9817_FusoPortal_Gene_1439

Protein

9817_FusoPortal_Gene_1439

Length

472 amino acids

Protein family membership

Asparaginase/glutaminase-like (IPR006034)
- L-asparaginase, type I (IPR006033)

Homologous superfamilies

Homologous superfamily
2 - 341
Asparaginase/glutaminase-like superfamily (IPR036152)
Homologous superfamily
2 - 213
L-asparaginase, N-terminal domain superfamily (IPR037152)
214 - 343
L-asparaginase, C-terminal (IPR027473)

1 50 100 150 200 250 300 350 400 472

Domains and repeats

Domain
4 - 197
L-asparaginase, N-terminal (IPR027474)

1 50 100 150 200 250 300 350 400 472

Detailed signature matches

IPR037152

L-asparaginase, N-terminal domain superfamily
1. G3DSA:3.40.50...
  
  2 - 213
  
  GENE3D
  G3DSA:3.40.50.1170 (G3DSA:3.40.50.1170)
IPR036152

Asparaginase/glutaminase-like superfamily
1. SSF53774 (Glutamina...)
  
  2 - 341
  
  SUPERFAMILY
  SSF53774 (Glutaminase/Asparaginase)
IPR027473

L-asparaginase, C-terminal
1. G3DSA:3.40.50.40
  
  214 - 343
  
  GENE3D
  G3DSA:3.40.50.40 (G3DSA:3.40.50.40)
IPR006034

Asparaginase/glutaminase-like
1. PR00139 (ASNGLNASE)
  
  83 - 101
  
  PRINTS
  PR00139 (ASNGLNASE)
  
  266 - 284
  
  PRINTS
  PR00139 (ASNGLNASE)
  
  5 - 16
  
  PRINTS
  PR00139 (ASNGLNASE)
2. PS51732 (ASN_GLN_ASE_3)
  
  3 - 335
  
  PROSITE profiles
  PS51732 (ASN_GLN_ASE_3)
IPR006033

L-asparaginase, type I
1. TIGR00519
  
  3 - 339
  
  TIGRFAMs
  TIGR00519 (TIGR00519)
IPR027474

L-asparaginase, N-terminal
1. PF00710 (Asparaginase)
  
  4 - 197
  
  Pfam
  PF00710 (Asparaginase)
IPR020827

Asparaginase/glutaminase, active site 1
1. PS00144 (ASN_GLN_ASE_1)
  
  7 - 15
  
  PROSITE patterns
  PS00144 (ASN_GLN_ASE_1)
IPR027475

Asparaginase/glutaminase, active site 2
1. PS00917 (ASN_GLN_ASE_2)
  
  84 - 94
  
  PROSITE patterns
  PS00917 (ASN_GLN_ASE_2)

no IPR

Unintegrated signatures

PTHR11707 (L-ASPARA...)

4 - 352

PANTHER
PTHR11707 (L-ASPARAGINASE)
PTHR11707:SF28 (60 ...)

4 - 352

PANTHER
PTHR11707:SF28 (60 KDA LYSOPHOSPHOLIPASE)
SFLDS00057 (Glutami...)

3 - 341

SFLD
SFLDS00057 (Glutaminase/Asparaginase)
cd08963 (L-asparagi...)

4 - 330

CDD
cd08963 (L-asparaginase_I)

Residue annotation

active site cd08963

12G

active site
12G, 13T, 60S, 61S, 90G, 91T, 92D, 117S, 168K
CDD
cd08963 (L-asparaginase_I)

13T

active site
12G, 13T, 60S, 61S, 90G, 91T, 92D, 117S, 168K
CDD
cd08963 (L-asparaginase_I)

60S

active site
12G, 13T, 60S, 61S, 90G, 91T, 92D, 117S, 168K
CDD
cd08963 (L-asparaginase_I)

61S

active site
12G, 13T, 60S, 61S, 90G, 91T, 92D, 117S, 168K
CDD
cd08963 (L-asparaginase_I)

90G

active site
12G, 13T, 60S, 61S, 90G, 91T, 92D, 117S, 168K
CDD
cd08963 (L-asparaginase_I)

91T

active site
12G, 13T, 60S, 61S, 90G, 91T, 92D, 117S, 168K
CDD
cd08963 (L-asparaginase_I)

92D

active site
12G, 13T, 60S, 61S, 90G, 91T, 92D, 117S, 168K
CDD
cd08963 (L-asparaginase_I)

117S

active site
12G, 13T, 60S, 61S, 90G, 91T, 92D, 117S, 168K
CDD
cd08963 (L-asparaginase_I)

168K

active site
12G, 13T, 60S, 61S, 90G, 91T, 92D, 117S, 168K
CDD
cd08963 (L-asparaginase_I)
SFLDS00057

13T

SFLD_Res01
13T, 115T
SFLD
SFLDS00057 (Glutaminase/Asparaginase)

115T

SFLD_Res01
13T, 115T
SFLD
SFLDS00057 (Glutaminase/Asparaginase)
homodimer interfac...

13T

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

27P

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

28L

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

29R

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

56P

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

59D

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

60S

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

61S

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

62D

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

63M

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

64S

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

65P

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

67I

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

68W

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

92D

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

93T

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

96F

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

118Q

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

119V

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

168K

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

169I

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

170D

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

171A

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

172T

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

173N

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

216E

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

217V

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

218V

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

219V

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

220L

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

221E

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

222L

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

223F

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

224P

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

225G

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

226L

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

228P

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

229S

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

232K

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

235F

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

236E

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

246K

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

248F

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

249G

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

250N

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

254P

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

278Q

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

281R

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

282G

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

283F

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

284V

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

285K

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

289Y

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

308P

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

312V

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

316M

homodimer interface
13T, 27P, 28L, 29R, 56P, 59D, 60S, 61S, 62D, 63M, 64S, 65P, 67I, 68W, 92D, 93T, 96F, 118Q, 119V, 168K, 169I, 170D, 171A, 172T, 173N, 216E, 217V, 218V, 219V, 220L, 221E, 222L, 223F, 224P, 225G, 226L, 228P, 229S, 232K, 235F, 236E, 246K, 248F, 249G, 250N, 254P, 278Q, 281R, 282G, 283F, 284V, 285K, 289Y, 308P, 312V, 316M
CDD
cd08963 (L-asparaginase_I)

GO term prediction

Biological Process

GO:0006520 cellular amino acid metabolic process

Molecular Function

GO:0004067 asparaginase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

9817_FusoPortal_Gene_1439

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component