49185_FusoPortal_Gene_927

Protein

49185_FusoPortal_Gene_927

Length

777 amino acids

Protein family membership

None predicted.

Homologous superfamilies

Homologous superfamily
144 - 241
Periplasmic sensor-like domain superfamily (IPR029151)
421 - 539
PAS domain superfamily (IPR035965)
550 - 622
Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily (IPR036097)
Homologous superfamily
614 - 777
Histidine kinase/HSP90-like ATPase superfamily (IPR036890)

1 100 200 300 400 500 600 700 777

Domains and repeats

Domain
42 - 335
Double Cache domain 1 (IPR033479)
373 - 425
HAMP domain (IPR003660)
430 - 541
PAS domain (IPR000014)
PAS fold-4 (IPR013656)
563 - 777
Histidine kinase domain (IPR005467)
Domain
558 - 621
Signal transduction histidine kinase, dimerisation/phosphoacceptor domain (IPR003661)
667 - 776
Histidine kinase/HSP90-like ATPase (IPR003594)
Domain
707 - 721
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)
725 - 735
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)
738 - 756
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)
762 - 775
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)

1 100 200 300 400 500 600 700 777

Detailed signature matches

IPR029151

Periplasmic sensor-like domain superfamily
1. SSF103190 (Sensory ...)
  
  144 - 241
  
  SUPERFAMILY
  SSF103190 (Sensory domain-like)
IPR035965

PAS domain superfamily
1. SSF55785 (PYP-like ...)
  
  421 - 539
  
  SUPERFAMILY
  SSF55785 (PYP-like sensor domain (PAS domain))
IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily
1. SSF47384 (Homodimer...)
  
  550 - 622
  
  SUPERFAMILY
  SSF47384 (Homodimeric domain of signal transducing histidine kinase)
IPR036890

Histidine kinase/HSP90-like ATPase superfamily
1. G3DSA:3.30.56...
  
  617 - 777
  
  GENE3D
  G3DSA:3.30.565.10 (G3DSA:3.30.565.10)
2. SSF55874 (ATPase do...)
  
  614 - 776
  
  SUPERFAMILY
  SSF55874 (ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase)
IPR033479

Double Cache domain 1
1. PF02743 (dCache_1)
  
  42 - 335
  
  Pfam
  PF02743 (dCache_1)
IPR003660

HAMP domain
1. PS50885 (HAMP)
  
  373 - 425
  
  PROSITE profiles
  PS50885 (HAMP)
2. cd06225 (HAMP)
  
  376 - 422
  
  CDD
  cd06225 (HAMP)
IPR000014

PAS domain
1. PS50112 (PAS)
  
  430 - 500
  
  PROSITE profiles
  PS50112 (PAS)
2. cd00130 (PAS)
  
  441 - 538
  
  CDD
  cd00130 (PAS)
IPR013656

PAS fold-4
1. PF08448 (PAS_4)
  
  438 - 541
  
  Pfam
  PF08448 (PAS_4)
IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain
1. cd00082 (HisKA)
  
  558 - 620
  
  CDD
  cd00082 (HisKA)
2. PF00512 (HisKA)
  
  558 - 621
  
  Pfam
  PF00512 (HisKA)
IPR005467

Histidine kinase domain
1. PS50109 (HIS_KIN)
  
  563 - 777
  
  PROSITE profiles
  PS50109 (HIS_KIN)
IPR003594

Histidine kinase/HSP90-like ATPase
1. PF02518 (HATPase_c)
  
  667 - 776
  
  Pfam
  PF02518 (HATPase_c)
2. cd00075 (HATPase_c)
  
  671 - 774
  
  CDD
  cd00075 (HATPase_c)
IPR004358

Signal transduction histidine kinase-related protein, C-terminal
1. PR00344 (BCTRLSENSOR)
  
  725 - 735
  
  PRINTS
  PR00344 (BCTRLSENSOR)
  
  762 - 775
  
  PRINTS
  PR00344 (BCTRLSENSOR)
  
  707 - 721
  
  PRINTS
  PR00344 (BCTRLSENSOR)
  
  738 - 756
  
  PRINTS
  PR00344 (BCTRLSENSOR)

no IPR

Unintegrated signatures

Coil

34 - 61

COILS
Coil (Coil)

591 - 611

COILS
Coil (Coil)
G3DSA:1.10.28...

550 - 616

GENE3D
G3DSA:1.10.287.130 (G3DSA:1.10.287.130)
G3DSA:3.30.45...

221 - 342

GENE3D
G3DSA:3.30.450.20 (G3DSA:3.30.450.20)

416 - 549

GENE3D
G3DSA:3.30.450.20 (G3DSA:3.30.450.20)

32 - 220

GENE3D
G3DSA:3.30.450.20 (G3DSA:3.30.450.20)
PTHR43065 (FAMILY N...)

423 - 777

PANTHER
PTHR43065 (FAMILY NOT NAMED)

49 - 78

PANTHER
PTHR43065 (FAMILY NOT NAMED)
PTHR43065:SF17 (SIG...)

423 - 777

PANTHER
PTHR43065:SF17 (SIGNAL TRANSDUCTION HISTIDINE-PROTEIN KINASE ATOS)

49 - 78

PANTHER
PTHR43065:SF17 (SIGNAL TRANSDUCTION HISTIDINE-PROTEIN KINASE ATOS)
SSF158472 (HAMP dom...)

376 - 424

SUPERFAMILY
SSF158472 (HAMP domain-like)

Residue annotation

dimerization inter...

376S

dimerization interface
376S, 379V, 380L, 382L, 383V, 386A, 387R, 389I, 405E, 406I, 408E, 409L, 412A, 413F, 415S, 416M, 419S, 420I
CDD
cd06225 (HAMP)

379V

dimerization interface
376S, 379V, 380L, 382L, 383V, 386A, 387R, 389I, 405E, 406I, 408E, 409L, 412A, 413F, 415S, 416M, 419S, 420I
CDD
cd06225 (HAMP)

380L

dimerization interface
376S, 379V, 380L, 382L, 383V, 386A, 387R, 389I, 405E, 406I, 408E, 409L, 412A, 413F, 415S, 416M, 419S, 420I
CDD
cd06225 (HAMP)

382L

dimerization interface
376S, 379V, 380L, 382L, 383V, 386A, 387R, 389I, 405E, 406I, 408E, 409L, 412A, 413F, 415S, 416M, 419S, 420I
CDD
cd06225 (HAMP)

383V

dimerization interface
376S, 379V, 380L, 382L, 383V, 386A, 387R, 389I, 405E, 406I, 408E, 409L, 412A, 413F, 415S, 416M, 419S, 420I
CDD
cd06225 (HAMP)

386A

dimerization interface
376S, 379V, 380L, 382L, 383V, 386A, 387R, 389I, 405E, 406I, 408E, 409L, 412A, 413F, 415S, 416M, 419S, 420I
CDD
cd06225 (HAMP)

387R

dimerization interface
376S, 379V, 380L, 382L, 383V, 386A, 387R, 389I, 405E, 406I, 408E, 409L, 412A, 413F, 415S, 416M, 419S, 420I
CDD
cd06225 (HAMP)

389I

dimerization interface
376S, 379V, 380L, 382L, 383V, 386A, 387R, 389I, 405E, 406I, 408E, 409L, 412A, 413F, 415S, 416M, 419S, 420I
CDD
cd06225 (HAMP)

405E

dimerization interface
376S, 379V, 380L, 382L, 383V, 386A, 387R, 389I, 405E, 406I, 408E, 409L, 412A, 413F, 415S, 416M, 419S, 420I
CDD
cd06225 (HAMP)

406I

dimerization interface
376S, 379V, 380L, 382L, 383V, 386A, 387R, 389I, 405E, 406I, 408E, 409L, 412A, 413F, 415S, 416M, 419S, 420I
CDD
cd06225 (HAMP)

408E

dimerization interface
376S, 379V, 380L, 382L, 383V, 386A, 387R, 389I, 405E, 406I, 408E, 409L, 412A, 413F, 415S, 416M, 419S, 420I
CDD
cd06225 (HAMP)

409L

dimerization interface
376S, 379V, 380L, 382L, 383V, 386A, 387R, 389I, 405E, 406I, 408E, 409L, 412A, 413F, 415S, 416M, 419S, 420I
CDD
cd06225 (HAMP)

412A

dimerization interface
376S, 379V, 380L, 382L, 383V, 386A, 387R, 389I, 405E, 406I, 408E, 409L, 412A, 413F, 415S, 416M, 419S, 420I
CDD
cd06225 (HAMP)

413F

dimerization interface
376S, 379V, 380L, 382L, 383V, 386A, 387R, 389I, 405E, 406I, 408E, 409L, 412A, 413F, 415S, 416M, 419S, 420I
CDD
cd06225 (HAMP)

415S

dimerization interface
376S, 379V, 380L, 382L, 383V, 386A, 387R, 389I, 405E, 406I, 408E, 409L, 412A, 413F, 415S, 416M, 419S, 420I
CDD
cd06225 (HAMP)

416M

dimerization interface
376S, 379V, 380L, 382L, 383V, 386A, 387R, 389I, 405E, 406I, 408E, 409L, 412A, 413F, 415S, 416M, 419S, 420I
CDD
cd06225 (HAMP)

419S

dimerization interface
376S, 379V, 380L, 382L, 383V, 386A, 387R, 389I, 405E, 406I, 408E, 409L, 412A, 413F, 415S, 416M, 419S, 420I
CDD
cd06225 (HAMP)

420I

dimerization interface
376S, 379V, 380L, 382L, 383V, 386A, 387R, 389I, 405E, 406I, 408E, 409L, 412A, 413F, 415S, 416M, 419S, 420I
CDD
cd06225 (HAMP)
putative active si...

457L

putative active site
457L, 461G, 467K, 480V, 481I, 482A, 483A, 509I
CDD
cd00130 (PAS)

461G

putative active site
457L, 461G, 467K, 480V, 481I, 482A, 483A, 509I
CDD
cd00130 (PAS)

467K

putative active site
457L, 461G, 467K, 480V, 481I, 482A, 483A, 509I
CDD
cd00130 (PAS)

480V

putative active site
457L, 461G, 467K, 480V, 481I, 482A, 483A, 509I
CDD
cd00130 (PAS)

481I

putative active site
457L, 461G, 467K, 480V, 481I, 482A, 483A, 509I
CDD
cd00130 (PAS)

482A

putative active site
457L, 461G, 467K, 480V, 481I, 482A, 483A, 509I
CDD
cd00130 (PAS)

483A

putative active site
457L, 461G, 467K, 480V, 481I, 482A, 483A, 509I
CDD
cd00130 (PAS)

509I

putative active site
457L, 461G, 467K, 480V, 481I, 482A, 483A, 509I
CDD
cd00130 (PAS)
heme pocket cd00130

477C

heme pocket
477C, 481I, 489P, 492K, 493L, 516I, 518Y
CDD
cd00130 (PAS)

481I

heme pocket
477C, 481I, 489P, 492K, 493L, 516I, 518Y
CDD
cd00130 (PAS)

489P

heme pocket
477C, 481I, 489P, 492K, 493L, 516I, 518Y
CDD
cd00130 (PAS)

492K

heme pocket
477C, 481I, 489P, 492K, 493L, 516I, 518Y
CDD
cd00130 (PAS)

493L

heme pocket
477C, 481I, 489P, 492K, 493L, 516I, 518Y
CDD
cd00130 (PAS)

516I

heme pocket
477C, 481I, 489P, 492K, 493L, 516I, 518Y
CDD
cd00130 (PAS)

518Y

heme pocket
477C, 481I, 489P, 492K, 493L, 516I, 518Y
CDD
cd00130 (PAS)
dimer interface cd...

560L

dimer interface
560L, 564I, 568L, 571P, 575I, 578S, 597Q, 601I, 604T, 608A, 611I, 615L
CDD
cd00082 (HisKA)

564I

dimer interface
560L, 564I, 568L, 571P, 575I, 578S, 597Q, 601I, 604T, 608A, 611I, 615L
CDD
cd00082 (HisKA)

568L

dimer interface
560L, 564I, 568L, 571P, 575I, 578S, 597Q, 601I, 604T, 608A, 611I, 615L
CDD
cd00082 (HisKA)

571P

dimer interface
560L, 564I, 568L, 571P, 575I, 578S, 597Q, 601I, 604T, 608A, 611I, 615L
CDD
cd00082 (HisKA)

575I

dimer interface
560L, 564I, 568L, 571P, 575I, 578S, 597Q, 601I, 604T, 608A, 611I, 615L
CDD
cd00082 (HisKA)

578S

dimer interface
560L, 564I, 568L, 571P, 575I, 578S, 597Q, 601I, 604T, 608A, 611I, 615L
CDD
cd00082 (HisKA)

597Q

dimer interface
560L, 564I, 568L, 571P, 575I, 578S, 597Q, 601I, 604T, 608A, 611I, 615L
CDD
cd00082 (HisKA)

601I

dimer interface
560L, 564I, 568L, 571P, 575I, 578S, 597Q, 601I, 604T, 608A, 611I, 615L
CDD
cd00082 (HisKA)

604T

dimer interface
560L, 564I, 568L, 571P, 575I, 578S, 597Q, 601I, 604T, 608A, 611I, 615L
CDD
cd00082 (HisKA)

608A

dimer interface
560L, 564I, 568L, 571P, 575I, 578S, 597Q, 601I, 604T, 608A, 611I, 615L
CDD
cd00082 (HisKA)

611I

dimer interface
560L, 564I, 568L, 571P, 575I, 578S, 597Q, 601I, 604T, 608A, 611I, 615L
CDD
cd00082 (HisKA)

615L

dimer interface
560L, 564I, 568L, 571P, 575I, 578S, 597Q, 601I, 604T, 608A, 611I, 615L
CDD
cd00082 (HisKA)
phosphorylation si...

566H

phosphorylation site
566H
CDD
cd00082 (HisKA)
ATP binding site c...

677N

ATP binding site
677N, 681N, 684T, 711I, 713D, 715G, 717G, 718I, 741G, 742L, 743G, 744L, 760I, 762S, 767G, 768T, 770V
CDD
cd00075 (HATPase_c)

681N

ATP binding site
677N, 681N, 684T, 711I, 713D, 715G, 717G, 718I, 741G, 742L, 743G, 744L, 760I, 762S, 767G, 768T, 770V
CDD
cd00075 (HATPase_c)

684T

ATP binding site
677N, 681N, 684T, 711I, 713D, 715G, 717G, 718I, 741G, 742L, 743G, 744L, 760I, 762S, 767G, 768T, 770V
CDD
cd00075 (HATPase_c)

711I

ATP binding site
677N, 681N, 684T, 711I, 713D, 715G, 717G, 718I, 741G, 742L, 743G, 744L, 760I, 762S, 767G, 768T, 770V
CDD
cd00075 (HATPase_c)

713D

ATP binding site
677N, 681N, 684T, 711I, 713D, 715G, 717G, 718I, 741G, 742L, 743G, 744L, 760I, 762S, 767G, 768T, 770V
CDD
cd00075 (HATPase_c)

715G

ATP binding site
677N, 681N, 684T, 711I, 713D, 715G, 717G, 718I, 741G, 742L, 743G, 744L, 760I, 762S, 767G, 768T, 770V
CDD
cd00075 (HATPase_c)

717G

ATP binding site
677N, 681N, 684T, 711I, 713D, 715G, 717G, 718I, 741G, 742L, 743G, 744L, 760I, 762S, 767G, 768T, 770V
CDD
cd00075 (HATPase_c)

718I

ATP binding site
677N, 681N, 684T, 711I, 713D, 715G, 717G, 718I, 741G, 742L, 743G, 744L, 760I, 762S, 767G, 768T, 770V
CDD
cd00075 (HATPase_c)

741G

ATP binding site
677N, 681N, 684T, 711I, 713D, 715G, 717G, 718I, 741G, 742L, 743G, 744L, 760I, 762S, 767G, 768T, 770V
CDD
cd00075 (HATPase_c)

742L

ATP binding site
677N, 681N, 684T, 711I, 713D, 715G, 717G, 718I, 741G, 742L, 743G, 744L, 760I, 762S, 767G, 768T, 770V
CDD
cd00075 (HATPase_c)

743G

ATP binding site
677N, 681N, 684T, 711I, 713D, 715G, 717G, 718I, 741G, 742L, 743G, 744L, 760I, 762S, 767G, 768T, 770V
CDD
cd00075 (HATPase_c)

744L

ATP binding site
677N, 681N, 684T, 711I, 713D, 715G, 717G, 718I, 741G, 742L, 743G, 744L, 760I, 762S, 767G, 768T, 770V
CDD
cd00075 (HATPase_c)

760I

ATP binding site
677N, 681N, 684T, 711I, 713D, 715G, 717G, 718I, 741G, 742L, 743G, 744L, 760I, 762S, 767G, 768T, 770V
CDD
cd00075 (HATPase_c)

762S

ATP binding site
677N, 681N, 684T, 711I, 713D, 715G, 717G, 718I, 741G, 742L, 743G, 744L, 760I, 762S, 767G, 768T, 770V
CDD
cd00075 (HATPase_c)

767G

ATP binding site
677N, 681N, 684T, 711I, 713D, 715G, 717G, 718I, 741G, 742L, 743G, 744L, 760I, 762S, 767G, 768T, 770V
CDD
cd00075 (HATPase_c)

768T

ATP binding site
677N, 681N, 684T, 711I, 713D, 715G, 717G, 718I, 741G, 742L, 743G, 744L, 760I, 762S, 767G, 768T, 770V
CDD
cd00075 (HATPase_c)

770V

ATP binding site
677N, 681N, 684T, 711I, 713D, 715G, 717G, 718I, 741G, 742L, 743G, 744L, 760I, 762S, 767G, 768T, 770V
CDD
cd00075 (HATPase_c)
Mg2+ binding site ...

681N

Mg2+ binding site
681N
CDD
cd00075 (HATPase_c)
G-X-G motif cd00075

715G

G-X-G motif
715G, 717G, 741G, 743G
CDD
cd00075 (HATPase_c)

717G

G-X-G motif
715G, 717G, 741G, 743G
CDD
cd00075 (HATPase_c)

741G

G-X-G motif
715G, 717G, 741G, 743G
CDD
cd00075 (HATPase_c)

743G

G-X-G motif
715G, 717G, 741G, 743G
CDD
cd00075 (HATPase_c)

GO term prediction

Biological Process

GO:0007165 signal transduction
GO:0016310 phosphorylation

Molecular Function

GO:0000155 phosphorelay sensor kinase activity
GO:0004871 signal transducer activity
GO:0016772 transferase activity, transferring phosphorus-containing groups

Cellular Component

GO:0016021 integral component of membrane

Filter view on

Entry type

Status

Per-residue features

49185_FusoPortal_Gene_927

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component