49185_FusoPortal_Gene_2819

Protein

49185_FusoPortal_Gene_2819

Length

475 amino acids

Protein family membership

Asparaginase/glutaminase-like (IPR006034)
- L-asparaginase, type I (IPR006033)

Homologous superfamilies

Homologous superfamily
1 - 216
L-asparaginase, N-terminal domain superfamily (IPR037152)
217 - 345
L-asparaginase, C-terminal (IPR027473)
Homologous superfamily
2 - 343
Asparaginase/glutaminase-like superfamily (IPR036152)

1 50 100 150 200 250 300 350 400 450 475

Domains and repeats

Domain
4 - 197
L-asparaginase, N-terminal (IPR027474)

1 50 100 150 200 250 300 350 400 450 475

Detailed signature matches

IPR037152

L-asparaginase, N-terminal domain superfamily
1. G3DSA:3.40.50...
  
  1 - 216
  
  GENE3D
  G3DSA:3.40.50.1170 (G3DSA:3.40.50.1170)
IPR036152

Asparaginase/glutaminase-like superfamily
1. SSF53774 (Glutamina...)
  
  2 - 343
  
  SUPERFAMILY
  SSF53774 (Glutaminase/Asparaginase)
IPR027473

L-asparaginase, C-terminal
1. G3DSA:3.40.50.40
  
  217 - 345
  
  GENE3D
  G3DSA:3.40.50.40 (G3DSA:3.40.50.40)
IPR006034

Asparaginase/glutaminase-like
1. PR00139 (ASNGLNASE)
  
  268 - 286
  
  PRINTS
  PR00139 (ASNGLNASE)
  
  83 - 101
  
  PRINTS
  PR00139 (ASNGLNASE)
  
  5 - 16
  
  PRINTS
  PR00139 (ASNGLNASE)
2. PS51732 (ASN_GLN_ASE_3)
  
  3 - 337
  
  PROSITE profiles
  PS51732 (ASN_GLN_ASE_3)
IPR006033

L-asparaginase, type I
1. TIGR00519
  
  3 - 341
  
  TIGRFAMs
  TIGR00519 (TIGR00519)
IPR027474

L-asparaginase, N-terminal
1. PF00710 (Asparaginase)
  
  4 - 197
  
  Pfam
  PF00710 (Asparaginase)
IPR020827

Asparaginase/glutaminase, active site 1
1. PS00144 (ASN_GLN_ASE_1)
  
  7 - 15
  
  PROSITE patterns
  PS00144 (ASN_GLN_ASE_1)
IPR027475

Asparaginase/glutaminase, active site 2
1. PS00917 (ASN_GLN_ASE_2)
  
  84 - 94
  
  PROSITE patterns
  PS00917 (ASN_GLN_ASE_2)

no IPR

Unintegrated signatures

PTHR11707 (L-ASPARA...)

4 - 351

PANTHER
PTHR11707 (L-ASPARAGINASE)
PTHR11707:SF28 (60 ...)

4 - 351

PANTHER
PTHR11707:SF28 (60 KDA LYSOPHOSPHOLIPASE)
SFLDS00057 (Glutami...)

3 - 343

SFLD
SFLDS00057 (Glutaminase/Asparaginase)
cd08963 (L-asparagi...)

4 - 332

CDD
cd08963 (L-asparaginase_I)

Residue annotation

active site cd08963

12G

active site
12G, 13T, 60S, 61S, 90G, 91T, 92D, 117S, 168K
CDD
cd08963 (L-asparaginase_I)

13T

active site
12G, 13T, 60S, 61S, 90G, 91T, 92D, 117S, 168K
CDD
cd08963 (L-asparaginase_I)

60S

active site
12G, 13T, 60S, 61S, 90G, 91T, 92D, 117S, 168K
CDD
cd08963 (L-asparaginase_I)

61S

active site
12G, 13T, 60S, 61S, 90G, 91T, 92D, 117S, 168K
CDD
cd08963 (L-asparaginase_I)

90G

active site
12G, 13T, 60S, 61S, 90G, 91T, 92D, 117S, 168K
CDD
cd08963 (L-asparaginase_I)

91T

active site
12G, 13T, 60S, 61S, 90G, 91T, 92D, 117S, 168K
CDD
cd08963 (L-asparaginase_I)

92D

active site
12G, 13T, 60S, 61S, 90G, 91T, 92D, 117S, 168K
CDD
cd08963 (L-asparaginase_I)

117S

active site
12G, 13T, 60S, 61S, 90G, 91T, 92D, 117S, 168K
CDD
cd08963 (L-asparaginase_I)

168K

active site
12G, 13T, 60S, 61S, 90G, 91T, 92D, 117S, 168K
CDD
cd08963 (L-asparaginase_I)
SFLDS00057

13T

SFLD_Res01
13T, 115T
SFLD
SFLDS00057 (Glutaminase/Asparaginase)

115T

SFLD_Res01
13T, 115T
SFLD
SFLDS00057 (Glutaminase/Asparaginase)
homodimer interfac...

13T

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

22G

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

28L

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

29R

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

56P

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

59D

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

60S

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

61S

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

62D

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

63M

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

64S

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

65P

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

67V

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

68W

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

92D

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

93T

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

96F

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

118Q

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

119V

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

168K

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

169I

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

170D

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

171A

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

172T

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

173N

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

217K

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

218V

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

219I

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

220I

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

221L

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

222E

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

223L

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

224F

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

225P

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

226G

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

227L

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

229P

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

230Q

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

233K

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

236F

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

237E

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

248K

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

250F

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

251G

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

252N

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

256P

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

280Q

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

283K

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

284G

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

285F

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

286V

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

287K

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

291Y

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

310P

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

314V

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

318M

homodimer interface
13T, 22G, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67V, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 217K, 218V, 219I, 220I, 221L, 222E, 223L, 224F, 225P, 226G, 227L, 229P, 230Q, 233K, 236F, 237E, 248K, 250F, 251G, 252N, 256P, 280Q, 283K, 284G, 285F, 286V, 287K, 291Y, 310P, 314V, 318M
CDD
cd08963 (L-asparaginase_I)

GO term prediction

Biological Process

GO:0006520 cellular amino acid metabolic process

Molecular Function

GO:0004067 asparaginase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

49185_FusoPortal_Gene_2819

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component