R, 72G, 73A, 97T, 232R, 280H, 283S, 289M
CDD
cd12173 (PGDH_4)

70R

ligand binding site
50R, 51T, 70R, 72G, 73A, 97T, 232R, 280H, 283S, 289M
CDD
cd12173 (PGDH_4)

72G

ligand binding site
50R, 51T, 70R, 72G, 73A, 97T, 232R, 280H, 283S, 289M
CDD
cd12173 (PGDH_4)

73A

ligand binding site
50R, 51T, 70R, 72G, 73A, 97T, 232R, 280H, 283S, 289M
CDD
cd12173 (PGDH_4)

97T

ligand binding site
50R, 51T, 70R, 72G, 73A, 97T, 232R, 280H, 283S, 289M
CDD
cd12173 (PGDH_4)

232R

ligand binding site
50R, 51T, 70R, 72G, 73A, 97T, 232R, 280H, 283S, 289M
CDD
cd12173 (PGDH_4)

280H

ligand binding site
50R, 51T, 70R, 72G, 73A, 97T, 232R, 280H, 283S, 289M
CDD
cd12173 (PGDH_4)

283S

ligand binding site
50R, 51T, 70R, 72G, 73A, 97T, 232R, 280H, 283S, 289M
CDD
cd12173 (PGDH_4)

289M

ligand binding site
50R, 51T, 70R, 72G, 73A, 97T, 232R, 280H, 283S, 289M
CDD
cd12173 (PGDH_4)
NAD binding site c...

73A

NAD binding site
73A, 97T, 101V, 148G, 150G, 151R, 152I, 171Y, 172D, 173P, 174F, 202H, 203M, 204P, 209N, 230C, 231A, 232R, 256D, 257V, 280H, 282A, 283S
CDD
cd12173 (PGDH_4)

97T

NAD binding site
73A, 97T, 101V, 148G, 150G, 151R, 152I, 171Y, 172D, 173P, 174F, 202H, 203M, 204P, 209N, 230C, 231A, 232R, 256D, 257V, 280H, 282A, 283S
CDD
cd12173 (PGDH_4)

101V

NAD binding site
73A, 97T, 101V, 148G, 150G, 151R, 152I, 171Y, 172D, 173P, 174F, 202H, 203M, 204P, 209N, 230C, 231A, 232R, 256D, 257V, 280H, 282A, 283S
CDD
cd12173 (PGDH_4)

148G

NAD binding site
73A, 97T, 101V, 148G, 150G, 151R, 152I, 171Y, 172D, 173P, 174F, 202H, 203M, 204P, 209N, 230C, 231A, 232R, 256D, 257V, 280H, 282A, 283S
CDD
cd12173 (PGDH_4)

150G

NAD binding site
73A, 97T, 101V, 148G, 150G, 151R, 152I, 171Y, 172D, 173P, 174F, 202H, 203M, 204P, 209N, 230C, 231A, 232R, 256D, 257V, 280H, 282A, 283S
CDD
cd12173 (PGDH_4)

151R

NAD binding site
73A, 97T, 101V, 148G, 150G, 151R, 152I, 171Y, 172D, 173P, 174F, 202H, 203M, 204P, 209N, 230C, 231A, 232R, 256D, 257V, 280H, 282A, 283S
CDD
cd12173 (PGDH_4)

152I

NAD binding site
73A, 97T, 101V, 148G, 150G, 151R, 152I, 171Y, 172D, 173P, 174F, 202H, 203M, 204P, 209N, 230C, 231A, 232R, 256D, 257V, 280H, 282A, 283S
CDD
cd12173 (PGDH_4)

171Y

NAD binding site
73A, 97T, 101V, 148G, 150G, 151R, 152I, 171Y, 172D, 173P, 174F, 202H, 203M, 204P, 209N, 230C, 231A, 232R, 256D, 257V, 280H, 282A, 283S
CDD
cd12173 (PGDH_4)

172D

NAD binding site
73A, 97T, 101V, 148G, 150G, 151R, 152I, 171Y, 172D, 173P, 174F, 202H, 203M, 204P, 209N, 230C, 231A, 232R, 256D, 257V, 280H, 282A, 283S
CDD
cd12173 (PGDH_4)

173P

NAD binding site
73A, 97T, 101V, 148G, 150G, 151R, 152I, 171Y, 172D, 173P, 174F, 202H, 203M, 204P, 209N, 230C, 231A, 232R, 256D, 257V, 280H, 282A, 283S
CDD
cd12173 (PGDH_4)

174F

NAD binding site
73A, 97T, 101V, 148G, 150G, 151R, 152I, 171Y, 172D, 173P, 174F, 202H, 203M, 204P, 209N, 230C, 231A, 232R, 256D, 257V, 280H, 282A, 283S
CDD
cd12173 (PGDH_4)

202H

NAD binding site
73A, 97T, 101V, 148G, 150G, 151R, 152I, 171Y, 172D, 173P, 174F, 202H, 203M, 204P, 209N, 230C, 231A, 232R, 256D, 257V, 280H, 282A, 283S
CDD
cd12173 (PGDH_4)

203M

NAD binding site
73A, 97T, 101V, 148G, 150G, 151R, 152I, 171Y, 172D, 173P, 174F, 202H, 203M, 204P, 209N, 230C, 231A, 232R, 256D, 257V, 280H, 282A, 283S
CDD
cd12173 (PGDH_4)

204P

NAD binding site
73A, 97T, 101V, 148G, 150G, 151R, 152I, 171Y, 172D, 173P, 174F, 202H, 203M, 204P, 209N, 230C, 231A, 232R, 256D, 257V, 280H, 282A, 283S
CDD
cd12173 (PGDH_4)

209N

NAD binding site
73A, 97T, 101V, 148G, 150G, 151R, 152I, 171Y, 172D, 173P, 174F, 202H, 203M, 204P, 209N, 230C, 231A, 232R, 256D, 257V, 280H, 282A, 283S
CDD
cd12173 (PGDH_4)

230C

NAD binding site
73A, 97T, 101V, 148G, 150G, 151R, 152I, 171Y, 172D, 173P, 174F, 202H, 203M, 204P, 209N, 230C, 231A, 232R, 256D, 257V, 280H, 282A, 283S
CDD
cd12173 (PGDH_4)

231A

NAD binding site
73A, 97T, 101V, 148G, 150G, 151R, 152I, 171Y, 172D, 173P, 174F, 202H, 203M, 204P, 209N, 230C, 231A, 232R, 256D, 257V, 280H, 282A, 283S
CDD
cd12173 (PGDH_4)

232R

NAD binding site
73A, 97T, 101V, 148G, 150G, 151R, 152I, 171Y, 172D, 173P, 174F, 202H, 203M, 204P, 209N, 230C, 231A, 232R, 256D, 257V, 280H, 282A, 283S
CDD
cd12173 (PGDH_4)

256D

NAD binding site
73A, 97T, 101V, 148G, 150G, 151R, 152I, 171Y, 172D, 173P, 174F, 202H, 203M, 204P, 209N, 230C, 231A, 232R, 256D, 257V, 280H, 282A, 283S
CDD
cd12173 (PGDH_4)

257V

NAD binding site
73A, 97T, 101V, 148G, 150G, 151R, 152I, 171Y, 172D, 173P, 174F, 202H, 203M, 204P, 209N, 230C, 231A, 232R, 256D, 257V, 280H, 282A, 283S
CDD
cd12173 (PGDH_4)

280H

NAD binding site
73A, 97T, 101V, 148G, 150G, 151R, 152I, 171Y, 172D, 173P, 174F, 202H, 203M, 204P, 209N, 230C, 231A, 232R, 256D, 257V, 280H, 282A, 283S
CDD
cd12173 (PGDH_4)

282A

NAD binding site
73A, 97T, 101V, 148G, 150G, 151R, 152I, 171Y, 172D, 173P, 174F, 202H, 203M, 204P, 209N, 230C, 231A, 232R, 256D, 257V, 280H, 282A, 283S
CDD
cd12173 (PGDH_4)

283S

NAD binding site
73A, 97T, 101V, 148G, 150G, 151R, 152I, 171Y, 172D, 173P, 174F, 202H, 203M, 204P, 209N, 230C, 231A, 232R, 256D, 257V, 280H, 282A, 283S
CDD
cd12173 (PGDH_4)
dimerization inter...

99N

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

100T

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

103E

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

104F

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

106L

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

107G

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

110L

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

111A

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

114K

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

116I

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

117F

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

119M

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

120N

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

123I

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

124K

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

126G

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

127D

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

128F

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

130F

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

134H

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

135K

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

136G

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

137M

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

138D

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

139L

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

140T

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

142K

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

159K

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

163G

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

164L

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

258F

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

261E

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

262P

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

263P

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

269L

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

270L

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

271S

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

272M

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

273D

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

275V

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

276I

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

277V

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

278T

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

279P

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

280H

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

281M

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

282A

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

284N

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

285T

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

286E

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

287E

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)

291L

dimerization interface
99N, 100T, 103E, 104F, 106L, 107G, 110L, 111A, 114K, 116I, 117F, 119M, 120N, 123I, 124K, 126G, 127D, 128F, 130F, 134H, 135K, 136G, 137M, 138D, 139L, 140T, 142K, 159K, 163G, 164L, 258F, 261E, 262P, 263P, 269L, 270L, 271S, 272M, 273D, 275V, 276I, 277V, 278T, 279P, 280H, 281M, 282A, 284N, 285T, 286E, 287E, 291L
CDD
cd12173 (PGDH_4)
catalytic site cd1...

232R

catalytic site
232R, 261E, 280H
CDD
cd12173 (PGDH_4)

261E

catalytic site
232R, 261E, 280H
CDD
cd12173 (PGDH_4)

280H

catalytic site
232R, 261E, 280H
CDD
cd12173 (PGDH_4)

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

49185_FusoPortal_Gene_1895

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component