9817_FusoPortal_Gene_2207

Protein

9817_FusoPortal_Gene_2207

Length

426 amino acids

Protein family membership

Cys/Met metabolism, pyridoxal phosphate-dependent enzyme (IPR000277)
- O-acetylhomoserine/O-acetylserine sulfhydrylase (IPR006235)

Homologous superfamilies

Homologous superfamily
6 - 290
Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (IPR015421)
292 - 426
Pyridoxal phosphate-dependent transferase, subdomain 2 (IPR015422)
Homologous superfamily
23 - 424
Pyridoxal phosphate-dependent transferase (IPR015424)

1 50 100 150 200 250 300 350 400 426

Domains and repeats

None predicted.

Detailed signature matches

IPR015421

Pyridoxal phosphate-dependent transferase, major region, subdomain 1
1. G3DSA:3.40.64...
  
  6 - 290
  
  GENE3D
  G3DSA:3.40.640.10 (G3DSA:3.40.640.10)
IPR015424

Pyridoxal phosphate-dependent transferase
1. SSF53383 (PLP-depen...)
  
  23 - 424
  
  SUPERFAMILY
  SSF53383 (PLP-dependent transferases)
IPR015422

Pyridoxal phosphate-dependent transferase, subdomain 2
1. G3DSA:3.90.11...
  
  292 - 426
  
  GENE3D
  G3DSA:3.90.1150.10 (G3DSA:3.90.1150.10)
IPR000277

Cys/Met metabolism, pyridoxal phosphate-dependent enzyme
1. cd00614 (CGS_like)
  
  24 - 424
  
  CDD
  cd00614 (CGS_like)
2. PIRSF001434 (CGS)
  
  1 - 426
  
  PIRSF
  PIRSF001434 (CGS)
3. PF01053 (Cys_Met_Me...)
  
  10 - 424
  
  Pfam
  PF01053 (Cys_Met_Meta_PP)
IPR006235

O-acetylhomoserine/O-acetylserine sulfhydrylase
1. TIGR01326
  
  9 - 424
  
  TIGRFAMs
  TIGR01326 (TIGR01326)

no IPR

Unintegrated signatures

PTHR43797 (FAMILY N...)

2 - 425

PANTHER
PTHR43797 (FAMILY NOT NAMED)
PTHR43797:SF3 (SUBF...)

2 - 425

PANTHER
PTHR43797:SF3 (SUBFAMILY NOT NAMED)

Residue annotation

homodimer interfac...

31Q

homodimer interface
31Q, 32T, 33T, 34T, 36D, 37Y, 56Y, 58R, 84A, 85S, 87Q, 88A, 111Y, 116N, 119K, 208T, 216A, 218L, 265V, 276N, 278F, 279N, 359K
CDD
cd00614 (CGS_like)

32T

homodimer interface
31Q, 32T, 33T, 34T, 36D, 37Y, 56Y, 58R, 84A, 85S, 87Q, 88A, 111Y, 116N, 119K, 208T, 216A, 218L, 265V, 276N, 278F, 279N, 359K
CDD
cd00614 (CGS_like)

33T

homodimer interface
31Q, 32T, 33T, 34T, 36D, 37Y, 56Y, 58R, 84A, 85S, 87Q, 88A, 111Y, 116N, 119K, 208T, 216A, 218L, 265V, 276N, 278F, 279N, 359K
CDD
cd00614 (CGS_like)

34T

homodimer interface
31Q, 32T, 33T, 34T, 36D, 37Y, 56Y, 58R, 84A, 85S, 87Q, 88A, 111Y, 116N, 119K, 208T, 216A, 218L, 265V, 276N, 278F, 279N, 359K
CDD
cd00614 (CGS_like)

36D

homodimer interface
31Q, 32T, 33T, 34T, 36D, 37Y, 56Y, 58R, 84A, 85S, 87Q, 88A, 111Y, 116N, 119K, 208T, 216A, 218L, 265V, 276N, 278F, 279N, 359K
CDD
cd00614 (CGS_like)

37Y

homodimer interface
31Q, 32T, 33T, 34T, 36D, 37Y, 56Y, 58R, 84A, 85S, 87Q, 88A, 111Y, 116N, 119K, 208T, 216A, 218L, 265V, 276N, 278F, 279N, 359K
CDD
cd00614 (CGS_like)

56Y

homodimer interface
31Q, 32T, 33T, 34T, 36D, 37Y, 56Y, 58R, 84A, 85S, 87Q, 88A, 111Y, 116N, 119K, 208T, 216A, 218L, 265V, 276N, 278F, 279N, 359K
CDD
cd00614 (CGS_like)

58R

homodimer interface
31Q, 32T, 33T, 34T, 36D, 37Y, 56Y, 58R, 84A, 85S, 87Q, 88A, 111Y, 116N, 119K, 208T, 216A, 218L, 265V, 276N, 278F, 279N, 359K
CDD
cd00614 (CGS_like)

84A

homodimer interface
31Q, 32T, 33T, 34T, 36D, 37Y, 56Y, 58R, 84A, 85S, 87Q, 88A, 111Y, 116N, 119K, 208T, 216A, 218L, 265V, 276N, 278F, 279N, 359K
CDD
cd00614 (CGS_like)

85S

homodimer interface
31Q, 32T, 33T, 34T, 36D, 37Y, 56Y, 58R, 84A, 85S, 87Q, 88A, 111Y, 116N, 119K, 208T, 216A, 218L, 265V, 276N, 278F, 279N, 359K
CDD
cd00614 (CGS_like)

87Q

homodimer interface
31Q, 32T, 33T, 34T, 36D, 37Y, 56Y, 58R, 84A, 85S, 87Q, 88A, 111Y, 116N, 119K, 208T, 216A, 218L, 265V, 276N, 278F, 279N, 359K
CDD
cd00614 (CGS_like)

88A

homodimer interface
31Q, 32T, 33T, 34T, 36D, 37Y, 56Y, 58R, 84A, 85S, 87Q, 88A, 111Y, 116N, 119K, 208T, 216A, 218L, 265V, 276N, 278F, 279N, 359K
CDD
cd00614 (CGS_like)

111Y

homodimer interface
31Q, 32T, 33T, 34T, 36D, 37Y, 56Y, 58R, 84A, 85S, 87Q, 88A, 111Y, 116N, 119K, 208T, 216A, 218L, 265V, 276N, 278F, 279N, 359K
CDD
cd00614 (CGS_like)

116N

homodimer interface
31Q, 32T, 33T, 34T, 36D, 37Y, 56Y, 58R, 84A, 85S, 87Q, 88A, 111Y, 116N, 119K, 208T, 216A, 218L, 265V, 276N, 278F, 279N, 359K
CDD
cd00614 (CGS_like)

119K

homodimer interface
31Q, 32T, 33T, 34T, 36D, 37Y, 56Y, 58R, 84A, 85S, 87Q, 88A, 111Y, 116N, 119K, 208T, 216A, 218L, 265V, 276N, 278F, 279N, 359K
CDD
cd00614 (CGS_like)

208T

homodimer interface
31Q, 32T, 33T, 34T, 36D, 37Y, 56Y, 58R, 84A, 85S, 87Q, 88A, 111Y, 116N, 119K, 208T, 216A, 218L, 265V, 276N, 278F, 279N, 359K
CDD
cd00614 (CGS_like)

216A

homodimer interface
31Q, 32T, 33T, 34T, 36D, 37Y, 56Y, 58R, 84A, 85S, 87Q, 88A, 111Y, 116N, 119K, 208T, 216A, 218L, 265V, 276N, 278F, 279N, 359K
CDD
cd00614 (CGS_like)

218L

homodimer interface
31Q, 32T, 33T, 34T, 36D, 37Y, 56Y, 58R, 84A, 85S, 87Q, 88A, 111Y, 116N, 119K, 208T, 216A, 218L, 265V, 276N, 278F, 279N, 359K
CDD
cd00614 (CGS_like)

265V

homodimer interface
31Q, 32T, 33T, 34T, 36D, 37Y, 56Y, 58R, 84A, 85S, 87Q, 88A, 111Y, 116N, 119K, 208T, 216A, 218L, 265V, 276N, 278F, 279N, 359K
CDD
cd00614 (CGS_like)

276N

homodimer interface
31Q, 32T, 33T, 34T, 36D, 37Y, 56Y, 58R, 84A, 85S, 87Q, 88A, 111Y, 116N, 119K, 208T, 216A, 218L, 265V, 276N, 278F, 279N, 359K
CDD
cd00614 (CGS_like)

278F

homodimer interface
31Q, 32T, 33T, 34T, 36D, 37Y, 56Y, 58R, 84A, 85S, 87Q, 88A, 111Y, 116N, 119K, 208T, 216A, 218L, 265V, 276N, 278F, 279N, 359K
CDD
cd00614 (CGS_like)

279N

homodimer interface
31Q, 32T, 33T, 34T, 36D, 37Y, 56Y, 58R, 84A, 85S, 87Q, 88A, 111Y, 116N, 119K, 208T, 216A, 218L, 265V, 276N, 278F, 279N, 359K
CDD
cd00614 (CGS_like)

359K

homodimer interface
31Q, 32T, 33T, 34T, 36D, 37Y, 56Y, 58R, 84A, 85S, 87Q, 88A, 111Y, 116N, 119K, 208T, 216A, 218L, 265V, 276N, 278F, 279N, 359K
CDD
cd00614 (CGS_like)
pyridoxal 5'-phosp...

85S

pyridoxal 5'-phosphate binding site
85S, 86G, 87Q, 111Y, 184D, 187L, 206S, 208T, 209K
CDD
cd00614 (CGS_like)

86G

pyridoxal 5'-phosphate binding site
85S, 86G, 87Q, 111Y, 184D, 187L, 206S, 208T, 209K
CDD
cd00614 (CGS_like)

87Q

pyridoxal 5'-phosphate binding site
85S, 86G, 87Q, 111Y, 184D, 187L, 206S, 208T, 209K
CDD
cd00614 (CGS_like)

111Y

pyridoxal 5'-phosphate binding site
85S, 86G, 87Q, 111Y, 184D, 187L, 206S, 208T, 209K
CDD
cd00614 (CGS_like)

184D

pyridoxal 5'-phosphate binding site
85S, 86G, 87Q, 111Y, 184D, 187L, 206S, 208T, 209K
CDD
cd00614 (CGS_like)

187L

pyridoxal 5'-phosphate binding site
85S, 86G, 87Q, 111Y, 184D, 187L, 206S, 208T, 209K
CDD
cd00614 (CGS_like)

206S

pyridoxal 5'-phosphate binding site
85S, 86G, 87Q, 111Y, 184D, 187L, 206S, 208T, 209K
CDD
cd00614 (CGS_like)

208T

pyridoxal 5'-phosphate binding site
85S, 86G, 87Q, 111Y, 184D, 187L, 206S, 208T, 209K
CDD
cd00614 (CGS_like)

209K

pyridoxal 5'-phosphate binding site
85S, 86G, 87Q, 111Y, 184D, 187L, 206S, 208T, 209K
CDD
cd00614 (CGS_like)
substrate-cofactor...

85S

substrate-cofactor binding pocket
85S, 86G, 87Q, 111Y, 155E, 184D, 206S, 208T, 209K, 218L
CDD
cd00614 (CGS_like)

86G

substrate-cofactor binding pocket
85S, 86G, 87Q, 111Y, 155E, 184D, 206S, 208T, 209K, 218L
CDD
cd00614 (CGS_like)

87Q

substrate-cofactor binding pocket
85S, 86G, 87Q, 111Y, 155E, 184D, 206S, 208T, 209K, 218L
CDD
cd00614 (CGS_like)

111Y

substrate-cofactor binding pocket
85S, 86G, 87Q, 111Y, 155E, 184D, 206S, 208T, 209K, 218L
CDD
cd00614 (CGS_like)

155E

substrate-cofactor binding pocket
85S, 86G, 87Q, 111Y, 155E, 184D, 206S, 208T, 209K, 218L
CDD
cd00614 (CGS_like)

184D

substrate-cofactor binding pocket
85S, 86G, 87Q, 111Y, 155E, 184D, 206S, 208T, 209K, 218L
CDD
cd00614 (CGS_like)

206S

substrate-cofactor binding pocket
85S, 86G, 87Q, 111Y, 155E, 184D, 206S, 208T, 209K, 218L
CDD
cd00614 (CGS_like)

208T

substrate-cofactor binding pocket
85S, 86G, 87Q, 111Y, 155E, 184D, 206S, 208T, 209K, 218L
CDD
cd00614 (CGS_like)

209K

substrate-cofactor binding pocket
85S, 86G, 87Q, 111Y, 155E, 184D, 206S, 208T, 209K, 218L
CDD
cd00614 (CGS_like)

218L

substrate-cofactor binding pocket
85S, 86G, 87Q, 111Y, 155E, 184D, 206S, 208T, 209K, 218L
CDD
cd00614 (CGS_like)
catalytic residue ...

209K

catalytic residue
209K
CDD
cd00614 (CGS_like)

GO term prediction

Biological Process

GO:0006520 cellular amino acid metabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0030170 pyridoxal phosphate binding

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

9817_FusoPortal_Gene_2207

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component