49185_FusoPortal_Gene_2145

Protein

49185_FusoPortal_Gene_2145

Length

359 amino acids

Protein family membership

GDP-mannose 4,6-dehydratase (IPR006368)

Homologous superfamilies

Homologous superfamily
3 - 346
NAD(P)-binding domain superfamily (IPR036291)

1 50 100 150 200 250 300 359

Domains and repeats

Domain
6 - 341
NAD(P)-binding domain (IPR016040)

1 50 100 150 200 250 300 359

Detailed signature matches

IPR036291

NAD(P)-binding domain superfamily
1. SSF51735 (NAD(P)-bi...)
  
  3 - 346
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR006368

GDP-mannose 4,6-dehydratase
1. TIGR01472
  
  3 - 346
  
  TIGRFAMs
  TIGR01472 (TIGR01472)
2. MF_00955 (GDP_Man_d...)
  
  3 - 351
  
  HAMAP
  MF_00955 (GDP_Man_dehydratase)
3. PTHR43715 (FAMILY N...)
  
  2 - 350
  
  PANTHER
  PTHR43715 (FAMILY NOT NAMED)
IPR016040

NAD(P)-binding domain
1. PF16363 (GDP_Man_Dehyd)
  
  6 - 341
  
  Pfam
  PF16363 (GDP_Man_Dehyd)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

1 - 210

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
G3DSA:3.90.25.10

253 - 359

GENE3D
G3DSA:3.90.25.10 (G3DSA:3.90.25.10)

211 - 252

GENE3D
G3DSA:3.90.25.10 (G3DSA:3.90.25.10)
cd05260 (GDP_MD_SDR_e)

5 - 346

CDD
cd05260 (GDP_MD_SDR_e)

Residue annotation

NADP-binding site ...

9G

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36A, 67G, 68D, 69M, 90L, 91A, 92A, 94S, 109S, 135A, 136S, 137T, 161Y, 165K, 188L, 189F, 190N, 191H, 192E
CDD
cd05260 (GDP_MD_SDR_e)

10I

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36A, 67G, 68D, 69M, 90L, 91A, 92A, 94S, 109S, 135A, 136S, 137T, 161Y, 165K, 188L, 189F, 190N, 191H, 192E
CDD
cd05260 (GDP_MD_SDR_e)

11T

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36A, 67G, 68D, 69M, 90L, 91A, 92A, 94S, 109S, 135A, 136S, 137T, 161Y, 165K, 188L, 189F, 190N, 191H, 192E
CDD
cd05260 (GDP_MD_SDR_e)

12G

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36A, 67G, 68D, 69M, 90L, 91A, 92A, 94S, 109S, 135A, 136S, 137T, 161Y, 165K, 188L, 189F, 190N, 191H, 192E
CDD
cd05260 (GDP_MD_SDR_e)

13Q

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36A, 67G, 68D, 69M, 90L, 91A, 92A, 94S, 109S, 135A, 136S, 137T, 161Y, 165K, 188L, 189F, 190N, 191H, 192E
CDD
cd05260 (GDP_MD_SDR_e)

14D

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36A, 67G, 68D, 69M, 90L, 91A, 92A, 94S, 109S, 135A, 136S, 137T, 161Y, 165K, 188L, 189F, 190N, 191H, 192E
CDD
cd05260 (GDP_MD_SDR_e)

34R

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36A, 67G, 68D, 69M, 90L, 91A, 92A, 94S, 109S, 135A, 136S, 137T, 161Y, 165K, 188L, 189F, 190N, 191H, 192E
CDD
cd05260 (GDP_MD_SDR_e)

35R

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36A, 67G, 68D, 69M, 90L, 91A, 92A, 94S, 109S, 135A, 136S, 137T, 161Y, 165K, 188L, 189F, 190N, 191H, 192E
CDD
cd05260 (GDP_MD_SDR_e)

36A

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36A, 67G, 68D, 69M, 90L, 91A, 92A, 94S, 109S, 135A, 136S, 137T, 161Y, 165K, 188L, 189F, 190N, 191H, 192E
CDD
cd05260 (GDP_MD_SDR_e)

67G

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36A, 67G, 68D, 69M, 90L, 91A, 92A, 94S, 109S, 135A, 136S, 137T, 161Y, 165K, 188L, 189F, 190N, 191H, 192E
CDD
cd05260 (GDP_MD_SDR_e)

68D

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36A, 67G, 68D, 69M, 90L, 91A, 92A, 94S, 109S, 135A, 136S, 137T, 161Y, 165K, 188L, 189F, 190N, 191H, 192E
CDD
cd05260 (GDP_MD_SDR_e)

69M

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36A, 67G, 68D, 69M, 90L, 91A, 92A, 94S, 109S, 135A, 136S, 137T, 161Y, 165K, 188L, 189F, 190N, 191H, 192E
CDD
cd05260 (GDP_MD_SDR_e)

90L

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36A, 67G, 68D, 69M, 90L, 91A, 92A, 94S, 109S, 135A, 136S, 137T, 161Y, 165K, 188L, 189F, 190N, 191H, 192E
CDD
cd05260 (GDP_MD_SDR_e)

91A

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36A, 67G, 68D, 69M, 90L, 91A, 92A, 94S, 109S, 135A, 136S, 137T, 161Y, 165K, 188L, 189F, 190N, 191H, 192E
CDD
cd05260 (GDP_MD_SDR_e)

92A

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36A, 67G, 68D, 69M, 90L, 91A, 92A, 94S, 109S, 135A, 136S, 137T, 161Y, 165K, 188L, 189F, 190N, 191H, 192E
CDD
cd05260 (GDP_MD_SDR_e)

94S

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36A, 67G, 68D, 69M, 90L, 91A, 92A, 94S, 109S, 135A, 136S, 137T, 161Y, 165K, 188L, 189F, 190N, 191H, 192E
CDD
cd05260 (GDP_MD_SDR_e)

109S

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36A, 67G, 68D, 69M, 90L, 91A, 92A, 94S, 109S, 135A, 136S, 137T, 161Y, 165K, 188L, 189F, 190N, 191H, 192E
CDD
cd05260 (GDP_MD_SDR_e)

135A

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36A, 67G, 68D, 69M, 90L, 91A, 92A, 94S, 109S, 135A, 136S, 137T, 161Y, 165K, 188L, 189F, 190N, 191H, 192E
CDD
cd05260 (GDP_MD_SDR_e)

136S

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36A, 67G, 68D, 69M, 90L, 91A, 92A, 94S, 109S, 135A, 136S, 137T, 161Y, 165K, 188L, 189F, 190N, 191H, 192E
CDD
cd05260 (GDP_MD_SDR_e)

137T

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36A, 67G, 68D, 69M, 90L, 91A, 92A, 94S, 109S, 135A, 136S, 137T, 161Y, 165K, 188L, 189F, 190N, 191H, 192E
CDD
cd05260 (GDP_MD_SDR_e)

161Y

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36A, 67G, 68D, 69M, 90L, 91A, 92A, 94S, 109S, 135A, 136S, 137T, 161Y, 165K, 188L, 189F, 190N, 191H, 192E
CDD
cd05260 (GDP_MD_SDR_e)

165K

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36A, 67G, 68D, 69M, 90L, 91A, 92A, 94S, 109S, 135A, 136S, 137T, 161Y, 165K, 188L, 189F, 190N, 191H, 192E
CDD
cd05260 (GDP_MD_SDR_e)

188L

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36A, 67G, 68D, 69M, 90L, 91A, 92A, 94S, 109S, 135A, 136S, 137T, 161Y, 165K, 188L, 189F, 190N, 191H, 192E
CDD
cd05260 (GDP_MD_SDR_e)

189F

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36A, 67G, 68D, 69M, 90L, 91A, 92A, 94S, 109S, 135A, 136S, 137T, 161Y, 165K, 188L, 189F, 190N, 191H, 192E
CDD
cd05260 (GDP_MD_SDR_e)

190N

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36A, 67G, 68D, 69M, 90L, 91A, 92A, 94S, 109S, 135A, 136S, 137T, 161Y, 165K, 188L, 189F, 190N, 191H, 192E
CDD
cd05260 (GDP_MD_SDR_e)

191H

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36A, 67G, 68D, 69M, 90L, 91A, 92A, 94S, 109S, 135A, 136S, 137T, 161Y, 165K, 188L, 189F, 190N, 191H, 192E
CDD
cd05260 (GDP_MD_SDR_e)

192E

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36A, 67G, 68D, 69M, 90L, 91A, 92A, 94S, 109S, 135A, 136S, 137T, 161Y, 165K, 188L, 189F, 190N, 191H, 192E
CDD
cd05260 (GDP_MD_SDR_e)
homotetramer inter...

11T

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

12G

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

34R

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

35R

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

36A

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

37S

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

38T

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

39F

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

42G

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

43R

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

66Y

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

67G

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

68D

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

70T

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

71D

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

72S

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

73M

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

74S

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

76T

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

77R

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

78L

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

80R

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

92A

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

93Q

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

94S

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

95H

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

98V

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

100F

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

101E

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

102V

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

103P

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

107A

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

108D

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

112V

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

115L

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

116R

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

119E

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

122R

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

123F

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

154P

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

155F

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

156Y

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

157P

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

159S

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

160P

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

163V

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

164A

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

166Q

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

167Y

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

170W

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

171I

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

173K

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

174N

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

175Y

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

177D

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

178A

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

179Y

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

199T

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

200F

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

308P

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

309S

homotetramer interface
11T, 12G, 34R, 35R, 36A, 37S, 38T, 39F, 42G, 43R, 66Y, 67G, 68D, 70T, 71D, 72S, 73M, 74S, 76T, 77R, 78L, 80R, 92A, 93Q, 94S, 95H, 98V, 100F, 101E, 102V, 103P, 107A, 108D, 112V, 115L, 116R, 119E, 122R, 123F, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 199T, 200F, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)
substrate binding ...

94S

substrate binding site
94S, 95H, 96V, 137T, 138S, 139E, 161Y, 190N, 199T, 200F, 201V, 204K, 221Y, 222L, 223G, 224N, 227A, 229R, 263V, 305Y, 307R, 310D, 311V
CDD
cd05260 (GDP_MD_SDR_e)

95H

substrate binding site
94S, 95H, 96V, 137T, 138S, 139E, 161Y, 190N, 199T, 200F, 201V, 204K, 221Y, 222L, 223G, 224N, 227A, 229R, 263V, 305Y, 307R, 310D, 311V
CDD
cd05260 (GDP_MD_SDR_e)

96V

substrate binding site
94S, 95H, 96V, 137T, 138S, 139E, 161Y, 190N, 199T, 200F, 201V, 204K, 221Y, 222L, 223G, 224N, 227A, 229R, 263V, 305Y, 307R, 310D, 311V
CDD
cd05260 (GDP_MD_SDR_e)

137T

substrate binding site
94S, 95H, 96V, 137T, 138S, 139E, 161Y, 190N, 199T, 200F, 201V, 204K, 221Y, 222L, 223G, 224N, 227A, 229R, 263V, 305Y, 307R, 310D, 311V
CDD
cd05260 (GDP_MD_SDR_e)

138S

substrate binding site
94S, 95H, 96V, 137T, 138S, 139E, 161Y, 190N, 199T, 200F, 201V, 204K, 221Y, 222L, 223G, 224N, 227A, 229R, 263V, 305Y, 307R, 310D, 311V
CDD
cd05260 (GDP_MD_SDR_e)

139E

substrate binding site
94S, 95H, 96V, 137T, 138S, 139E, 161Y, 190N, 199T, 200F, 201V, 204K, 221Y, 222L, 223G, 224N, 227A, 229R, 263V, 305Y, 307R, 310D, 311V
CDD
cd05260 (GDP_MD_SDR_e)

161Y

substrate binding site
94S, 95H, 96V, 137T, 138S, 139E, 161Y, 190N, 199T, 200F, 201V, 204K, 221Y, 222L, 223G, 224N, 227A, 229R, 263V, 305Y, 307R, 310D, 311V
CDD
cd05260 (GDP_MD_SDR_e)

190N

substrate binding site
94S, 95H, 96V, 137T, 138S, 139E, 161Y, 190N, 199T, 200F, 201V, 204K, 221Y, 222L, 223G, 224N, 227A, 229R, 263V, 305Y, 307R, 310D, 311V
CDD
cd05260 (GDP_MD_SDR_e)

199T

substrate binding site
94S, 95H, 96V, 137T, 138S, 139E, 161Y, 190N, 199T, 200F, 201V, 204K, 221Y, 222L, 223G, 224N, 227A, 229R, 263V, 305Y, 307R, 310D, 311V
CDD
cd05260 (GDP_MD_SDR_e)

200F

substrate binding site
94S, 95H, 96V, 137T, 138S, 139E, 161Y, 190N, 199T, 200F, 201V, 204K, 221Y, 222L, 223G, 224N, 227A, 229R, 263V, 305Y, 307R, 310D, 311V
CDD
cd05260 (GDP_MD_SDR_e)

201V

substrate binding site
94S, 95H, 96V, 137T, 138S, 139E, 161Y, 190N, 199T, 200F, 201V, 204K, 221Y, 222L, 223G, 224N, 227A, 229R, 263V, 305Y, 307R, 310D, 311V
CDD
cd05260 (GDP_MD_SDR_e)

204K

substrate binding site
94S, 95H, 96V, 137T, 138S, 139E, 161Y, 190N, 199T, 200F, 201V, 204K, 221Y, 222L, 223G, 224N, 227A, 229R, 263V, 305Y, 307R, 310D, 311V
CDD
cd05260 (GDP_MD_SDR_e)

221Y

substrate binding site
94S, 95H, 96V, 137T, 138S, 139E, 161Y, 190N, 199T, 200F, 201V, 204K, 221Y, 222L, 223G, 224N, 227A, 229R, 263V, 305Y, 307R, 310D, 311V
CDD
cd05260 (GDP_MD_SDR_e)

222L

substrate binding site
94S, 95H, 96V, 137T, 138S, 139E, 161Y, 190N, 199T, 200F, 201V, 204K, 221Y, 222L, 223G, 224N, 227A, 229R, 263V, 305Y, 307R, 310D, 311V
CDD
cd05260 (GDP_MD_SDR_e)

223G

substrate binding site
94S, 95H, 96V, 137T, 138S, 139E, 161Y, 190N, 199T, 200F, 201V, 204K, 221Y, 222L, 223G, 224N, 227A, 229R, 263V, 305Y, 307R, 310D, 311V
CDD
cd05260 (GDP_MD_SDR_e)

224N

substrate binding site
94S, 95H, 96V, 137T, 138S, 139E, 161Y, 190N, 199T, 200F, 201V, 204K, 221Y, 222L, 223G, 224N, 227A, 229R, 263V, 305Y, 307R, 310D, 311V
CDD
cd05260 (GDP_MD_SDR_e)

227A

substrate binding site
94S, 95H, 96V, 137T, 138S, 139E, 161Y, 190N, 199T, 200F, 201V, 204K, 221Y, 222L, 223G, 224N, 227A, 229R, 263V, 305Y, 307R, 310D, 311V
CDD
cd05260 (GDP_MD_SDR_e)

229R

substrate binding site
94S, 95H, 96V, 137T, 138S, 139E, 161Y, 190N, 199T, 200F, 201V, 204K, 221Y, 222L, 223G, 224N, 227A, 229R, 263V, 305Y, 307R, 310D, 311V
CDD
cd05260 (GDP_MD_SDR_e)

263V

substrate binding site
94S, 95H, 96V, 137T, 138S, 139E, 161Y, 190N, 199T, 200F, 201V, 204K, 221Y, 222L, 223G, 224N, 227A, 229R, 263V, 305Y, 307R, 310D, 311V
CDD
cd05260 (GDP_MD_SDR_e)

305Y

substrate binding site
94S, 95H, 96V, 137T, 138S, 139E, 161Y, 190N, 199T, 200F, 201V, 204K, 221Y, 222L, 223G, 224N, 227A, 229R, 263V, 305Y, 307R, 310D, 311V
CDD
cd05260 (GDP_MD_SDR_e)

307R

substrate binding site
94S, 95H, 96V, 137T, 138S, 139E, 161Y, 190N, 199T, 200F, 201V, 204K, 221Y, 222L, 223G, 224N, 227A, 229R, 263V, 305Y, 307R, 310D, 311V
CDD
cd05260 (GDP_MD_SDR_e)

310D

substrate binding site
94S, 95H, 96V, 137T, 138S, 139E, 161Y, 190N, 199T, 200F, 201V, 204K, 221Y, 222L, 223G, 224N, 227A, 229R, 263V, 305Y, 307R, 310D, 311V
CDD
cd05260 (GDP_MD_SDR_e)

311V

substrate binding site
94S, 95H, 96V, 137T, 138S, 139E, 161Y, 190N, 199T, 200F, 201V, 204K, 221Y, 222L, 223G, 224N, 227A, 229R, 263V, 305Y, 307R, 310D, 311V
CDD
cd05260 (GDP_MD_SDR_e)
homodimer interfac...

100F

homodimer interface
100F, 103P, 107A, 108D, 111A, 112V, 115L, 116R, 119E, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

103P

homodimer interface
100F, 103P, 107A, 108D, 111A, 112V, 115L, 116R, 119E, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

107A

homodimer interface
100F, 103P, 107A, 108D, 111A, 112V, 115L, 116R, 119E, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

108D

homodimer interface
100F, 103P, 107A, 108D, 111A, 112V, 115L, 116R, 119E, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

111A

homodimer interface
100F, 103P, 107A, 108D, 111A, 112V, 115L, 116R, 119E, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

112V

homodimer interface
100F, 103P, 107A, 108D, 111A, 112V, 115L, 116R, 119E, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

115L

homodimer interface
100F, 103P, 107A, 108D, 111A, 112V, 115L, 116R, 119E, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

116R

homodimer interface
100F, 103P, 107A, 108D, 111A, 112V, 115L, 116R, 119E, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

119E

homodimer interface
100F, 103P, 107A, 108D, 111A, 112V, 115L, 116R, 119E, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

154P

homodimer interface
100F, 103P, 107A, 108D, 111A, 112V, 115L, 116R, 119E, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

155F

homodimer interface
100F, 103P, 107A, 108D, 111A, 112V, 115L, 116R, 119E, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

156Y

homodimer interface
100F, 103P, 107A, 108D, 111A, 112V, 115L, 116R, 119E, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

157P

homodimer interface
100F, 103P, 107A, 108D, 111A, 112V, 115L, 116R, 119E, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

159S

homodimer interface
100F, 103P, 107A, 108D, 111A, 112V, 115L, 116R, 119E, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

160P

homodimer interface
100F, 103P, 107A, 108D, 111A, 112V, 115L, 116R, 119E, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

163V

homodimer interface
100F, 103P, 107A, 108D, 111A, 112V, 115L, 116R, 119E, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

164A

homodimer interface
100F, 103P, 107A, 108D, 111A, 112V, 115L, 116R, 119E, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

166Q

homodimer interface
100F, 103P, 107A, 108D, 111A, 112V, 115L, 116R, 119E, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

167Y

homodimer interface
100F, 103P, 107A, 108D, 111A, 112V, 115L, 116R, 119E, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

170W

homodimer interface
100F, 103P, 107A, 108D, 111A, 112V, 115L, 116R, 119E, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

171I

homodimer interface
100F, 103P, 107A, 108D, 111A, 112V, 115L, 116R, 119E, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

173K

homodimer interface
100F, 103P, 107A, 108D, 111A, 112V, 115L, 116R, 119E, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

174N

homodimer interface
100F, 103P, 107A, 108D, 111A, 112V, 115L, 116R, 119E, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

175Y

homodimer interface
100F, 103P, 107A, 108D, 111A, 112V, 115L, 116R, 119E, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

177D

homodimer interface
100F, 103P, 107A, 108D, 111A, 112V, 115L, 116R, 119E, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

178A

homodimer interface
100F, 103P, 107A, 108D, 111A, 112V, 115L, 116R, 119E, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

179Y

homodimer interface
100F, 103P, 107A, 108D, 111A, 112V, 115L, 116R, 119E, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

308P

homodimer interface
100F, 103P, 107A, 108D, 111A, 112V, 115L, 116R, 119E, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)

309S

homodimer interface
100F, 103P, 107A, 108D, 111A, 112V, 115L, 116R, 119E, 154P, 155F, 156Y, 157P, 159S, 160P, 163V, 164A, 166Q, 167Y, 170W, 171I, 173K, 174N, 175Y, 177D, 178A, 179Y, 308P, 309S
CDD
cd05260 (GDP_MD_SDR_e)
active site cd05260

110N

active site
110N, 137T, 161Y, 165K
CDD
cd05260 (GDP_MD_SDR_e)

137T

active site
110N, 137T, 161Y, 165K
CDD
cd05260 (GDP_MD_SDR_e)

161Y

active site
110N, 137T, 161Y, 165K
CDD
cd05260 (GDP_MD_SDR_e)

165K

active site
110N, 137T, 161Y, 165K
CDD
cd05260 (GDP_MD_SDR_e)

GO term prediction

Biological Process

GO:0019673 GDP-mannose metabolic process

Molecular Function

GO:0008446 GDP-mannose 4,6-dehydratase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

49185_FusoPortal_Gene_2145

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component