49185_FusoPortal_Gene_2304

Protein

49185_FusoPortal_Gene_2304

Length

258 amino acids

Protein family membership

Crotonase superfamily (IPR001753)

Homologous superfamilies

Homologous superfamily
1 - 251
ClpP/crotonase-like domain superfamily (IPR029045)
Homologous superfamily
218 - 253
Crontonase, C-terminal (IPR014748)

1 50 100 150 200 258

Domains and repeats

None predicted.

Detailed signature matches

IPR029045

ClpP/crotonase-like domain superfamily
1. SSF52096 (ClpP/crot...)
  
  1 - 251
  
  SUPERFAMILY
  SSF52096 (ClpP/crotonase)
IPR014748

Crontonase, C-terminal
1. G3DSA:1.10.12.10
  
  218 - 253
  
  GENE3D
  G3DSA:1.10.12.10 (G3DSA:1.10.12.10)
IPR001753

Crotonase superfamily
1. PF00378 (ECH_1)
  
  10 - 252
  
  Pfam
  PF00378 (ECH_1)
IPR018376

Enoyl-CoA hydratase/isomerase, conserved site
1. PS00166 (ENOYL_COA_...)
  
  98 - 118
  
  PROSITE patterns
  PS00166 (ENOYL_COA_HYDRATASE)

no IPR

Unintegrated signatures

G3DSA:3.90.22...

1 - 217

GENE3D
G3DSA:3.90.226.10 (G3DSA:3.90.226.10)
PTHR11941 (ENOYL-CO...)

10 - 251

PANTHER
PTHR11941 (ENOYL-COA HYDRATASE-RELATED)
cd06558 (crotonase-...)

4 - 196

CDD
cd06558 (crotonase-like)

Residue annotation

substrate binding ...

23L

substrate binding site
23L, 25A, 57K, 61A, 62G, 63A, 64D, 65I, 104F, 106L, 107G, 108G, 130P, 131E, 134L
CDD
cd06558 (crotonase-like)

25A

substrate binding site
23L, 25A, 57K, 61A, 62G, 63A, 64D, 65I, 104F, 106L, 107G, 108G, 130P, 131E, 134L
CDD
cd06558 (crotonase-like)

57K

substrate binding site
23L, 25A, 57K, 61A, 62G, 63A, 64D, 65I, 104F, 106L, 107G, 108G, 130P, 131E, 134L
CDD
cd06558 (crotonase-like)

61A

substrate binding site
23L, 25A, 57K, 61A, 62G, 63A, 64D, 65I, 104F, 106L, 107G, 108G, 130P, 131E, 134L
CDD
cd06558 (crotonase-like)

62G

substrate binding site
23L, 25A, 57K, 61A, 62G, 63A, 64D, 65I, 104F, 106L, 107G, 108G, 130P, 131E, 134L
CDD
cd06558 (crotonase-like)

63A

substrate binding site
23L, 25A, 57K, 61A, 62G, 63A, 64D, 65I, 104F, 106L, 107G, 108G, 130P, 131E, 134L
CDD
cd06558 (crotonase-like)

64D

substrate binding site
23L, 25A, 57K, 61A, 62G, 63A, 64D, 65I, 104F, 106L, 107G, 108G, 130P, 131E, 134L
CDD
cd06558 (crotonase-like)

65I

substrate binding site
23L, 25A, 57K, 61A, 62G, 63A, 64D, 65I, 104F, 106L, 107G, 108G, 130P, 131E, 134L
CDD
cd06558 (crotonase-like)

104F

substrate binding site
23L, 25A, 57K, 61A, 62G, 63A, 64D, 65I, 104F, 106L, 107G, 108G, 130P, 131E, 134L
CDD
cd06558 (crotonase-like)

106L

substrate binding site
23L, 25A, 57K, 61A, 62G, 63A, 64D, 65I, 104F, 106L, 107G, 108G, 130P, 131E, 134L
CDD
cd06558 (crotonase-like)

107G

substrate binding site
23L, 25A, 57K, 61A, 62G, 63A, 64D, 65I, 104F, 106L, 107G, 108G, 130P, 131E, 134L
CDD
cd06558 (crotonase-like)

108G

substrate binding site
23L, 25A, 57K, 61A, 62G, 63A, 64D, 65I, 104F, 106L, 107G, 108G, 130P, 131E, 134L
CDD
cd06558 (crotonase-like)

130P

substrate binding site
23L, 25A, 57K, 61A, 62G, 63A, 64D, 65I, 104F, 106L, 107G, 108G, 130P, 131E, 134L
CDD
cd06558 (crotonase-like)

131E

substrate binding site
23L, 25A, 57K, 61A, 62G, 63A, 64D, 65I, 104F, 106L, 107G, 108G, 130P, 131E, 134L
CDD
cd06558 (crotonase-like)

134L

substrate binding site
23L, 25A, 57K, 61A, 62G, 63A, 64D, 65I, 104F, 106L, 107G, 108G, 130P, 131E, 134L
CDD
cd06558 (crotonase-like)
oxyanion hole (OAH...

63A

oxyanion hole (OAH) forming residues
63A, 108G
CDD
cd06558 (crotonase-like)

108G

oxyanion hole (OAH) forming residues
63A, 108G
CDD
cd06558 (crotonase-like)
trimer interface c...

88R

trimer interface
88R, 96P, 117D, 118I, 119R, 120I, 132V, 133G, 134L, 135G, 141G, 143T, 144Q, 145R, 147A, 148R, 153G, 154K, 156K, 157E, 159I, 160Y, 163T, 174G, 177N, 192L, 195K, 196I
CDD
cd06558 (crotonase-like)

96P

trimer interface
88R, 96P, 117D, 118I, 119R, 120I, 132V, 133G, 134L, 135G, 141G, 143T, 144Q, 145R, 147A, 148R, 153G, 154K, 156K, 157E, 159I, 160Y, 163T, 174G, 177N, 192L, 195K, 196I
CDD
cd06558 (crotonase-like)

117D

trimer interface
88R, 96P, 117D, 118I, 119R, 120I, 132V, 133G, 134L, 135G, 141G, 143T, 144Q, 145R, 147A, 148R, 153G, 154K, 156K, 157E, 159I, 160Y, 163T, 174G, 177N, 192L, 195K, 196I
CDD
cd06558 (crotonase-like)

118I

trimer interface
88R, 96P, 117D, 118I, 119R, 120I, 132V, 133G, 134L, 135G, 141G, 143T, 144Q, 145R, 147A, 148R, 153G, 154K, 156K, 157E, 159I, 160Y, 163T, 174G, 177N, 192L, 195K, 196I
CDD
cd06558 (crotonase-like)

119R

trimer interface
88R, 96P, 117D, 118I, 119R, 120I, 132V, 133G, 134L, 135G, 141G, 143T, 144Q, 145R, 147A, 148R, 153G, 154K, 156K, 157E, 159I, 160Y, 163T, 174G, 177N, 192L, 195K, 196I
CDD
cd06558 (crotonase-like)

120I

trimer interface
88R, 96P, 117D, 118I, 119R, 120I, 132V, 133G, 134L, 135G, 141G, 143T, 144Q, 145R, 147A, 148R, 153G, 154K, 156K, 157E, 159I, 160Y, 163T, 174G, 177N, 192L, 195K, 196I
CDD
cd06558 (crotonase-like)

132V

trimer interface
88R, 96P, 117D, 118I, 119R, 120I, 132V, 133G, 134L, 135G, 141G, 143T, 144Q, 145R, 147A, 148R, 153G, 154K, 156K, 157E, 159I, 160Y, 163T, 174G, 177N, 192L, 195K, 196I
CDD
cd06558 (crotonase-like)

133G

trimer interface
88R, 96P, 117D, 118I, 119R, 120I, 132V, 133G, 134L, 135G, 141G, 143T, 144Q, 145R, 147A, 148R, 153G, 154K, 156K, 157E, 159I, 160Y, 163T, 174G, 177N, 192L, 195K, 196I
CDD
cd06558 (crotonase-like)

134L

trimer interface
88R, 96P, 117D, 118I, 119R, 120I, 132V, 133G, 134L, 135G, 141G, 143T, 144Q, 145R, 147A, 148R, 153G, 154K, 156K, 157E, 159I, 160Y, 163T, 174G, 177N, 192L, 195K, 196I
CDD
cd06558 (crotonase-like)

135G

trimer interface
88R, 96P, 117D, 118I, 119R, 120I, 132V, 133G, 134L, 135G, 141G, 143T, 144Q, 145R, 147A, 148R, 153G, 154K, 156K, 157E, 159I, 160Y, 163T, 174G, 177N, 192L, 195K, 196I
CDD
cd06558 (crotonase-like)

141G

trimer interface
88R, 96P, 117D, 118I, 119R, 120I, 132V, 133G, 134L, 135G, 141G, 143T, 144Q, 145R, 147A, 148R, 153G, 154K, 156K, 157E, 159I, 160Y, 163T, 174G, 177N, 192L, 195K, 196I
CDD
cd06558 (crotonase-like)

143T

trimer interface
88R, 96P, 117D, 118I, 119R, 120I, 132V, 133G, 134L, 135G, 141G, 143T, 144Q, 145R, 147A, 148R, 153G, 154K, 156K, 157E, 159I, 160Y, 163T, 174G, 177N, 192L, 195K, 196I
CDD
cd06558 (crotonase-like)

144Q

trimer interface
88R, 96P, 117D, 118I, 119R, 120I, 132V, 133G, 134L, 135G, 141G, 143T, 144Q, 145R, 147A, 148R, 153G, 154K, 156K, 157E, 159I, 160Y, 163T, 174G, 177N, 192L, 195K, 196I
CDD
cd06558 (crotonase-like)

145R

trimer interface
88R, 96P, 117D, 118I, 119R, 120I, 132V, 133G, 134L, 135G, 141G, 143T, 144Q, 145R, 147A, 148R, 153G, 154K, 156K, 157E, 159I, 160Y, 163T, 174G, 177N, 192L, 195K, 196I
CDD
cd06558 (crotonase-like)

147A

trimer interface
88R, 96P, 117D, 118I, 119R, 120I, 132V, 133G, 134L, 135G, 141G, 143T, 144Q, 145R, 147A, 148R, 153G, 154K, 156K, 157E, 159I, 160Y, 163T, 174G, 177N, 192L, 195K, 196I
CDD
cd06558 (crotonase-like)

148R

trimer interface
88R, 96P, 117D, 118I, 119R, 120I, 132V, 133G, 134L, 135G, 141G, 143T, 144Q, 145R, 147A, 148R, 153G, 154K, 156K, 157E, 159I, 160Y, 163T, 174G, 177N, 192L, 195K, 196I
CDD
cd06558 (crotonase-like)

153G

trimer interface
88R, 96P, 117D, 118I, 119R, 120I, 132V, 133G, 134L, 135G, 141G, 143T, 144Q, 145R, 147A, 148R, 153G, 154K, 156K, 157E, 159I, 160Y, 163T, 174G, 177N, 192L, 195K, 196I
CDD
cd06558 (crotonase-like)

154K

trimer interface
88R, 96P, 117D, 118I, 119R, 120I, 132V, 133G, 134L, 135G, 141G, 143T, 144Q, 145R, 147A, 148R, 153G, 154K, 156K, 157E, 159I, 160Y, 163T, 174G, 177N, 192L, 195K, 196I
CDD
cd06558 (crotonase-like)

156K

trimer interface
88R, 96P, 117D, 118I, 119R, 120I, 132V, 133G, 134L, 135G, 141G, 143T, 144Q, 145R, 147A, 148R, 153G, 154K, 156K, 157E, 159I, 160Y, 163T, 174G, 177N, 192L, 195K, 196I
CDD
cd06558 (crotonase-like)

157E

trimer interface
88R, 96P, 117D, 118I, 119R, 120I, 132V, 133G, 134L, 135G, 141G, 143T, 144Q, 145R, 147A, 148R, 153G, 154K, 156K, 157E, 159I, 160Y, 163T, 174G, 177N, 192L, 195K, 196I
CDD
cd06558 (crotonase-like)

159I

trimer interface
88R, 96P, 117D, 118I, 119R, 120I, 132V, 133G, 134L, 135G, 141G, 143T, 144Q, 145R, 147A, 148R, 153G, 154K, 156K, 157E, 159I, 160Y, 163T, 174G, 177N, 192L, 195K, 196I
CDD
cd06558 (crotonase-like)

160Y

trimer interface
88R, 96P, 117D, 118I, 119R, 120I, 132V, 133G, 134L, 135G, 141G, 143T, 144Q, 145R, 147A, 148R, 153G, 154K, 156K, 157E, 159I, 160Y, 163T, 174G, 177N, 192L, 195K, 196I
CDD
cd06558 (crotonase-like)

163T

trimer interface
88R, 96P, 117D, 118I, 119R, 120I, 132V, 133G, 134L, 135G, 141G, 143T, 144Q, 145R, 147A, 148R, 153G, 154K, 156K, 157E, 159I, 160Y, 163T, 174G, 177N, 192L, 195K, 196I
CDD
cd06558 (crotonase-like)

174G

trimer interface
88R, 96P, 117D, 118I, 119R, 120I, 132V, 133G, 134L, 135G, 141G, 143T, 144Q, 145R, 147A, 148R, 153G, 154K, 156K, 157E, 159I, 160Y, 163T, 174G, 177N, 192L, 195K, 196I
CDD
cd06558 (crotonase-like)

177N

trimer interface
88R, 96P, 117D, 118I, 119R, 120I, 132V, 133G, 134L, 135G, 141G, 143T, 144Q, 145R, 147A, 148R, 153G, 154K, 156K, 157E, 159I, 160Y, 163T, 174G, 177N, 192L, 195K, 196I
CDD
cd06558 (crotonase-like)

192L

trimer interface
88R, 96P, 117D, 118I, 119R, 120I, 132V, 133G, 134L, 135G, 141G, 143T, 144Q, 145R, 147A, 148R, 153G, 154K, 156K, 157E, 159I, 160Y, 163T, 174G, 177N, 192L, 195K, 196I
CDD
cd06558 (crotonase-like)

195K

trimer interface
88R, 96P, 117D, 118I, 119R, 120I, 132V, 133G, 134L, 135G, 141G, 143T, 144Q, 145R, 147A, 148R, 153G, 154K, 156K, 157E, 159I, 160Y, 163T, 174G, 177N, 192L, 195K, 196I
CDD
cd06558 (crotonase-like)

196I

trimer interface
88R, 96P, 117D, 118I, 119R, 120I, 132V, 133G, 134L, 135G, 141G, 143T, 144Q, 145R, 147A, 148R, 153G, 154K, 156K, 157E, 159I, 160Y, 163T, 174G, 177N, 192L, 195K, 196I
CDD
cd06558 (crotonase-like)

GO term prediction

Biological Process

GO:0008152 metabolic process

Molecular Function

GO:0003824 catalytic activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

49185_FusoPortal_Gene_2304

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component