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Protein

9817_FusoPortal_Gene_1190

Length

397 amino acids

Protein family membership

Cys/Met metabolism, pyridoxal phosphate-dependent enzyme (IPR000277)
- L-methionine gamma-lyase (IPR006237)

Homologous superfamilies

Homologous superfamily
8 - 262
Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (IPR015421)
264 - 397
Pyridoxal phosphate-dependent transferase, subdomain 2 (IPR015422)
Homologous superfamily
23 - 394
Pyridoxal phosphate-dependent transferase (IPR015424)

1 50 100 150 200 250 300 350 397

Domains and repeats

None predicted.

Detailed signature matches

IPR015421

Pyridoxal phosphate-dependent transferase, major region, subdomain 1

G3DSA:3.40.64...

8 - 262

GENE3D
G3DSA:3.40.640.10 (G3DSA:3.40.640.10)

IPR015424

Pyridoxal phosphate-dependent transferase

SSF53383 (PLP-depen...)

23 - 394

SUPERFAMILY
SSF53383 (PLP-dependent transferases)

IPR015422

Pyridoxal phosphate-dependent transferase, subdomain 2

G3DSA:3.90.11...

264 - 397

GENE3D
G3DSA:3.90.1150.10 (G3DSA:3.90.1150.10)

IPR000277

Cys/Met metabolism, pyridoxal phosphate-dependent enzyme

cd00614 (CGS_like)

24 - 394

CDD
cd00614 (CGS_like)
PTHR11808 (TRANS-SU...)

7 - 395

PANTHER
PTHR11808 (TRANS-SULFURATION ENZYME FAMILY MEMBER)
PIRSF001434 (CGS)

1 - 397

PIRSF
PIRSF001434 (CGS)
PS00868 (CYS_MET_ME...)

203 - 217

PROSITE patterns
PS00868 (CYS_MET_METAB_PP)
PF01053 (Cys_Met_Me...)

11 - 394

Pfam
PF01053 (Cys_Met_Meta_PP)

IPR006237

L-methionine gamma-lyase

TIGR01328

8 - 394

TIGRFAMs
TIGR01328 (TIGR01328)

no IPR

Unintegrated signatures

PTHR11808:SF72 (CYS...)

7 - 395

PANTHER
PTHR11808:SF72 (CYSTATHIONINE BETA LYASE)

Residue annotation

homodimer interfac...

32Q

homodimer interface
32Q, 33T, 34S, 35T, 37V, 38F, 57Y, 59R, 85S, 86S, 88M, 89G, 112Y, 117A, 120S, 210T, 218D, 220I, 236T, 248G, 250N, 251E, 330N
CDD
cd00614 (CGS_like)

33T

homodimer interface
32Q, 33T, 34S, 35T, 37V, 38F, 57Y, 59R, 85S, 86S, 88M, 89G, 112Y, 117A, 120S, 210T, 218D, 220I, 236T, 248G, 250N, 251E, 330N
CDD
cd00614 (CGS_like)

34S

homodimer interface
32Q, 33T, 34S, 35T, 37V, 38F, 57Y, 59R, 85S, 86S, 88M, 89G, 112Y, 117A, 120S, 210T, 218D, 220I, 236T, 248G, 250N, 251E, 330N
CDD
cd00614 (CGS_like)

35T

homodimer interface
32Q, 33T, 34S, 35T, 37V, 38F, 57Y, 59R, 85S, 86S, 88M, 89G, 112Y, 117A, 120S, 210T, 218D, 220I, 236T, 248G, 250N, 251E, 330N
CDD
cd00614 (CGS_like)

37V

homodimer interface
32Q, 33T, 34S, 35T, 37V, 38F, 57Y, 59R, 85S, 86S, 88M, 89G, 112Y, 117A, 120S, 210T, 218D, 220I, 236T, 248G, 250N, 251E, 330N
CDD
cd00614 (CGS_like)

38F

homodimer interface
32Q, 33T, 34S, 35T, 37V, 38F, 57Y, 59R, 85S, 86S, 88M, 89G, 112Y, 117A, 120S, 210T, 218D, 220I, 236T, 248G, 250N, 251E, 330N
CDD
cd00614 (CGS_like)

57Y

homodimer interface
32Q, 33T, 34S, 35T, 37V, 38F, 57Y, 59R, 85S, 86S, 88M, 89G, 112Y, 117A, 120S, 210T, 218D, 220I, 236T, 248G, 250N, 251E, 330N
CDD
cd00614 (CGS_like)

59R

homodimer interface
32Q, 33T, 34S, 35T, 37V, 38F, 57Y, 59R, 85S, 86S, 88M, 89G, 112Y, 117A, 120S, 210T, 218D, 220I, 236T, 248G, 250N, 251E, 330N
CDD
cd00614 (CGS_like)

85S

homodimer interface
32Q, 33T, 34S, 35T, 37V, 38F, 57Y, 59R, 85S, 86S, 88M, 89G, 112Y, 117A, 120S, 210T, 218D, 220I, 236T, 248G, 250N, 251E, 330N
CDD
cd00614 (CGS_like)

86S

homodimer interface
32Q, 33T, 34S, 35T, 37V, 38F, 57Y, 59R, 85S, 86S, 88M, 89G, 112Y, 117A, 120S, 210T, 218D, 220I, 236T, 248G, 250N, 251E, 330N
CDD
cd00614 (CGS_like)

88M

homodimer interface
32Q, 33T, 34S, 35T, 37V, 38F, 57Y, 59R, 85S, 86S, 88M, 89G, 112Y, 117A, 120S, 210T, 218D, 220I, 236T, 248G, 250N, 251E, 330N
CDD
cd00614 (CGS_like)

89G

homodimer interface
32Q, 33T, 34S, 35T, 37V, 38F, 57Y, 59R, 85S, 86S, 88M, 89G, 112Y, 117A, 120S, 210T, 218D, 220I, 236T, 248G, 250N, 251E, 330N
CDD
cd00614 (CGS_like)

112Y

homodimer interface
32Q, 33T, 34S, 35T, 37V, 38F, 57Y, 59R, 85S, 86S, 88M, 89G, 112Y, 117A, 120S, 210T, 218D, 220I, 236T, 248G, 250N, 251E, 330N
CDD
cd00614 (CGS_like)

117A

homodimer interface
32Q, 33T, 34S, 35T, 37V, 38F, 57Y, 59R, 85S, 86S, 88M, 89G, 112Y, 117A, 120S, 210T, 218D, 220I, 236T, 248G, 250N, 251E, 330N
CDD
cd00614 (CGS_like)

120S

homodimer interface
32Q, 33T, 34S, 35T, 37V, 38F, 57Y, 59R, 85S, 86S, 88M, 89G, 112Y, 117A, 120S, 210T, 218D, 220I, 236T, 248G, 250N, 251E, 330N
CDD
cd00614 (CGS_like)

210T

homodimer interface
32Q, 33T, 34S, 35T, 37V, 38F, 57Y, 59R, 85S, 86S, 88M, 89G, 112Y, 117A, 120S, 210T, 218D, 220I, 236T, 248G, 250N, 251E, 330N
CDD
cd00614 (CGS_like)

218D

homodimer interface
32Q, 33T, 34S, 35T, 37V, 38F, 57Y, 59R, 85S, 86S, 88M, 89G, 112Y, 117A, 120S, 210T, 218D, 220I, 236T, 248G, 250N, 251E, 330N
CDD
cd00614 (CGS_like)

220I

homodimer interface
32Q, 33T, 34S, 35T, 37V, 38F, 57Y, 59R, 85S, 86S, 88M, 89G, 112Y, 117A, 120S, 210T, 218D, 220I, 236T, 248G, 250N, 251E, 330N
CDD
cd00614 (CGS_like)

236T

homodimer interface
32Q, 33T, 34S, 35T, 37V, 38F, 57Y, 59R, 85S, 86S, 88M, 89G, 112Y, 117A, 120S, 210T, 218D, 220I, 236T, 248G, 250N, 251E, 330N
CDD
cd00614 (CGS_like)

248G

homodimer interface
32Q, 33T, 34S, 35T, 37V, 38F, 57Y, 59R, 85S, 86S, 88M, 89G, 112Y, 117A, 120S, 210T, 218D, 220I, 236T, 248G, 250N, 251E, 330N
CDD
cd00614 (CGS_like)

250N

homodimer interface
32Q, 33T, 34S, 35T, 37V, 38F, 57Y, 59R, 85S, 86S, 88M, 89G, 112Y, 117A, 120S, 210T, 218D, 220I, 236T, 248G, 250N, 251E, 330N
CDD
cd00614 (CGS_like)

251E

homodimer interface
32Q, 33T, 34S, 35T, 37V, 38F, 57Y, 59R, 85S, 86S, 88M, 89G, 112Y, 117A, 120S, 210T, 218D, 220I, 236T, 248G, 250N, 251E, 330N
CDD
cd00614 (CGS_like)

330N

homodimer interface
32Q, 33T, 34S, 35T, 37V, 38F, 57Y, 59R, 85S, 86S, 88M, 89G, 112Y, 117A, 120S, 210T, 218D, 220I, 236T, 248G, 250N, 251E, 330N
CDD
cd00614 (CGS_like)
pyridoxal 5'-phosp...

86S

pyridoxal 5'-phosphate binding site
86S, 87G, 88M, 112Y, 186D, 189F, 208S, 210T, 211K
CDD
cd00614 (CGS_like)

87G

pyridoxal 5'-phosphate binding site
86S, 87G, 88M, 112Y, 186D, 189F, 208S, 210T, 211K
CDD
cd00614 (CGS_like)

88M

pyridoxal 5'-phosphate binding site
86S, 87G, 88M, 112Y, 186D, 189F, 208S, 210T, 211K
CDD
cd00614 (CGS_like)

112Y

pyridoxal 5'-phosphate binding site
86S, 87G, 88M, 112Y, 186D, 189F, 208S, 210T, 211K
CDD
cd00614 (CGS_like)

186D

pyridoxal 5'-phosphate binding site
86S, 87G, 88M, 112Y, 186D, 189F, 208S, 210T, 211K
CDD
cd00614 (CGS_like)

189F

pyridoxal 5'-phosphate binding site
86S, 87G, 88M, 112Y, 186D, 189F, 208S, 210T, 211K
CDD
cd00614 (CGS_like)

208S

pyridoxal 5'-phosphate binding site
86S, 87G, 88M, 112Y, 186D, 189F, 208S, 210T, 211K
CDD
cd00614 (CGS_like)

210T

pyridoxal 5'-phosphate binding site
86S, 87G, 88M, 112Y, 186D, 189F, 208S, 210T, 211K
CDD
cd00614 (CGS_like)

211K

pyridoxal 5'-phosphate binding site
86S, 87G, 88M, 112Y, 186D, 189F, 208S, 210T, 211K
CDD
cd00614 (CGS_like)
substrate-cofactor...

86S

substrate-cofactor binding pocket
86S, 87G, 88M, 112Y, 155E, 186D, 208S, 210T, 211K, 220I
CDD
cd00614 (CGS_like)

87G

substrate-cofactor binding pocket
86S, 87G, 88M, 112Y, 155E, 186D, 208S, 210T, 211K, 220I
CDD
cd00614 (CGS_like)

88M

substrate-cofactor binding pocket
86S, 87G, 88M, 112Y, 155E, 186D, 208S, 210T, 211K, 220I
CDD
cd00614 (CGS_like)

112Y

substrate-cofactor binding pocket
86S, 87G, 88M, 112Y, 155E, 186D, 208S, 210T, 211K, 220I
CDD
cd00614 (CGS_like)

155E

substrate-cofactor binding pocket
86S, 87G, 88M, 112Y, 155E, 186D, 208S, 210T, 211K, 220I
CDD
cd00614 (CGS_like)

186D

substrate-cofactor binding pocket
86S, 87G, 88M, 112Y, 155E, 186D, 208S, 210T, 211K, 220I
CDD
cd00614 (CGS_like)

208S

substrate-cofactor binding pocket
86S, 87G, 88M, 112Y, 155E, 186D, 208S, 210T, 211K, 220I
CDD
cd00614 (CGS_like)

210T

substrate-cofactor binding pocket
86S, 87G, 88M, 112Y, 155E, 186D, 208S, 210T, 211K, 220I
CDD
cd00614 (CGS_like)

211K

substrate-cofactor binding pocket
86S, 87G, 88M, 112Y, 155E, 186D, 208S, 210T, 211K, 220I
CDD
cd00614 (CGS_like)

220I

substrate-cofactor binding pocket
86S, 87G, 88M, 112Y, 155E, 186D, 208S, 210T, 211K, 220I
CDD
cd00614 (CGS_like)
catalytic residue ...

211K

catalytic residue
211K
CDD
cd00614 (CGS_like)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003824 catalytic activity
GO:0018826 methionine gamma-lyase activity
GO:0030170 pyridoxal phosphate binding

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

9817_FusoPortal_Gene_1190

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component