49185_FusoPortal_Gene_307

Protein

49185_FusoPortal_Gene_307

Length

633 amino acids

Protein family membership

None predicted.

Homologous superfamilies

Homologous superfamily
151 - 230
Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily (IPR036097)
382 - 491
HPT domain superfamily (IPR036641)
504 - 622
CheY-like superfamily (IPR011006)
Homologous superfamily
218 - 381
Histidine kinase/HSP90-like ATPase superfamily (IPR036890)

1 100 200 300 400 500 633

Domains and repeats

Domain
162 - 229
Signal transduction histidine kinase, dimerisation/phosphoacceptor domain (IPR003661)
311 - 325
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)
329 - 339
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)
342 - 360
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)
366 - 379
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)
507 - 623
Signal transduction response regulator, receiver domain (IPR001789)
Domain
171 - 382
Histidine kinase domain (IPR005467)
Domain
276 - 381
Histidine kinase/HSP90-like ATPase (IPR003594)

1 100 200 300 400 500 633

Detailed signature matches

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily
1. SSF47384 (Homodimer...)
  
  151 - 230
  
  SUPERFAMILY
  SSF47384 (Homodimeric domain of signal transducing histidine kinase)
IPR036890

Histidine kinase/HSP90-like ATPase superfamily
1. G3DSA:3.30.56...
  
  224 - 381
  
  GENE3D
  G3DSA:3.30.565.10 (G3DSA:3.30.565.10)
2. SSF55874 (ATPase do...)
  
  218 - 380
  
  SUPERFAMILY
  SSF55874 (ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase)
IPR036641

HPT domain superfamily
1. G3DSA:1.20.12...
  
  382 - 491
  
  GENE3D
  G3DSA:1.20.120.160 (G3DSA:1.20.120.160)
2. SSF47226 (Histidine...)
  
  392 - 486
  
  SUPERFAMILY
  SSF47226 (Histidine-containing phosphotransfer domain, HPT domain)
IPR011006

CheY-like superfamily
1. SSF52172 (CheY-like)
  
  504 - 622
  
  SUPERFAMILY
  SSF52172 (CheY-like)
IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain
1. cd00082 (HisKA)
  
  162 - 225
  
  CDD
  cd00082 (HisKA)
2. PF00512 (HisKA)
  
  164 - 229
  
  Pfam
  PF00512 (HisKA)
IPR005467

Histidine kinase domain
1. PS50109 (HIS_KIN)
  
  171 - 382
  
  PROSITE profiles
  PS50109 (HIS_KIN)
IPR003594

Histidine kinase/HSP90-like ATPase
1. PF02518 (HATPase_c)
  
  276 - 381
  
  Pfam
  PF02518 (HATPase_c)
2. cd00075 (HATPase_c)
  
  280 - 378
  
  CDD
  cd00075 (HATPase_c)
IPR004358

Signal transduction histidine kinase-related protein, C-terminal
1. PR00344 (BCTRLSENSOR)
  
  311 - 325
  
  PRINTS
  PR00344 (BCTRLSENSOR)
  
  329 - 339
  
  PRINTS
  PR00344 (BCTRLSENSOR)
  
  366 - 379
  
  PRINTS
  PR00344 (BCTRLSENSOR)
  
  342 - 360
  
  PRINTS
  PR00344 (BCTRLSENSOR)
IPR001789

Signal transduction response regulator, receiver domain
1. PS50110 (RESPONSE_R...)
  
  507 - 623
  
  PROSITE profiles
  PS50110 (RESPONSE_REGULATORY)
2. PF00072 (Response_reg)
  
  509 - 618
  
  Pfam
  PF00072 (Response_reg)
3. cd00156 (REC)
  
  509 - 620
  
  CDD
  cd00156 (REC)

no IPR

Unintegrated signatures

Coil

112 - 146

COILS
Coil (Coil)
G3DSA:1.10.28...

155 - 223

GENE3D
G3DSA:1.10.287.130 (G3DSA:1.10.287.130)
G3DSA:3.40.50...

501 - 623

GENE3D
G3DSA:3.40.50.2300 (G3DSA:3.40.50.2300)
PTHR43047 (FAMILY N...)

103 - 615

PANTHER
PTHR43047 (FAMILY NOT NAMED)
PTHR43047:SF5 (HYBR...)

103 - 615

PANTHER
PTHR43047:SF5 (HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE H)

Residue annotation

dimer interface cd...

168F

dimer interface
168F, 172I, 176M, 179P, 183I, 186Y, 202K, 206I, 209S, 213L, 216F, 220L
CDD
cd00082 (HisKA)

172I

dimer interface
168F, 172I, 176M, 179P, 183I, 186Y, 202K, 206I, 209S, 213L, 216F, 220L
CDD
cd00082 (HisKA)

176M

dimer interface
168F, 172I, 176M, 179P, 183I, 186Y, 202K, 206I, 209S, 213L, 216F, 220L
CDD
cd00082 (HisKA)

179P

dimer interface
168F, 172I, 176M, 179P, 183I, 186Y, 202K, 206I, 209S, 213L, 216F, 220L
CDD
cd00082 (HisKA)

183I

dimer interface
168F, 172I, 176M, 179P, 183I, 186Y, 202K, 206I, 209S, 213L, 216F, 220L
CDD
cd00082 (HisKA)

186Y

dimer interface
168F, 172I, 176M, 179P, 183I, 186Y, 202K, 206I, 209S, 213L, 216F, 220L
CDD
cd00082 (HisKA)

202K

dimer interface
168F, 172I, 176M, 179P, 183I, 186Y, 202K, 206I, 209S, 213L, 216F, 220L
CDD
cd00082 (HisKA)

206I

dimer interface
168F, 172I, 176M, 179P, 183I, 186Y, 202K, 206I, 209S, 213L, 216F, 220L
CDD
cd00082 (HisKA)

209S

dimer interface
168F, 172I, 176M, 179P, 183I, 186Y, 202K, 206I, 209S, 213L, 216F, 220L
CDD
cd00082 (HisKA)

213L

dimer interface
168F, 172I, 176M, 179P, 183I, 186Y, 202K, 206I, 209S, 213L, 216F, 220L
CDD
cd00082 (HisKA)

216F

dimer interface
168F, 172I, 176M, 179P, 183I, 186Y, 202K, 206I, 209S, 213L, 216F, 220L
CDD
cd00082 (HisKA)

220L

dimer interface
168F, 172I, 176M, 179P, 183I, 186Y, 202K, 206I, 209S, 213L, 216F, 220L
CDD
cd00082 (HisKA)
phosphorylation si...

174H

phosphorylation site
174H
CDD
cd00082 (HisKA)
ATP binding site c...

286N

ATP binding site
286N, 290N, 293K, 315V, 317D, 319G, 321G, 322I, 345G, 346L, 347G, 348L, 364V, 366S, 371G, 372T, 374F
CDD
cd00075 (HATPase_c)

290N

ATP binding site
286N, 290N, 293K, 315V, 317D, 319G, 321G, 322I, 345G, 346L, 347G, 348L, 364V, 366S, 371G, 372T, 374F
CDD
cd00075 (HATPase_c)

293K

ATP binding site
286N, 290N, 293K, 315V, 317D, 319G, 321G, 322I, 345G, 346L, 347G, 348L, 364V, 366S, 371G, 372T, 374F
CDD
cd00075 (HATPase_c)

315V

ATP binding site
286N, 290N, 293K, 315V, 317D, 319G, 321G, 322I, 345G, 346L, 347G, 348L, 364V, 366S, 371G, 372T, 374F
CDD
cd00075 (HATPase_c)

317D

ATP binding site
286N, 290N, 293K, 315V, 317D, 319G, 321G, 322I, 345G, 346L, 347G, 348L, 364V, 366S, 371G, 372T, 374F
CDD
cd00075 (HATPase_c)

319G

ATP binding site
286N, 290N, 293K, 315V, 317D, 319G, 321G, 322I, 345G, 346L, 347G, 348L, 364V, 366S, 371G, 372T, 374F
CDD
cd00075 (HATPase_c)

321G

ATP binding site
286N, 290N, 293K, 315V, 317D, 319G, 321G, 322I, 345G, 346L, 347G, 348L, 364V, 366S, 371G, 372T, 374F
CDD
cd00075 (HATPase_c)

322I

ATP binding site
286N, 290N, 293K, 315V, 317D, 319G, 321G, 322I, 345G, 346L, 347G, 348L, 364V, 366S, 371G, 372T, 374F
CDD
cd00075 (HATPase_c)

345G

ATP binding site
286N, 290N, 293K, 315V, 317D, 319G, 321G, 322I, 345G, 346L, 347G, 348L, 364V, 366S, 371G, 372T, 374F
CDD
cd00075 (HATPase_c)

346L

ATP binding site
286N, 290N, 293K, 315V, 317D, 319G, 321G, 322I, 345G, 346L, 347G, 348L, 364V, 366S, 371G, 372T, 374F
CDD
cd00075 (HATPase_c)

347G

ATP binding site
286N, 290N, 293K, 315V, 317D, 319G, 321G, 322I, 345G, 346L, 347G, 348L, 364V, 366S, 371G, 372T, 374F
CDD
cd00075 (HATPase_c)

348L

ATP binding site
286N, 290N, 293K, 315V, 317D, 319G, 321G, 322I, 345G, 346L, 347G, 348L, 364V, 366S, 371G, 372T, 374F
CDD
cd00075 (HATPase_c)

364V

ATP binding site
286N, 290N, 293K, 315V, 317D, 319G, 321G, 322I, 345G, 346L, 347G, 348L, 364V, 366S, 371G, 372T, 374F
CDD
cd00075 (HATPase_c)

366S

ATP binding site
286N, 290N, 293K, 315V, 317D, 319G, 321G, 322I, 345G, 346L, 347G, 348L, 364V, 366S, 371G, 372T, 374F
CDD
cd00075 (HATPase_c)

371G

ATP binding site
286N, 290N, 293K, 315V, 317D, 319G, 321G, 322I, 345G, 346L, 347G, 348L, 364V, 366S, 371G, 372T, 374F
CDD
cd00075 (HATPase_c)

372T

ATP binding site
286N, 290N, 293K, 315V, 317D, 319G, 321G, 322I, 345G, 346L, 347G, 348L, 364V, 366S, 371G, 372T, 374F
CDD
cd00075 (HATPase_c)

374F

ATP binding site
286N, 290N, 293K, 315V, 317D, 319G, 321G, 322I, 345G, 346L, 347G, 348L, 364V, 366S, 371G, 372T, 374F
CDD
cd00075 (HATPase_c)
Mg2+ binding site ...

290N

Mg2+ binding site
290N
CDD
cd00075 (HATPase_c)
G-X-G motif cd00075

319G

G-X-G motif
319G, 321G, 345G, 347G
CDD
cd00075 (HATPase_c)

321G

G-X-G motif
319G, 321G, 345G, 347G
CDD
cd00075 (HATPase_c)

345G

G-X-G motif
319G, 321G, 345G, 347G
CDD
cd00075 (HATPase_c)

347G

G-X-G motif
319G, 321G, 345G, 347G
CDD
cd00075 (HATPase_c)
active site cd00156

512E

active site
512E, 513D, 556D, 564G, 586T, 605Y, 608K, 609P
CDD
cd00156 (REC)

513D

active site
512E, 513D, 556D, 564G, 586T, 605Y, 608K, 609P
CDD
cd00156 (REC)

556D

active site
512E, 513D, 556D, 564G, 586T, 605Y, 608K, 609P
CDD
cd00156 (REC)

564G

active site
512E, 513D, 556D, 564G, 586T, 605Y, 608K, 609P
CDD
cd00156 (REC)

586T

active site
512E, 513D, 556D, 564G, 586T, 605Y, 608K, 609P
CDD
cd00156 (REC)

605Y

active site
512E, 513D, 556D, 564G, 586T, 605Y, 608K, 609P
CDD
cd00156 (REC)

608K

active site
512E, 513D, 556D, 564G, 586T, 605Y, 608K, 609P
CDD
cd00156 (REC)

609P

active site
512E, 513D, 556D, 564G, 586T, 605Y, 608K, 609P
CDD
cd00156 (REC)
phosphorylation si...

556D

phosphorylation site
556D
CDD
cd00156 (REC)
intermolecular rec...

559M

intermolecular recognition site
559M, 560P, 562M, 563D, 564G
CDD
cd00156 (REC)

560P

intermolecular recognition site
559M, 560P, 562M, 563D, 564G
CDD
cd00156 (REC)

562M

intermolecular recognition site
559M, 560P, 562M, 563D, 564G
CDD
cd00156 (REC)

563D

intermolecular recognition site
559M, 560P, 562M, 563D, 564G
CDD
cd00156 (REC)

564G

intermolecular recognition site
559M, 560P, 562M, 563D, 564G
CDD
cd00156 (REC)
dimerization inter...

608K

dimerization interface
608K, 609P, 610I
CDD
cd00156 (REC)

609P

dimerization interface
608K, 609P, 610I
CDD
cd00156 (REC)

610I

dimerization interface
608K, 609P, 610I
CDD
cd00156 (REC)

GO term prediction

Biological Process

GO:0000160 phosphorelay signal transduction system
GO:0007165 signal transduction
GO:0016310 phosphorylation

Molecular Function

GO:0000155 phosphorelay sensor kinase activity
GO:0004871 signal transducer activity
GO:0016772 transferase activity, transferring phosphorus-containing groups

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

49185_FusoPortal_Gene_307

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component