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Protein

49185_FusoPortal_Gene_2895

Length

268 amino acids

Protein family membership

None predicted.

Homologous superfamilies

Homologous superfamily
1 - 259
Ribokinase-like (IPR029056)

1 50 100 150 200 268

Domains and repeats

Domain
3 - 256
Pyridoxamine kinase/Phosphomethylpyrimidine kinase (IPR013749)
Hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase (IPR004399)

1 50 100 150 200 268

Detailed signature matches

IPR029056

Ribokinase-like

G3DSA:3.40.11...

1 - 249

GENE3D
G3DSA:3.40.1190.20 (G3DSA:3.40.1190.20)
SSF53613 (Ribokinas...)

1 - 259

SUPERFAMILY
SSF53613 (Ribokinase-like)

IPR013749

Pyridoxamine kinase/Phosphomethylpyrimidine kinase

PF08543 (Phos_pyr_kin)

11 - 253

Pfam
PF08543 (Phos_pyr_kin)

IPR004399

Hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase

cd01169 (HMPP_kinase)

3 - 243

CDD
cd01169 (HMPP_kinase)
TIGR00097

4 - 256

TIGRFAMs
TIGR00097 (TIGR00097)

no IPR

Unintegrated signatures

PTHR20858 (PHOSPHOM...)

2 - 259

PANTHER
PTHR20858 (PHOSPHOMETHYLPYRIMIDINE KINASE)
PTHR20858:SF17 (HYD...)

2 - 259

PANTHER
PTHR20858:SF17 (HYDROXYMETHYLPYRIMIDINE/PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED)

Residue annotation

dimer interface cd...

3K

dimer interface
3K, 10S, 12S, 13C, 15G, 19Q, 22I, 23K, 26S, 29G, 30V, 31Y, 32G, 33M, 34S, 36I, 39V, 40T, 41A, 42Q, 43N, 48S, 49G, 51F, 53M, 54P, 57I, 60E, 64A, 65I
CDD
cd01169 (HMPP_kinase)

10S

dimer interface
3K, 10S, 12S, 13C, 15G, 19Q, 22I, 23K, 26S, 29G, 30V, 31Y, 32G, 33M, 34S, 36I, 39V, 40T, 41A, 42Q, 43N, 48S, 49G, 51F, 53M, 54P, 57I, 60E, 64A, 65I
CDD
cd01169 (HMPP_kinase)

12S

dimer interface
3K, 10S, 12S, 13C, 15G, 19Q, 22I, 23K, 26S, 29G, 30V, 31Y, 32G, 33M, 34S, 36I, 39V, 40T, 41A, 42Q, 43N, 48S, 49G, 51F, 53M, 54P, 57I, 60E, 64A, 65I
CDD
cd01169 (HMPP_kinase)

13C

dimer interface
3K, 10S, 12S, 13C, 15G, 19Q, 22I, 23K, 26S, 29G, 30V, 31Y, 32G, 33M, 34S, 36I, 39V, 40T, 41A, 42Q, 43N, 48S, 49G, 51F, 53M, 54P, 57I, 60E, 64A, 65I
CDD
cd01169 (HMPP_kinase)

15G

dimer interface
3K, 10S, 12S, 13C, 15G, 19Q, 22I, 23K, 26S, 29G, 30V, 31Y, 32G, 33M, 34S, 36I, 39V, 40T, 41A, 42Q, 43N, 48S, 49G, 51F, 53M, 54P, 57I, 60E, 64A, 65I
CDD
cd01169 (HMPP_kinase)

19Q

dimer interface
3K, 10S, 12S, 13C, 15G, 19Q, 22I, 23K, 26S, 29G, 30V, 31Y, 32G, 33M, 34S, 36I, 39V, 40T, 41A, 42Q, 43N, 48S, 49G, 51F, 53M, 54P, 57I, 60E, 64A, 65I
CDD
cd01169 (HMPP_kinase)

22I

dimer interface
3K, 10S, 12S, 13C, 15G, 19Q, 22I, 23K, 26S, 29G, 30V, 31Y, 32G, 33M, 34S, 36I, 39V, 40T, 41A, 42Q, 43N, 48S, 49G, 51F, 53M, 54P, 57I, 60E, 64A, 65I
CDD
cd01169 (HMPP_kinase)

23K

dimer interface
3K, 10S, 12S, 13C, 15G, 19Q, 22I, 23K, 26S, 29G, 30V, 31Y, 32G, 33M, 34S, 36I, 39V, 40T, 41A, 42Q, 43N, 48S, 49G, 51F, 53M, 54P, 57I, 60E, 64A, 65I
CDD
cd01169 (HMPP_kinase)

26S

dimer interface
3K, 10S, 12S, 13C, 15G, 19Q, 22I, 23K, 26S, 29G, 30V, 31Y, 32G, 33M, 34S, 36I, 39V, 40T, 41A, 42Q, 43N, 48S, 49G, 51F, 53M, 54P, 57I, 60E, 64A, 65I
CDD
cd01169 (HMPP_kinase)

29G

dimer interface
3K, 10S, 12S, 13C, 15G, 19Q, 22I, 23K, 26S, 29G, 30V, 31Y, 32G, 33M, 34S, 36I, 39V, 40T, 41A, 42Q, 43N, 48S, 49G, 51F, 53M, 54P, 57I, 60E, 64A, 65I
CDD
cd01169 (HMPP_kinase)

30V

dimer interface
3K, 10S, 12S, 13C, 15G, 19Q, 22I, 23K, 26S, 29G, 30V, 31Y, 32G, 33M, 34S, 36I, 39V, 40T, 41A, 42Q, 43N, 48S, 49G, 51F, 53M, 54P, 57I, 60E, 64A, 65I
CDD
cd01169 (HMPP_kinase)

31Y

dimer interface
3K, 10S, 12S, 13C, 15G, 19Q, 22I, 23K, 26S, 29G, 30V, 31Y, 32G, 33M, 34S, 36I, 39V, 40T, 41A, 42Q, 43N, 48S, 49G, 51F, 53M, 54P, 57I, 60E, 64A, 65I
CDD
cd01169 (HMPP_kinase)

32G

dimer interface
3K, 10S, 12S, 13C, 15G, 19Q, 22I, 23K, 26S, 29G, 30V, 31Y, 32G, 33M, 34S, 36I, 39V, 40T, 41A, 42Q, 43N, 48S, 49G, 51F, 53M, 54P, 57I, 60E, 64A, 65I
CDD
cd01169 (HMPP_kinase)

33M

dimer interface
3K, 10S, 12S, 13C, 15G, 19Q, 22I, 23K, 26S, 29G, 30V, 31Y, 32G, 33M, 34S, 36I, 39V, 40T, 41A, 42Q, 43N, 48S, 49G, 51F, 53M, 54P, 57I, 60E, 64A, 65I
CDD
cd01169 (HMPP_kinase)

34S

dimer interface
3K, 10S, 12S, 13C, 15G, 19Q, 22I, 23K, 26S, 29G, 30V, 31Y, 32G, 33M, 34S, 36I, 39V, 40T, 41A, 42Q, 43N, 48S, 49G, 51F, 53M, 54P, 57I, 60E, 64A, 65I
CDD
cd01169 (HMPP_kinase)

36I

dimer interface
3K, 10S, 12S, 13C, 15G, 19Q, 22I, 23K, 26S, 29G, 30V, 31Y, 32G, 33M, 34S, 36I, 39V, 40T, 41A, 42Q, 43N, 48S, 49G, 51F, 53M, 54P, 57I, 60E, 64A, 65I
CDD
cd01169 (HMPP_kinase)

39V

dimer interface
3K, 10S, 12S, 13C, 15G, 19Q, 22I, 23K, 26S, 29G, 30V, 31Y, 32G, 33M, 34S, 36I, 39V, 40T, 41A, 42Q, 43N, 48S, 49G, 51F, 53M, 54P, 57I, 60E, 64A, 65I
CDD
cd01169 (HMPP_kinase)

40T

dimer interface
3K, 10S, 12S, 13C, 15G, 19Q, 22I, 23K, 26S, 29G, 30V, 31Y, 32G, 33M, 34S, 36I, 39V, 40T, 41A, 42Q, 43N, 48S, 49G, 51F, 53M, 54P, 57I, 60E, 64A, 65I
CDD
cd01169 (HMPP_kinase)

41A

dimer interface
3K, 10S, 12S, 13C, 15G, 19Q, 22I, 23K, 26S, 29G, 30V, 31Y, 32G, 33M, 34S, 36I, 39V, 40T, 41A, 42Q, 43N, 48S, 49G, 51F, 53M, 54P, 57I, 60E, 64A, 65I
CDD
cd01169 (HMPP_kinase)

42Q

dimer interface
3K, 10S, 12S, 13C, 15G, 19Q, 22I, 23K, 26S, 29G, 30V, 31Y, 32G, 33M, 34S, 36I, 39V, 40T, 41A, 42Q, 43N, 48S, 49G, 51F, 53M, 54P, 57I, 60E, 64A, 65I
CDD
cd01169 (HMPP_kinase)

43N

dimer interface
3K, 10S, 12S, 13C, 15G, 19Q, 22I, 23K, 26S, 29G, 30V, 31Y, 32G, 33M, 34S, 36I, 39V, 40T, 41A, 42Q, 43N, 48S, 49G, 51F, 53M, 54P, 57I, 60E, 64A, 65I
CDD
cd01169 (HMPP_kinase)

48S

dimer interface
3K, 10S, 12S, 13C, 15G, 19Q, 22I, 23K, 26S, 29G, 30V, 31Y, 32G, 33M, 34S, 36I, 39V, 40T, 41A, 42Q, 43N, 48S, 49G, 51F, 53M, 54P, 57I, 60E, 64A, 65I
CDD
cd01169 (HMPP_kinase)

49G

dimer interface
3K, 10S, 12S, 13C, 15G, 19Q, 22I, 23K, 26S, 29G, 30V, 31Y, 32G, 33M, 34S, 36I, 39V, 40T, 41A, 42Q, 43N, 48S, 49G, 51F, 53M, 54P, 57I, 60E, 64A, 65I
CDD
cd01169 (HMPP_kinase)

51F

dimer interface
3K, 10S, 12S, 13C, 15G, 19Q, 22I, 23K, 26S, 29G, 30V, 31Y, 32G, 33M, 34S, 36I, 39V, 40T, 41A, 42Q, 43N, 48S, 49G, 51F, 53M, 54P, 57I, 60E, 64A, 65I
CDD
cd01169 (HMPP_kinase)

53M

dimer interface
3K, 10S, 12S, 13C, 15G, 19Q, 22I, 23K, 26S, 29G, 30V, 31Y, 32G, 33M, 34S, 36I, 39V, 40T, 41A, 42Q, 43N, 48S, 49G, 51F, 53M, 54P, 57I, 60E, 64A, 65I
CDD
cd01169 (HMPP_kinase)

54P

dimer interface
3K, 10S, 12S, 13C, 15G, 19Q, 22I, 23K, 26S, 29G, 30V, 31Y, 32G, 33M, 34S, 36I, 39V, 40T, 41A, 42Q, 43N, 48S, 49G, 51F, 53M, 54P, 57I, 60E, 64A, 65I
CDD
cd01169 (HMPP_kinase)

57I

dimer interface
3K, 10S, 12S, 13C, 15G, 19Q, 22I, 23K, 26S, 29G, 30V, 31Y, 32G, 33M, 34S, 36I, 39V, 40T, 41A, 42Q, 43N, 48S, 49G, 51F, 53M, 54P, 57I, 60E, 64A, 65I
CDD
cd01169 (HMPP_kinase)

60E

dimer interface
3K, 10S, 12S, 13C, 15G, 19Q, 22I, 23K, 26S, 29G, 30V, 31Y, 32G, 33M, 34S, 36I, 39V, 40T, 41A, 42Q, 43N, 48S, 49G, 51F, 53M, 54P, 57I, 60E, 64A, 65I
CDD
cd01169 (HMPP_kinase)

64A

dimer interface
3K, 10S, 12S, 13C, 15G, 19Q, 22I, 23K, 26S, 29G, 30V, 31Y, 32G, 33M, 34S, 36I, 39V, 40T, 41A, 42Q, 43N, 48S, 49G, 51F, 53M, 54P, 57I, 60E, 64A, 65I
CDD
cd01169 (HMPP_kinase)

65I

dimer interface
3K, 10S, 12S, 13C, 15G, 19Q, 22I, 23K, 26S, 29G, 30V, 31Y, 32G, 33M, 34S, 36I, 39V, 40T, 41A, 42Q, 43N, 48S, 49G, 51F, 53M, 54P, 57I, 60E, 64A, 65I
CDD
cd01169 (HMPP_kinase)
substrate binding ...

9G

substrate binding site
9G, 21D, 42Q, 78M, 209C
CDD
cd01169 (HMPP_kinase)

21D

substrate binding site
9G, 21D, 42Q, 78M, 209C
CDD
cd01169 (HMPP_kinase)

42Q

substrate binding site
9G, 21D, 42Q, 78M, 209C
CDD
cd01169 (HMPP_kinase)

78M

substrate binding site
9G, 21D, 42Q, 78M, 209C
CDD
cd01169 (HMPP_kinase)

209C

substrate binding site
9G, 21D, 42Q, 78M, 209C
CDD
cd01169 (HMPP_kinase)
ATP binding site c...

103D

ATP binding site
103D, 139E, 172K, 206G, 208G
CDD
cd01169 (HMPP_kinase)

139E

ATP binding site
103D, 139E, 172K, 206G, 208G
CDD
cd01169 (HMPP_kinase)

172K

ATP binding site
103D, 139E, 172K, 206G, 208G
CDD
cd01169 (HMPP_kinase)

206G

ATP binding site
103D, 139E, 172K, 206G, 208G
CDD
cd01169 (HMPP_kinase)

208G

ATP binding site
103D, 139E, 172K, 206G, 208G
CDD
cd01169 (HMPP_kinase)

GO term prediction

Biological Process

GO:0009228 thiamine biosynthetic process

Molecular Function

GO:0008972 phosphomethylpyrimidine kinase activity

Cellular Component