49185_FusoPortal_Gene_493

Protein

49185_FusoPortal_Gene_493

Length

199 amino acids

Protein family membership

Nitroreductase Frm2/Hbn1-like (IPR033877)

Homologous superfamilies

Homologous superfamily
5 - 199
Nitroreductase-like (IPR000415)

1 20 40 60 80 100 120 140 160 180 199

Domains and repeats

Domain
11 - 179
Nitroreductase (IPR029479)

1 20 40 60 80 100 120 140 160 180 199

Detailed signature matches

IPR000415

Nitroreductase-like
1. G3DSA:3.40.10...
  
  5 - 199
  
  GENE3D
  G3DSA:3.40.109.10 (G3DSA:3.40.109.10)
2. SSF55469 (FMN-depen...)
  
  5 - 198
  
  SUPERFAMILY
  SSF55469 (FMN-dependent nitroreductase-like)
IPR033877

Nitroreductase Frm2/Hbn1-like
1. PTHR43035 (FAMILY N...)
  
  2 - 198
  
  PANTHER
  PTHR43035 (FAMILY NOT NAMED)
2. cd02140 (Nitroreduc...)
  
  6 - 196
  
  CDD
  cd02140 (Nitroreductase_4)
IPR029479

Nitroreductase
1. PF00881 (Nitroreduc...)
  
  11 - 179
  
  Pfam
  PF00881 (Nitroreductase)

Residue annotation

dimer interface cd...

6F

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

10L

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

11K

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

13R

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

27N

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

35K

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

37A

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

39K

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

40H

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

42P

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

46N

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

48Q

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

50A

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

51R

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

52V

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

53M

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

54I

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

55L

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

56Y

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

59N

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

123W

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

125E

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

126Q

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

130M

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

133F

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

134A

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

141E

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

150H

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

163F

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

188E

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

189F

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

190L

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

192I

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

195R

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)

196V

dimer interface
6F, 10L, 11K, 13R, 27N, 35K, 37A, 39K, 40H, 42P, 46N, 48Q, 50A, 51R, 52V, 53M, 54I, 55L, 56Y, 59N, 123W, 125E, 126Q, 130M, 133F, 134A, 141E, 150H, 163F, 188E, 189F, 190L, 192I, 195R, 196V
CDD
cd02140 (Nitroreductase_4)
FMN binding site c...

13R

FMN binding site
13R, 14R, 15T, 17Y, 148L, 149Q, 150H, 187K
CDD
cd02140 (Nitroreductase_4)

14R

FMN binding site
13R, 14R, 15T, 17Y, 148L, 149Q, 150H, 187K
CDD
cd02140 (Nitroreductase_4)

15T

FMN binding site
13R, 14R, 15T, 17Y, 148L, 149Q, 150H, 187K
CDD
cd02140 (Nitroreductase_4)

17Y

FMN binding site
13R, 14R, 15T, 17Y, 148L, 149Q, 150H, 187K
CDD
cd02140 (Nitroreductase_4)

148L

FMN binding site
13R, 14R, 15T, 17Y, 148L, 149Q, 150H, 187K
CDD
cd02140 (Nitroreductase_4)

149Q

FMN binding site
13R, 14R, 15T, 17Y, 148L, 149Q, 150H, 187K
CDD
cd02140 (Nitroreductase_4)

150H

FMN binding site
13R, 14R, 15T, 17Y, 148L, 149Q, 150H, 187K
CDD
cd02140 (Nitroreductase_4)

187K

FMN binding site
13R, 14R, 15T, 17Y, 148L, 149Q, 150H, 187K
CDD
cd02140 (Nitroreductase_4)

GO term prediction

Biological Process

GO:0034599 cellular response to oxidative stress

Molecular Function

GO:0016491 oxidoreductase activity
GO:0016657 oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

49185_FusoPortal_Gene_493

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component