49185_FusoPortal_Gene_2199

Protein

49185_FusoPortal_Gene_2199

Length

344 amino acids

Protein family membership

GDP-mannose 4,6-dehydratase (IPR006368)

Homologous superfamilies

Homologous superfamily
3 - 332
NAD(P)-binding domain superfamily (IPR036291)

1 50 100 150 200 250 300 344

Domains and repeats

Domain
6 - 327
NAD(P)-binding domain (IPR016040)

1 50 100 150 200 250 300 344

Detailed signature matches

IPR036291

NAD(P)-binding domain superfamily
1. SSF51735 (NAD(P)-bi...)
  
  3 - 332
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR006368

GDP-mannose 4,6-dehydratase
1. TIGR01472
  
  3 - 334
  
  TIGRFAMs
  TIGR01472 (TIGR01472)
2. MF_00955 (GDP_Man_d...)
  
  3 - 337
  
  HAMAP
  MF_00955 (GDP_Man_dehydratase)
3. PTHR43715 (FAMILY N...)
  
  2 - 339
  
  PANTHER
  PTHR43715 (FAMILY NOT NAMED)
IPR016040

NAD(P)-binding domain
1. PF16363 (GDP_Man_Dehyd)
  
  6 - 327
  
  Pfam
  PF16363 (GDP_Man_Dehyd)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

1 - 197

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
G3DSA:3.90.25.10

198 - 240

GENE3D
G3DSA:3.90.25.10 (G3DSA:3.90.25.10)

241 - 343

GENE3D
G3DSA:3.90.25.10 (G3DSA:3.90.25.10)
cd05260 (GDP_MD_SDR_e)

5 - 333

CDD
cd05260 (GDP_MD_SDR_e)

Residue annotation

NADP-binding site ...

9G

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36K, 56A, 57D, 58M, 79L, 80A, 81A, 83S, 98I, 122A, 123S, 124T, 148Y, 152K, 175L, 176F, 177N, 178H, 179E
CDD
cd05260 (GDP_MD_SDR_e)

10I

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36K, 56A, 57D, 58M, 79L, 80A, 81A, 83S, 98I, 122A, 123S, 124T, 148Y, 152K, 175L, 176F, 177N, 178H, 179E
CDD
cd05260 (GDP_MD_SDR_e)

11T

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36K, 56A, 57D, 58M, 79L, 80A, 81A, 83S, 98I, 122A, 123S, 124T, 148Y, 152K, 175L, 176F, 177N, 178H, 179E
CDD
cd05260 (GDP_MD_SDR_e)

12G

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36K, 56A, 57D, 58M, 79L, 80A, 81A, 83S, 98I, 122A, 123S, 124T, 148Y, 152K, 175L, 176F, 177N, 178H, 179E
CDD
cd05260 (GDP_MD_SDR_e)

13Q

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36K, 56A, 57D, 58M, 79L, 80A, 81A, 83S, 98I, 122A, 123S, 124T, 148Y, 152K, 175L, 176F, 177N, 178H, 179E
CDD
cd05260 (GDP_MD_SDR_e)

14D

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36K, 56A, 57D, 58M, 79L, 80A, 81A, 83S, 98I, 122A, 123S, 124T, 148Y, 152K, 175L, 176F, 177N, 178H, 179E
CDD
cd05260 (GDP_MD_SDR_e)

34R

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36K, 56A, 57D, 58M, 79L, 80A, 81A, 83S, 98I, 122A, 123S, 124T, 148Y, 152K, 175L, 176F, 177N, 178H, 179E
CDD
cd05260 (GDP_MD_SDR_e)

35R

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36K, 56A, 57D, 58M, 79L, 80A, 81A, 83S, 98I, 122A, 123S, 124T, 148Y, 152K, 175L, 176F, 177N, 178H, 179E
CDD
cd05260 (GDP_MD_SDR_e)

36K

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36K, 56A, 57D, 58M, 79L, 80A, 81A, 83S, 98I, 122A, 123S, 124T, 148Y, 152K, 175L, 176F, 177N, 178H, 179E
CDD
cd05260 (GDP_MD_SDR_e)

56A

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36K, 56A, 57D, 58M, 79L, 80A, 81A, 83S, 98I, 122A, 123S, 124T, 148Y, 152K, 175L, 176F, 177N, 178H, 179E
CDD
cd05260 (GDP_MD_SDR_e)

57D

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36K, 56A, 57D, 58M, 79L, 80A, 81A, 83S, 98I, 122A, 123S, 124T, 148Y, 152K, 175L, 176F, 177N, 178H, 179E
CDD
cd05260 (GDP_MD_SDR_e)

58M

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36K, 56A, 57D, 58M, 79L, 80A, 81A, 83S, 98I, 122A, 123S, 124T, 148Y, 152K, 175L, 176F, 177N, 178H, 179E
CDD
cd05260 (GDP_MD_SDR_e)

79L

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36K, 56A, 57D, 58M, 79L, 80A, 81A, 83S, 98I, 122A, 123S, 124T, 148Y, 152K, 175L, 176F, 177N, 178H, 179E
CDD
cd05260 (GDP_MD_SDR_e)

80A

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36K, 56A, 57D, 58M, 79L, 80A, 81A, 83S, 98I, 122A, 123S, 124T, 148Y, 152K, 175L, 176F, 177N, 178H, 179E
CDD
cd05260 (GDP_MD_SDR_e)

81A

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36K, 56A, 57D, 58M, 79L, 80A, 81A, 83S, 98I, 122A, 123S, 124T, 148Y, 152K, 175L, 176F, 177N, 178H, 179E
CDD
cd05260 (GDP_MD_SDR_e)

83S

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36K, 56A, 57D, 58M, 79L, 80A, 81A, 83S, 98I, 122A, 123S, 124T, 148Y, 152K, 175L, 176F, 177N, 178H, 179E
CDD
cd05260 (GDP_MD_SDR_e)

98I

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36K, 56A, 57D, 58M, 79L, 80A, 81A, 83S, 98I, 122A, 123S, 124T, 148Y, 152K, 175L, 176F, 177N, 178H, 179E
CDD
cd05260 (GDP_MD_SDR_e)

122A

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36K, 56A, 57D, 58M, 79L, 80A, 81A, 83S, 98I, 122A, 123S, 124T, 148Y, 152K, 175L, 176F, 177N, 178H, 179E
CDD
cd05260 (GDP_MD_SDR_e)

123S

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36K, 56A, 57D, 58M, 79L, 80A, 81A, 83S, 98I, 122A, 123S, 124T, 148Y, 152K, 175L, 176F, 177N, 178H, 179E
CDD
cd05260 (GDP_MD_SDR_e)

124T

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36K, 56A, 57D, 58M, 79L, 80A, 81A, 83S, 98I, 122A, 123S, 124T, 148Y, 152K, 175L, 176F, 177N, 178H, 179E
CDD
cd05260 (GDP_MD_SDR_e)

148Y

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36K, 56A, 57D, 58M, 79L, 80A, 81A, 83S, 98I, 122A, 123S, 124T, 148Y, 152K, 175L, 176F, 177N, 178H, 179E
CDD
cd05260 (GDP_MD_SDR_e)

152K

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36K, 56A, 57D, 58M, 79L, 80A, 81A, 83S, 98I, 122A, 123S, 124T, 148Y, 152K, 175L, 176F, 177N, 178H, 179E
CDD
cd05260 (GDP_MD_SDR_e)

175L

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36K, 56A, 57D, 58M, 79L, 80A, 81A, 83S, 98I, 122A, 123S, 124T, 148Y, 152K, 175L, 176F, 177N, 178H, 179E
CDD
cd05260 (GDP_MD_SDR_e)

176F

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36K, 56A, 57D, 58M, 79L, 80A, 81A, 83S, 98I, 122A, 123S, 124T, 148Y, 152K, 175L, 176F, 177N, 178H, 179E
CDD
cd05260 (GDP_MD_SDR_e)

177N

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36K, 56A, 57D, 58M, 79L, 80A, 81A, 83S, 98I, 122A, 123S, 124T, 148Y, 152K, 175L, 176F, 177N, 178H, 179E
CDD
cd05260 (GDP_MD_SDR_e)

178H

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36K, 56A, 57D, 58M, 79L, 80A, 81A, 83S, 98I, 122A, 123S, 124T, 148Y, 152K, 175L, 176F, 177N, 178H, 179E
CDD
cd05260 (GDP_MD_SDR_e)

179E

NADP-binding site
9G, 10I, 11T, 12G, 13Q, 14D, 34R, 35R, 36K, 56A, 57D, 58M, 79L, 80A, 81A, 83S, 98I, 122A, 123S, 124T, 148Y, 152K, 175L, 176F, 177N, 178H, 179E
CDD
cd05260 (GDP_MD_SDR_e)
homotetramer inter...

11T

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

12G

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

34R

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

35R

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

36K

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

37S

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

38V

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

39V

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

42G

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

43N

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

55Y

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

56A

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

57D

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

59T

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

60D

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

61L

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

62I

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

63S

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

65I

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

66N

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

67A

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

69N

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

81A

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

82Q

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

83S

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

84F

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

87T

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

89W

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

90E

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

91Q

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

92P

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

96A

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

97E

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

101V

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

104T

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

105N

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

108E

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

111R

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

112N

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

141P

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

142F

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

143Y

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

144P

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

146S

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

147P

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

150V

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

151A

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

153L

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

154Y

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

157W

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

158I

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

160K

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

161N

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

162Y

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

164E

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

165S

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

166Y

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

186E

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

187F

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

295P

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

296A

homotetramer interface
11T, 12G, 34R, 35R, 36K, 37S, 38V, 39V, 42G, 43N, 55Y, 56A, 57D, 59T, 60D, 61L, 62I, 63S, 65I, 66N, 67A, 69N, 81A, 82Q, 83S, 84F, 87T, 89W, 90E, 91Q, 92P, 96A, 97E, 101V, 104T, 105N, 108E, 111R, 112N, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 186E, 187F, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)
substrate binding ...

83S

substrate binding site
83S, 84F, 85V, 124T, 125S, 126E, 148Y, 177N, 186E, 187F, 188V, 191K, 208E, 209L, 210G, 211N, 214S, 216R, 250V, 292F, 294R, 297E, 298V
CDD
cd05260 (GDP_MD_SDR_e)

84F

substrate binding site
83S, 84F, 85V, 124T, 125S, 126E, 148Y, 177N, 186E, 187F, 188V, 191K, 208E, 209L, 210G, 211N, 214S, 216R, 250V, 292F, 294R, 297E, 298V
CDD
cd05260 (GDP_MD_SDR_e)

85V

substrate binding site
83S, 84F, 85V, 124T, 125S, 126E, 148Y, 177N, 186E, 187F, 188V, 191K, 208E, 209L, 210G, 211N, 214S, 216R, 250V, 292F, 294R, 297E, 298V
CDD
cd05260 (GDP_MD_SDR_e)

124T

substrate binding site
83S, 84F, 85V, 124T, 125S, 126E, 148Y, 177N, 186E, 187F, 188V, 191K, 208E, 209L, 210G, 211N, 214S, 216R, 250V, 292F, 294R, 297E, 298V
CDD
cd05260 (GDP_MD_SDR_e)

125S

substrate binding site
83S, 84F, 85V, 124T, 125S, 126E, 148Y, 177N, 186E, 187F, 188V, 191K, 208E, 209L, 210G, 211N, 214S, 216R, 250V, 292F, 294R, 297E, 298V
CDD
cd05260 (GDP_MD_SDR_e)

126E

substrate binding site
83S, 84F, 85V, 124T, 125S, 126E, 148Y, 177N, 186E, 187F, 188V, 191K, 208E, 209L, 210G, 211N, 214S, 216R, 250V, 292F, 294R, 297E, 298V
CDD
cd05260 (GDP_MD_SDR_e)

148Y

substrate binding site
83S, 84F, 85V, 124T, 125S, 126E, 148Y, 177N, 186E, 187F, 188V, 191K, 208E, 209L, 210G, 211N, 214S, 216R, 250V, 292F, 294R, 297E, 298V
CDD
cd05260 (GDP_MD_SDR_e)

177N

substrate binding site
83S, 84F, 85V, 124T, 125S, 126E, 148Y, 177N, 186E, 187F, 188V, 191K, 208E, 209L, 210G, 211N, 214S, 216R, 250V, 292F, 294R, 297E, 298V
CDD
cd05260 (GDP_MD_SDR_e)

186E

substrate binding site
83S, 84F, 85V, 124T, 125S, 126E, 148Y, 177N, 186E, 187F, 188V, 191K, 208E, 209L, 210G, 211N, 214S, 216R, 250V, 292F, 294R, 297E, 298V
CDD
cd05260 (GDP_MD_SDR_e)

187F

substrate binding site
83S, 84F, 85V, 124T, 125S, 126E, 148Y, 177N, 186E, 187F, 188V, 191K, 208E, 209L, 210G, 211N, 214S, 216R, 250V, 292F, 294R, 297E, 298V
CDD
cd05260 (GDP_MD_SDR_e)

188V

substrate binding site
83S, 84F, 85V, 124T, 125S, 126E, 148Y, 177N, 186E, 187F, 188V, 191K, 208E, 209L, 210G, 211N, 214S, 216R, 250V, 292F, 294R, 297E, 298V
CDD
cd05260 (GDP_MD_SDR_e)

191K

substrate binding site
83S, 84F, 85V, 124T, 125S, 126E, 148Y, 177N, 186E, 187F, 188V, 191K, 208E, 209L, 210G, 211N, 214S, 216R, 250V, 292F, 294R, 297E, 298V
CDD
cd05260 (GDP_MD_SDR_e)

208E

substrate binding site
83S, 84F, 85V, 124T, 125S, 126E, 148Y, 177N, 186E, 187F, 188V, 191K, 208E, 209L, 210G, 211N, 214S, 216R, 250V, 292F, 294R, 297E, 298V
CDD
cd05260 (GDP_MD_SDR_e)

209L

substrate binding site
83S, 84F, 85V, 124T, 125S, 126E, 148Y, 177N, 186E, 187F, 188V, 191K, 208E, 209L, 210G, 211N, 214S, 216R, 250V, 292F, 294R, 297E, 298V
CDD
cd05260 (GDP_MD_SDR_e)

210G

substrate binding site
83S, 84F, 85V, 124T, 125S, 126E, 148Y, 177N, 186E, 187F, 188V, 191K, 208E, 209L, 210G, 211N, 214S, 216R, 250V, 292F, 294R, 297E, 298V
CDD
cd05260 (GDP_MD_SDR_e)

211N

substrate binding site
83S, 84F, 85V, 124T, 125S, 126E, 148Y, 177N, 186E, 187F, 188V, 191K, 208E, 209L, 210G, 211N, 214S, 216R, 250V, 292F, 294R, 297E, 298V
CDD
cd05260 (GDP_MD_SDR_e)

214S

substrate binding site
83S, 84F, 85V, 124T, 125S, 126E, 148Y, 177N, 186E, 187F, 188V, 191K, 208E, 209L, 210G, 211N, 214S, 216R, 250V, 292F, 294R, 297E, 298V
CDD
cd05260 (GDP_MD_SDR_e)

216R

substrate binding site
83S, 84F, 85V, 124T, 125S, 126E, 148Y, 177N, 186E, 187F, 188V, 191K, 208E, 209L, 210G, 211N, 214S, 216R, 250V, 292F, 294R, 297E, 298V
CDD
cd05260 (GDP_MD_SDR_e)

250V

substrate binding site
83S, 84F, 85V, 124T, 125S, 126E, 148Y, 177N, 186E, 187F, 188V, 191K, 208E, 209L, 210G, 211N, 214S, 216R, 250V, 292F, 294R, 297E, 298V
CDD
cd05260 (GDP_MD_SDR_e)

292F

substrate binding site
83S, 84F, 85V, 124T, 125S, 126E, 148Y, 177N, 186E, 187F, 188V, 191K, 208E, 209L, 210G, 211N, 214S, 216R, 250V, 292F, 294R, 297E, 298V
CDD
cd05260 (GDP_MD_SDR_e)

294R

substrate binding site
83S, 84F, 85V, 124T, 125S, 126E, 148Y, 177N, 186E, 187F, 188V, 191K, 208E, 209L, 210G, 211N, 214S, 216R, 250V, 292F, 294R, 297E, 298V
CDD
cd05260 (GDP_MD_SDR_e)

297E

substrate binding site
83S, 84F, 85V, 124T, 125S, 126E, 148Y, 177N, 186E, 187F, 188V, 191K, 208E, 209L, 210G, 211N, 214S, 216R, 250V, 292F, 294R, 297E, 298V
CDD
cd05260 (GDP_MD_SDR_e)

298V

substrate binding site
83S, 84F, 85V, 124T, 125S, 126E, 148Y, 177N, 186E, 187F, 188V, 191K, 208E, 209L, 210G, 211N, 214S, 216R, 250V, 292F, 294R, 297E, 298V
CDD
cd05260 (GDP_MD_SDR_e)
homodimer interfac...

89W

homodimer interface
89W, 92P, 96A, 97E, 100A, 101V, 104T, 105N, 108E, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

92P

homodimer interface
89W, 92P, 96A, 97E, 100A, 101V, 104T, 105N, 108E, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

96A

homodimer interface
89W, 92P, 96A, 97E, 100A, 101V, 104T, 105N, 108E, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

97E

homodimer interface
89W, 92P, 96A, 97E, 100A, 101V, 104T, 105N, 108E, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

100A

homodimer interface
89W, 92P, 96A, 97E, 100A, 101V, 104T, 105N, 108E, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

101V

homodimer interface
89W, 92P, 96A, 97E, 100A, 101V, 104T, 105N, 108E, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

104T

homodimer interface
89W, 92P, 96A, 97E, 100A, 101V, 104T, 105N, 108E, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

105N

homodimer interface
89W, 92P, 96A, 97E, 100A, 101V, 104T, 105N, 108E, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

108E

homodimer interface
89W, 92P, 96A, 97E, 100A, 101V, 104T, 105N, 108E, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

141P

homodimer interface
89W, 92P, 96A, 97E, 100A, 101V, 104T, 105N, 108E, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

142F

homodimer interface
89W, 92P, 96A, 97E, 100A, 101V, 104T, 105N, 108E, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

143Y

homodimer interface
89W, 92P, 96A, 97E, 100A, 101V, 104T, 105N, 108E, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

144P

homodimer interface
89W, 92P, 96A, 97E, 100A, 101V, 104T, 105N, 108E, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

146S

homodimer interface
89W, 92P, 96A, 97E, 100A, 101V, 104T, 105N, 108E, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

147P

homodimer interface
89W, 92P, 96A, 97E, 100A, 101V, 104T, 105N, 108E, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

150V

homodimer interface
89W, 92P, 96A, 97E, 100A, 101V, 104T, 105N, 108E, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

151A

homodimer interface
89W, 92P, 96A, 97E, 100A, 101V, 104T, 105N, 108E, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

153L

homodimer interface
89W, 92P, 96A, 97E, 100A, 101V, 104T, 105N, 108E, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

154Y

homodimer interface
89W, 92P, 96A, 97E, 100A, 101V, 104T, 105N, 108E, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

157W

homodimer interface
89W, 92P, 96A, 97E, 100A, 101V, 104T, 105N, 108E, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

158I

homodimer interface
89W, 92P, 96A, 97E, 100A, 101V, 104T, 105N, 108E, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

160K

homodimer interface
89W, 92P, 96A, 97E, 100A, 101V, 104T, 105N, 108E, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

161N

homodimer interface
89W, 92P, 96A, 97E, 100A, 101V, 104T, 105N, 108E, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

162Y

homodimer interface
89W, 92P, 96A, 97E, 100A, 101V, 104T, 105N, 108E, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

164E

homodimer interface
89W, 92P, 96A, 97E, 100A, 101V, 104T, 105N, 108E, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

165S

homodimer interface
89W, 92P, 96A, 97E, 100A, 101V, 104T, 105N, 108E, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

166Y

homodimer interface
89W, 92P, 96A, 97E, 100A, 101V, 104T, 105N, 108E, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

295P

homodimer interface
89W, 92P, 96A, 97E, 100A, 101V, 104T, 105N, 108E, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)

296A

homodimer interface
89W, 92P, 96A, 97E, 100A, 101V, 104T, 105N, 108E, 141P, 142F, 143Y, 144P, 146S, 147P, 150V, 151A, 153L, 154Y, 157W, 158I, 160K, 161N, 162Y, 164E, 165S, 166Y, 295P, 296A
CDD
cd05260 (GDP_MD_SDR_e)
active site cd05260

99D

active site
99D, 124T, 148Y, 152K
CDD
cd05260 (GDP_MD_SDR_e)

124T

active site
99D, 124T, 148Y, 152K
CDD
cd05260 (GDP_MD_SDR_e)

148Y

active site
99D, 124T, 148Y, 152K
CDD
cd05260 (GDP_MD_SDR_e)

152K

active site
99D, 124T, 148Y, 152K
CDD
cd05260 (GDP_MD_SDR_e)

GO term prediction

Biological Process

GO:0019673 GDP-mannose metabolic process

Molecular Function

GO:0008446 GDP-mannose 4,6-dehydratase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

49185_FusoPortal_Gene_2199

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component