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Protein

9817_FusoPortal_Gene_845

Length

393 amino acids

Protein family membership

Cys/Met metabolism, pyridoxal phosphate-dependent enzyme (IPR000277)
- L-methionine gamma-lyase (IPR006237)

Homologous superfamilies

Homologous superfamily
4 - 257
Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (IPR015421)
259 - 393
Pyridoxal phosphate-dependent transferase, subdomain 2 (IPR015422)
Homologous superfamily
20 - 391
Pyridoxal phosphate-dependent transferase (IPR015424)

1 50 100 150 200 250 300 350 393

Domains and repeats

None predicted.

Detailed signature matches

IPR015421

Pyridoxal phosphate-dependent transferase, major region, subdomain 1

G3DSA:3.40.64...

4 - 257

GENE3D
G3DSA:3.40.640.10 (G3DSA:3.40.640.10)

IPR015424

Pyridoxal phosphate-dependent transferase

SSF53383 (PLP-depen...)

20 - 391

SUPERFAMILY
SSF53383 (PLP-dependent transferases)

IPR015422

Pyridoxal phosphate-dependent transferase, subdomain 2

G3DSA:3.90.11...

259 - 393

GENE3D
G3DSA:3.90.1150.10 (G3DSA:3.90.1150.10)

IPR000277

Cys/Met metabolism, pyridoxal phosphate-dependent enzyme

cd00614 (CGS_like)

20 - 390

CDD
cd00614 (CGS_like)
PTHR11808 (TRANS-SU...)

7 - 392

PANTHER
PTHR11808 (TRANS-SULFURATION ENZYME FAMILY MEMBER)
PIRSF001434 (CGS)

1 - 393

PIRSF
PIRSF001434 (CGS)
PF01053 (Cys_Met_Me...)

7 - 389

Pfam
PF01053 (Cys_Met_Meta_PP)

IPR006237

L-methionine gamma-lyase

TIGR01328

4 - 391

TIGRFAMs
TIGR01328 (TIGR01328)

no IPR

Unintegrated signatures

PTHR11808:SF72 (CYS...)

7 - 392

PANTHER
PTHR11808:SF72 (CYSTATHIONINE BETA LYASE)

Residue annotation

homodimer interfac...

28Q

homodimer interface
28Q, 29T, 30S, 31T, 33V, 34F, 53Y, 55R, 81S, 82S, 84I, 85G, 108Y, 113A, 116N, 205T, 213D, 215I, 231L, 243G, 245T, 246E, 325N
CDD
cd00614 (CGS_like)

29T

homodimer interface
28Q, 29T, 30S, 31T, 33V, 34F, 53Y, 55R, 81S, 82S, 84I, 85G, 108Y, 113A, 116N, 205T, 213D, 215I, 231L, 243G, 245T, 246E, 325N
CDD
cd00614 (CGS_like)

30S

homodimer interface
28Q, 29T, 30S, 31T, 33V, 34F, 53Y, 55R, 81S, 82S, 84I, 85G, 108Y, 113A, 116N, 205T, 213D, 215I, 231L, 243G, 245T, 246E, 325N
CDD
cd00614 (CGS_like)

31T

homodimer interface
28Q, 29T, 30S, 31T, 33V, 34F, 53Y, 55R, 81S, 82S, 84I, 85G, 108Y, 113A, 116N, 205T, 213D, 215I, 231L, 243G, 245T, 246E, 325N
CDD
cd00614 (CGS_like)

33V

homodimer interface
28Q, 29T, 30S, 31T, 33V, 34F, 53Y, 55R, 81S, 82S, 84I, 85G, 108Y, 113A, 116N, 205T, 213D, 215I, 231L, 243G, 245T, 246E, 325N
CDD
cd00614 (CGS_like)

34F

homodimer interface
28Q, 29T, 30S, 31T, 33V, 34F, 53Y, 55R, 81S, 82S, 84I, 85G, 108Y, 113A, 116N, 205T, 213D, 215I, 231L, 243G, 245T, 246E, 325N
CDD
cd00614 (CGS_like)

53Y

homodimer interface
28Q, 29T, 30S, 31T, 33V, 34F, 53Y, 55R, 81S, 82S, 84I, 85G, 108Y, 113A, 116N, 205T, 213D, 215I, 231L, 243G, 245T, 246E, 325N
CDD
cd00614 (CGS_like)

55R

homodimer interface
28Q, 29T, 30S, 31T, 33V, 34F, 53Y, 55R, 81S, 82S, 84I, 85G, 108Y, 113A, 116N, 205T, 213D, 215I, 231L, 243G, 245T, 246E, 325N
CDD
cd00614 (CGS_like)

81S

homodimer interface
28Q, 29T, 30S, 31T, 33V, 34F, 53Y, 55R, 81S, 82S, 84I, 85G, 108Y, 113A, 116N, 205T, 213D, 215I, 231L, 243G, 245T, 246E, 325N
CDD
cd00614 (CGS_like)

82S

homodimer interface
28Q, 29T, 30S, 31T, 33V, 34F, 53Y, 55R, 81S, 82S, 84I, 85G, 108Y, 113A, 116N, 205T, 213D, 215I, 231L, 243G, 245T, 246E, 325N
CDD
cd00614 (CGS_like)

84I

homodimer interface
28Q, 29T, 30S, 31T, 33V, 34F, 53Y, 55R, 81S, 82S, 84I, 85G, 108Y, 113A, 116N, 205T, 213D, 215I, 231L, 243G, 245T, 246E, 325N
CDD
cd00614 (CGS_like)

85G

homodimer interface
28Q, 29T, 30S, 31T, 33V, 34F, 53Y, 55R, 81S, 82S, 84I, 85G, 108Y, 113A, 116N, 205T, 213D, 215I, 231L, 243G, 245T, 246E, 325N
CDD
cd00614 (CGS_like)

108Y

homodimer interface
28Q, 29T, 30S, 31T, 33V, 34F, 53Y, 55R, 81S, 82S, 84I, 85G, 108Y, 113A, 116N, 205T, 213D, 215I, 231L, 243G, 245T, 246E, 325N
CDD
cd00614 (CGS_like)

113A

homodimer interface
28Q, 29T, 30S, 31T, 33V, 34F, 53Y, 55R, 81S, 82S, 84I, 85G, 108Y, 113A, 116N, 205T, 213D, 215I, 231L, 243G, 245T, 246E, 325N
CDD
cd00614 (CGS_like)

116N

homodimer interface
28Q, 29T, 30S, 31T, 33V, 34F, 53Y, 55R, 81S, 82S, 84I, 85G, 108Y, 113A, 116N, 205T, 213D, 215I, 231L, 243G, 245T, 246E, 325N
CDD
cd00614 (CGS_like)

205T

homodimer interface
28Q, 29T, 30S, 31T, 33V, 34F, 53Y, 55R, 81S, 82S, 84I, 85G, 108Y, 113A, 116N, 205T, 213D, 215I, 231L, 243G, 245T, 246E, 325N
CDD
cd00614 (CGS_like)

213D

homodimer interface
28Q, 29T, 30S, 31T, 33V, 34F, 53Y, 55R, 81S, 82S, 84I, 85G, 108Y, 113A, 116N, 205T, 213D, 215I, 231L, 243G, 245T, 246E, 325N
CDD
cd00614 (CGS_like)

215I

homodimer interface
28Q, 29T, 30S, 31T, 33V, 34F, 53Y, 55R, 81S, 82S, 84I, 85G, 108Y, 113A, 116N, 205T, 213D, 215I, 231L, 243G, 245T, 246E, 325N
CDD
cd00614 (CGS_like)

231L

homodimer interface
28Q, 29T, 30S, 31T, 33V, 34F, 53Y, 55R, 81S, 82S, 84I, 85G, 108Y, 113A, 116N, 205T, 213D, 215I, 231L, 243G, 245T, 246E, 325N
CDD
cd00614 (CGS_like)

243G

homodimer interface
28Q, 29T, 30S, 31T, 33V, 34F, 53Y, 55R, 81S, 82S, 84I, 85G, 108Y, 113A, 116N, 205T, 213D, 215I, 231L, 243G, 245T, 246E, 325N
CDD
cd00614 (CGS_like)

245T

homodimer interface
28Q, 29T, 30S, 31T, 33V, 34F, 53Y, 55R, 81S, 82S, 84I, 85G, 108Y, 113A, 116N, 205T, 213D, 215I, 231L, 243G, 245T, 246E, 325N
CDD
cd00614 (CGS_like)

246E

homodimer interface
28Q, 29T, 30S, 31T, 33V, 34F, 53Y, 55R, 81S, 82S, 84I, 85G, 108Y, 113A, 116N, 205T, 213D, 215I, 231L, 243G, 245T, 246E, 325N
CDD
cd00614 (CGS_like)

325N

homodimer interface
28Q, 29T, 30S, 31T, 33V, 34F, 53Y, 55R, 81S, 82S, 84I, 85G, 108Y, 113A, 116N, 205T, 213D, 215I, 231L, 243G, 245T, 246E, 325N
CDD
cd00614 (CGS_like)
pyridoxal 5'-phosp...

82S

pyridoxal 5'-phosphate binding site
82S, 83G, 84I, 108Y, 181D, 184F, 203S, 205T, 206K
CDD
cd00614 (CGS_like)

83G

pyridoxal 5'-phosphate binding site
82S, 83G, 84I, 108Y, 181D, 184F, 203S, 205T, 206K
CDD
cd00614 (CGS_like)

84I

pyridoxal 5'-phosphate binding site
82S, 83G, 84I, 108Y, 181D, 184F, 203S, 205T, 206K
CDD
cd00614 (CGS_like)

108Y

pyridoxal 5'-phosphate binding site
82S, 83G, 84I, 108Y, 181D, 184F, 203S, 205T, 206K
CDD
cd00614 (CGS_like)

181D

pyridoxal 5'-phosphate binding site
82S, 83G, 84I, 108Y, 181D, 184F, 203S, 205T, 206K
CDD
cd00614 (CGS_like)

184F

pyridoxal 5'-phosphate binding site
82S, 83G, 84I, 108Y, 181D, 184F, 203S, 205T, 206K
CDD
cd00614 (CGS_like)

203S

pyridoxal 5'-phosphate binding site
82S, 83G, 84I, 108Y, 181D, 184F, 203S, 205T, 206K
CDD
cd00614 (CGS_like)

205T

pyridoxal 5'-phosphate binding site
82S, 83G, 84I, 108Y, 181D, 184F, 203S, 205T, 206K
CDD
cd00614 (CGS_like)

206K

pyridoxal 5'-phosphate binding site
82S, 83G, 84I, 108Y, 181D, 184F, 203S, 205T, 206K
CDD
cd00614 (CGS_like)
substrate-cofactor...

82S

substrate-cofactor binding pocket
82S, 83G, 84I, 108Y, 151E, 181D, 203S, 205T, 206K, 215I
CDD
cd00614 (CGS_like)

83G

substrate-cofactor binding pocket
82S, 83G, 84I, 108Y, 151E, 181D, 203S, 205T, 206K, 215I
CDD
cd00614 (CGS_like)

84I

substrate-cofactor binding pocket
82S, 83G, 84I, 108Y, 151E, 181D, 203S, 205T, 206K, 215I
CDD
cd00614 (CGS_like)

108Y

substrate-cofactor binding pocket
82S, 83G, 84I, 108Y, 151E, 181D, 203S, 205T, 206K, 215I
CDD
cd00614 (CGS_like)

151E

substrate-cofactor binding pocket
82S, 83G, 84I, 108Y, 151E, 181D, 203S, 205T, 206K, 215I
CDD
cd00614 (CGS_like)

181D

substrate-cofactor binding pocket
82S, 83G, 84I, 108Y, 151E, 181D, 203S, 205T, 206K, 215I
CDD
cd00614 (CGS_like)

203S

substrate-cofactor binding pocket
82S, 83G, 84I, 108Y, 151E, 181D, 203S, 205T, 206K, 215I
CDD
cd00614 (CGS_like)

205T

substrate-cofactor binding pocket
82S, 83G, 84I, 108Y, 151E, 181D, 203S, 205T, 206K, 215I
CDD
cd00614 (CGS_like)

206K

substrate-cofactor binding pocket
82S, 83G, 84I, 108Y, 151E, 181D, 203S, 205T, 206K, 215I
CDD
cd00614 (CGS_like)

215I

substrate-cofactor binding pocket
82S, 83G, 84I, 108Y, 151E, 181D, 203S, 205T, 206K, 215I
CDD
cd00614 (CGS_like)
catalytic residue ...

206K

catalytic residue
206K
CDD
cd00614 (CGS_like)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003824 catalytic activity
GO:0018826 methionine gamma-lyase activity
GO:0030170 pyridoxal phosphate binding

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

9817_FusoPortal_Gene_845

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component