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Protein

9817_FusoPortal_Gene_2588

Length

139 amino acids

Protein family membership

Glutamate mutase sigma subunit (IPR006394)

Homologous superfamilies

Homologous superfamily
4 - 136
Cobalamin-binding domain superfamily (IPR036724)

1 20 40 60 80 100 120 139

Domains and repeats

Domain
5 - 139
Cobalamin (vitamin B12)-binding domain (IPR006158)
Methylmalonyl-CoA mutase, C-terminal (IPR006159)

1 20 40 60 80 100 120 139

Detailed signature matches

IPR036724

Cobalamin-binding domain superfamily

SSF52242 (Cobalamin...)

4 - 136

SUPERFAMILY
SSF52242 (Cobalamin (vitamin B12)-binding domain)

IPR006394

Glutamate mutase sigma subunit

cd02072 (Glm_B12_BD)

7 - 134

CDD
cd02072 (Glm_B12_BD)
MF_00526 (Me_Asp_mu...)

1 - 139

HAMAP
MF_00526 (Me_Asp_mutase_S)
TIGR01501

6 - 137

TIGRFAMs
TIGR01501 (TIGR01501)

IPR006158

Cobalamin (vitamin B12)-binding domain

PF02310 (B12-binding)

7 - 97

Pfam
PF02310 (B12-binding)
PS51332 (B12_BINDING)

5 - 139

PROSITE profiles
PS51332 (B12_BINDING)

IPR006159

Methylmalonyl-CoA mutase, C-terminal

TIGR00640

7 - 136

TIGRFAMs
TIGR00640 (TIGR00640)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

1 - 139

GENE3D
G3DSA:3.40.50.280 (G3DSA:3.40.50.280)

Residue annotation

heterodimer interf...

15S

heterodimer interface
15S, 17C, 19A, 20V, 23K, 24I, 27H, 39V, 40G, 41V, 42L, 66Y, 68H, 70E, 71L, 72D, 95N, 98V, 99G, 100K, 109R, 121P
CDD
cd02072 (Glm_B12_BD)

17C

heterodimer interface
15S, 17C, 19A, 20V, 23K, 24I, 27H, 39V, 40G, 41V, 42L, 66Y, 68H, 70E, 71L, 72D, 95N, 98V, 99G, 100K, 109R, 121P
CDD
cd02072 (Glm_B12_BD)

19A

heterodimer interface
15S, 17C, 19A, 20V, 23K, 24I, 27H, 39V, 40G, 41V, 42L, 66Y, 68H, 70E, 71L, 72D, 95N, 98V, 99G, 100K, 109R, 121P
CDD
cd02072 (Glm_B12_BD)

20V

heterodimer interface
15S, 17C, 19A, 20V, 23K, 24I, 27H, 39V, 40G, 41V, 42L, 66Y, 68H, 70E, 71L, 72D, 95N, 98V, 99G, 100K, 109R, 121P
CDD
cd02072 (Glm_B12_BD)

23K

heterodimer interface
15S, 17C, 19A, 20V, 23K, 24I, 27H, 39V, 40G, 41V, 42L, 66Y, 68H, 70E, 71L, 72D, 95N, 98V, 99G, 100K, 109R, 121P
CDD
cd02072 (Glm_B12_BD)

24I

heterodimer interface
15S, 17C, 19A, 20V, 23K, 24I, 27H, 39V, 40G, 41V, 42L, 66Y, 68H, 70E, 71L, 72D, 95N, 98V, 99G, 100K, 109R, 121P
CDD
cd02072 (Glm_B12_BD)

27H

heterodimer interface
15S, 17C, 19A, 20V, 23K, 24I, 27H, 39V, 40G, 41V, 42L, 66Y, 68H, 70E, 71L, 72D, 95N, 98V, 99G, 100K, 109R, 121P
CDD
cd02072 (Glm_B12_BD)

39V

heterodimer interface
15S, 17C, 19A, 20V, 23K, 24I, 27H, 39V, 40G, 41V, 42L, 66Y, 68H, 70E, 71L, 72D, 95N, 98V, 99G, 100K, 109R, 121P
CDD
cd02072 (Glm_B12_BD)

40G

heterodimer interface
15S, 17C, 19A, 20V, 23K, 24I, 27H, 39V, 40G, 41V, 42L, 66Y, 68H, 70E, 71L, 72D, 95N, 98V, 99G, 100K, 109R, 121P
CDD
cd02072 (Glm_B12_BD)

41V

heterodimer interface
15S, 17C, 19A, 20V, 23K, 24I, 27H, 39V, 40G, 41V, 42L, 66Y, 68H, 70E, 71L, 72D, 95N, 98V, 99G, 100K, 109R, 121P
CDD
cd02072 (Glm_B12_BD)

42L

heterodimer interface
15S, 17C, 19A, 20V, 23K, 24I, 27H, 39V, 40G, 41V, 42L, 66Y, 68H, 70E, 71L, 72D, 95N, 98V, 99G, 100K, 109R, 121P
CDD
cd02072 (Glm_B12_BD)

66Y

heterodimer interface
15S, 17C, 19A, 20V, 23K, 24I, 27H, 39V, 40G, 41V, 42L, 66Y, 68H, 70E, 71L, 72D, 95N, 98V, 99G, 100K, 109R, 121P
CDD
cd02072 (Glm_B12_BD)

68H

heterodimer interface
15S, 17C, 19A, 20V, 23K, 24I, 27H, 39V, 40G, 41V, 42L, 66Y, 68H, 70E, 71L, 72D, 95N, 98V, 99G, 100K, 109R, 121P
CDD
cd02072 (Glm_B12_BD)

70E

heterodimer interface
15S, 17C, 19A, 20V, 23K, 24I, 27H, 39V, 40G, 41V, 42L, 66Y, 68H, 70E, 71L, 72D, 95N, 98V, 99G, 100K, 109R, 121P
CDD
cd02072 (Glm_B12_BD)

71L

heterodimer interface
15S, 17C, 19A, 20V, 23K, 24I, 27H, 39V, 40G, 41V, 42L, 66Y, 68H, 70E, 71L, 72D, 95N, 98V, 99G, 100K, 109R, 121P
CDD
cd02072 (Glm_B12_BD)

72D

heterodimer interface
15S, 17C, 19A, 20V, 23K, 24I, 27H, 39V, 40G, 41V, 42L, 66Y, 68H, 70E, 71L, 72D, 95N, 98V, 99G, 100K, 109R, 121P
CDD
cd02072 (Glm_B12_BD)

95N

heterodimer interface
15S, 17C, 19A, 20V, 23K, 24I, 27H, 39V, 40G, 41V, 42L, 66Y, 68H, 70E, 71L, 72D, 95N, 98V, 99G, 100K, 109R, 121P
CDD
cd02072 (Glm_B12_BD)

98V

heterodimer interface
15S, 17C, 19A, 20V, 23K, 24I, 27H, 39V, 40G, 41V, 42L, 66Y, 68H, 70E, 71L, 72D, 95N, 98V, 99G, 100K, 109R, 121P
CDD
cd02072 (Glm_B12_BD)

99G

heterodimer interface
15S, 17C, 19A, 20V, 23K, 24I, 27H, 39V, 40G, 41V, 42L, 66Y, 68H, 70E, 71L, 72D, 95N, 98V, 99G, 100K, 109R, 121P
CDD
cd02072 (Glm_B12_BD)

100K

heterodimer interface
15S, 17C, 19A, 20V, 23K, 24I, 27H, 39V, 40G, 41V, 42L, 66Y, 68H, 70E, 71L, 72D, 95N, 98V, 99G, 100K, 109R, 121P
CDD
cd02072 (Glm_B12_BD)

109R

heterodimer interface
15S, 17C, 19A, 20V, 23K, 24I, 27H, 39V, 40G, 41V, 42L, 66Y, 68H, 70E, 71L, 72D, 95N, 98V, 99G, 100K, 109R, 121P
CDD
cd02072 (Glm_B12_BD)

121P

heterodimer interface
15S, 17C, 19A, 20V, 23K, 24I, 27H, 39V, 40G, 41V, 42L, 66Y, 68H, 70E, 71L, 72D, 95N, 98V, 99G, 100K, 109R, 121P
CDD
cd02072 (Glm_B12_BD)
B12 binding site c...

15S

B12 binding site
15S, 16D, 17C, 18H, 19A, 20V, 21G, 24I, 61I, 62V, 63S, 65L, 66Y, 67G, 95N, 119Y, 122G, 128T
CDD
cd02072 (Glm_B12_BD)

16D

B12 binding site
15S, 16D, 17C, 18H, 19A, 20V, 21G, 24I, 61I, 62V, 63S, 65L, 66Y, 67G, 95N, 119Y, 122G, 128T
CDD
cd02072 (Glm_B12_BD)

17C

B12 binding site
15S, 16D, 17C, 18H, 19A, 20V, 21G, 24I, 61I, 62V, 63S, 65L, 66Y, 67G, 95N, 119Y, 122G, 128T
CDD
cd02072 (Glm_B12_BD)

18H

B12 binding site
15S, 16D, 17C, 18H, 19A, 20V, 21G, 24I, 61I, 62V, 63S, 65L, 66Y, 67G, 95N, 119Y, 122G, 128T
CDD
cd02072 (Glm_B12_BD)

19A

B12 binding site
15S, 16D, 17C, 18H, 19A, 20V, 21G, 24I, 61I, 62V, 63S, 65L, 66Y, 67G, 95N, 119Y, 122G, 128T
CDD
cd02072 (Glm_B12_BD)

20V

B12 binding site
15S, 16D, 17C, 18H, 19A, 20V, 21G, 24I, 61I, 62V, 63S, 65L, 66Y, 67G, 95N, 119Y, 122G, 128T
CDD
cd02072 (Glm_B12_BD)

21G

B12 binding site
15S, 16D, 17C, 18H, 19A, 20V, 21G, 24I, 61I, 62V, 63S, 65L, 66Y, 67G, 95N, 119Y, 122G, 128T
CDD
cd02072 (Glm_B12_BD)

24I

B12 binding site
15S, 16D, 17C, 18H, 19A, 20V, 21G, 24I, 61I, 62V, 63S, 65L, 66Y, 67G, 95N, 119Y, 122G, 128T
CDD
cd02072 (Glm_B12_BD)

61I

B12 binding site
15S, 16D, 17C, 18H, 19A, 20V, 21G, 24I, 61I, 62V, 63S, 65L, 66Y, 67G, 95N, 119Y, 122G, 128T
CDD
cd02072 (Glm_B12_BD)

62V

B12 binding site
15S, 16D, 17C, 18H, 19A, 20V, 21G, 24I, 61I, 62V, 63S, 65L, 66Y, 67G, 95N, 119Y, 122G, 128T
CDD
cd02072 (Glm_B12_BD)

63S

B12 binding site
15S, 16D, 17C, 18H, 19A, 20V, 21G, 24I, 61I, 62V, 63S, 65L, 66Y, 67G, 95N, 119Y, 122G, 128T
CDD
cd02072 (Glm_B12_BD)

65L

B12 binding site
15S, 16D, 17C, 18H, 19A, 20V, 21G, 24I, 61I, 62V, 63S, 65L, 66Y, 67G, 95N, 119Y, 122G, 128T
CDD
cd02072 (Glm_B12_BD)

66Y

B12 binding site
15S, 16D, 17C, 18H, 19A, 20V, 21G, 24I, 61I, 62V, 63S, 65L, 66Y, 67G, 95N, 119Y, 122G, 128T
CDD
cd02072 (Glm_B12_BD)

67G

B12 binding site
15S, 16D, 17C, 18H, 19A, 20V, 21G, 24I, 61I, 62V, 63S, 65L, 66Y, 67G, 95N, 119Y, 122G, 128T
CDD
cd02072 (Glm_B12_BD)

95N

B12 binding site
15S, 16D, 17C, 18H, 19A, 20V, 21G, 24I, 61I, 62V, 63S, 65L, 66Y, 67G, 95N, 119Y, 122G, 128T
CDD
cd02072 (Glm_B12_BD)

119Y

B12 binding site
15S, 16D, 17C, 18H, 19A, 20V, 21G, 24I, 61I, 62V, 63S, 65L, 66Y, 67G, 95N, 119Y, 122G, 128T
CDD
cd02072 (Glm_B12_BD)

122G

B12 binding site
15S, 16D, 17C, 18H, 19A, 20V, 21G, 24I, 61I, 62V, 63S, 65L, 66Y, 67G, 95N, 119Y, 122G, 128T
CDD
cd02072 (Glm_B12_BD)

128T

B12 binding site
15S, 16D, 17C, 18H, 19A, 20V, 21G, 24I, 61I, 62V, 63S, 65L, 66Y, 67G, 95N, 119Y, 122G, 128T
CDD
cd02072 (Glm_B12_BD)
cobalt ligand cd02...

18H

cobalt ligand
18H
CDD
cd02072 (Glm_B12_BD)

GO term prediction

Biological Process

GO:0019670 anaerobic glutamate catabolic process

Molecular Function

GO:0016853 isomerase activity
GO:0016866 intramolecular transferase activity
GO:0031419 cobalamin binding
GO:0046872 metal ion binding

Cellular Component

None predicted.