49185_FusoPortal_Gene_234

Protein

49185_FusoPortal_Gene_234

Length

490 amino acids

Protein family membership

Glutamate mutase epsilon subunit (IPR006396)

Homologous superfamilies

Homologous superfamily
1 - 483
Cobalamin (vitamin B12)-dependent enzyme, catalytic (IPR016176)
Homologous superfamily
418 - 482
Glutamate mutase E subunit, C-terminal domain superfamily (IPR014714)

1 50 100 150 200 250 300 350 400 450 490

Domains and repeats

None predicted.

Detailed signature matches

IPR016176

Cobalamin (vitamin B12)-dependent enzyme, catalytic
1. G3DSA:3.20.20...
  
  1 - 417
  
  GENE3D
  G3DSA:3.20.20.240 (G3DSA:3.20.20.240)
2. SSF51703 (Cobalamin...)
  
  1 - 483
  
  SUPERFAMILY
  SSF51703 (Cobalamin (vitamin B12)-dependent enzymes)
IPR014714

Glutamate mutase E subunit, C-terminal domain superfamily
1. G3DSA:3.90.97...
  
  418 - 482
  
  GENE3D
  G3DSA:3.90.970.10 (G3DSA:3.90.970.10)
IPR006396

Glutamate mutase epsilon subunit
1. MF_01923 (Me_Asp_mu...)
  
  2 - 482
  
  HAMAP
  MF_01923 (Me_Asp_mutase_E)
2. TIGR01503
  
  3 - 482
  
  TIGRFAMs
  TIGR01503 (TIGR01503)
3. PIRSF001495 (Met_as...)
  
  1 - 483
  
  PIRSF
  PIRSF001495 (Met_asp_mut_epsi)
4. cd00245 (Glm_e)
  
  46 - 473
  
  CDD
  cd00245 (Glm_e)
5. PF06368 (Met_asp_mut_E)
  
  42 - 482
  
  Pfam
  PF06368 (Met_asp_mut_E)

Residue annotation

substrate binding ...

66R

substrate binding site
66R, 94T, 100R, 149R, 150H, 171E, 177Y, 181Y, 216F
CDD
cd00245 (Glm_e)

94T

substrate binding site
66R, 94T, 100R, 149R, 150H, 171E, 177Y, 181Y, 216F
CDD
cd00245 (Glm_e)

100R

substrate binding site
66R, 94T, 100R, 149R, 150H, 171E, 177Y, 181Y, 216F
CDD
cd00245 (Glm_e)

149R

substrate binding site
66R, 94T, 100R, 149R, 150H, 171E, 177Y, 181Y, 216F
CDD
cd00245 (Glm_e)

150H

substrate binding site
66R, 94T, 100R, 149R, 150H, 171E, 177Y, 181Y, 216F
CDD
cd00245 (Glm_e)

171E

substrate binding site
66R, 94T, 100R, 149R, 150H, 171E, 177Y, 181Y, 216F
CDD
cd00245 (Glm_e)

177Y

substrate binding site
66R, 94T, 100R, 149R, 150H, 171E, 177Y, 181Y, 216F
CDD
cd00245 (Glm_e)

181Y

substrate binding site
66R, 94T, 100R, 149R, 150H, 171E, 177Y, 181Y, 216F
CDD
cd00245 (Glm_e)

216F

substrate binding site
66R, 94T, 100R, 149R, 150H, 171E, 177Y, 181Y, 216F
CDD
cd00245 (Glm_e)
B12 cofactor bindi...

94T

B12 cofactor binding site
94T, 180P, 220T, 294M, 295G, 296G, 297F, 329H, 330E, 333G, 334V, 471F
CDD
cd00245 (Glm_e)

180P

B12 cofactor binding site
94T, 180P, 220T, 294M, 295G, 296G, 297F, 329H, 330E, 333G, 334V, 471F
CDD
cd00245 (Glm_e)

220T

B12 cofactor binding site
94T, 180P, 220T, 294M, 295G, 296G, 297F, 329H, 330E, 333G, 334V, 471F
CDD
cd00245 (Glm_e)

294M

B12 cofactor binding site
94T, 180P, 220T, 294M, 295G, 296G, 297F, 329H, 330E, 333G, 334V, 471F
CDD
cd00245 (Glm_e)

295G

B12 cofactor binding site
94T, 180P, 220T, 294M, 295G, 296G, 297F, 329H, 330E, 333G, 334V, 471F
CDD
cd00245 (Glm_e)

296G

B12 cofactor binding site
94T, 180P, 220T, 294M, 295G, 296G, 297F, 329H, 330E, 333G, 334V, 471F
CDD
cd00245 (Glm_e)

297F

B12 cofactor binding site
94T, 180P, 220T, 294M, 295G, 296G, 297F, 329H, 330E, 333G, 334V, 471F
CDD
cd00245 (Glm_e)

329H

B12 cofactor binding site
94T, 180P, 220T, 294M, 295G, 296G, 297F, 329H, 330E, 333G, 334V, 471F
CDD
cd00245 (Glm_e)

330E

B12 cofactor binding site
94T, 180P, 220T, 294M, 295G, 296G, 297F, 329H, 330E, 333G, 334V, 471F
CDD
cd00245 (Glm_e)

333G

B12 cofactor binding site
94T, 180P, 220T, 294M, 295G, 296G, 297F, 329H, 330E, 333G, 334V, 471F
CDD
cd00245 (Glm_e)

334V

B12 cofactor binding site
94T, 180P, 220T, 294M, 295G, 296G, 297F, 329H, 330E, 333G, 334V, 471F
CDD
cd00245 (Glm_e)

471F

B12 cofactor binding site
94T, 180P, 220T, 294M, 295G, 296G, 297F, 329H, 330E, 333G, 334V, 471F
CDD
cd00245 (Glm_e)
heterodimer (sigma...

97S

heterodimer (sigma-epsilon) interface
97S, 98Y, 101Q, 122L, 123N, 180P, 181Y, 183K, 331A, 332I, 467V
CDD
cd00245 (Glm_e)

98Y

heterodimer (sigma-epsilon) interface
97S, 98Y, 101Q, 122L, 123N, 180P, 181Y, 183K, 331A, 332I, 467V
CDD
cd00245 (Glm_e)

101Q

heterodimer (sigma-epsilon) interface
97S, 98Y, 101Q, 122L, 123N, 180P, 181Y, 183K, 331A, 332I, 467V
CDD
cd00245 (Glm_e)

122L

heterodimer (sigma-epsilon) interface
97S, 98Y, 101Q, 122L, 123N, 180P, 181Y, 183K, 331A, 332I, 467V
CDD
cd00245 (Glm_e)

123N

heterodimer (sigma-epsilon) interface
97S, 98Y, 101Q, 122L, 123N, 180P, 181Y, 183K, 331A, 332I, 467V
CDD
cd00245 (Glm_e)

180P

heterodimer (sigma-epsilon) interface
97S, 98Y, 101Q, 122L, 123N, 180P, 181Y, 183K, 331A, 332I, 467V
CDD
cd00245 (Glm_e)

181Y

heterodimer (sigma-epsilon) interface
97S, 98Y, 101Q, 122L, 123N, 180P, 181Y, 183K, 331A, 332I, 467V
CDD
cd00245 (Glm_e)

183K

heterodimer (sigma-epsilon) interface
97S, 98Y, 101Q, 122L, 123N, 180P, 181Y, 183K, 331A, 332I, 467V
CDD
cd00245 (Glm_e)

331A

heterodimer (sigma-epsilon) interface
97S, 98Y, 101Q, 122L, 123N, 180P, 181Y, 183K, 331A, 332I, 467V
CDD
cd00245 (Glm_e)

332I

heterodimer (sigma-epsilon) interface
97S, 98Y, 101Q, 122L, 123N, 180P, 181Y, 183K, 331A, 332I, 467V
CDD
cd00245 (Glm_e)

467V

heterodimer (sigma-epsilon) interface
97S, 98Y, 101Q, 122L, 123N, 180P, 181Y, 183K, 331A, 332I, 467V
CDD
cd00245 (Glm_e)
homodimer (epsilon...

256G

homodimer (epsilon-epsilon) interface
256G, 258L, 300D, 302A, 303K, 309S, 310N, 313S, 342M, 345K, 346A, 349M, 352N, 425V, 473V
CDD
cd00245 (Glm_e)

258L

homodimer (epsilon-epsilon) interface
256G, 258L, 300D, 302A, 303K, 309S, 310N, 313S, 342M, 345K, 346A, 349M, 352N, 425V, 473V
CDD
cd00245 (Glm_e)

300D

homodimer (epsilon-epsilon) interface
256G, 258L, 300D, 302A, 303K, 309S, 310N, 313S, 342M, 345K, 346A, 349M, 352N, 425V, 473V
CDD
cd00245 (Glm_e)

302A

homodimer (epsilon-epsilon) interface
256G, 258L, 300D, 302A, 303K, 309S, 310N, 313S, 342M, 345K, 346A, 349M, 352N, 425V, 473V
CDD
cd00245 (Glm_e)

303K

homodimer (epsilon-epsilon) interface
256G, 258L, 300D, 302A, 303K, 309S, 310N, 313S, 342M, 345K, 346A, 349M, 352N, 425V, 473V
CDD
cd00245 (Glm_e)

309S

homodimer (epsilon-epsilon) interface
256G, 258L, 300D, 302A, 303K, 309S, 310N, 313S, 342M, 345K, 346A, 349M, 352N, 425V, 473V
CDD
cd00245 (Glm_e)

310N

homodimer (epsilon-epsilon) interface
256G, 258L, 300D, 302A, 303K, 309S, 310N, 313S, 342M, 345K, 346A, 349M, 352N, 425V, 473V
CDD
cd00245 (Glm_e)

313S

homodimer (epsilon-epsilon) interface
256G, 258L, 300D, 302A, 303K, 309S, 310N, 313S, 342M, 345K, 346A, 349M, 352N, 425V, 473V
CDD
cd00245 (Glm_e)

342M

homodimer (epsilon-epsilon) interface
256G, 258L, 300D, 302A, 303K, 309S, 310N, 313S, 342M, 345K, 346A, 349M, 352N, 425V, 473V
CDD
cd00245 (Glm_e)

345K

homodimer (epsilon-epsilon) interface
256G, 258L, 300D, 302A, 303K, 309S, 310N, 313S, 342M, 345K, 346A, 349M, 352N, 425V, 473V
CDD
cd00245 (Glm_e)

346A

homodimer (epsilon-epsilon) interface
256G, 258L, 300D, 302A, 303K, 309S, 310N, 313S, 342M, 345K, 346A, 349M, 352N, 425V, 473V
CDD
cd00245 (Glm_e)

349M

homodimer (epsilon-epsilon) interface
256G, 258L, 300D, 302A, 303K, 309S, 310N, 313S, 342M, 345K, 346A, 349M, 352N, 425V, 473V
CDD
cd00245 (Glm_e)

352N

homodimer (epsilon-epsilon) interface
256G, 258L, 300D, 302A, 303K, 309S, 310N, 313S, 342M, 345K, 346A, 349M, 352N, 425V, 473V
CDD
cd00245 (Glm_e)

425V

homodimer (epsilon-epsilon) interface
256G, 258L, 300D, 302A, 303K, 309S, 310N, 313S, 342M, 345K, 346A, 349M, 352N, 425V, 473V
CDD
cd00245 (Glm_e)

473V

homodimer (epsilon-epsilon) interface
256G, 258L, 300D, 302A, 303K, 309S, 310N, 313S, 342M, 345K, 346A, 349M, 352N, 425V, 473V
CDD
cd00245 (Glm_e)

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0019670 anaerobic glutamate catabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0016866 intramolecular transferase activity
GO:0031419 cobalamin binding
GO:0050097 methylaspartate mutase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

49185_FusoPortal_Gene_234

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component