49185_FusoPortal_Gene_2285

Protein

49185_FusoPortal_Gene_2285

Length

667 amino acids

Protein family membership

None predicted.

Homologous superfamilies

Homologous superfamily
325 - 435
PAS domain superfamily (IPR035965)
507 - 667
Histidine kinase/HSP90-like ATPase superfamily (IPR036890)
Homologous superfamily
444 - 517
Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily (IPR036097)

1 100 200 300 400 500 600 667

Domains and repeats

Domain
57 - 280
Solute-binding protein family 3/N-terminal domain of MltF (IPR001638)
459 - 667
Histidine kinase domain (IPR005467)
Domain
330 - 426
PAS domain (IPR000014)
PAS fold (IPR013767)
454 - 513
Signal transduction histidine kinase, dimerisation/phosphoacceptor domain (IPR003661)
566 - 665
Histidine kinase/HSP90-like ATPase (IPR003594)
Domain
598 - 612
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)
616 - 626
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)
629 - 647
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)
653 - 666
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)

1 100 200 300 400 500 600 667

Detailed signature matches

IPR035965

PAS domain superfamily
1. SSF55785 (PYP-like ...)
  
  325 - 435
  
  SUPERFAMILY
  SSF55785 (PYP-like sensor domain (PAS domain))
IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily
1. SSF47384 (Homodimer...)
  
  444 - 517
  
  SUPERFAMILY
  SSF47384 (Homodimeric domain of signal transducing histidine kinase)
IPR036890

Histidine kinase/HSP90-like ATPase superfamily
1. G3DSA:3.30.56...
  
  513 - 667
  
  GENE3D
  G3DSA:3.30.565.10 (G3DSA:3.30.565.10)
2. SSF55874 (ATPase do...)
  
  507 - 665
  
  SUPERFAMILY
  SSF55874 (ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase)
IPR001638

Solute-binding protein family 3/N-terminal domain of MltF
1. PF00497 (SBP_bac_3)
  
  57 - 280
  
  Pfam
  PF00497 (SBP_bac_3)
IPR000014

PAS domain
1. PS50112 (PAS)
  
  330 - 410
  
  PROSITE profiles
  PS50112 (PAS)
2. cd00130 (PAS)
  
  341 - 380
  
  CDD
  cd00130 (PAS)
IPR013767

PAS fold
1. PF00989 (PAS)
  
  337 - 426
  
  Pfam
  PF00989 (PAS)
IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain
1. cd00082 (HisKA)
  
  454 - 513
  
  CDD
  cd00082 (HisKA)
2. PF00512 (HisKA)
  
  454 - 513
  
  Pfam
  PF00512 (HisKA)
IPR005467

Histidine kinase domain
1. PS50109 (HIS_KIN)
  
  459 - 667
  
  PROSITE profiles
  PS50109 (HIS_KIN)
IPR003594

Histidine kinase/HSP90-like ATPase
1. PF02518 (HATPase_c)
  
  566 - 665
  
  Pfam
  PF02518 (HATPase_c)
2. cd00075 (HATPase_c)
  
  566 - 665
  
  CDD
  cd00075 (HATPase_c)
IPR004358

Signal transduction histidine kinase-related protein, C-terminal
1. PR00344 (BCTRLSENSOR)
  
  629 - 647
  
  PRINTS
  PR00344 (BCTRLSENSOR)
  
  653 - 666
  
  PRINTS
  PR00344 (BCTRLSENSOR)
  
  598 - 612
  
  PRINTS
  PR00344 (BCTRLSENSOR)
  
  616 - 626
  
  PRINTS
  PR00344 (BCTRLSENSOR)

no IPR

Unintegrated signatures

G3DSA:1.10.28...

447 - 512

GENE3D
G3DSA:1.10.287.130 (G3DSA:1.10.287.130)
G3DSA:3.30.45...

314 - 446

GENE3D
G3DSA:3.30.450.20 (G3DSA:3.30.450.20)
G3DSA:3.40.19...

177 - 286

GENE3D
G3DSA:3.40.190.10 (G3DSA:3.40.190.10)

51 - 176

GENE3D
G3DSA:3.40.190.10 (G3DSA:3.40.190.10)
PTHR43065 (FAMILY N...)

299 - 663

PANTHER
PTHR43065 (FAMILY NOT NAMED)
PTHR43065:SF7 (SUBF...)

299 - 663

PANTHER
PTHR43065:SF7 (SUBFAMILY NOT NAMED)
SSF53850 (Periplasm...)

55 - 281

SUPERFAMILY
SSF53850 (Periplasmic binding protein-like II)
cd01007 (PBP2_BvgS_...)

54 - 279

CDD
cd01007 (PBP2_BvgS_HisK_like)

Residue annotation

putative active si...

357C

putative active site
357C, 361F, 367Q, 380F
CDD
cd00130 (PAS)

361F

putative active site
357C, 361F, 367Q, 380F
CDD
cd00130 (PAS)

367Q

putative active site
357C, 361F, 367Q, 380F
CDD
cd00130 (PAS)

380F

putative active site
357C, 361F, 367Q, 380F
CDD
cd00130 (PAS)
heme pocket cd00130

377L

heme pocket
377L
CDD
cd00130 (PAS)
dimer interface cd...

456I

dimer interface
456I, 460L, 464I, 467P, 471I, 474G, 490A, 494M, 497S, 501V, 504L, 508L
CDD
cd00082 (HisKA)

460L

dimer interface
456I, 460L, 464I, 467P, 471I, 474G, 490A, 494M, 497S, 501V, 504L, 508L
CDD
cd00082 (HisKA)

464I

dimer interface
456I, 460L, 464I, 467P, 471I, 474G, 490A, 494M, 497S, 501V, 504L, 508L
CDD
cd00082 (HisKA)

467P

dimer interface
456I, 460L, 464I, 467P, 471I, 474G, 490A, 494M, 497S, 501V, 504L, 508L
CDD
cd00082 (HisKA)

471I

dimer interface
456I, 460L, 464I, 467P, 471I, 474G, 490A, 494M, 497S, 501V, 504L, 508L
CDD
cd00082 (HisKA)

474G

dimer interface
456I, 460L, 464I, 467P, 471I, 474G, 490A, 494M, 497S, 501V, 504L, 508L
CDD
cd00082 (HisKA)

490A

dimer interface
456I, 460L, 464I, 467P, 471I, 474G, 490A, 494M, 497S, 501V, 504L, 508L
CDD
cd00082 (HisKA)

494M

dimer interface
456I, 460L, 464I, 467P, 471I, 474G, 490A, 494M, 497S, 501V, 504L, 508L
CDD
cd00082 (HisKA)

497S

dimer interface
456I, 460L, 464I, 467P, 471I, 474G, 490A, 494M, 497S, 501V, 504L, 508L
CDD
cd00082 (HisKA)

501V

dimer interface
456I, 460L, 464I, 467P, 471I, 474G, 490A, 494M, 497S, 501V, 504L, 508L
CDD
cd00082 (HisKA)

504L

dimer interface
456I, 460L, 464I, 467P, 471I, 474G, 490A, 494M, 497S, 501V, 504L, 508L
CDD
cd00082 (HisKA)

508L

dimer interface
456I, 460L, 464I, 467P, 471I, 474G, 490A, 494M, 497S, 501V, 504L, 508L
CDD
cd00082 (HisKA)
phosphorylation si...

462H

phosphorylation site
462H
CDD
cd00082 (HisKA)
ATP binding site c...

569N

ATP binding site
569N, 573N, 576D, 602I, 604D, 606G, 608G, 609I, 632G, 633L, 634G, 635L, 651V, 653S, 658G, 659T, 661F
CDD
cd00075 (HATPase_c)

573N

ATP binding site
569N, 573N, 576D, 602I, 604D, 606G, 608G, 609I, 632G, 633L, 634G, 635L, 651V, 653S, 658G, 659T, 661F
CDD
cd00075 (HATPase_c)

576D

ATP binding site
569N, 573N, 576D, 602I, 604D, 606G, 608G, 609I, 632G, 633L, 634G, 635L, 651V, 653S, 658G, 659T, 661F
CDD
cd00075 (HATPase_c)

602I

ATP binding site
569N, 573N, 576D, 602I, 604D, 606G, 608G, 609I, 632G, 633L, 634G, 635L, 651V, 653S, 658G, 659T, 661F
CDD
cd00075 (HATPase_c)

604D

ATP binding site
569N, 573N, 576D, 602I, 604D, 606G, 608G, 609I, 632G, 633L, 634G, 635L, 651V, 653S, 658G, 659T, 661F
CDD
cd00075 (HATPase_c)

606G

ATP binding site
569N, 573N, 576D, 602I, 604D, 606G, 608G, 609I, 632G, 633L, 634G, 635L, 651V, 653S, 658G, 659T, 661F
CDD
cd00075 (HATPase_c)

608G

ATP binding site
569N, 573N, 576D, 602I, 604D, 606G, 608G, 609I, 632G, 633L, 634G, 635L, 651V, 653S, 658G, 659T, 661F
CDD
cd00075 (HATPase_c)

609I

ATP binding site
569N, 573N, 576D, 602I, 604D, 606G, 608G, 609I, 632G, 633L, 634G, 635L, 651V, 653S, 658G, 659T, 661F
CDD
cd00075 (HATPase_c)

632G

ATP binding site
569N, 573N, 576D, 602I, 604D, 606G, 608G, 609I, 632G, 633L, 634G, 635L, 651V, 653S, 658G, 659T, 661F
CDD
cd00075 (HATPase_c)

633L

ATP binding site
569N, 573N, 576D, 602I, 604D, 606G, 608G, 609I, 632G, 633L, 634G, 635L, 651V, 653S, 658G, 659T, 661F
CDD
cd00075 (HATPase_c)

634G

ATP binding site
569N, 573N, 576D, 602I, 604D, 606G, 608G, 609I, 632G, 633L, 634G, 635L, 651V, 653S, 658G, 659T, 661F
CDD
cd00075 (HATPase_c)

635L

ATP binding site
569N, 573N, 576D, 602I, 604D, 606G, 608G, 609I, 632G, 633L, 634G, 635L, 651V, 653S, 658G, 659T, 661F
CDD
cd00075 (HATPase_c)

651V

ATP binding site
569N, 573N, 576D, 602I, 604D, 606G, 608G, 609I, 632G, 633L, 634G, 635L, 651V, 653S, 658G, 659T, 661F
CDD
cd00075 (HATPase_c)

653S

ATP binding site
569N, 573N, 576D, 602I, 604D, 606G, 608G, 609I, 632G, 633L, 634G, 635L, 651V, 653S, 658G, 659T, 661F
CDD
cd00075 (HATPase_c)

658G

ATP binding site
569N, 573N, 576D, 602I, 604D, 606G, 608G, 609I, 632G, 633L, 634G, 635L, 651V, 653S, 658G, 659T, 661F
CDD
cd00075 (HATPase_c)

659T

ATP binding site
569N, 573N, 576D, 602I, 604D, 606G, 608G, 609I, 632G, 633L, 634G, 635L, 651V, 653S, 658G, 659T, 661F
CDD
cd00075 (HATPase_c)

661F

ATP binding site
569N, 573N, 576D, 602I, 604D, 606G, 608G, 609I, 632G, 633L, 634G, 635L, 651V, 653S, 658G, 659T, 661F
CDD
cd00075 (HATPase_c)
Mg2+ binding site ...

573N

Mg2+ binding site
573N
CDD
cd00075 (HATPase_c)
G-X-G motif cd00075

606G

G-X-G motif
606G, 608G, 632G, 634G
CDD
cd00075 (HATPase_c)

608G

G-X-G motif
606G, 608G, 632G, 634G
CDD
cd00075 (HATPase_c)

632G

G-X-G motif
606G, 608G, 632G, 634G
CDD
cd00075 (HATPase_c)

634G

G-X-G motif
606G, 608G, 632G, 634G
CDD
cd00075 (HATPase_c)

GO term prediction

Biological Process

GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0016310 phosphorylation

Molecular Function

GO:0000155 phosphorelay sensor kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

49185_FusoPortal_Gene_2285

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component