49185_FusoPortal_Gene_1897

Protein

49185_FusoPortal_Gene_1897

Length

511 amino acids

Protein family membership

Aromatic amino acid lyase (IPR001106)
- Histidine ammonia-lyase (IPR005921)

Homologous superfamilies

Homologous superfamily
1 - 197
Fumarase/histidase, N-terminal (IPR024083)
Homologous superfamily
3 - 500
L-Aspartase-like (IPR008948)

1 50 100 150 200 250 300 350 400 450 511

Domains and repeats

None predicted.

Detailed signature matches

IPR024083

Fumarase/histidase, N-terminal
1. G3DSA:1.10.27...
  
  1 - 197
  
  GENE3D
  G3DSA:1.10.275.10 (G3DSA:1.10.275.10)
IPR008948

L-Aspartase-like
1. SSF48557 (L-asparta...)
  
  3 - 500
  
  SUPERFAMILY
  SSF48557 (L-aspartase-like)
IPR001106

Aromatic amino acid lyase
1. PF00221 (Lyase_arom...)
  
  10 - 471
  
  Pfam
  PF00221 (Lyase_aromatic)
2. cd00332 (PAL-HAL)
  
  8 - 451
  
  CDD
  cd00332 (PAL-HAL)
IPR005921

Histidine ammonia-lyase
1. TIGR01225
  
  4 - 504
  
  TIGRFAMs
  TIGR01225 (TIGR01225)
2. MF_00229 (His_ammon...)
  
  2 - 504
  
  HAMAP
  MF_00229 (His_ammonia_lyase)
IPR022313

Phenylalanine/histidine ammonia-lyases, active site
1. PS00488 (PAL_HISTIDASE)
  
  138 - 154
  
  PROSITE patterns
  PS00488 (PAL_HISTIDASE)

no IPR

Unintegrated signatures

G3DSA:1.20.20...

199 - 510

GENE3D
G3DSA:1.20.200.10 (G3DSA:1.20.200.10)
PTHR10362 (HISTIDIN...)

3 - 508

PANTHER
PTHR10362 (HISTIDINE AMMONIA-LYASE)
PTHR10362:SF7 (HIST...)

3 - 508

PANTHER
PTHR10362:SF7 (HISTIDINE AMMONIA-LYASE)

Residue annotation

active sites cd00332

53Y

active sites
53Y, 54G, 55I, 57T, 59F, 76Q, 79L, 188S, 189K, 190E, 191G, 192L, 196N, 279Y, 282R, 312N, 324S
CDD
cd00332 (PAL-HAL)

54G

active sites
53Y, 54G, 55I, 57T, 59F, 76Q, 79L, 188S, 189K, 190E, 191G, 192L, 196N, 279Y, 282R, 312N, 324S
CDD
cd00332 (PAL-HAL)

55I

active sites
53Y, 54G, 55I, 57T, 59F, 76Q, 79L, 188S, 189K, 190E, 191G, 192L, 196N, 279Y, 282R, 312N, 324S
CDD
cd00332 (PAL-HAL)

57T

active sites
53Y, 54G, 55I, 57T, 59F, 76Q, 79L, 188S, 189K, 190E, 191G, 192L, 196N, 279Y, 282R, 312N, 324S
CDD
cd00332 (PAL-HAL)

59F

active sites
53Y, 54G, 55I, 57T, 59F, 76Q, 79L, 188S, 189K, 190E, 191G, 192L, 196N, 279Y, 282R, 312N, 324S
CDD
cd00332 (PAL-HAL)

76Q

active sites
53Y, 54G, 55I, 57T, 59F, 76Q, 79L, 188S, 189K, 190E, 191G, 192L, 196N, 279Y, 282R, 312N, 324S
CDD
cd00332 (PAL-HAL)

79L

active sites
53Y, 54G, 55I, 57T, 59F, 76Q, 79L, 188S, 189K, 190E, 191G, 192L, 196N, 279Y, 282R, 312N, 324S
CDD
cd00332 (PAL-HAL)

188S

active sites
53Y, 54G, 55I, 57T, 59F, 76Q, 79L, 188S, 189K, 190E, 191G, 192L, 196N, 279Y, 282R, 312N, 324S
CDD
cd00332 (PAL-HAL)

189K

active sites
53Y, 54G, 55I, 57T, 59F, 76Q, 79L, 188S, 189K, 190E, 191G, 192L, 196N, 279Y, 282R, 312N, 324S
CDD
cd00332 (PAL-HAL)

190E

active sites
53Y, 54G, 55I, 57T, 59F, 76Q, 79L, 188S, 189K, 190E, 191G, 192L, 196N, 279Y, 282R, 312N, 324S
CDD
cd00332 (PAL-HAL)

191G

active sites
53Y, 54G, 55I, 57T, 59F, 76Q, 79L, 188S, 189K, 190E, 191G, 192L, 196N, 279Y, 282R, 312N, 324S
CDD
cd00332 (PAL-HAL)

192L

active sites
53Y, 54G, 55I, 57T, 59F, 76Q, 79L, 188S, 189K, 190E, 191G, 192L, 196N, 279Y, 282R, 312N, 324S
CDD
cd00332 (PAL-HAL)

196N

active sites
53Y, 54G, 55I, 57T, 59F, 76Q, 79L, 188S, 189K, 190E, 191G, 192L, 196N, 279Y, 282R, 312N, 324S
CDD
cd00332 (PAL-HAL)

279Y

active sites
53Y, 54G, 55I, 57T, 59F, 76Q, 79L, 188S, 189K, 190E, 191G, 192L, 196N, 279Y, 282R, 312N, 324S
CDD
cd00332 (PAL-HAL)

282R

active sites
53Y, 54G, 55I, 57T, 59F, 76Q, 79L, 188S, 189K, 190E, 191G, 192L, 196N, 279Y, 282R, 312N, 324S
CDD
cd00332 (PAL-HAL)

312N

active sites
53Y, 54G, 55I, 57T, 59F, 76Q, 79L, 188S, 189K, 190E, 191G, 192L, 196N, 279Y, 282R, 312N, 324S
CDD
cd00332 (PAL-HAL)

324S

active sites
53Y, 54G, 55I, 57T, 59F, 76Q, 79L, 188S, 189K, 190E, 191G, 192L, 196N, 279Y, 282R, 312N, 324S
CDD
cd00332 (PAL-HAL)
tetramer interface...

58G

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

59F

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

78N

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

81M

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

82S

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

83H

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

84S

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

85C

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

86G

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

87V

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

88G

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

109K

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

137K

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

138G

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

151H

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

154L

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

240R

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

241V

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

244V

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

245R

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

247H

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

250Q

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

276Q

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

278P

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

279Y

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

280T

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

282R

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

283C

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

286Q

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

287I

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

293D

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

294A

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

297F

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

300E

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

301K

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

304I

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

305E

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

308A

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

309V

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

314I

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

315I

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

316F

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

321D

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

323I

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

324S

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

325G

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

326G

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

327N

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

328F

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

329H

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

331Q

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

332P

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

335L

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

339F

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

346E

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

349N

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

353R

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

357R

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

360N

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

363L

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

376G

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

377V

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

379S

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

380G

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

382M

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

383I

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

384V

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

385Q

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

387S

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

389A

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

390S

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

391L

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

392V

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

393S

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

394E

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

396K

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

397V

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

398L

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

399A

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

410S

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

411A

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

412N

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

413Q

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

414E

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

415D

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

416H

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

419M

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

425R

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

426K

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

429E

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

432K

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

433N

tetramer interface
58G, 59F, 78N, 81M, 82S, 83H, 84S, 85C, 86G, 87V, 88G, 109K, 137K, 138G, 151H, 154L, 240R, 241V, 244V, 245R, 247H, 250Q, 276Q, 278P, 279Y, 280T, 282R, 283C, 286Q, 287I, 293D, 294A, 297F, 300E, 301K, 304I, 305E, 308A, 309V, 314I, 315I, 316F, 321D, 323I, 324S, 325G, 326G, 327N, 328F, 329H, 331Q, 332P, 335L, 339F, 346E, 349N, 353R, 357R, 360N, 363L, 376G, 377V, 379S, 380G, 382M, 383I, 384V, 385Q, 387S, 389A, 390S, 391L, 392V, 393S, 394E, 396K, 397V, 398L, 399A, 410S, 411A, 412N, 413Q, 414E, 415D, 416H, 419M, 425R, 426K, 429E, 432K, 433N
CDD
cd00332 (PAL-HAL)

GO term prediction

Biological Process

GO:0006548 histidine catabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0004397 histidine ammonia-lyase activity
GO:0016841 ammonia-lyase activity

Cellular Component

GO:0005737 cytoplasm

Filter view on

Entry type

Status

Per-residue features

49185_FusoPortal_Gene_1897

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component