49185_FusoPortal_Gene_1922

Protein

49185_FusoPortal_Gene_1922

Length

441 amino acids

Protein family membership

None predicted.

Homologous superfamilies

Homologous superfamily
208 - 291
Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily (IPR036097)
295 - 440
Histidine kinase/HSP90-like ATPase superfamily (IPR036890)

1 50 100 150 200 250 300 350 400 441

Domains and repeats

Domain
171 - 223
HAMP domain (IPR003660)
231 - 424
Histidine kinase domain (IPR005467)
Domain
222 - 290
Signal transduction histidine kinase, dimerisation/phosphoacceptor domain (IPR003661)
340 - 436
Histidine kinase/HSP90-like ATPase (IPR003594)

1 50 100 150 200 250 300 350 400 441

Detailed signature matches

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily
1. SSF47384 (Homodimer...)
  
  208 - 291
  
  SUPERFAMILY
  SSF47384 (Homodimeric domain of signal transducing histidine kinase)
IPR036890

Histidine kinase/HSP90-like ATPase superfamily
1. G3DSA:3.30.56...
  
  295 - 440
  
  GENE3D
  G3DSA:3.30.565.10 (G3DSA:3.30.565.10)
2. SSF55874 (ATPase do...)
  
  295 - 426
  
  SUPERFAMILY
  SSF55874 (ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase)
IPR003660

HAMP domain
1. PS50885 (HAMP)
  
  171 - 223
  
  PROSITE profiles
  PS50885 (HAMP)
2. cd06225 (HAMP)
  
  173 - 218
  
  CDD
  cd06225 (HAMP)
IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain
1. cd00082 (HisKA)
  
  222 - 287
  
  CDD
  cd00082 (HisKA)
2. PF00512 (HisKA)
  
  225 - 290
  
  Pfam
  PF00512 (HisKA)
IPR005467

Histidine kinase domain
1. PS50109 (HIS_KIN)
  
  231 - 424
  
  PROSITE profiles
  PS50109 (HIS_KIN)
IPR003594

Histidine kinase/HSP90-like ATPase
1. PF02518 (HATPase_c)
  
  340 - 436
  
  Pfam
  PF02518 (HATPase_c)
2. cd00075 (HATPase_c)
  
  340 - 418
  
  CDD
  cd00075 (HATPase_c)

no IPR

Unintegrated signatures

G3DSA:1.10.28...

201 - 287

GENE3D
G3DSA:1.10.287.130 (G3DSA:1.10.287.130)
PTHR42878 (FAMILY N...)

9 - 63

PANTHER
PTHR42878 (FAMILY NOT NAMED)

134 - 438

PANTHER
PTHR42878 (FAMILY NOT NAMED)
PTHR42878:SF3 (SUBF...)

134 - 438

PANTHER
PTHR42878:SF3 (SUBFAMILY NOT NAMED)

9 - 63

PANTHER
PTHR42878:SF3 (SUBFAMILY NOT NAMED)
SSF158472 (HAMP dom...)

173 - 219

SUPERFAMILY
SSF158472 (HAMP domain-like)

Residue annotation

dimerization inter...

173I

dimerization interface
173I, 174T, 177I, 178K, 180L, 181N, 184A, 185G, 187I, 203E, 204I, 206E, 207L, 210S, 211I, 213K, 214M, 217N, 218L
CDD
cd06225 (HAMP)

174T

dimerization interface
173I, 174T, 177I, 178K, 180L, 181N, 184A, 185G, 187I, 203E, 204I, 206E, 207L, 210S, 211I, 213K, 214M, 217N, 218L
CDD
cd06225 (HAMP)

177I

dimerization interface
173I, 174T, 177I, 178K, 180L, 181N, 184A, 185G, 187I, 203E, 204I, 206E, 207L, 210S, 211I, 213K, 214M, 217N, 218L
CDD
cd06225 (HAMP)

178K

dimerization interface
173I, 174T, 177I, 178K, 180L, 181N, 184A, 185G, 187I, 203E, 204I, 206E, 207L, 210S, 211I, 213K, 214M, 217N, 218L
CDD
cd06225 (HAMP)

180L

dimerization interface
173I, 174T, 177I, 178K, 180L, 181N, 184A, 185G, 187I, 203E, 204I, 206E, 207L, 210S, 211I, 213K, 214M, 217N, 218L
CDD
cd06225 (HAMP)

181N

dimerization interface
173I, 174T, 177I, 178K, 180L, 181N, 184A, 185G, 187I, 203E, 204I, 206E, 207L, 210S, 211I, 213K, 214M, 217N, 218L
CDD
cd06225 (HAMP)

184A

dimerization interface
173I, 174T, 177I, 178K, 180L, 181N, 184A, 185G, 187I, 203E, 204I, 206E, 207L, 210S, 211I, 213K, 214M, 217N, 218L
CDD
cd06225 (HAMP)

185G

dimerization interface
173I, 174T, 177I, 178K, 180L, 181N, 184A, 185G, 187I, 203E, 204I, 206E, 207L, 210S, 211I, 213K, 214M, 217N, 218L
CDD
cd06225 (HAMP)

187I

dimerization interface
173I, 174T, 177I, 178K, 180L, 181N, 184A, 185G, 187I, 203E, 204I, 206E, 207L, 210S, 211I, 213K, 214M, 217N, 218L
CDD
cd06225 (HAMP)

203E

dimerization interface
173I, 174T, 177I, 178K, 180L, 181N, 184A, 185G, 187I, 203E, 204I, 206E, 207L, 210S, 211I, 213K, 214M, 217N, 218L
CDD
cd06225 (HAMP)

204I

dimerization interface
173I, 174T, 177I, 178K, 180L, 181N, 184A, 185G, 187I, 203E, 204I, 206E, 207L, 210S, 211I, 213K, 214M, 217N, 218L
CDD
cd06225 (HAMP)

206E

dimerization interface
173I, 174T, 177I, 178K, 180L, 181N, 184A, 185G, 187I, 203E, 204I, 206E, 207L, 210S, 211I, 213K, 214M, 217N, 218L
CDD
cd06225 (HAMP)

207L

dimerization interface
173I, 174T, 177I, 178K, 180L, 181N, 184A, 185G, 187I, 203E, 204I, 206E, 207L, 210S, 211I, 213K, 214M, 217N, 218L
CDD
cd06225 (HAMP)

210S

dimerization interface
173I, 174T, 177I, 178K, 180L, 181N, 184A, 185G, 187I, 203E, 204I, 206E, 207L, 210S, 211I, 213K, 214M, 217N, 218L
CDD
cd06225 (HAMP)

211I

dimerization interface
173I, 174T, 177I, 178K, 180L, 181N, 184A, 185G, 187I, 203E, 204I, 206E, 207L, 210S, 211I, 213K, 214M, 217N, 218L
CDD
cd06225 (HAMP)

213K

dimerization interface
173I, 174T, 177I, 178K, 180L, 181N, 184A, 185G, 187I, 203E, 204I, 206E, 207L, 210S, 211I, 213K, 214M, 217N, 218L
CDD
cd06225 (HAMP)

214M

dimerization interface
173I, 174T, 177I, 178K, 180L, 181N, 184A, 185G, 187I, 203E, 204I, 206E, 207L, 210S, 211I, 213K, 214M, 217N, 218L
CDD
cd06225 (HAMP)

217N

dimerization interface
173I, 174T, 177I, 178K, 180L, 181N, 184A, 185G, 187I, 203E, 204I, 206E, 207L, 210S, 211I, 213K, 214M, 217N, 218L
CDD
cd06225 (HAMP)

218L

dimerization interface
173I, 174T, 177I, 178K, 180L, 181N, 184A, 185G, 187I, 203E, 204I, 206E, 207L, 210S, 211I, 213K, 214M, 217N, 218L
CDD
cd06225 (HAMP)
dimer interface cd...

228F

dimer interface
228F, 232A, 236L, 239P, 243I, 246Y, 264Y, 268I, 271E, 275M, 278L, 282L
CDD
cd00082 (HisKA)

232A

dimer interface
228F, 232A, 236L, 239P, 243I, 246Y, 264Y, 268I, 271E, 275M, 278L, 282L
CDD
cd00082 (HisKA)

236L

dimer interface
228F, 232A, 236L, 239P, 243I, 246Y, 264Y, 268I, 271E, 275M, 278L, 282L
CDD
cd00082 (HisKA)

239P

dimer interface
228F, 232A, 236L, 239P, 243I, 246Y, 264Y, 268I, 271E, 275M, 278L, 282L
CDD
cd00082 (HisKA)

243I

dimer interface
228F, 232A, 236L, 239P, 243I, 246Y, 264Y, 268I, 271E, 275M, 278L, 282L
CDD
cd00082 (HisKA)

246Y

dimer interface
228F, 232A, 236L, 239P, 243I, 246Y, 264Y, 268I, 271E, 275M, 278L, 282L
CDD
cd00082 (HisKA)

264Y

dimer interface
228F, 232A, 236L, 239P, 243I, 246Y, 264Y, 268I, 271E, 275M, 278L, 282L
CDD
cd00082 (HisKA)

268I

dimer interface
228F, 232A, 236L, 239P, 243I, 246Y, 264Y, 268I, 271E, 275M, 278L, 282L
CDD
cd00082 (HisKA)

271E

dimer interface
228F, 232A, 236L, 239P, 243I, 246Y, 264Y, 268I, 271E, 275M, 278L, 282L
CDD
cd00082 (HisKA)

275M

dimer interface
228F, 232A, 236L, 239P, 243I, 246Y, 264Y, 268I, 271E, 275M, 278L, 282L
CDD
cd00082 (HisKA)

278L

dimer interface
228F, 232A, 236L, 239P, 243I, 246Y, 264Y, 268I, 271E, 275M, 278L, 282L
CDD
cd00082 (HisKA)

282L

dimer interface
228F, 232A, 236L, 239P, 243I, 246Y, 264Y, 268I, 271E, 275M, 278L, 282L
CDD
cd00082 (HisKA)
phosphorylation si...

234H

phosphorylation site
234H
CDD
cd00082 (HisKA)
ATP binding site c...

346N

ATP binding site
346N, 350N, 353K, 374N, 376V, 378G, 380G, 406G, 407L, 408G, 409L
CDD
cd00075 (HATPase_c)

350N

ATP binding site
346N, 350N, 353K, 374N, 376V, 378G, 380G, 406G, 407L, 408G, 409L
CDD
cd00075 (HATPase_c)

353K

ATP binding site
346N, 350N, 353K, 374N, 376V, 378G, 380G, 406G, 407L, 408G, 409L
CDD
cd00075 (HATPase_c)

374N

ATP binding site
346N, 350N, 353K, 374N, 376V, 378G, 380G, 406G, 407L, 408G, 409L
CDD
cd00075 (HATPase_c)

376V

ATP binding site
346N, 350N, 353K, 374N, 376V, 378G, 380G, 406G, 407L, 408G, 409L
CDD
cd00075 (HATPase_c)

378G

ATP binding site
346N, 350N, 353K, 374N, 376V, 378G, 380G, 406G, 407L, 408G, 409L
CDD
cd00075 (HATPase_c)

380G

ATP binding site
346N, 350N, 353K, 374N, 376V, 378G, 380G, 406G, 407L, 408G, 409L
CDD
cd00075 (HATPase_c)

406G

ATP binding site
346N, 350N, 353K, 374N, 376V, 378G, 380G, 406G, 407L, 408G, 409L
CDD
cd00075 (HATPase_c)

407L

ATP binding site
346N, 350N, 353K, 374N, 376V, 378G, 380G, 406G, 407L, 408G, 409L
CDD
cd00075 (HATPase_c)

408G

ATP binding site
346N, 350N, 353K, 374N, 376V, 378G, 380G, 406G, 407L, 408G, 409L
CDD
cd00075 (HATPase_c)

409L

ATP binding site
346N, 350N, 353K, 374N, 376V, 378G, 380G, 406G, 407L, 408G, 409L
CDD
cd00075 (HATPase_c)
Mg2+ binding site ...

350N

Mg2+ binding site
350N
CDD
cd00075 (HATPase_c)
G-X-G motif cd00075

378G

G-X-G motif
378G, 380G, 406G, 408G
CDD
cd00075 (HATPase_c)

380G

G-X-G motif
378G, 380G, 406G, 408G
CDD
cd00075 (HATPase_c)

406G

G-X-G motif
378G, 380G, 406G, 408G
CDD
cd00075 (HATPase_c)

408G

G-X-G motif
378G, 380G, 406G, 408G
CDD
cd00075 (HATPase_c)

GO term prediction

Biological Process

GO:0007165 signal transduction

Molecular Function

GO:0000155 phosphorelay sensor kinase activity
GO:0004871 signal transducer activity

Cellular Component

GO:0016021 integral component of membrane

Filter view on

Entry type

Status

Per-residue features

49185_FusoPortal_Gene_1922

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component