9817_FusoPortal_Gene_2283

Protein

9817_FusoPortal_Gene_2283

Length

759 amino acids

Protein family membership

DNA topoisomerase, type IA (IPR000380)
- DNA topoisomerase I, type IA (IPR028612)
  - DNA topoisomerase I, bacterial-type (IPR005733)

Homologous superfamilies

Homologous superfamily
11 - 560
DNA topoisomerase, type IA, core domain (IPR023405)
Homologous superfamily
330 - 445
DNA topoisomerase, type IA, central region, subdomain 2 (IPR013825)

1 100 200 300 400 500 600 700 759

Domains and repeats

Domain
11 - 133
TOPRIM domain (IPR006171)
DNA topoisomerase 1, TOPRIM domain (IPR034149)
Domain
85 - 98
DNA topoisomerase, type IA, central (IPR013497)
135 - 557
DNA topoisomerase, type IA, central (IPR013497)
579 - 598
DNA topoisomerase, type IA, zn finger (IPR013498)
722 - 759
DNA topoisomerase, type IA, zn finger (IPR013498)

1 100 200 300 400 500 600 700 759

Detailed signature matches

IPR023405

DNA topoisomerase, type IA, core domain
1. SSF56712 (Prokaryot...)
  
  11 - 560
  
  SUPERFAMILY
  SSF56712 (Prokaryotic type I DNA topoisomerase)
IPR013825

DNA topoisomerase, type IA, central region, subdomain 2
1. G3DSA:2.70.20.10
  
  330 - 445
  
  GENE3D
  G3DSA:2.70.20.10 (G3DSA:2.70.20.10)
IPR000380

DNA topoisomerase, type IA
1. PTHR42785 (FAMILY N...)
  
  718 - 758
  
  PANTHER
  PTHR42785 (FAMILY NOT NAMED)
  
  7 - 674
  
  PANTHER
  PTHR42785 (FAMILY NOT NAMED)
IPR028612

DNA topoisomerase I, type IA
1. MF_00952 (Topoisom_...)
  
  11 - 736
  
  HAMAP
  MF_00952 (Topoisom_1_prok)
IPR005733

DNA topoisomerase I, bacterial-type
1. TIGR01051
  
  13 - 608
  
  TIGRFAMs
  TIGR01051 (TIGR01051)
IPR006171

TOPRIM domain
1. PF01751 (Toprim)
  
  13 - 121
  
  Pfam
  PF01751 (Toprim)
2. PS50880 (TOPRIM)
  
  11 - 121
  
  PROSITE profiles
  PS50880 (TOPRIM)
IPR034149

DNA topoisomerase 1, TOPRIM domain
1. cd03363 (TOPRIM_Top...)
  
  11 - 133
  
  CDD
  cd03363 (TOPRIM_TopoIA_TopoI)
IPR013497

DNA topoisomerase, type IA, central
1. PR00417 (PRTPISMRASEI)
  
  472 - 486
  
  PRINTS
  PR00417 (PRTPISMRASEI)
  
  297 - 306
  
  PRINTS
  PR00417 (PRTPISMRASEI)
  
  170 - 188
  
  PRINTS
  PR00417 (PRTPISMRASEI)
  
  373 - 389
  
  PRINTS
  PR00417 (PRTPISMRASEI)
  
  85 - 98
  
  PRINTS
  PR00417 (PRTPISMRASEI)
2. PF01131 (Topoisom_bac)
  
  135 - 546
  
  Pfam
  PF01131 (Topoisom_bac)
3. cd00186 (TOP1Ac)
  
  138 - 557
  
  CDD
  cd00186 (TOP1Ac)
IPR013498

DNA topoisomerase, type IA, zn finger
1. PF01396 (zf-C4_Topo...)
  
  722 - 759
  
  Pfam
  PF01396 (zf-C4_Topoisom)
  
  579 - 598
  
  Pfam
  PF01396 (zf-C4_Topoisom)
IPR023406

DNA topoisomerase, type IA, active site
1. PS00396 (TOPOISOMER...)
  
  284 - 306
  
  PROSITE patterns
  PS00396 (TOPOISOMERASE_I_PROK)

no IPR

Unintegrated signatures

Coil

550 - 570

COILS
Coil (Coil)
G3DSA:1.10.46...

143 - 329

GENE3D
G3DSA:1.10.460.10 (G3DSA:1.10.460.10)

446 - 564

GENE3D
G3DSA:1.10.460.10 (G3DSA:1.10.460.10)
G3DSA:2.20.20.30

39 - 58

GENE3D
G3DSA:2.20.20.30 (G3DSA:2.20.20.30)
G3DSA:3.30.65.10

565 - 620

GENE3D
G3DSA:3.30.65.10 (G3DSA:3.30.65.10)

709 - 759

GENE3D
G3DSA:3.30.65.10 (G3DSA:3.30.65.10)
G3DSA:3.40.50...

9 - 38

GENE3D
G3DSA:3.40.50.140 (G3DSA:3.40.50.140)

59 - 142

GENE3D
G3DSA:3.40.50.140 (G3DSA:3.40.50.140)
SSF57783 (Zinc beta...)

721 - 757

SUPERFAMILY
SSF57783 (Zinc beta-ribbon)

Residue annotation

active site cd03363

17E

active site
17E, 18S, 21K, 90D, 92D, 94E
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

18S

active site
17E, 18S, 21K, 90D, 92D, 94E
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

21K

active site
17E, 18S, 21K, 90D, 92D, 94E
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

90D

active site
17E, 18S, 21K, 90D, 92D, 94E
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

92D

active site
17E, 18S, 21K, 90D, 92D, 94E
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

94E

active site
17E, 18S, 21K, 90D, 92D, 94E
CDD
cd03363 (TOPRIM_TopoIA_TopoI)
interdomain intera...

24T

interdomain interaction site
24T, 91P, 93R, 100W, 101H, 103A, 104H
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

91P

interdomain interaction site
24T, 91P, 93R, 100W, 101H, 103A, 104H
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

93R

interdomain interaction site
24T, 91P, 93R, 100W, 101H, 103A, 104H
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

100W

interdomain interaction site
24T, 91P, 93R, 100W, 101H, 103A, 104H
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

101H

interdomain interaction site
24T, 91P, 93R, 100W, 101H, 103A, 104H
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

103A

interdomain interaction site
24T, 91P, 93R, 100W, 101H, 103A, 104H
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

104H

interdomain interaction site
24T, 91P, 93R, 100W, 101H, 103A, 104H
CDD
cd03363 (TOPRIM_TopoIA_TopoI)
putative metal-bin...

90D

putative metal-binding site
90D, 92D
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

92D

putative metal-binding site
90D, 92D
CDD
cd03363 (TOPRIM_TopoIA_TopoI)
nucleotide binding...

93R

nucleotide binding site
93R
CDD
cd03363 (TOPRIM_TopoIA_TopoI)
domain I cd00186

138M

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

139D

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

140K

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

141V

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

142N

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

143A

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

144Q

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

145Q

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

146A

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

147R

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

148R

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

149I

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

150L

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

151D

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

152R

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

153L

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

154V

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

155G

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

156Y

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

157G

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

158I

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

159S

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

160S

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

161L

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

162L

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

163W

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

164K

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

165S

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

170T

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

171S

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

172A

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

173G

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

174R

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

175V

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

176Q

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

177S

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

178V

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

179A

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

180L

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

181K

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

182L

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

183V

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

184C

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

185D

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

186L

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

187E

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

188Q

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

189E

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)

190I

domain I
138M, 139D, 140K, 141V, 142N, 143A, 144Q, 145Q, 146A, 147R, 148R, 149I, 150L, 151D, 152R, 153L, 154V, 155G, 156Y, 157G, 158I, 159S, 160S, 161L, 162L, 163W, 164K, 165S, 170T, 171S, 172A, 173G, 174R, 175V, 176Q, 177S, 178V, 179A, 180L, 181K, 182L, 183V, 184C, 185D, 186L, 187E, 188Q, 189E, 190I
CDD
cd00186 (TOP1Ac)
DNA binding groove...

147R

DNA binding groove
147R, 148R, 151D, 155G, 159S, 284Q, 288E, 304R, 477S, 478T, 481T, 482I, 484E, 488K, 489R
CDD
cd00186 (TOP1Ac)

148R

DNA binding groove
147R, 148R, 151D, 155G, 159S, 284Q, 288E, 304R, 477S, 478T, 481T, 482I, 484E, 488K, 489R
CDD
cd00186 (TOP1Ac)

151D

DNA binding groove
147R, 148R, 151D, 155G, 159S, 284Q, 288E, 304R, 477S, 478T, 481T, 482I, 484E, 488K, 489R
CDD
cd00186 (TOP1Ac)

155G

DNA binding groove
147R, 148R, 151D, 155G, 159S, 284Q, 288E, 304R, 477S, 478T, 481T, 482I, 484E, 488K, 489R
CDD
cd00186 (TOP1Ac)

159S

DNA binding groove
147R, 148R, 151D, 155G, 159S, 284Q, 288E, 304R, 477S, 478T, 481T, 482I, 484E, 488K, 489R
CDD
cd00186 (TOP1Ac)

284Q

DNA binding groove
147R, 148R, 151D, 155G, 159S, 284Q, 288E, 304R, 477S, 478T, 481T, 482I, 484E, 488K, 489R
CDD
cd00186 (TOP1Ac)

288E

DNA binding groove
147R, 148R, 151D, 155G, 159S, 284Q, 288E, 304R, 477S, 478T, 481T, 482I, 484E, 488K, 489R
CDD
cd00186 (TOP1Ac)

304R

DNA binding groove
147R, 148R, 151D, 155G, 159S, 284Q, 288E, 304R, 477S, 478T, 481T, 482I, 484E, 488K, 489R
CDD
cd00186 (TOP1Ac)

477S

DNA binding groove
147R, 148R, 151D, 155G, 159S, 284Q, 288E, 304R, 477S, 478T, 481T, 482I, 484E, 488K, 489R
CDD
cd00186 (TOP1Ac)

478T

DNA binding groove
147R, 148R, 151D, 155G, 159S, 284Q, 288E, 304R, 477S, 478T, 481T, 482I, 484E, 488K, 489R
CDD
cd00186 (TOP1Ac)

481T

DNA binding groove
147R, 148R, 151D, 155G, 159S, 284Q, 288E, 304R, 477S, 478T, 481T, 482I, 484E, 488K, 489R
CDD
cd00186 (TOP1Ac)

482I

DNA binding groove
147R, 148R, 151D, 155G, 159S, 284Q, 288E, 304R, 477S, 478T, 481T, 482I, 484E, 488K, 489R
CDD
cd00186 (TOP1Ac)

484E

DNA binding groove
147R, 148R, 151D, 155G, 159S, 284Q, 288E, 304R, 477S, 478T, 481T, 482I, 484E, 488K, 489R
CDD
cd00186 (TOP1Ac)

488K

DNA binding groove
147R, 148R, 151D, 155G, 159S, 284Q, 288E, 304R, 477S, 478T, 481T, 482I, 484E, 488K, 489R
CDD
cd00186 (TOP1Ac)

489R

DNA binding groove
147R, 148R, 151D, 155G, 159S, 284Q, 288E, 304R, 477S, 478T, 481T, 482I, 484E, 488K, 489R
CDD
cd00186 (TOP1Ac)
phosphate binding ...

181K

phosphate binding site
181K, 185D, 513D
CDD
cd00186 (TOP1Ac)

185D

phosphate binding site
181K, 185D, 513D
CDD
cd00186 (TOP1Ac)

513D

phosphate binding site
181K, 185D, 513D
CDD
cd00186 (TOP1Ac)
domain II cd00186

195P

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

196V

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

197K

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

198F

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

199W

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

200E

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

201V

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

202K

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

240E

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

241F

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

242D

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

243I

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

244T

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

245E

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

246A

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

247K

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

248V

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

249T

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

250K

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

251R

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

252T

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

253K

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

254N

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

387A

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

388P

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

389M

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

390K

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

391Y

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

392E

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

393Q

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

394F

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

395E

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

396L

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

397V

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

398A

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

399T

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

400Y

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

401D

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

403F

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

404D

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

405F

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

406R

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

407G

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

408T

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

409I

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

410N

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

411K

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

412I

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

413I

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

414F

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

415D

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

416G

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

417Y

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

418Y

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

419K

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

420I

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

421F

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

444E

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

445K

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

446L

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

447H

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

448I

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

449K

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

450E

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

451D

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

452F

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

453T

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)

454K

domain II
195P, 196V, 197K, 198F, 199W, 200E, 201V, 202K, 240E, 241F, 242D, 243I, 244T, 245E, 246A, 247K, 248V, 249T, 250K, 251R, 252T, 253K, 254N, 387A, 388P, 389M, 390K, 391Y, 392E, 393Q, 394F, 395E, 396L, 397V, 398A, 399T, 400Y, 401D, 403F, 404D, 405F, 406R, 407G, 408T, 409I, 410N, 411K, 412I, 413I, 414F, 415D, 416G, 417Y, 418Y, 419K, 420I, 421F, 444E, 445K, 446L, 447H, 448I, 449K, 450E, 451D, 452F, 453T, 454K
CDD
cd00186 (TOP1Ac)
domain III cd00186

255S

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

256P

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

257L

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

258P

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

259L

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

260K

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

261T

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

263T

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

264L

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

265Q

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

266Q

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

267L

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

268A

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

269S

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

270S

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

271Y

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

272L

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

273G

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

274F

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

275S

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

276A

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

277S

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

278K

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

279T

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

280M

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

281R

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

282I

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

283A

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

284Q

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

285G

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

286L

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

287Y

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

288E

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

297K

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

298G

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

299L

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

300I

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

301T

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

302Y

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

303M

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

304R

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

305T

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

306D

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

307S

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

308T

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

309R

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

310I

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

311S

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

312E

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

313D

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

314A

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

315Q

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

316E

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

317M

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

318A

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

319K

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

320N

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

321Y

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

322I

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

323L

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

324E

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

325N

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

326F

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

346A

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

347H

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

348E

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

349A

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

350I

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

351R

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

352P

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

353T

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

354D

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

366L

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

367D

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

368K

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

369D

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

370Q

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

371L

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

372K

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

373L

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

374Y

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

375K

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

376L

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

377I

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

378W

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

379D

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

380R

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

381F

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

382L

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

383I

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

384S

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

385Q

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)

386L

domain III
255S, 256P, 257L, 258P, 259L, 260K, 261T, 263T, 264L, 265Q, 266Q, 267L, 268A, 269S, 270S, 271Y, 272L, 273G, 274F, 275S, 276A, 277S, 278K, 279T, 280M, 281R, 282I, 283A, 284Q, 285G, 286L, 287Y, 288E, 297K, 298G, 299L, 300I, 301T, 302Y, 303M, 304R, 305T, 306D, 307S, 308T, 309R, 310I, 311S, 312E, 313D, 314A, 315Q, 316E, 317M, 318A, 319K, 320N, 321Y, 322I, 323L, 324E, 325N, 326F, 346A, 347H, 348E, 349A, 350I, 351R, 352P, 353T, 354D, 366L, 367D, 368K, 369D, 370Q, 371L, 372K, 373L, 374Y, 375K, 376L, 377I, 378W, 379D, 380R, 381F, 382L, 383I, 384S, 385Q, 386L
CDD
cd00186 (TOP1Ac)
nucleotide binding...

266Q

nucleotide binding site
266Q, 270S, 271Y, 272L, 347H, 372K, 375K, 379D, 475R, 477S, 499F
CDD
cd00186 (TOP1Ac)

270S

nucleotide binding site
266Q, 270S, 271Y, 272L, 347H, 372K, 375K, 379D, 475R, 477S, 499F
CDD
cd00186 (TOP1Ac)

271Y

nucleotide binding site
266Q, 270S, 271Y, 272L, 347H, 372K, 375K, 379D, 475R, 477S, 499F
CDD
cd00186 (TOP1Ac)

272L

nucleotide binding site
266Q, 270S, 271Y, 272L, 347H, 372K, 375K, 379D, 475R, 477S, 499F
CDD
cd00186 (TOP1Ac)

347H

nucleotide binding site
266Q, 270S, 271Y, 272L, 347H, 372K, 375K, 379D, 475R, 477S, 499F
CDD
cd00186 (TOP1Ac)

372K

nucleotide binding site
266Q, 270S, 271Y, 272L, 347H, 372K, 375K, 379D, 475R, 477S, 499F
CDD
cd00186 (TOP1Ac)

375K

nucleotide binding site
266Q, 270S, 271Y, 272L, 347H, 372K, 375K, 379D, 475R, 477S, 499F
CDD
cd00186 (TOP1Ac)

379D

nucleotide binding site
266Q, 270S, 271Y, 272L, 347H, 372K, 375K, 379D, 475R, 477S, 499F
CDD
cd00186 (TOP1Ac)

475R

nucleotide binding site
266Q, 270S, 271Y, 272L, 347H, 372K, 375K, 379D, 475R, 477S, 499F
CDD
cd00186 (TOP1Ac)

477S

nucleotide binding site
266Q, 270S, 271Y, 272L, 347H, 372K, 375K, 379D, 475R, 477S, 499F
CDD
cd00186 (TOP1Ac)

499F

nucleotide binding site
266Q, 270S, 271Y, 272L, 347H, 372K, 375K, 379D, 475R, 477S, 499F
CDD
cd00186 (TOP1Ac)
catalytic site cd0...

302Y

catalytic site
302Y, 304R, 347H
CDD
cd00186 (TOP1Ac)

304R

catalytic site
302Y, 304R, 347H
CDD
cd00186 (TOP1Ac)

347H

catalytic site
302Y, 304R, 347H
CDD
cd00186 (TOP1Ac)
domain IV cd00186

455P

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

456P

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

457S

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

458R

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

459F

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

460T

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

461E

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

462S

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

463S

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

464L

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

465V

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

466K

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

467K

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

468L

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

469E

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

470A

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

471E

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

472G

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

473I

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

474G

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

475R

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

476P

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

477S

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

478T

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

479Y

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

480A

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

481T

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

482I

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

483I

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

484E

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

485T

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

486L

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

487K

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

488K

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

489R

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

490E

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

491Y

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

492V

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

493K

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

494I

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

495E

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

499F

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

500I

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

501P

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

502T

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

503E

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

504L

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

505G

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

506F

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

507E

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

508I

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

509E

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

510E

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

511S

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

512L

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

513D

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

519I

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

520M

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

521N

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

522V

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

523K

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

524F

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

525T

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

526A

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

527E

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

528M

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

529E

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

530N

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

531E

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

532L

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

533D

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

534E

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

535I

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

536A

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

537D

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

538G

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

539E

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

540K

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

541D

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

542W

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

543V

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

544K

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

545L

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

546L

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

547S

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

548D

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

549F

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

550Y

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

551K

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

552E

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

553L

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

554K

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

555E

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

556Y

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

557I

domain IV
455P, 456P, 457S, 458R, 459F, 460T, 461E, 462S, 463S, 464L, 465V, 466K, 467K, 468L, 469E, 470A, 471E, 472G, 473I, 474G, 475R, 476P, 477S, 478T, 479Y, 480A, 481T, 482I, 483I, 484E, 485T, 486L, 487K, 488K, 489R, 490E, 491Y, 492V, 493K, 494I, 495E, 499F, 500I, 501P, 502T, 503E, 504L, 505G, 506F, 507E, 508I, 509E, 510E, 511S, 512L, 513D, 519I, 520M, 521N, 522V, 523K, 524F, 525T, 526A, 527E, 528M, 529E, 530N, 531E, 532L, 533D, 534E, 535I, 536A, 537D, 538G, 539E, 540K, 541D, 542W, 543V, 544K, 545L, 546L, 547S, 548D, 549F, 550Y, 551K, 552E, 553L, 554K, 555E, 556Y, 557I
CDD
cd00186 (TOP1Ac)

GO term prediction

Biological Process

GO:0006265 DNA topological change

Molecular Function

GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003917 DNA topoisomerase type I activity

Cellular Component

GO:0005694 chromosome

Filter view on

Entry type

Status

Per-residue features

9817_FusoPortal_Gene_2283

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component