49185_FusoPortal_Gene_2820

Protein

49185_FusoPortal_Gene_2820

Length

473 amino acids

Protein family membership

Fumarate lyase family (IPR000362)

Homologous superfamilies

Homologous superfamily
2 - 137
Fumarase/histidase, N-terminal (IPR024083)
Homologous superfamily
4 - 461
L-Aspartase-like (IPR008948)

1 50 100 150 200 250 300 350 400 473

Domains and repeats

Domain
12 - 341
Fumarate lyase, N-terminal (IPR022761)
407 - 460
Fumarase C, C-terminal (IPR018951)

1 50 100 150 200 250 300 350 400 473

Detailed signature matches

IPR024083

Fumarase/histidase, N-terminal
1. G3DSA:1.10.27...
  
  2 - 137
  
  GENE3D
  G3DSA:1.10.275.10 (G3DSA:1.10.275.10)
IPR008948

L-Aspartase-like
1. SSF48557 (L-asparta...)
  
  4 - 461
  
  SUPERFAMILY
  SSF48557 (L-aspartase-like)
IPR000362

Fumarate lyase family
1. PR00149 (FUMRATELYASE)
  
  270 - 297
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  134 - 152
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  179 - 197
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  316 - 332
  
  PRINTS
  PR00149 (FUMRATELYASE)
IPR022761

Fumarate lyase, N-terminal
1. PF00206 (Lyase_1)
  
  12 - 341
  
  Pfam
  PF00206 (Lyase_1)
IPR018951

Fumarase C, C-terminal
1. PF10415 (FumaraseC_C)
  
  407 - 460
  
  Pfam
  PF10415 (FumaraseC_C)
IPR020557

Fumarate lyase, conserved site
1. PS00163 (FUMARATE_L...)
  
  316 - 325
  
  PROSITE patterns
  PS00163 (FUMARATE_LYASES)

no IPR

Unintegrated signatures

G3DSA:1.10.40.30

415 - 463

GENE3D
G3DSA:1.10.40.30 (G3DSA:1.10.40.30)
G3DSA:1.20.20...

138 - 414

GENE3D
G3DSA:1.20.200.10 (G3DSA:1.20.200.10)
PR00145 (ARGSUCLYASE)

133 - 155

PRINTS
PR00145 (ARGSUCLYASE)

316 - 332

PRINTS
PR00145 (ARGSUCLYASE)

174 - 194

PRINTS
PR00145 (ARGSUCLYASE)
PTHR42696 (FAMILY N...)

4 - 468

PANTHER
PTHR42696 (FAMILY NOT NAMED)
cd01357 (Aspartase)

5 - 454

CDD
cd01357 (Aspartase)

Residue annotation

active sites cd01357

97G

active sites
97G, 98A, 99G, 100T, 139S, 140T, 141N, 186T, 187H, 323K, 325N, 330E
CDD
cd01357 (Aspartase)

98A

active sites
97G, 98A, 99G, 100T, 139S, 140T, 141N, 186T, 187H, 323K, 325N, 330E
CDD
cd01357 (Aspartase)

99G

active sites
97G, 98A, 99G, 100T, 139S, 140T, 141N, 186T, 187H, 323K, 325N, 330E
CDD
cd01357 (Aspartase)

100T

active sites
97G, 98A, 99G, 100T, 139S, 140T, 141N, 186T, 187H, 323K, 325N, 330E
CDD
cd01357 (Aspartase)

139S

active sites
97G, 98A, 99G, 100T, 139S, 140T, 141N, 186T, 187H, 323K, 325N, 330E
CDD
cd01357 (Aspartase)

140T

active sites
97G, 98A, 99G, 100T, 139S, 140T, 141N, 186T, 187H, 323K, 325N, 330E
CDD
cd01357 (Aspartase)

141N

active sites
97G, 98A, 99G, 100T, 139S, 140T, 141N, 186T, 187H, 323K, 325N, 330E
CDD
cd01357 (Aspartase)

186T

active sites
97G, 98A, 99G, 100T, 139S, 140T, 141N, 186T, 187H, 323K, 325N, 330E
CDD
cd01357 (Aspartase)

187H

active sites
97G, 98A, 99G, 100T, 139S, 140T, 141N, 186T, 187H, 323K, 325N, 330E
CDD
cd01357 (Aspartase)

323K

active sites
97G, 98A, 99G, 100T, 139S, 140T, 141N, 186T, 187H, 323K, 325N, 330E
CDD
cd01357 (Aspartase)

325N

active sites
97G, 98A, 99G, 100T, 139S, 140T, 141N, 186T, 187H, 323K, 325N, 330E
CDD
cd01357 (Aspartase)

330E

active sites
97G, 98A, 99G, 100T, 139S, 140T, 141N, 186T, 187H, 323K, 325N, 330E
CDD
cd01357 (Aspartase)
tetramer interface...

185R

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

186T

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

187H

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

188L

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

192V

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

198Q

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

199E

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

205G

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

209R

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

213R

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

231V

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

261P

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

262D

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

265D

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

268R

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

269N

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

271D

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

274V

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

275W

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

278S

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

281K

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

282T

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

285V

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

286N

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

288S

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

289K

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

292N

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

293D

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

343D

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

351E

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

354Q

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

355L

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

356E

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

409T

tetramer interface
185R, 186T, 187H, 188L, 192V, 198Q, 199E, 205G, 209R, 213R, 231V, 261P, 262D, 265D, 268R, 269N, 271D, 274V, 275W, 278S, 281K, 282T, 285V, 286N, 288S, 289K, 292N, 293D, 343D, 351E, 354Q, 355L, 356E, 409T
CDD
cd01357 (Aspartase)

GO term prediction

Biological Process

GO:0006099 tricarboxylic acid cycle

Molecular Function

GO:0003824 catalytic activity
GO:0016829 lyase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

49185_FusoPortal_Gene_2820

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component