9817_FusoPortal_Gene_1267

Protein

9817_FusoPortal_Gene_1267

Length

613 amino acids

Protein family membership

None predicted.

Homologous superfamilies

Homologous superfamily
257 - 370
PAS domain superfamily (IPR035965)
442 - 612
Histidine kinase/HSP90-like ATPase superfamily (IPR036890)
Homologous superfamily
369 - 452
Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily (IPR036097)

1 100 200 300 400 500 613

Domains and repeats

Domain
201 - 253
HAMP domain (IPR003660)
262 - 383
PAS domain (IPR000014)
PAS fold (IPR013767)
504 - 609
Histidine kinase/HSP90-like ATPase (IPR003594)
Domain
382 - 451
Signal transduction histidine kinase, dimerisation/phosphoacceptor domain (IPR003661)
537 - 551
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)
555 - 565
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)
572 - 590
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)
596 - 609
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)
Domain
391 - 612
Histidine kinase domain (IPR005467)

1 100 200 300 400 500 613

Detailed signature matches

IPR035965

PAS domain superfamily
1. SSF55785 (PYP-like ...)
  
  257 - 370
  
  SUPERFAMILY
  SSF55785 (PYP-like sensor domain (PAS domain))
IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily
1. SSF47384 (Homodimer...)
  
  369 - 452
  
  SUPERFAMILY
  SSF47384 (Homodimeric domain of signal transducing histidine kinase)
IPR036890

Histidine kinase/HSP90-like ATPase superfamily
1. G3DSA:3.30.56...
  
  447 - 612
  
  GENE3D
  G3DSA:3.30.565.10 (G3DSA:3.30.565.10)
2. SSF55874 (ATPase do...)
  
  442 - 609
  
  SUPERFAMILY
  SSF55874 (ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase)
IPR003660

HAMP domain
1. PS50885 (HAMP)
  
  201 - 253
  
  PROSITE profiles
  PS50885 (HAMP)
2. cd06225 (HAMP)
  
  203 - 250
  
  CDD
  cd06225 (HAMP)
IPR000014

PAS domain
1. PS50112 (PAS)
  
  262 - 345
  
  PROSITE profiles
  PS50112 (PAS)
2. cd00130 (PAS)
  
  273 - 375
  
  CDD
  cd00130 (PAS)
3. TIGR00229
  
  267 - 383
  
  TIGRFAMs
  TIGR00229 (TIGR00229)
IPR013767

PAS fold
1. PF00989 (PAS)
  
  267 - 375
  
  Pfam
  PF00989 (PAS)
IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain
1. cd00082 (HisKA)
  
  382 - 435
  
  CDD
  cd00082 (HisKA)
2. PF00512 (HisKA)
  
  384 - 451
  
  Pfam
  PF00512 (HisKA)
IPR005467

Histidine kinase domain
1. PS50109 (HIS_KIN)
  
  391 - 612
  
  PROSITE profiles
  PS50109 (HIS_KIN)
IPR003594

Histidine kinase/HSP90-like ATPase
1. PF02518 (HATPase_c)
  
  504 - 609
  
  Pfam
  PF02518 (HATPase_c)
2. cd00075 (HATPase_c)
  
  506 - 608
  
  CDD
  cd00075 (HATPase_c)
IPR004358

Signal transduction histidine kinase-related protein, C-terminal
1. PR00344 (BCTRLSENSOR)
  
  572 - 590
  
  PRINTS
  PR00344 (BCTRLSENSOR)
  
  596 - 609
  
  PRINTS
  PR00344 (BCTRLSENSOR)
  
  555 - 565
  
  PRINTS
  PR00344 (BCTRLSENSOR)
  
  537 - 551
  
  PRINTS
  PR00344 (BCTRLSENSOR)

no IPR

Unintegrated signatures

G3DSA:1.10.28...

390 - 446

GENE3D
G3DSA:1.10.287.130 (G3DSA:1.10.287.130)
G3DSA:3.30.45...

262 - 389

GENE3D
G3DSA:3.30.450.20 (G3DSA:3.30.450.20)
PTHR42878 (FAMILY N...)

1 - 612

PANTHER
PTHR42878 (FAMILY NOT NAMED)
PTHR42878:SF5 (SUBF...)

1 - 612

PANTHER
PTHR42878:SF5 (SUBFAMILY NOT NAMED)

Residue annotation

dimerization inter...

203I

dimerization interface
203I, 204L, 207F, 208D, 210F, 211V, 214I, 215E, 217V, 233E, 234F, 236K, 237M, 240A, 241F, 243Q, 244M, 247K, 248L
CDD
cd06225 (HAMP)

204L

dimerization interface
203I, 204L, 207F, 208D, 210F, 211V, 214I, 215E, 217V, 233E, 234F, 236K, 237M, 240A, 241F, 243Q, 244M, 247K, 248L
CDD
cd06225 (HAMP)

207F

dimerization interface
203I, 204L, 207F, 208D, 210F, 211V, 214I, 215E, 217V, 233E, 234F, 236K, 237M, 240A, 241F, 243Q, 244M, 247K, 248L
CDD
cd06225 (HAMP)

208D

dimerization interface
203I, 204L, 207F, 208D, 210F, 211V, 214I, 215E, 217V, 233E, 234F, 236K, 237M, 240A, 241F, 243Q, 244M, 247K, 248L
CDD
cd06225 (HAMP)

210F

dimerization interface
203I, 204L, 207F, 208D, 210F, 211V, 214I, 215E, 217V, 233E, 234F, 236K, 237M, 240A, 241F, 243Q, 244M, 247K, 248L
CDD
cd06225 (HAMP)

211V

dimerization interface
203I, 204L, 207F, 208D, 210F, 211V, 214I, 215E, 217V, 233E, 234F, 236K, 237M, 240A, 241F, 243Q, 244M, 247K, 248L
CDD
cd06225 (HAMP)

214I

dimerization interface
203I, 204L, 207F, 208D, 210F, 211V, 214I, 215E, 217V, 233E, 234F, 236K, 237M, 240A, 241F, 243Q, 244M, 247K, 248L
CDD
cd06225 (HAMP)

215E

dimerization interface
203I, 204L, 207F, 208D, 210F, 211V, 214I, 215E, 217V, 233E, 234F, 236K, 237M, 240A, 241F, 243Q, 244M, 247K, 248L
CDD
cd06225 (HAMP)

217V

dimerization interface
203I, 204L, 207F, 208D, 210F, 211V, 214I, 215E, 217V, 233E, 234F, 236K, 237M, 240A, 241F, 243Q, 244M, 247K, 248L
CDD
cd06225 (HAMP)

233E

dimerization interface
203I, 204L, 207F, 208D, 210F, 211V, 214I, 215E, 217V, 233E, 234F, 236K, 237M, 240A, 241F, 243Q, 244M, 247K, 248L
CDD
cd06225 (HAMP)

234F

dimerization interface
203I, 204L, 207F, 208D, 210F, 211V, 214I, 215E, 217V, 233E, 234F, 236K, 237M, 240A, 241F, 243Q, 244M, 247K, 248L
CDD
cd06225 (HAMP)

236K

dimerization interface
203I, 204L, 207F, 208D, 210F, 211V, 214I, 215E, 217V, 233E, 234F, 236K, 237M, 240A, 241F, 243Q, 244M, 247K, 248L
CDD
cd06225 (HAMP)

237M

dimerization interface
203I, 204L, 207F, 208D, 210F, 211V, 214I, 215E, 217V, 233E, 234F, 236K, 237M, 240A, 241F, 243Q, 244M, 247K, 248L
CDD
cd06225 (HAMP)

240A

dimerization interface
203I, 204L, 207F, 208D, 210F, 211V, 214I, 215E, 217V, 233E, 234F, 236K, 237M, 240A, 241F, 243Q, 244M, 247K, 248L
CDD
cd06225 (HAMP)

241F

dimerization interface
203I, 204L, 207F, 208D, 210F, 211V, 214I, 215E, 217V, 233E, 234F, 236K, 237M, 240A, 241F, 243Q, 244M, 247K, 248L
CDD
cd06225 (HAMP)

243Q

dimerization interface
203I, 204L, 207F, 208D, 210F, 211V, 214I, 215E, 217V, 233E, 234F, 236K, 237M, 240A, 241F, 243Q, 244M, 247K, 248L
CDD
cd06225 (HAMP)

244M

dimerization interface
203I, 204L, 207F, 208D, 210F, 211V, 214I, 215E, 217V, 233E, 234F, 236K, 237M, 240A, 241F, 243Q, 244M, 247K, 248L
CDD
cd06225 (HAMP)

247K

dimerization interface
203I, 204L, 207F, 208D, 210F, 211V, 214I, 215E, 217V, 233E, 234F, 236K, 237M, 240A, 241F, 243Q, 244M, 247K, 248L
CDD
cd06225 (HAMP)

248L

dimerization interface
203I, 204L, 207F, 208D, 210F, 211V, 214I, 215E, 217V, 233E, 234F, 236K, 237M, 240A, 241F, 243Q, 244M, 247K, 248L
CDD
cd06225 (HAMP)
putative active si...

289V

putative active site
289V, 293A, 299I, 312A, 313I, 315N, 316K, 342L, 346E
CDD
cd00130 (PAS)

293A

putative active site
289V, 293A, 299I, 312A, 313I, 315N, 316K, 342L, 346E
CDD
cd00130 (PAS)

299I

putative active site
289V, 293A, 299I, 312A, 313I, 315N, 316K, 342L, 346E
CDD
cd00130 (PAS)

312A

putative active site
289V, 293A, 299I, 312A, 313I, 315N, 316K, 342L, 346E
CDD
cd00130 (PAS)

313I

putative active site
289V, 293A, 299I, 312A, 313I, 315N, 316K, 342L, 346E
CDD
cd00130 (PAS)

315N

putative active site
289V, 293A, 299I, 312A, 313I, 315N, 316K, 342L, 346E
CDD
cd00130 (PAS)

316K

putative active site
289V, 293A, 299I, 312A, 313I, 315N, 316K, 342L, 346E
CDD
cd00130 (PAS)

342L

putative active site
289V, 293A, 299I, 312A, 313I, 315N, 316K, 342L, 346E
CDD
cd00130 (PAS)

346E

putative active site
289V, 293A, 299I, 312A, 313I, 315N, 316K, 342L, 346E
CDD
cd00130 (PAS)
heme pocket cd00130

309F

heme pocket
309F, 313I, 322V, 325I, 326L, 353V, 355I
CDD
cd00130 (PAS)

313I

heme pocket
309F, 313I, 322V, 325I, 326L, 353V, 355I
CDD
cd00130 (PAS)

322V

heme pocket
309F, 313I, 322V, 325I, 326L, 353V, 355I
CDD
cd00130 (PAS)

325I

heme pocket
309F, 313I, 322V, 325I, 326L, 353V, 355I
CDD
cd00130 (PAS)

326L

heme pocket
309F, 313I, 322V, 325I, 326L, 353V, 355I
CDD
cd00130 (PAS)

353V

heme pocket
309F, 313I, 322V, 325I, 326L, 353V, 355I
CDD
cd00130 (PAS)

355I

heme pocket
309F, 313I, 322V, 325I, 326L, 353V, 355I
CDD
cd00130 (PAS)
dimer interface cd...

388F

dimer interface
388F, 392V, 396F, 399P, 403I, 406A, 425L, 429I, 432D
CDD
cd00082 (HisKA)

392V

dimer interface
388F, 392V, 396F, 399P, 403I, 406A, 425L, 429I, 432D
CDD
cd00082 (HisKA)

396F

dimer interface
388F, 392V, 396F, 399P, 403I, 406A, 425L, 429I, 432D
CDD
cd00082 (HisKA)

399P

dimer interface
388F, 392V, 396F, 399P, 403I, 406A, 425L, 429I, 432D
CDD
cd00082 (HisKA)

403I

dimer interface
388F, 392V, 396F, 399P, 403I, 406A, 425L, 429I, 432D
CDD
cd00082 (HisKA)

406A

dimer interface
388F, 392V, 396F, 399P, 403I, 406A, 425L, 429I, 432D
CDD
cd00082 (HisKA)

425L

dimer interface
388F, 392V, 396F, 399P, 403I, 406A, 425L, 429I, 432D
CDD
cd00082 (HisKA)

429I

dimer interface
388F, 392V, 396F, 399P, 403I, 406A, 425L, 429I, 432D
CDD
cd00082 (HisKA)

432D

dimer interface
388F, 392V, 396F, 399P, 403I, 406A, 425L, 429I, 432D
CDD
cd00082 (HisKA)
phosphorylation si...

394H

phosphorylation site
394H
CDD
cd00082 (HisKA)
ATP binding site c...

509N

ATP binding site
509N, 513N, 516K, 541V, 543D, 545G, 547G, 548I, 575G, 576L, 577G, 578L, 594V, 596S, 601G, 602S, 604F
CDD
cd00075 (HATPase_c)

513N

ATP binding site
509N, 513N, 516K, 541V, 543D, 545G, 547G, 548I, 575G, 576L, 577G, 578L, 594V, 596S, 601G, 602S, 604F
CDD
cd00075 (HATPase_c)

516K

ATP binding site
509N, 513N, 516K, 541V, 543D, 545G, 547G, 548I, 575G, 576L, 577G, 578L, 594V, 596S, 601G, 602S, 604F
CDD
cd00075 (HATPase_c)

541V

ATP binding site
509N, 513N, 516K, 541V, 543D, 545G, 547G, 548I, 575G, 576L, 577G, 578L, 594V, 596S, 601G, 602S, 604F
CDD
cd00075 (HATPase_c)

543D

ATP binding site
509N, 513N, 516K, 541V, 543D, 545G, 547G, 548I, 575G, 576L, 577G, 578L, 594V, 596S, 601G, 602S, 604F
CDD
cd00075 (HATPase_c)

545G

ATP binding site
509N, 513N, 516K, 541V, 543D, 545G, 547G, 548I, 575G, 576L, 577G, 578L, 594V, 596S, 601G, 602S, 604F
CDD
cd00075 (HATPase_c)

547G

ATP binding site
509N, 513N, 516K, 541V, 543D, 545G, 547G, 548I, 575G, 576L, 577G, 578L, 594V, 596S, 601G, 602S, 604F
CDD
cd00075 (HATPase_c)

548I

ATP binding site
509N, 513N, 516K, 541V, 543D, 545G, 547G, 548I, 575G, 576L, 577G, 578L, 594V, 596S, 601G, 602S, 604F
CDD
cd00075 (HATPase_c)

575G

ATP binding site
509N, 513N, 516K, 541V, 543D, 545G, 547G, 548I, 575G, 576L, 577G, 578L, 594V, 596S, 601G, 602S, 604F
CDD
cd00075 (HATPase_c)

576L

ATP binding site
509N, 513N, 516K, 541V, 543D, 545G, 547G, 548I, 575G, 576L, 577G, 578L, 594V, 596S, 601G, 602S, 604F
CDD
cd00075 (HATPase_c)

577G

ATP binding site
509N, 513N, 516K, 541V, 543D, 545G, 547G, 548I, 575G, 576L, 577G, 578L, 594V, 596S, 601G, 602S, 604F
CDD
cd00075 (HATPase_c)

578L

ATP binding site
509N, 513N, 516K, 541V, 543D, 545G, 547G, 548I, 575G, 576L, 577G, 578L, 594V, 596S, 601G, 602S, 604F
CDD
cd00075 (HATPase_c)

594V

ATP binding site
509N, 513N, 516K, 541V, 543D, 545G, 547G, 548I, 575G, 576L, 577G, 578L, 594V, 596S, 601G, 602S, 604F
CDD
cd00075 (HATPase_c)

596S

ATP binding site
509N, 513N, 516K, 541V, 543D, 545G, 547G, 548I, 575G, 576L, 577G, 578L, 594V, 596S, 601G, 602S, 604F
CDD
cd00075 (HATPase_c)

601G

ATP binding site
509N, 513N, 516K, 541V, 543D, 545G, 547G, 548I, 575G, 576L, 577G, 578L, 594V, 596S, 601G, 602S, 604F
CDD
cd00075 (HATPase_c)

602S

ATP binding site
509N, 513N, 516K, 541V, 543D, 545G, 547G, 548I, 575G, 576L, 577G, 578L, 594V, 596S, 601G, 602S, 604F
CDD
cd00075 (HATPase_c)

604F

ATP binding site
509N, 513N, 516K, 541V, 543D, 545G, 547G, 548I, 575G, 576L, 577G, 578L, 594V, 596S, 601G, 602S, 604F
CDD
cd00075 (HATPase_c)
Mg2+ binding site ...

513N

Mg2+ binding site
513N
CDD
cd00075 (HATPase_c)
G-X-G motif cd00075

545G

G-X-G motif
545G, 547G, 575G, 577G
CDD
cd00075 (HATPase_c)

547G

G-X-G motif
545G, 547G, 575G, 577G
CDD
cd00075 (HATPase_c)

575G

G-X-G motif
545G, 547G, 575G, 577G
CDD
cd00075 (HATPase_c)

577G

G-X-G motif
545G, 547G, 575G, 577G
CDD
cd00075 (HATPase_c)

GO term prediction

Biological Process

GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0016310 phosphorylation

Molecular Function

GO:0000155 phosphorelay sensor kinase activity
GO:0004871 signal transducer activity
GO:0016772 transferase activity, transferring phosphorus-containing groups

Cellular Component

GO:0016021 integral component of membrane

Filter view on

Entry type

Status

Per-residue features

9817_FusoPortal_Gene_1267

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component