49185_FusoPortal_Gene_2172

Protein

49185_FusoPortal_Gene_2172

Length

296 amino acids

Protein family membership

Pyridoxine kinase (IPR004625)

Homologous superfamilies

Homologous superfamily
3 - 293
Ribokinase-like (IPR029056)

1 50 100 150 200 250 296

Domains and repeats

Domain
31 - 263
Pyridoxamine kinase/Phosphomethylpyrimidine kinase (IPR013749)

1 50 100 150 200 250 296

Detailed signature matches

IPR029056

Ribokinase-like
1. G3DSA:3.40.11...
  
  3 - 293
  
  GENE3D
  G3DSA:3.40.1190.20 (G3DSA:3.40.1190.20)
2. SSF53613 (Ribokinas...)
  
  5 - 284
  
  SUPERFAMILY
  SSF53613 (Ribokinase-like)
IPR004625

Pyridoxine kinase
1. PTHR10534 (PYRIDOXA...)
  
  6 - 261
  
  PANTHER
  PTHR10534 (PYRIDOXAL KINASE)
2. cd01173 (pyridoxal_...)
  
  7 - 263
  
  CDD
  cd01173 (pyridoxal_pyridoxamine_kinase)
IPR013749

Pyridoxamine kinase/Phosphomethylpyrimidine kinase
1. PF08543 (Phos_pyr_kin)
  
  31 - 263
  
  Pfam
  PF08543 (Phos_pyr_kin)

no IPR

Unintegrated signatures

PTHR10534:SF2 (PYRI...)

6 - 261

PANTHER
PTHR10534:SF2 (PYRIDOXAL KINASE)

Residue annotation

dimer interface cd...

7K

dimer interface
7K, 14L, 16G, 17Y, 19R, 23T, 27P, 30S, 35Q, 36V, 37C, 38P, 39V, 40P, 43V, 46T, 55S, 56F, 58D, 65Q, 66H, 73L
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

14L

dimer interface
7K, 14L, 16G, 17Y, 19R, 23T, 27P, 30S, 35Q, 36V, 37C, 38P, 39V, 40P, 43V, 46T, 55S, 56F, 58D, 65Q, 66H, 73L
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

16G

dimer interface
7K, 14L, 16G, 17Y, 19R, 23T, 27P, 30S, 35Q, 36V, 37C, 38P, 39V, 40P, 43V, 46T, 55S, 56F, 58D, 65Q, 66H, 73L
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

17Y

dimer interface
7K, 14L, 16G, 17Y, 19R, 23T, 27P, 30S, 35Q, 36V, 37C, 38P, 39V, 40P, 43V, 46T, 55S, 56F, 58D, 65Q, 66H, 73L
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

19R

dimer interface
7K, 14L, 16G, 17Y, 19R, 23T, 27P, 30S, 35Q, 36V, 37C, 38P, 39V, 40P, 43V, 46T, 55S, 56F, 58D, 65Q, 66H, 73L
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

23T

dimer interface
7K, 14L, 16G, 17Y, 19R, 23T, 27P, 30S, 35Q, 36V, 37C, 38P, 39V, 40P, 43V, 46T, 55S, 56F, 58D, 65Q, 66H, 73L
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

27P

dimer interface
7K, 14L, 16G, 17Y, 19R, 23T, 27P, 30S, 35Q, 36V, 37C, 38P, 39V, 40P, 43V, 46T, 55S, 56F, 58D, 65Q, 66H, 73L
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

30S

dimer interface
7K, 14L, 16G, 17Y, 19R, 23T, 27P, 30S, 35Q, 36V, 37C, 38P, 39V, 40P, 43V, 46T, 55S, 56F, 58D, 65Q, 66H, 73L
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

35Q

dimer interface
7K, 14L, 16G, 17Y, 19R, 23T, 27P, 30S, 35Q, 36V, 37C, 38P, 39V, 40P, 43V, 46T, 55S, 56F, 58D, 65Q, 66H, 73L
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

36V

dimer interface
7K, 14L, 16G, 17Y, 19R, 23T, 27P, 30S, 35Q, 36V, 37C, 38P, 39V, 40P, 43V, 46T, 55S, 56F, 58D, 65Q, 66H, 73L
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

37C

dimer interface
7K, 14L, 16G, 17Y, 19R, 23T, 27P, 30S, 35Q, 36V, 37C, 38P, 39V, 40P, 43V, 46T, 55S, 56F, 58D, 65Q, 66H, 73L
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

38P

dimer interface
7K, 14L, 16G, 17Y, 19R, 23T, 27P, 30S, 35Q, 36V, 37C, 38P, 39V, 40P, 43V, 46T, 55S, 56F, 58D, 65Q, 66H, 73L
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

39V

dimer interface
7K, 14L, 16G, 17Y, 19R, 23T, 27P, 30S, 35Q, 36V, 37C, 38P, 39V, 40P, 43V, 46T, 55S, 56F, 58D, 65Q, 66H, 73L
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

40P

dimer interface
7K, 14L, 16G, 17Y, 19R, 23T, 27P, 30S, 35Q, 36V, 37C, 38P, 39V, 40P, 43V, 46T, 55S, 56F, 58D, 65Q, 66H, 73L
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

43V

dimer interface
7K, 14L, 16G, 17Y, 19R, 23T, 27P, 30S, 35Q, 36V, 37C, 38P, 39V, 40P, 43V, 46T, 55S, 56F, 58D, 65Q, 66H, 73L
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

46T

dimer interface
7K, 14L, 16G, 17Y, 19R, 23T, 27P, 30S, 35Q, 36V, 37C, 38P, 39V, 40P, 43V, 46T, 55S, 56F, 58D, 65Q, 66H, 73L
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

55S

dimer interface
7K, 14L, 16G, 17Y, 19R, 23T, 27P, 30S, 35Q, 36V, 37C, 38P, 39V, 40P, 43V, 46T, 55S, 56F, 58D, 65Q, 66H, 73L
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

56F

dimer interface
7K, 14L, 16G, 17Y, 19R, 23T, 27P, 30S, 35Q, 36V, 37C, 38P, 39V, 40P, 43V, 46T, 55S, 56F, 58D, 65Q, 66H, 73L
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

58D

dimer interface
7K, 14L, 16G, 17Y, 19R, 23T, 27P, 30S, 35Q, 36V, 37C, 38P, 39V, 40P, 43V, 46T, 55S, 56F, 58D, 65Q, 66H, 73L
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

65Q

dimer interface
7K, 14L, 16G, 17Y, 19R, 23T, 27P, 30S, 35Q, 36V, 37C, 38P, 39V, 40P, 43V, 46T, 55S, 56F, 58D, 65Q, 66H, 73L
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

66H

dimer interface
7K, 14L, 16G, 17Y, 19R, 23T, 27P, 30S, 35Q, 36V, 37C, 38P, 39V, 40P, 43V, 46T, 55S, 56F, 58D, 65Q, 66H, 73L
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

73L

dimer interface
7K, 14L, 16G, 17Y, 19R, 23T, 27P, 30S, 35Q, 36V, 37C, 38P, 39V, 40P, 43V, 46T, 55S, 56F, 58D, 65Q, 66H, 73L
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)
pyridoxal binding ...

13D

pyridoxal binding site
13D, 20S, 21S, 44L, 47H, 48T, 53G, 84F, 86G, 223P, 224G, 227D
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

20S

pyridoxal binding site
13D, 20S, 21S, 44L, 47H, 48T, 53G, 84F, 86G, 223P, 224G, 227D
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

21S

pyridoxal binding site
13D, 20S, 21S, 44L, 47H, 48T, 53G, 84F, 86G, 223P, 224G, 227D
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

44L

pyridoxal binding site
13D, 20S, 21S, 44L, 47H, 48T, 53G, 84F, 86G, 223P, 224G, 227D
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

47H

pyridoxal binding site
13D, 20S, 21S, 44L, 47H, 48T, 53G, 84F, 86G, 223P, 224G, 227D
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

48T

pyridoxal binding site
13D, 20S, 21S, 44L, 47H, 48T, 53G, 84F, 86G, 223P, 224G, 227D
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

53G

pyridoxal binding site
13D, 20S, 21S, 44L, 47H, 48T, 53G, 84F, 86G, 223P, 224G, 227D
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

84F

pyridoxal binding site
13D, 20S, 21S, 44L, 47H, 48T, 53G, 84F, 86G, 223P, 224G, 227D
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

86G

pyridoxal binding site
13D, 20S, 21S, 44L, 47H, 48T, 53G, 84F, 86G, 223P, 224G, 227D
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

223P

pyridoxal binding site
13D, 20S, 21S, 44L, 47H, 48T, 53G, 84F, 86G, 223P, 224G, 227D
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

224G

pyridoxal binding site
13D, 20S, 21S, 44L, 47H, 48T, 53G, 84F, 86G, 223P, 224G, 227D
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

227D

pyridoxal binding site
13D, 20S, 21S, 44L, 47H, 48T, 53G, 84F, 86G, 223P, 224G, 227D
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)
ATP binding site c...

111D

ATP binding site
111D, 116D, 143T, 145N, 148E, 184T, 185S, 197K, 212K, 214S, 215C, 222Y, 225T, 226G, 227D, 229Y, 254I, 258I
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

116D

ATP binding site
111D, 116D, 143T, 145N, 148E, 184T, 185S, 197K, 212K, 214S, 215C, 222Y, 225T, 226G, 227D, 229Y, 254I, 258I
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

143T

ATP binding site
111D, 116D, 143T, 145N, 148E, 184T, 185S, 197K, 212K, 214S, 215C, 222Y, 225T, 226G, 227D, 229Y, 254I, 258I
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

145N

ATP binding site
111D, 116D, 143T, 145N, 148E, 184T, 185S, 197K, 212K, 214S, 215C, 222Y, 225T, 226G, 227D, 229Y, 254I, 258I
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

148E

ATP binding site
111D, 116D, 143T, 145N, 148E, 184T, 185S, 197K, 212K, 214S, 215C, 222Y, 225T, 226G, 227D, 229Y, 254I, 258I
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

184T

ATP binding site
111D, 116D, 143T, 145N, 148E, 184T, 185S, 197K, 212K, 214S, 215C, 222Y, 225T, 226G, 227D, 229Y, 254I, 258I
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

185S

ATP binding site
111D, 116D, 143T, 145N, 148E, 184T, 185S, 197K, 212K, 214S, 215C, 222Y, 225T, 226G, 227D, 229Y, 254I, 258I
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

197K

ATP binding site
111D, 116D, 143T, 145N, 148E, 184T, 185S, 197K, 212K, 214S, 215C, 222Y, 225T, 226G, 227D, 229Y, 254I, 258I
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

212K

ATP binding site
111D, 116D, 143T, 145N, 148E, 184T, 185S, 197K, 212K, 214S, 215C, 222Y, 225T, 226G, 227D, 229Y, 254I, 258I
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

214S

ATP binding site
111D, 116D, 143T, 145N, 148E, 184T, 185S, 197K, 212K, 214S, 215C, 222Y, 225T, 226G, 227D, 229Y, 254I, 258I
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

215C

ATP binding site
111D, 116D, 143T, 145N, 148E, 184T, 185S, 197K, 212K, 214S, 215C, 222Y, 225T, 226G, 227D, 229Y, 254I, 258I
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

222Y

ATP binding site
111D, 116D, 143T, 145N, 148E, 184T, 185S, 197K, 212K, 214S, 215C, 222Y, 225T, 226G, 227D, 229Y, 254I, 258I
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

225T

ATP binding site
111D, 116D, 143T, 145N, 148E, 184T, 185S, 197K, 212K, 214S, 215C, 222Y, 225T, 226G, 227D, 229Y, 254I, 258I
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

226G

ATP binding site
111D, 116D, 143T, 145N, 148E, 184T, 185S, 197K, 212K, 214S, 215C, 222Y, 225T, 226G, 227D, 229Y, 254I, 258I
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

227D

ATP binding site
111D, 116D, 143T, 145N, 148E, 184T, 185S, 197K, 212K, 214S, 215C, 222Y, 225T, 226G, 227D, 229Y, 254I, 258I
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

229Y

ATP binding site
111D, 116D, 143T, 145N, 148E, 184T, 185S, 197K, 212K, 214S, 215C, 222Y, 225T, 226G, 227D, 229Y, 254I, 258I
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

254I

ATP binding site
111D, 116D, 143T, 145N, 148E, 184T, 185S, 197K, 212K, 214S, 215C, 222Y, 225T, 226G, 227D, 229Y, 254I, 258I
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

258I

ATP binding site
111D, 116D, 143T, 145N, 148E, 184T, 185S, 197K, 212K, 214S, 215C, 222Y, 225T, 226G, 227D, 229Y, 254I, 258I
CDD
cd01173 (pyridoxal_pyridoxamine_kinase)

GO term prediction

Biological Process

GO:0009443 pyridoxal 5'-phosphate salvage

Molecular Function

GO:0008478 pyridoxal kinase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

49185_FusoPortal_Gene_2172

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component