9817_FusoPortal_Gene_1058

Protein

9817_FusoPortal_Gene_1058

Length

285 amino acids

Protein family membership

tRNA pseudouridine synthase II, TruB (IPR014780)

Homologous superfamilies

Homologous superfamily
1 - 224
Pseudouridine synthase, catalytic domain superfamily (IPR020103)

1 50 100 150 200 250 285

Domains and repeats

Domain
23 - 171
Pseudouridine synthase II, N-terminal (IPR002501)
172 - 227
tRNA pseudouridylate synthase B, C-terminal (IPR032819)
242 - 280
tRNA pseudouridine synthase II, TruB, subfamily 1, C-terminal (IPR015240)

1 50 100 150 200 250 285

Detailed signature matches

IPR020103

Pseudouridine synthase, catalytic domain superfamily
1. SSF55120 (Pseudouri...)
  
  1 - 224
  
  SUPERFAMILY
  SSF55120 (Pseudouridine synthase)
IPR014780

tRNA pseudouridine synthase II, TruB
1. MF_01080 (TruB_bact)
  
  1 - 285
  
  HAMAP
  MF_01080 (TruB_bact)
2. PTHR13767 (TRNA-PSE...)
  
  2 - 228
  
  PANTHER
  PTHR13767 (TRNA-PSEUDOURIDINE SYNTHASE)
3. TIGR00431
  
  1 - 209
  
  TIGRFAMs
  TIGR00431 (TIGR00431)
IPR002501

Pseudouridine synthase II, N-terminal
1. PF01509 (TruB_N)
  
  23 - 171
  
  Pfam
  PF01509 (TruB_N)
IPR032819

tRNA pseudouridylate synthase B, C-terminal
1. PF16198 (TruB_C_2)
  
  172 - 227
  
  Pfam
  PF16198 (TruB_C_2)
IPR015240

tRNA pseudouridine synthase II, TruB, subfamily 1, C-terminal
1. PF09157 (TruB-C_2)
  
  242 - 280
  
  Pfam
  PF09157 (TruB-C_2)

no IPR

Unintegrated signatures

G3DSA:3.30.23...

1 - 219

GENE3D
G3DSA:3.30.2350.10 (G3DSA:3.30.2350.10)
cd02573 (PseudoU_sy...)

3 - 213

CDD
cd02573 (PseudoU_synth_EcTruB)

Residue annotation

RNA binding site c...

14T

RNA binding site
14T, 16F, 19I, 31I, 32G, 33H, 35G, 36T, 37L, 38D, 39P, 53T, 56V, 57Q, 60E, 64K, 66Y, 117Y, 118S, 119A, 120L, 121K, 142R, 167K, 168G, 169T, 170Y, 171I, 172R, 193R
CDD
cd02573 (PseudoU_synth_EcTruB)

16F

RNA binding site
14T, 16F, 19I, 31I, 32G, 33H, 35G, 36T, 37L, 38D, 39P, 53T, 56V, 57Q, 60E, 64K, 66Y, 117Y, 118S, 119A, 120L, 121K, 142R, 167K, 168G, 169T, 170Y, 171I, 172R, 193R
CDD
cd02573 (PseudoU_synth_EcTruB)

19I

RNA binding site
14T, 16F, 19I, 31I, 32G, 33H, 35G, 36T, 37L, 38D, 39P, 53T, 56V, 57Q, 60E, 64K, 66Y, 117Y, 118S, 119A, 120L, 121K, 142R, 167K, 168G, 169T, 170Y, 171I, 172R, 193R
CDD
cd02573 (PseudoU_synth_EcTruB)

31I

RNA binding site
14T, 16F, 19I, 31I, 32G, 33H, 35G, 36T, 37L, 38D, 39P, 53T, 56V, 57Q, 60E, 64K, 66Y, 117Y, 118S, 119A, 120L, 121K, 142R, 167K, 168G, 169T, 170Y, 171I, 172R, 193R
CDD
cd02573 (PseudoU_synth_EcTruB)

32G

RNA binding site
14T, 16F, 19I, 31I, 32G, 33H, 35G, 36T, 37L, 38D, 39P, 53T, 56V, 57Q, 60E, 64K, 66Y, 117Y, 118S, 119A, 120L, 121K, 142R, 167K, 168G, 169T, 170Y, 171I, 172R, 193R
CDD
cd02573 (PseudoU_synth_EcTruB)

33H

RNA binding site
14T, 16F, 19I, 31I, 32G, 33H, 35G, 36T, 37L, 38D, 39P, 53T, 56V, 57Q, 60E, 64K, 66Y, 117Y, 118S, 119A, 120L, 121K, 142R, 167K, 168G, 169T, 170Y, 171I, 172R, 193R
CDD
cd02573 (PseudoU_synth_EcTruB)

35G

RNA binding site
14T, 16F, 19I, 31I, 32G, 33H, 35G, 36T, 37L, 38D, 39P, 53T, 56V, 57Q, 60E, 64K, 66Y, 117Y, 118S, 119A, 120L, 121K, 142R, 167K, 168G, 169T, 170Y, 171I, 172R, 193R
CDD
cd02573 (PseudoU_synth_EcTruB)

36T

RNA binding site
14T, 16F, 19I, 31I, 32G, 33H, 35G, 36T, 37L, 38D, 39P, 53T, 56V, 57Q, 60E, 64K, 66Y, 117Y, 118S, 119A, 120L, 121K, 142R, 167K, 168G, 169T, 170Y, 171I, 172R, 193R
CDD
cd02573 (PseudoU_synth_EcTruB)

37L

RNA binding site
14T, 16F, 19I, 31I, 32G, 33H, 35G, 36T, 37L, 38D, 39P, 53T, 56V, 57Q, 60E, 64K, 66Y, 117Y, 118S, 119A, 120L, 121K, 142R, 167K, 168G, 169T, 170Y, 171I, 172R, 193R
CDD
cd02573 (PseudoU_synth_EcTruB)

38D

RNA binding site
14T, 16F, 19I, 31I, 32G, 33H, 35G, 36T, 37L, 38D, 39P, 53T, 56V, 57Q, 60E, 64K, 66Y, 117Y, 118S, 119A, 120L, 121K, 142R, 167K, 168G, 169T, 170Y, 171I, 172R, 193R
CDD
cd02573 (PseudoU_synth_EcTruB)

39P

RNA binding site
14T, 16F, 19I, 31I, 32G, 33H, 35G, 36T, 37L, 38D, 39P, 53T, 56V, 57Q, 60E, 64K, 66Y, 117Y, 118S, 119A, 120L, 121K, 142R, 167K, 168G, 169T, 170Y, 171I, 172R, 193R
CDD
cd02573 (PseudoU_synth_EcTruB)

53T

RNA binding site
14T, 16F, 19I, 31I, 32G, 33H, 35G, 36T, 37L, 38D, 39P, 53T, 56V, 57Q, 60E, 64K, 66Y, 117Y, 118S, 119A, 120L, 121K, 142R, 167K, 168G, 169T, 170Y, 171I, 172R, 193R
CDD
cd02573 (PseudoU_synth_EcTruB)

56V

RNA binding site
14T, 16F, 19I, 31I, 32G, 33H, 35G, 36T, 37L, 38D, 39P, 53T, 56V, 57Q, 60E, 64K, 66Y, 117Y, 118S, 119A, 120L, 121K, 142R, 167K, 168G, 169T, 170Y, 171I, 172R, 193R
CDD
cd02573 (PseudoU_synth_EcTruB)

57Q

RNA binding site
14T, 16F, 19I, 31I, 32G, 33H, 35G, 36T, 37L, 38D, 39P, 53T, 56V, 57Q, 60E, 64K, 66Y, 117Y, 118S, 119A, 120L, 121K, 142R, 167K, 168G, 169T, 170Y, 171I, 172R, 193R
CDD
cd02573 (PseudoU_synth_EcTruB)

60E

RNA binding site
14T, 16F, 19I, 31I, 32G, 33H, 35G, 36T, 37L, 38D, 39P, 53T, 56V, 57Q, 60E, 64K, 66Y, 117Y, 118S, 119A, 120L, 121K, 142R, 167K, 168G, 169T, 170Y, 171I, 172R, 193R
CDD
cd02573 (PseudoU_synth_EcTruB)

64K

RNA binding site
14T, 16F, 19I, 31I, 32G, 33H, 35G, 36T, 37L, 38D, 39P, 53T, 56V, 57Q, 60E, 64K, 66Y, 117Y, 118S, 119A, 120L, 121K, 142R, 167K, 168G, 169T, 170Y, 171I, 172R, 193R
CDD
cd02573 (PseudoU_synth_EcTruB)

66Y

RNA binding site
14T, 16F, 19I, 31I, 32G, 33H, 35G, 36T, 37L, 38D, 39P, 53T, 56V, 57Q, 60E, 64K, 66Y, 117Y, 118S, 119A, 120L, 121K, 142R, 167K, 168G, 169T, 170Y, 171I, 172R, 193R
CDD
cd02573 (PseudoU_synth_EcTruB)

117Y

RNA binding site
14T, 16F, 19I, 31I, 32G, 33H, 35G, 36T, 37L, 38D, 39P, 53T, 56V, 57Q, 60E, 64K, 66Y, 117Y, 118S, 119A, 120L, 121K, 142R, 167K, 168G, 169T, 170Y, 171I, 172R, 193R
CDD
cd02573 (PseudoU_synth_EcTruB)

118S

RNA binding site
14T, 16F, 19I, 31I, 32G, 33H, 35G, 36T, 37L, 38D, 39P, 53T, 56V, 57Q, 60E, 64K, 66Y, 117Y, 118S, 119A, 120L, 121K, 142R, 167K, 168G, 169T, 170Y, 171I, 172R, 193R
CDD
cd02573 (PseudoU_synth_EcTruB)

119A

RNA binding site
14T, 16F, 19I, 31I, 32G, 33H, 35G, 36T, 37L, 38D, 39P, 53T, 56V, 57Q, 60E, 64K, 66Y, 117Y, 118S, 119A, 120L, 121K, 142R, 167K, 168G, 169T, 170Y, 171I, 172R, 193R
CDD
cd02573 (PseudoU_synth_EcTruB)

120L

RNA binding site
14T, 16F, 19I, 31I, 32G, 33H, 35G, 36T, 37L, 38D, 39P, 53T, 56V, 57Q, 60E, 64K, 66Y, 117Y, 118S, 119A, 120L, 121K, 142R, 167K, 168G, 169T, 170Y, 171I, 172R, 193R
CDD
cd02573 (PseudoU_synth_EcTruB)

121K

RNA binding site
14T, 16F, 19I, 31I, 32G, 33H, 35G, 36T, 37L, 38D, 39P, 53T, 56V, 57Q, 60E, 64K, 66Y, 117Y, 118S, 119A, 120L, 121K, 142R, 167K, 168G, 169T, 170Y, 171I, 172R, 193R
CDD
cd02573 (PseudoU_synth_EcTruB)

142R

RNA binding site
14T, 16F, 19I, 31I, 32G, 33H, 35G, 36T, 37L, 38D, 39P, 53T, 56V, 57Q, 60E, 64K, 66Y, 117Y, 118S, 119A, 120L, 121K, 142R, 167K, 168G, 169T, 170Y, 171I, 172R, 193R
CDD
cd02573 (PseudoU_synth_EcTruB)

167K

RNA binding site
14T, 16F, 19I, 31I, 32G, 33H, 35G, 36T, 37L, 38D, 39P, 53T, 56V, 57Q, 60E, 64K, 66Y, 117Y, 118S, 119A, 120L, 121K, 142R, 167K, 168G, 169T, 170Y, 171I, 172R, 193R
CDD
cd02573 (PseudoU_synth_EcTruB)

168G

RNA binding site
14T, 16F, 19I, 31I, 32G, 33H, 35G, 36T, 37L, 38D, 39P, 53T, 56V, 57Q, 60E, 64K, 66Y, 117Y, 118S, 119A, 120L, 121K, 142R, 167K, 168G, 169T, 170Y, 171I, 172R, 193R
CDD
cd02573 (PseudoU_synth_EcTruB)

169T

RNA binding site
14T, 16F, 19I, 31I, 32G, 33H, 35G, 36T, 37L, 38D, 39P, 53T, 56V, 57Q, 60E, 64K, 66Y, 117Y, 118S, 119A, 120L, 121K, 142R, 167K, 168G, 169T, 170Y, 171I, 172R, 193R
CDD
cd02573 (PseudoU_synth_EcTruB)

170Y

RNA binding site
14T, 16F, 19I, 31I, 32G, 33H, 35G, 36T, 37L, 38D, 39P, 53T, 56V, 57Q, 60E, 64K, 66Y, 117Y, 118S, 119A, 120L, 121K, 142R, 167K, 168G, 169T, 170Y, 171I, 172R, 193R
CDD
cd02573 (PseudoU_synth_EcTruB)

171I

RNA binding site
14T, 16F, 19I, 31I, 32G, 33H, 35G, 36T, 37L, 38D, 39P, 53T, 56V, 57Q, 60E, 64K, 66Y, 117Y, 118S, 119A, 120L, 121K, 142R, 167K, 168G, 169T, 170Y, 171I, 172R, 193R
CDD
cd02573 (PseudoU_synth_EcTruB)

172R

RNA binding site
14T, 16F, 19I, 31I, 32G, 33H, 35G, 36T, 37L, 38D, 39P, 53T, 56V, 57Q, 60E, 64K, 66Y, 117Y, 118S, 119A, 120L, 121K, 142R, 167K, 168G, 169T, 170Y, 171I, 172R, 193R
CDD
cd02573 (PseudoU_synth_EcTruB)

193R

RNA binding site
14T, 16F, 19I, 31I, 32G, 33H, 35G, 36T, 37L, 38D, 39P, 53T, 56V, 57Q, 60E, 64K, 66Y, 117Y, 118S, 119A, 120L, 121K, 142R, 167K, 168G, 169T, 170Y, 171I, 172R, 193R
CDD
cd02573 (PseudoU_synth_EcTruB)
active site cd02573

35G

active site
35G, 36T, 37L, 38D, 172R
CDD
cd02573 (PseudoU_synth_EcTruB)

36T

active site
35G, 36T, 37L, 38D, 172R
CDD
cd02573 (PseudoU_synth_EcTruB)

37L

active site
35G, 36T, 37L, 38D, 172R
CDD
cd02573 (PseudoU_synth_EcTruB)

38D

active site
35G, 36T, 37L, 38D, 172R
CDD
cd02573 (PseudoU_synth_EcTruB)

172R

active site
35G, 36T, 37L, 38D, 172R
CDD
cd02573 (PseudoU_synth_EcTruB)

GO term prediction

Biological Process

GO:0001522 pseudouridine synthesis
GO:0006396 RNA processing
GO:0009451 RNA modification

Molecular Function

GO:0003723 RNA binding
GO:0009982 pseudouridine synthase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

9817_FusoPortal_Gene_1058

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component